Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules

Combinatorial Chemistry and High Throughput Screening

Volumn 8, Issue 2, 2005, Pages 161-171

  Ludwig, Andreas ^a   Hundhausen, Christian ^a   Lambert, Millard H ^b   Broadway, Neil ^c   Andrews, Robert C ^d   Bickett, D Mark ^b   Leesnitzer, M Anthony ^b   Becherer, J David ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b GLAXOSMITHKLINE   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d Transtech Pharma   (United States)

Author keywords

ADAM10; ADAM17; Hydroxamate inhibitors; Interleukin 6; Metalloproteinase; Shedding; Transmembrane chemokines

Indexed keywords

(2,3) 3 (FORMYL HYDROXYAMINO) 2 (2 METHYL 1 PROPYL) HEXANOIC ACID [(1) 2,2 DIMETHYL 1 METHYLCARBAMOYLAMINO 1 (1,3 THIAZOL 2 YLCARBAMOYL) 1 PENTYL] AMIDE; (2,3) 3 (FORMYL HYDROXYAMINO) 2 (3 PHENYL 1 PROPYL) BUTANOIC ACID [(1) 2,2 DIMETHYL 1 METHYLCARBAMOY 1 PROPYL] AMIDE; DISINTEGRIN; GW254023X; GW280264X; METALLOPROTEINASE; METALLOPROTEINASE ADAM 10; METALLOPROTEINASE INHIBITOR; PHORBOL ESTER; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

CELL SURFACE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MODEL; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; CELLS, CULTURED; CHEMOKINES; CHEMOKINES, CX3C; CHEMOKINES, CXC; DRUG INTERACTIONS; ENDOPEPTIDASES; HYDROXAMIC ACIDS; INTERLEUKIN-6; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; PHORBOL ESTERS; PROTEASE INHIBITORS;

EID: 15244349837     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/1386207053258488     Document Type: Review

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