α-secretase in Alzheimer's disease and beyond: Mechanistic, regulation and function in the shedding of membrane proteins

Current Alzheimer Research

Volumn 9, Issue 2, 2012, Pages 140-156

  Vincent, Bruno ^a,b   Checler, Frédéric ^a  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Alzheimer; Disintegrin; Metabolism; Metalloprotease; Regulation; Transmembrane proteins

Indexed keywords

ADAM10 ENDOPEPTIDASE; ADAM15 PROTEIN; ADAM9 PROTEIN; ALPHA SECRETASE; BETA SECRETASE 1; EPHRIN; G PROTEIN COUPLED RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEMBRANE PROTEIN; METALLOPROTEINASE; NONSTEROID ANTIINFLAMMATORY AGENT; PRESENILIN; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEOPLASM; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TESTOSTERONE BLOOD LEVEL;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; HUMANS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 84857704802     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720512799361646     Document Type: Review

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