Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for γ-secretase

Journal of Biological Chemistry

Volumn 284, Issue 4, 2009, Pages 2296-2306

  Kummer, Markus P ^a,c   Maruyama, Hiroko ^a   Huelsmann, Claudia ^c   Baches, Sandra ^b   Weggen, Sascha ^b   Koo, Edward H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINES; AMINO ACIDS; BLOOD VESSELS; CELL MEMBRANES; ENZYME ACTIVITY; NUCLEIC ACIDS; ORGANIC ACIDS; PORT TERMINALS; RNA;

ALZHEIMER; AMYLOIDOGENESIS; C-TERMINAL FRAGMENTS; CLEAVAGE SITES; ECTODOMAIN; HUNTINGTON DISEASE; INTRACELLULAR DOMAINS; MELANIN PIGMENTS; METALLOPROTEINASE; METALLOPROTEINASES; NOTCH RECEPTORS; SECRETASE; SECRETASE COMPLEXES; TRANS-MEMBRANE DOMAINS;

GLYCOPROTEINS;

ADAM PROTEIN; AMYLOID; GAMMA SECRETASE; GLYCOPROTEIN GP 100; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; NOTCH RECEPTOR; PHORBOL ESTER; PROTEIN ADAM10; SERINE PROTEINASE; SMALL INTERFERING RNA; TAPI 2 ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME RELEASE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; AMYLOID; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; HUMANS; MEMBRANE GLYCOPROTEINS; METALLOPROTEASES; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PHORBOL ESTERS; PROTEASE INHIBITORS; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY;

EID: 59049094283     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808904200     Document Type: Article

References (48)

