Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 3, 2000, Pages 1202-1205

  Gouras, Gunnar K ^a,b   Xu, Huaxi ^a   Gross, Rachel S ^a   Greenfield, Jeffrey P ^a   Hai, Bing ^a   Wang, Rong ^a   Greengard, Paul ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; TESTOSTERONE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ESTROGEN THERAPY; MOUSE; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CHOLESTEROL; CORTICOSTERONE; ESTRADIOL; FEMALE; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; NEURONS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SECRETORY RATE; TESTOSTERONE;

ANIMALIA;

EID: 0033950794     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.3.1202     Document Type: Article

References (19)

1. Selkoe, D. J. (1998) Trends Cell. Biol. 8, 447-453.
2. Tang, M. X., Jacobs, D., Stern, Y., Marder, K., Schofield, P., Guriand, B., Andrews, H. & Mayeux, R. (1996) Lancet 348, 429-432.
3. Kawas, C, Resnick, S., Morrison, A., Brookmeyer, R., Corrada, M., Zonderman, A., Bacal, C., Lingle, D. D. & Metter, E. (1997) Neurology 48, 1517-1521.
4. Xu, H., Gouras, G. K., Greenfield, J. P., Vincent, B., Naslund, J., Mazzarelli, L., Fried, G., Jovanovic, J. N., Seeger, M., Relkin, N. R., et al. (1998) Nat. Med. 4, 447-451.
5. Sternbach, H. (1998) Am. J. Psychiatry 155, 1310-1318
6. Winters, S. J. (1999) Arch. Fam. Med. 8, 257-263.
7. Rako, S. (1998) J. Women's Health 7, 825-829.
8. Prakasam, G., Yeh, J. K., Chen, M. M., Castro-Magana, M., Liang, C. T. & Aloia, J. F. (1999) Bone 24, 491-497.
9. Tirassa, P., Thiblin, I., Agren, G., Vigneti, E., Aloe, L. & Stenfors, C. (1997) J. Neurosci. Res. 47, 198-207.
10. Seidman, S. N. & Walsh, B. T. (1999) Am. J. Geriatr. Psychiatry 7, 8-33.
11. Gouras, G. K., Xu, H., Jovanovic, J. N., Buxbaum, J. D., Wang, R., Greengard, P., Relkin, N. R. & Gandy, S. (1998) J. Neurochem. 71, 1920-1925.
12. Bodovitz, S. & Klein, W. L. (1996) J. Biol. Chem. 271, 4436-4440.
13. Racchi, M., Baetta, R., Salvietti, N., Ianna, P., Franceschini, G., Paoletti, R., Fumagalli, R., Govoni, S., Trabucchi, M. & Soma, M. (1997) Biochem. J. 322, 893-898.
14. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C. G. & Simons, K. (1998) Proc. Natl. Acad. Sci. USA 95, 6460-6464.
15. Howland, D. S., Trusko, S. P., Savage, M. J., Reaume, A. G., Lang, D. M., Hirsch, J. D., Maeda, N., Siman, R., Greenberg, B.D., Scott, R. W., et al. (1998) J. Biol. Chem. 273, 16576-16582.
16. Mizuno, T., Haass, C., Michikawa, M. & Yanagisawa, K. (1998) Biochim. Biophys. Acta. 1373, 119-130.
17. Weiner, M. F., Vobach, S., Olsson, K., Svetlik, D. & Risser, R. C. (1997) Biol. Psychiatry 42, 1030-1038.
18. Carlson, L. E., Sherwin, B. B. & Chertkow, H. M. (1999) Horm. Behav. 35, 254-263.
19. Mizoguchi, K., Kunishita, T., Chui, D. H. & Tabira, T. (1992) Neurosci, Lett. 138, 157-160.