Proprotein convertase activity contributes to the processing of the Alzheimer's β-amyloid precursor protein in human cells: Evidence for a role of the prohormone convertase PC7 in the constitutive α-secretase pathway

Journal of Neurochemistry

Volumn 73, Issue 5, 1999, Pages 2056-2072

  Lopez Perez, Elvira ^a   Seidah, Nabil G ^b   Checler, Frédéric ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

HEK293 cells; Prohormone convertase PC7; Secretase; 1 Antitrypsin Portland; Amyloid precursor protein

Indexed keywords

ALPHA 1 ANTITRYPSIN; AMYLOID PRECURSOR PROTEIN; FURIN; PRESENILIN 1; PROTEINASE;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN SECRETION;

MAMMALIA;

EID: 0032692624     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.02056.x     Document Type: Article

References (34)

1. Ancolio K., Marambaud P., Dauch P., and Checler F. (1997) α-Secretase-derived product of β-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. J. Neurochem. 69, 2494-2499.
2. Ancolio K., Dumanchin C., Barelli H., Warter J. M., Brice A., Campion D., Frébourg T., and Checler F. (1999) Unusual phenotypic alteration of β-amyloid precursor protein (βAPP) maturation by a new Val→Met βAPP-770 mutation responsible for probable early-onset Alzheimer's disease. Proc. Natl. Acad. Sci. USA 96, 4119-4124.
3. Anderson E. D., Thomas L., Hayflick J. S., and Thomas G. (1993) Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. J. Biol. Chem. 268, 24887-24891.
4. Barelli H., Lebeau A., Vizzavona J., Delaere P., Chevallier N., Drouot C., Marambaud P., Ancolio K., Buxbaum J. D., Khorkova O., Heroux J., Sahasrabudhe S., Martinez J., Warter J.-M., Mohr M., and Checler F. (1997) Characterization of new polyclonal antibodies specific for 40 and 42 aminoacid-long amyloid β peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases. Mol. Med. 3, 695-707.
5. Benjannet S., Savaria D., Laslop A., Munzer J. S., Chrétien M., Marcinkiewicz M., and Seidah N. G. (1997) α1-Antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway. J. Biol. Chem. 272, 26210-26218.
6. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-259.
7. Buxbaum J. D., Liu K.-N., Luo Y., Slack J. L., Stocking K. L., Peschon J. J., Johnson R. S., Castner B. J., Cerretti D. P., and Black R. A. (1998) Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273, 27765-27767.
8. Checler F. (1995) Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65, 1431-1444.
9. Checler F. (1999) Presenilins: structural aspects and post-translational events. Mol. Neurobiol. (in press).
10. De Strooper B., Creemers J. W. M., Moechars D., Huylebroeck D., Van De Ven W. J. M., Van Leuven F., and Van den Berghe H. (1995) Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes. Biochim. Biophys. Acta 1246, 185-188.
11. Glenner G. G. and Wong C. W. (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890.
12. Gouras G. K., Xu H., Jovanovic J. N., Buxbaum J. D., Wang R., Greengard P., Relkin N. R., and Gandy S. (1998) Generation and regulation of β-amyloid peptide variants by neurons. J. Neurochem. 71, 1920-1925.
13. Haass C. (1996) Presenile because of presinilin: the presenilin genes and early onset Alzheimer's disease. Curr. Opin. Neurol. 9, 254-259.
14. Haass C. and Selkoe D. J. (1993) Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75, 1039-1042.
15. Haass C., Lemere C. A., Capell A., Citron M., Seubert P., Schenk D., Lannfelt L., and Selkoe D. (1995) The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway. Nat. Med. 1, 1291-1296.
16. Hardy J. (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20, 154-159.
17. Hyman B. T., Tanzi R. B., Marzloff K., Barbour R., and Schenk D. B. (1991) Kunitz protease inhibitor containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 51, 76-83.
18. Jean F., Stella K., Thomas L., Liu G., Xiang Y., Reason A. J., and Thomas G. (1998) α1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc. Natl. Acad. Sci. USA 95, 7293-7298.
19. Komano H., Seeger M., Gandy S., Wang G. T., Krafft G. A., and Fuller R. S. (1998) Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in α-secretase-type cleavage and ectodomain solubilization of human Alzheimer β-amyloid precursor protein in yeast. J. Biol. Chem. 273, 31648-31651.
20. Lammich S., Kojro E., Postina R., Gilbert S., Pfeiffer R., Jasionowski M., Haass C., and Farenholz F. (1999) Constitutive and regulated α-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. USA 96, 3922-3927.
21. Logeat F., Bessia C., Brou C., LeBail O., Jarriault S., Seidah N. G., and Israel A. (1998) The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc. Natl. Acad. Sci. USA 95, 8108-8112.
22. Marambaud P., Chevallier N., Barelli H., Wilk S., and Checler F. (1997) Proteasome contributes to the α-secretase pathway of amyloid precursor protein in human cells. J. Neurochem. 68, 698-703.
23. Marambaud P., Ancolio K., and Checler F. (1998) Protein kinase A inhibitors drastically reduce constitutive production of Aβ40 and Aβ42 by human cells expressing normal and familial Alzheimer's disease-linked mutated βAPP and presenilin1. Br. J. Pharmacol. 126, 1186-1190.
24. Masters C. L., Simons G., Weinman N. A., Multhaup G., McDonald B. L., and Beyreuther K. (1985) Amyloid plaque core protein in Alzheimer's disease and Down syndrome. Proc. Natl. Acad. Sci. USA 82, 4245-4249.
25. Maury C. P. J. (1995) Molecular pathogenesis of β-amyloidosis in Alzheimer's disease and other cerebral amyloidoses. Lab. Invest. 72, 4-16.
26. Munzer J. S., Basak A., Zhong M., Mamarbachi A., Hamelin J., Savaria D., Lazure C., Benjannet S., Chretien M., and Seidah N. G. (1997) In vitro characterization of the novel proprotein convertase PC7. J. Biol. Chem. 272, 19672-19681.
27. Sambamurti K., Shioi J., Anderson J. P., Papolla M. A., and Robakis N. (1992) Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. J. Neurosci. Res. 33, 319-329.
28. Seidah N. G., Hamelin J., Mamarbachi M., Dong W., Tadros H., Mbikay M., Chretien M., and Day R. (1996) cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexinlike proteinases. Proc. Natl. Acad. Sci. USA 93, 3388-3393.
29. Seidah N. G., Day R., Marcinkiewicz M., and Chrétien M. (1998) Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins. Ann. NY Acad. Sci. 839, 9-24.
30. Selkoe D. J. (1991) The molecular pathology of Alzheimer's disease. Neuron 6, 487-498.
31. Selkoe D. J. (1994) Normal and abnormal biology of the beta-amyloid precursor protein. Annu. Rev. Neurosci. 17, 489-517.
32. Sisodia S. (1992) β-Amyloid precursor protein cleavage by a membrane-bound protease. Proc. Natl. Acad. Sci. USA 89, 6075-6079.
33. Steiner D. F. (1998) The proprotein convertases. Curr. Opin. Chem. Biol. 2, 31-39.
34. Thinakaran G., Borchelt D. R., Lee M. K., Slunt H. H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., Hardy J., Levey A. I., Gandy S. E., Jenkins N. A., Copeland N. G., Price D. L., and Sisodia S. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190.