Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins

Journal of Cell Biology

Volumn 155, Issue 3, 2001, Pages 661-673

  Mechtersheimer, Sabine ^a   Gutwein, Paul ^a   Agmon Levin, Nancy ^a   Stoeck, Alexander ^a   Oleszewski, Matthias ^a   Riedle, Svenja ^a   Postina, Rolf ^d   Fahrenholz, Falk ^d   Fogel, Mina ^b   Lemmon, Vance ^c   Altevogt, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b KAPLAN HOSPITAL   (Israel)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

ADAM10; Cell migration; Integrins; L1; Shedding

Indexed keywords

CELL ADHESION MOLECULE; DISINTEGRIN; METALLOPROTEINASE;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BRAIN DEVELOPMENT; CELL MIGRATION; CHO CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NERVOUS SYSTEM; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECRETION; TUMOR;

ANIMALIA;

EID: 0035969235     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Notch signaling: Cell fate control and signal integration in development
2. Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule
3. ADAMs: Focus on the protease domain
4. Remarkable roles of proteolysis on and beyond the cell surface
5. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
6. Neural cell recognition molecule L1: From cell biology to human hereditary brain malformations
7. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin
8. Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities
9. The cell adhesion molecule L1 is developmentally regulated in the renal epithelium and is involved in kidney branching morphogenesis
10. A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth
11. CAMs and axonal growth: A critical evaluation of the role of calcium and the MAPK cascade
12. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor
13. L1 adhesion molecule on human lymphocytes and monocytes: Expression and involvement in binding to alpha v beta 3 integrin
14. A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins
15. Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes memorial award lecture
16. Regulation of cell migration by the integrin beta subunit ectodomain
17. Function of an axonal chemoattractant modulated by metalloprotease activity
18. The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading
19. Integrin signaling
20. Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells
21. Regulated cleavage of a contact-mediated axon repellent
22. The L1 family of neural cell adhesion molecules: Old proteins performing new tricks
23. Membrane protein secretases
24. Integrins: Versatility, modulation, and signaling in cell adhesion
25. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
26. Gene expression of neural cell adhesion molecule L1 in malignant gliomas and biological significance of L1 in glioma invasion
27. Neural cell adhesion molecule L1: Signaling pathways and growth cone motility
28. Expression of neural cell adhesion molecule L1 in human lung cancer cell lines
29. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin
30. Expression and function of the neural cell adhesion molecule L1 in mouse leukocytes
31. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
32. Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts
33. Hydroxamate-type matrix metallopro-teinase inhibitor batimastat promotes liver metastasis
34. Plasminogen activator release at the neuronal growth cone
35. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metallo-protease
36. Expression of the neural axon adhesion molecule L1 in the developing and adult rat brain
37. Differential expression of cell adhesion molecules in variants of K1735 melanoma cells differing in metastatic capacity
38. Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secrerase ADAM10 in mouse and human brain
39. Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin αvβ3
40. A ligand-induced extracellular cleavage regulates gamma-secrerase-like proteolytic activation of Notchl
41. Shedding of c-Met is regulated by crossralk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive meralloproreinase
42. A potential role for the plasmin(ogen) system in the posttranslational cleavage of the neural cell adhesion molecule L1
43. A novel model of glioma cell invasion using organotypic brain slice culture
44. Integrin and neurocan binding to L1 involves distinct Ig domains
45. Characterization of the L1-neurocan-binding site. Implications for L1-L1 homophilic binding
46. Expression and regulation of the neural cell adhesion molecule L1 on human cells of myelomonocytic and lymphoid origin
47. The 200/220 kD antigen recognized by monoclonal antibody (MAb) UJ127.11 on neural tissues and tumors is the human L1 adhesion molecule
48. An essential role for ectodomain shedding in mammalian development
49. The cell biology of the plasminogen system
50. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
51. Variants of human L1 cell adhesion molecule arise through alternate splicing of RNA
52. Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis
53. The L1 adhesion molecule is a cellular ligand for VLA-5
54. Biochemical characterization of different molecular forms of the neural cell adhesion molecule L1
55. Neural recognition molecules and synaptic plasticity
56. Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
57. Signaling networks linking integrins and rho family GTPases
58. Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene
59. FAK integrates growth-factor and integrin signals to promote cell migration
60. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment
61. Regulated shedding ofsyndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation
62. Enhancement of neurite outgrowth by the soluble form of human L1 (neural cell adhesion molecule)
63. The molecular biology of axon guidance
64. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing
65. Role for ADAM-family proteinases as membrane protein secretases
66. The Arg-Gly-Asp motif in the cell adhesion molecule L1 promotes neurite outgrowth via interaction with the alphavbeta3 integrin