Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases

Blood

Volumn 113, Issue 19, 2009, Pages 4799-4809

  Koenen, Rory R ^a   Pruessmeyer, Jessica ^a   Soehnlein, Oliver ^a,b   Fraemohs, Line ^a   Zernecke, Alma ^a   Schwarz, Nicole ^a   Reiss, Karina ^c   Sarabi, Alisina ^a   Lindbom, Lennart ^b   Hackeng, Tilman M ^d   Weber, Christian ^a,d   Ludwig, Andreas ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF KIEL   (Germany)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; CYTOKINE; GAMMA INTERFERON; JUNCTIONAL ADHESION MOLECULE A; METALLOPROTEINASE INHIBITOR; PROTEIN ADAM10; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; ADAM10 PROTEIN, MOUSE; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; F11R PROTEIN, MOUSE; IMMUNOGLOBULIN; JUNCTIONAL ADHESION MOLECULE A , HUMAN; JUNCTIONAL ADHESION MOLECULE-A , HUMAN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEINASE INHIBITOR; SECRETASE; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ANIMAL EXPERIMENT; AORTA; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CELL MIGRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANIMAL EMBRYO; BLADDER TUMOR; C57BL MOUSE; CELL ADHESION; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENETICS; KIDNEY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AORTA; BLOTTING, WESTERN; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; CYTOKINES; EMBRYO, MAMMALIAN; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULINS; KIDNEY; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PROTEASE INHIBITORS; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UMBILICAL VEINS; URINARY BLADDER NEOPLASMS;

EID: 66549086638     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-04-152330     Document Type: Article

References (38)

