Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)

Journal of Biological Chemistry

Volumn 280, Issue 34, 2005, Pages 30113-30119

  Lambert, Daniel W ^a   Yarski, Mike ^b   Warner, Fiona J ^b   Thornhill, Paul ^a   Parkin, Edward T ^a   Smith, A Ian ^b   Hooper, Nigel M ^a   Turner, Anthony J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARDIOVASCULAR SYSTEM; CELL MEMBRANES; DISEASES; ENZYMES; ESTERS; PHYSIOLOGY; PROTEINS; VIRUSES;

FACTOR-Α CONVERTASE (ADAM17); N-TERMINAL DOMAINS; SEVERE-SCUTE RESPIRATORY SYNDROME (SARS); TUMOR NECROSIS;

TUMORS;

ANGIOTENSIN CONVERTING ENZYME 2; CELL RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; DOUBLE STRANDED RNA; MEMBRANE PROTEIN; METALLOPROTEINASE; PHORBOL ESTER; PROTEINASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG; VIRUS RECEPTOR; VIRUS SPIKE PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN; CELL STRAIN HEK293; CELL STRAIN HUH7; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING; REGULATORY MECHANISM; SARS CORONAVIRUS; VIRUS ADSORPTION; VIRUS SHEDDING;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CARBOXYPEPTIDASES; CELL LINE; CYTOPLASM; DISINTEGRINS; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; HUMANS; IMMUNOBLOTTING; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; PEPTIDE HYDROLASES; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; PHORBOL ESTERS; PLASMIDS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RNA; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; SARS VIRUS; TIME FACTORS; TRANSFECTION;

CORONAVIRUS; SARS COV;

EID: 24044444558     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505111200     Document Type: Article

References (40)

