The α-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo

Journal of Biological Chemistry

Volumn 284, Issue 51, 2009, Pages 35973-35986

  Guillot Sestier, Marie Victoire ^a   Sunyach, Claire ^a,b   Druon, Charlotte ^a   Scarzello, Sabine ^a   Checler, Frédéric ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b Turing Center for Living Systems CENTURI Aix Marseille University   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ACTIVITIES; CASPASE-3 ACTIVATION; CELL SURVIVAL; CELLULAR PRION; CELLULAR PRION PROTEINS; CLEAVAGE PRODUCTS; ELECTRORETINOGRAMS; END-LABELING; IN-VITRO; IN-VIVO; INDUCED APOPTOSIS; ISCHEMIA MODEL; N-TERMINALS; PARTIAL RECOVERY; RETINAL GANGLION CELLS; SECRETASES; STAUROSPORINES; TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE;

AMINES; CELL DEATH;

MODULATION;

ALPHA SECRETASE; DNA NUCLEOTIDYLEXOTRANSFERASE; PEPTIDE FRAGMENT; PRION PROTEIN; PROTEIN P53; URIDINE TRIPHOSPHATE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B WAVE; BIOTINYLATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; ELECTRORETINOGRAPHY; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; RETINA ISCHEMIA;

ANIMALS; APOPTOSIS; CASPASE 3; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; MICE; PRPC PROTEINS; RATS; RECOMBINANT PROTEINS; RETINAL GANGLION CELLS; STAUROSPORINE; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

RATTUS;

EID: 72149127389     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.051086     Document Type: Article

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