1. Slominski, A., Tobin, D. J., Shibahara, S., and Wortsman, J. (2004) Physiol. Rev. 84, 1155-1228
2. Berson, J. F., Harper, D. C., Tenza, D., Raposo, G., and Marks, M. S. (2001) Mol. Biol. Cell 12, 3451-3464
3. Berson, J. F., Theos, A. C., Harper, D. C., Tenza, D., Raposo, G., and Marks, M. S. (2003) J. Cell Biol. 161, 521-533
4. Theos, A. C., Truschel, S. T., Raposo, G., and Marks, M. S. (2005) Pigment Cell Res. 18, 322-336
5. Brunberg, E., Andersson, L., Cothran, G., Sandberg, K., Mikko, S., and Lindgren, G. (2006) BMC Genet. 7, 46
6. Kwon, B. S., Halaban, R., Ponnazhagan, S., Kim, K., Chintamaneni, C., Bennett, D., and Pickard, R. T. (1995) Nucleic Acids Res. 23, 154-158
7. Spanakis, E., Lamina, P., and Bennett, D. C. (1992) Development 114, 675-680
8. Hoashi, T., Muller, J., Vieira, W. D., Rouzaud, F., Kikuchi, K., Tamaki, K., and Hearing, V. J. (2006) J. Biol. Chem. 281, 21198-21208
9. Adema, G. J., de Boer, A. J., Vogel, A. M., Loenen, W. A., and Figdor, C. G. (1994) J. Biol. Chem. 269, 20126-20133
10. Nichols, S. E., Harper, D. C., Berson, J. F., and Marks, M. S. (2003) J. Investig. Dermatol. 121, 821-830
11. Fowler, D. M., Koulov, A. V., Alory-Jost, C., Marks, M. S., Balch, W. E., and Kelly, J. W. (2005) PLoS Biol. 4, e6
12. Chiamenti, A. M., Vella, F., Bonetti, F., Pea, M., Ferrari, S., Martignoni, G., Benedetti, A., and Suzuki, H. (1996) Melanoma Res. 6, 291-298
13. Hoashi, T., Watabe, H., Muller, J., Yamaguchi, Y., Vieira, W. D., and Hearing, V. J. (2005) J. Biol. Chem. 280, 14006-14016
14. Yasumoto, K., Watabe, H., Valencia, J. C., Kushimoto, T., Kobayashi, T., Appella, E., and Hearing, V. J. (2004) J. Biol. Chem. 279, 28330-28338
15. De Strooper, B. (2003) Neuron 38, 9-12
16. Wang, R., Tang, P., Wang, P., Boissy, R. E., and Zheng, H. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 353-358
17. Edbauer, D., Winkler, E., Haass, C., and Steiner, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8666-8671
18. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
19. Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A., Tian, X., Pan, D. J., Ray, W. J., and Kopan, R. (2000) Mol. Cell 5, 197-206
20. Kushimoto, T., Basrur, V., Valencia, J., Matsunaga, J., Vieira, W. D., Ferrans, V. J., Muller, J., Appella, E., and Hearing, V. J. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10698-10703
21. Raposo, G., Tenza, D., Murphy, D. M., Berson, J. F., and Marks, M. S. (2001) J. Cell Biol. 152, 809-824
22. Brunkan, A. L., and Goate, A. M. (2005) J. Neurochem. 93, 769-792
23. Cupers, P., Orlans, I., Craessaerts, K., Annaert, W., and De Strooper, B. (2001) J. Neurochem. 78, 1168-1178
24. Edbauer, D., Willem, M., Lammich, S., Steiner, H., and Haass, C. (2002) J. Biol. Chem. 277, 13389-13393
25. Cheng, Q. C., Tikhomirov, O., Zhou, W., and Carpenter, G. (2003) J. Biol. Chem. 278, 38421-38427
26. Anderson, J. P., Esch, F. S., Keim, P. S., Sambamurti, K., Lieberburg, I., and Robakis, N. K. (1991) Neurosci. Lett. 128, 126-128
27. Brown, M. S., Ye, J., Rawson, R. B., and Goldstein, J. L. (2000) Cell 100, 391-398
28. Huovila, A. P., Turner, A. J., Pelto-Huikko, M., Karkkainen, I., and Ortiz, R. M. (2005) Trends Biochem. Sci. 30, 413-422
29. Kang, T., Zhao, Y. G., Pei, D., Sucic, J. F., and Sang, Q. X. (2002) J. Biol. Chem. 277, 25583-25591
30. Srour, N., Lebel, A., McMahon, S., Fournier, I., Fugere, M., Day, R., and Dubois, C. M. (2003) FEBS Lett. 554, 275-283
31. Koo, B. H., Longpre, J. M., Somerville, R. P., Alexander, J. P., Leduc, R., and Apte, S. S. (2006) J. Biol. Chem. 281, 12485-12494
32. Yang, H. Q., Pan, J., Ba, M. W., Sun, Z. K., Ma, G. Z., Lu, G. Q., Xiao, Q., and Chen, S. D. (2007) Eur. J. Neurosci. 26, 381-391
33. Hwang, E. M., Kim, S. K., Sohn, J. H., Lee, J. Y., Kim, Y., Kim, Y. S., and Mook-Jung, I. (2006) Biochem. Biophys. Res. Commun. 349, 654-659
34. Osenkowski, P., Toth, M., and Fridman, R. (2004) J. Cell. Physiol. 200, 2-10
35. Chi, A., Valencia, J. C., Hu, Z. Z., Watabe, H., Yamaguchi, H., Mangini, N. J., Huang, H., Canfield, V. A., Cheng, K. C., Yang, F., Abe, R., Yamagishi, S., Shabanowitz, J., Hearing, V. J., Wu, C., Appella, E., and Hunt, D. F. (2006) J. Proteome Res. 5, 3135-3144
36. Hikita, A., Yana, I., Wakeyama, H., Nakamura, M., Kadono, Y., Oshima, Y., Nakamura, K., Seiki, M., and Tanaka, S. (2006) J. Biol. Chem. 281, 36846-36855
37. Maresh, G. A., Wang, W. C., Beam, K. S., Malacko, A. R., Hellstrom, I., Hellstrom, K. E., and Marquardt, H. (1994) Arch. Biochem. Biophys. 311, 95-102
38. Rio, C., Buxbaum, J. D., Peschon, J. J., and Corfas, G. (2000) J. Biol. Chem. 275, 10379-10387
39. Hinkle, C. L., Sunnarborg, S. W., Loiselle, D., Parker, C. E., Stevenson, M., Russell, W. E., and Lee, D. C. (2004) J. Biol. Chem. 279, 24179-24188
40. Canet-Aviles, R. M., Anderton, M., Hooper, N. M., Turner, A. J., and Vaughan, P. F. (2002) Brain Res. Mol. Brain Res. 102, 62-72
41. LaVoie, M. J., and Selkoe, D. J. (2003) J. Biol. Chem. 278, 34427-34437
42. Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., Nelson, N., Boiani, N., Schooley, K. A., Gerhart, M., Davis, R., Fitzner, J. N., Johnson, R. S., Paxton, R. J., March, C. J., and Cerretti, D. P. (1997) Nature 385, 729-733
43. Hu, D. N., McCormick, S. A., Orlow, S. J., Rosemblat, S., and Lin, A. Y. (1997) Exp. Eye Res. 64, 397-404
44. Schroeter, E. H., Kisslinger, J. A., and Kopan, R. (1998) Nature 393, 382-386
45. Hebert, S. S., Serneels, L., Tolia, A., Craessaerts, K., Derks, C., Filippov, M. A., Muller, U., and De Strooper, B. (2006) EMBO Rep. 7, 739-745
46. Kopan, R., and Ilagan, M. X. (2004) Nat. Rev. Mol. Cell. Biol. 5, 499-504
47. Page, L. J., Suk, J. Y., Huff, M. E., Lim, H. J., Venable, J., Yates, J., Kelly, J. W., and Balch, W. E. (2005) EMBO J. 24, 4124-4132
48. Chen, C. D., Huff, M. E., Matteson, J., Page, L., Phillips, R., Kelly, J. W., and Balch, W. E. (2001) EMBO J. 20, 6277-6287