1. Erdos, E. G. (1975) Circ. Res. 36, 247-255
2. Ehlers, M. R. W., and Riordan, J. F. (1989) Biochemistry 28, 5311-5318
3. Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E., Christie, G., and Turner, A. J. (2000) J. Biol. Chem. 275, 33238-33243
4. Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Woolf, B., Robison, K., Jeyaseelan, R., Breitbart, R. E., and Acton, S. (2000) Circ. Res. 87, e1-e9
5. Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., Scholey, J., Ferrario, C. M., Manoukian, A. S., Chappell, M. C., Backx, P. H., Yagil, Y., and Penninger, J. M. (2002) Nature 417, 822-828
6. Zisman, L. S., Keller, R. S., Weaver, B., Lin, Q., Speth, R., Bristow, M. R., and Canver, C. C. (2003) Circulation 108, 1707-1712
7. Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., Choe, H., and Farzan, M. (2003) Nature 426, 450-454
8. Wang, P., Chen, J., Zheng, A., Nie, Y., Shi, X., Wang, W., Wang, G., Luo, M., Liu, H., Tan, T., Song, X., Wang, Z., Yin, X., Qu, X., Wang, X., Qing, T., Ding, M., and Deng, H. (2004) Biochem. Biophys. Res. Comm. 315, 439-444
9. Eriksson, U., Danilczyk, U., and Penninger, M. P. (2002) Curr. Biol. 12, R745-R752
10. Hamming, I., Timens, W., Bulthuis, M. L., Lely, A. T., Navis, G. J., and van Goor, H. (2004) J. Pathol. 203, 631-637
11. Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., Nelson, N., Boiani, N., Schooley, K. A., Gerhart, M., Davis, R., Fitzner, J. N., Johnson, R. S., Paxton, R. J., March, C. J., and Cerretti, D. P. (1997) Nature 385, 729-733
12. Hundhausen, C., Misztela, D., Berkhout, T. A., Broadway, N., Saftig, P., Reiss, K., Hartmann, D., Fahrenholz, F., Postina, R., Matthews, V., Kallen, K-J., Rose-John, S., and Ludwig, A. (2003) Blood 102, 1186-1195
13. Beldent, V., Michaud, A., Wei, L., Chauvet, M., and Corvol, P. (1993) J. Biol. Chem. 268, 26428-26433
14. Hussain, I., Hawkins, J., Shikotra, A., Riddell, D. R., Faller, A., and Dingwall, C. (2003) J. Biol. Chem. 278, 36264-36268
15. Palecanda, A., Walcheck, B., Bishop, D. K., and Jutila, M. A. (1992) Eur. J. Immunol. 22, 1279-1286
16. Arribas, J., and Massagué, J. (1995) J. Cell Biol. 128, 433-441
17. Parkin, E. T., Watt, N. T., Turner, A. J., and Hooper, N. M. (2004) J. Biol. Chem. 279, 11170-11178
18. Bosenberg, M. W., Pandiella, A., and Massagué, J. (1993) J. Cell Biol. 122, 95-101
19. Hirata, M., Umata, T., Takahashi, T., Ohnuma, M., Miura, Y., Iwamoto, R., and Mekada, E. (2001) Biochem. Biophys. Res. Comm. 283, 915-922
20. Arribas, J., and Borroto, A. (2002) Chem. Rev. 102, 4627-4638
21. Garton, K. J., Gough, P. J., Philalay, J., Wille, P. T., Blobel, C. P., Whitehead, R. H., Dempsey, P. J., and Raines, E. W. (2003) J. Biol. Chem. 278, 37459-37464
22. Wang, X., He, K., Gerhart, M., Huang, Y., Jiang, J., Paxton, R. J., Yang, S., Lu, C., Menon, R. K., Black, R. A., Baumann, G., and Frank, S. J. (2002) J. Biol. Chem. 277, 50510-50519
23. Peschon, J. J., Slack, J. L., Reddy, P., Stocking, K. L., Sunnarborg, S. W., Lee, D. C., Russell, W. E., Castner, B. J., Johnson, R. S., Fitzner, J. N., Boyce, R. W., Nelson, N., Kozlosky, C. J., Wolfson, M. F., Rauch, C. T., Cerretti, D. P., Paxton, R. J., March, C. J., and Black, R. A. (1998) Science 282, 1281-1284
24. Koike, H., Tomioka, S., Sorimachi, H., Saido, T. C., Maruyama, K., Okuyama, A., Fujisawa-Sehara, A., Ohno, S., Suzuki, K., and Ishiura, S. (1999) Biochem. J. 343, 371-375
25. Rosendahl, M. S., Ko, S. C., Long, D. L., Brewer, M. T., Rosenzweig, B., Hedl, E., Andersen, L., Pyle, S. M., Moreland, J., Meyers, M. A., Kohno, T., Lyons, D., and Lichenstein, H. S. (1997) J. Biol. Chem. 272, 24588-24593
26. Gough, P. J., Garton, K. J., Wille, P. T., Rychlewski, M., Dempsey, P. J., and Raines, E. (2004) J. Immunol. 172, 3678-3685
27. Asakura, M., Kitakaze, M., Takashima, S., Liao, Y., Ishikura, F., Yoshinaka, T., Ohmoto, H., Node, K., Yoshino, K., Ishiguro, H., Asanuma, H., Sanada, S., Matsumura, Y., Takeda, H., Beppu, S., Tada, M., Hori, M., and Higashiyama, S. (2002) Nat. Med. 8, 35-40
28. Lee, M-H., Verma, V., Maskos, K., Nath, D., Knauper, V., Dodds, P., Amour, A., and Murphy, G. (2002) Biochem. J. 364, 227-234
29. Amour, A., Slocombe, P. M., Webster, A., Butler, M., Knight, C. G., Smith, B. J., Stephens, P. E., Shelley, C., Hutton, M., Knauper, V., Docherty, A. J. P., and Murphy, G. (1998) FEBS Lett. 435, 39-44
30. Amour, A., Knight, C. G., Webster, A., Slocombe, P. M., Stephens, P. E., Knauper, V., Docherty, A. J. P., and Murphy, G. (2000) FEBS Lett. 473, 275-279
31. Gillim-Ross, L., Taylor, J., Scholl, D.R., Ridenour, J., Masters, P. S., and Wentworth, D. E. (2004) J. Clin. Microbiol. 42, 3196-3206
32. Amour, A., Knight, C. G., English, W. R., Webster, A., Slocombe, P. M., Knauper, V., Docherty, A. J. P., Becherer, J. D., Blobel, C. P., and Murphy, G. (2002) FEBS Lett. 524, 154-158
33. Parvathy, S., Hussain, I., Karran, E., Turner, A. J., and Hooper, N. M. (1998) Biochemistry 37, 1680-1685
34. Allinson, T. M. J., Parkin, E. T., Condon, T. P., Schwager, S. L. U., Sturrock, E. D., Turner, A. J., and Hooper, N. M. (2004) Eur. J. Biochem. 271, 2539-2547
35. Sadhukhan, R., Santhamma, K. R., Reddy, P., Peschon, J. J., Black, R. A., and Sen. I. (1999) J. Biol. Chem. 274, 10511-10516
36. Ehlers, M. R. W., Schwager, S. L. U., Scholle, R. R., Manji, G. A., Brandt, W. F., and Riordan, J. F. (1996) Biochemistry 35, 9549-9559
37. Woodman, Z. L., Schwager, S. L. U., Redelinghuys, P., Carmona, A. K., Ehlers, M. R. W., and Sturrock, E. D. (2005) Biochem. J., in press
38. Pang, S., Chubb, A. J., Schwager, S. L. U., Ehlers, M. R. W., Sturrock, E. D., and Hooper, N. M. (2001) Biochem. J. 358, 185-192
39. Donoghue, M., Wakimoto, H., Maguire, C. T., Acton, S., Hales, P., Stagliano, N., Fairchild-Huntress, V., Xu, J., Lorenz, J. N., Kadambi, V., Berul, C. I., and Breitbart, R. E. (2003) J. Mol. Cell. Cardiol. 35, 1043-1053
40. Brosnihan, K. B., Neves, L. A. A., Joyner, J., Averill, D. B., Chappell, M. C., Sarao, R., Penninger, J., and Ferrario, C. M. (2003) Hypertension 42, 749-753