Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Journal of Cell Biology

Volumn 164, Issue 5, 2004, Pages 769-779

  Sahin, Umut ^a,b   Weskamp, Gisela ^a   Kelly, Kristine ^a,c   Zhou, Hong Ming ^a   Higashiyama, Shigeki ^d   Peschon, Jacques ^e   Hartmann, Dieter ^f   Saftig, Paul ^g   Blobel, Carl P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b BROWN UNIVERSITY   (United States)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

^d EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e AMGEN INC   (United States)

^f DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^g UNIVERSITY OF KIEL   (Germany)

Author keywords

ADAMs; Ectodomain shedding; EGF receptor; EGF receptor ligands; Growth factor signaling

Indexed keywords

AMPHIREGULIN; BETACELLULIN; CELL PROTEIN; DISINTEGRIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIREGULIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LIGAND; PROTEIN ADAM10; PROTEIN ADAM12; PROTEIN ADAM15; PROTEIN ADAM17; PROTEIN ADAM19; PROTEIN ADAM9; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EVALUATION; IN VIVO STUDY; INHIBITION KINETICS; KNOCKOUT MOUSE; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN SECRETION;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELLS, CULTURED; DISINTEGRINS; EMBRYO; ENDOPEPTIDASES; EPIDERMAL GROWTH FACTOR; FIBROBLASTS; GENOTYPE; GLYCOPROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; PHENYLALANINE; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; TETRADECANOYLPHORBOL ACETATE; THIOPHENES; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMALIA;

EID: 1442358746     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200307137     Document Type: Article

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