1. Weber C, Fraemohs L, Dejana E. The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol. 2007;7:467-477. (Pubitemid 46834851)
2. Nourshargh S, Krombach F, Dejana E. The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues. J Leukoc Biol. 2006;80:714-718. (Pubitemid 44835886)
3. Bradfield PF, Nourshargh S, Aurrand-Lions M, Imhof BA. JAM family and related proteins in leukocyte migration (Vestweber series). Arterioscler Thromb Vasc Biol. 2007;27:2104-2112. (Pubitemid 350287237)
4. Mandell KJ, Holley GP, Parkos CA, Edelhauser HF. Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling. Invest Ophthalmol Vis Sci. 2006;47:2408-2416.
5. Aurrand-Lions M, Duncan L, Ballestrem C, Imhof BA. JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells. J Biol Chem. 2001;276:2733-2741. (Pubitemid 37376652)
6. Cooke VG, Naik MU, Naik UP. Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient mice. Arterioscler Thromb Vasc Biol. 2006;26:2005-2011.
7. Naik MU, Naik UP. Junctional adhesion molecule-A-induced endothelial cell migration on vitronectin is integrin alpha v beta 3 specific. J Cell Sci. 2006;119:490-499.
8. Woodfin A, Reichel CA, Khandoga A, et al. JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood. 2007;110:1848-1856. (Pubitemid 47443896)
9. Khandoga A, Kessler JS, Meissner H, et al. Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration. Blood. 2005;106:725-733. (Pubitemid 40981273)
10. Corada M, Chimenti S, Cera MR, et al. Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2005;102:10634-10639.
11. Ozaki H, Ishii K, Horiuchi H, et al. Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol. 1999;163:553-557. (Pubitemid 29328054)
12. Ostermann G, Weber KS, Zernecke A, Schroder A, Weber C. JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol. 2002;3:151-158.
13. Garton KJ, Gough PJ, Raines EW. Emerging roles for ectodomain shedding in the regulation of inflammatory responses. J Leukoc Biol. 2006;79:1105-1116.
14. Pruessmeyer J, Ludwig A. The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer. Semin Cell Dev Biol. 2009;20:164-174.
15. Ludwig A, Weber C. Transmembrane chemokines: versatile "special agents" in vascular inflammation. Thromb Haemost. 2007;97:694-703.
16. Reiss K, Ludwig A, Saftig P. Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion. Pharmacol Ther. 2006;111:985-1006. (Pubitemid 44118440)
17. Garton KJ, Gough PJ, Blobel CP, et al. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem. 2001;276:37993-38001. (Pubitemid 37384050)
18. Garton KJ, Gough PJ, Philalay J, et al. Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17). J Biol Chem. 2003;278:37459-37464. (Pubitemid 37175266)
19. Hundhausen C, Misztela D, Berkhout TA, et al. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood. 2003;102:1186-1195. (Pubitemid 36988021)
20. Peschon JJ, Slack JL, Reddy P, et al. An essential role for ectodomain shedding in mammalian development. Science. 1998;282:1281-1284. (Pubitemid 28524483)
21. Abel S, Hundhausen C, Mentlein R, et al. The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J Immunol. 2004;172:6362-6372. (Pubitemid 38621245)
22. Schulte A, Schulz B, Andrzejewski MG, et al. Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases. Biochem Biophys Res Commun. 2007;358:233-240. (Pubitemid 46719108)
23. Gough PJ, Garton KJ, Wille PT, et al. A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. J Immunol. 2004;172:3678-3685.
24. Hundhausen C, Schulte A, Schulz B, et al. Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes. J Immunol. 2007;178:8064-8072. (Pubitemid 46898078)
25. Ostermann G, Fraemohs L, Baltus T, et al. Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A. Arterioscler Thromb Vasc Biol. 2005;25:729-735. (Pubitemid 40463861)
26. Ludwig A, Hundhausen C, Lambert MH, et al. Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol esterinducible shedding of cell surface molecules. Comb Chem High Throughput Screen. 2005;8:161-171. (Pubitemid 40388743)
27. Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997;385:729-733. (Pubitemid 27098094)
28. Hartmann D, de Strooper B, Serneels L, et al. The disintegrin/ metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet. 2002;11:2615-2624. (Pubitemid 35174691)
29. Scholz F, Schulte A, Adamski F, et al. Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin. J Invest Dermatol. 2007;127:1444-1455. (Pubitemid 46763000)
30. Liehn EA, Schober A, Weber C. Blockade of keratinocyte- derived chemokine inhibits endothelial recovery and enhances plaque formation after arterial injury in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2004;24:1891-1896. (Pubitemid 39350309)
31. Cera MR, Del Prete A, Vecchi A, et al. Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice. J Clin Invest. 2004;114:729-738. (Pubitemid 39578763)
32. Soehnlein O, Zernecke A, Eriksson EE, et al. Neutrophil secretion products pave the way for inflammatory monocytes. Blood. 2008;112:1461-1471.
33. Schulz B, Pruessmeyer J, Maretzky T, et al. ADAM10 regulates endothelial permeability and T-cell transmigration by proteolysis of vascular endothelial cadherin. Circ Res. 2008;102:1192-1201.
34. Martinez-Estrada OM, Manzi L, Tonetti P, Dejana E, Bazzoni G. Opposite effects of tumor necrosis factor and soluble fibronectin on junctional adhesion molecule-A in endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2005;288:L1081-L1088. (Pubitemid 40695433)
35. Cavusoglu E, Kornecki E, Sobocka MB, et al. Association of plasma levels of F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) with human atherosclerosis. J Am Coll Cardiol. 2007;50:1768-1776.
36. Laukoetter MG, Nava P, Lee WY, et al. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med. 2007;204:3067-3076.
37. Wojcikiewicz EP, Koenen RR, Fraemohs L, et al. LFA-1 binding destabilizes the JAM-A homophilic interaction during leukocyte transmigration. Biophys J. 2009;96:285-293.
38. Prota AE, Campbell JA, Schelling P, et al. Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding. Proc Natl Acad Sci U S A. 2003;100:5366-5371. (Pubitemid 36542711)