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Volumn 73, Issue 3, 2012, Pages 232-239

Nature and nurture in Foxp3 + regulatory T cell development, stability, and function

Author keywords

Cellular differentiation; Foxp3; Immune regulation; Regulatory T lymphocyte

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

EID: 84857121188     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.12.012     Document Type: Review
Times cited : (58)

References (133)
  • 1
    • 77955288962 scopus 로고    scopus 로고
    • Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation
    • Jäger A., Kuchroo V.K. Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol 2010, 72:173-184.
    • (2010) Scand J Immunol , vol.72 , pp. 173-184
    • Jäger, A.1    Kuchroo, V.K.2
  • 2
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot J.D., Rudensky A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005, 6:331-337.
    • (2005) Nat Immunol , vol.6 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 5
    • 60549115770 scopus 로고    scopus 로고
    • Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • Komatsu N., Mariotti-Ferrandiz M.E., Wang Y., Malissen B., Waldmann H., Hori S. Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A 2009, 106:1903-1908.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1903-1908
    • Komatsu, N.1    Mariotti-Ferrandiz, M.E.2    Wang, Y.3    Malissen, B.4    Waldmann, H.5    Hori, S.6
  • 6
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    • Curotto de Lafaille M.A., Lafaille J.J. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?. Immunity 2009, 30:626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 7
    • 49849094011 scopus 로고    scopus 로고
    • Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other
    • Horwitz D.A., Zheng S.G., Gray J.D. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol 2008, 29:429-435.
    • (2008) Trends Immunol , vol.29 , pp. 429-435
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3
  • 8
    • 70349247895 scopus 로고    scopus 로고
    • CD4-CD8 lineage differentiation: Thpok-ing into the nucleus
    • Wang L., Bosselut R. CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. J Immunol 2009, 183:2903-2910.
    • (2009) J Immunol , vol.183 , pp. 2903-2910
    • Wang, L.1    Bosselut, R.2
  • 9
    • 58849086223 scopus 로고    scopus 로고
    • RUNX proteins in transcription factor networks that regulate T-cell lineage choice
    • Collins A., Littman D.R., Taniuchi I. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol 2009, 9:106-115.
    • (2009) Nat Rev Immunol , vol.9 , pp. 106-115
    • Collins, A.1    Littman, D.R.2    Taniuchi, I.3
  • 10
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 12
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y., Josefowicz S.Z., Kas A., Chu T.T., Gavin M.A., Rudensky A.Y. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007, 445:936-940.
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3    Chu, T.T.4    Gavin, M.A.5    Rudensky, A.Y.6
  • 14
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y., Josefowicz S., Chaudhry A., Peng X.P., Forbush K., Rudensky A.Y. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010, 463:808-812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 15
    • 44849118564 scopus 로고    scopus 로고
    • Rethinking the molecular definition of regulatory T cells
    • Hori S. Rethinking the molecular definition of regulatory T cells. Eur J Immunol 2008, 38:928-930.
    • (2008) Eur J Immunol , vol.38 , pp. 928-930
    • Hori, S.1
  • 17
    • 70449717294 scopus 로고    scopus 로고
    • Epigenetic mechanisms of regulation of Foxp3 expression
    • Lal G., Bromberg J.S. Epigenetic mechanisms of regulation of Foxp3 expression. Blood 2009, 114:3727-3735.
    • (2009) Blood , vol.114 , pp. 3727-3735
    • Lal, G.1    Bromberg, J.S.2
  • 18
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
    • Lal G., Zhang N., van der Touw W., Ding Y., Ju W., Bottinger E.P., et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol 2009, 182:259-273.
    • (2009) J Immunol , vol.182 , pp. 259-273
    • Lal, G.1    Zhang, N.2    van der Touw, W.3    Ding, Y.4    Ju, W.5    Bottinger, E.P.6
  • 19
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp3(+) regulatory T cells is driven by the c-Rel enhanceosome
    • Ruan Q., Kameswaran V., Tone Y., Li L., Liou H.C., Greene M.I., et al. Development of Foxp3(+) regulatory T cells is driven by the c-Rel enhanceosome. Immunity 2009, 31:932-940.
    • (2009) Immunity , vol.31 , pp. 932-940
    • Ruan, Q.1    Kameswaran, V.2    Tone, Y.3    Li, L.4    Liou, H.C.5    Greene, M.I.6
  • 23
    • 77953415548 scopus 로고    scopus 로고
    • CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors
    • Lio C.W., Dodson L.F., Deppong C.M., Hsieh C.S., Green J.M. CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors. J Immunol 2010, 184:6007-6013.
    • (2010) J Immunol , vol.184 , pp. 6007-6013
    • Lio, C.W.1    Dodson, L.F.2    Deppong, C.M.3    Hsieh, C.S.4    Green, J.M.5
  • 24
    • 0035920510 scopus 로고    scopus 로고
    • Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells
    • Bensinger S.J., Bandeira A., Jordan M.S., Caton A.J., Laufer T.M. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med 2001, 194:427-438.
    • (2001) J Exp Med , vol.194 , pp. 427-438
    • Bensinger, S.J.1    Bandeira, A.2    Jordan, M.S.3    Caton, A.J.4    Laufer, T.M.5
  • 25
    • 38449091619 scopus 로고    scopus 로고
    • Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection
    • Ribot J., Enault G., Pilipenko S., Huchenq A., Calise M., Hudrisier D., et al. Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection. J Immunol 2007, 179:6741-6748.
    • (2007) J Immunol , vol.179 , pp. 6741-6748
    • Ribot, J.1    Enault, G.2    Pilipenko, S.3    Huchenq, A.4    Calise, M.5    Hudrisier, D.6
  • 29
    • 42149137398 scopus 로고    scopus 로고
    • + regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen
    • + regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen. J Immunol 2008, 180:2149-2157.
    • (2008) J Immunol , vol.180 , pp. 2149-2157
    • Larkin, J.1    Rankin, A.L.2    Picca, C.C.3    Riley, M.P.4    Jenks, S.A.5    Sant, A.J.6
  • 30
    • 47949106921 scopus 로고    scopus 로고
    • Retrogenic modeling of experimental allergic encephalomyelitis associates T cell frequency but not TCR functional affinity with pathogenicity
    • Alli R., Nguyen P., Geiger T.L. Retrogenic modeling of experimental allergic encephalomyelitis associates T cell frequency but not TCR functional affinity with pathogenicity. J Immunol 2008, 181:136-145.
    • (2008) J Immunol , vol.181 , pp. 136-145
    • Alli, R.1    Nguyen, P.2    Geiger, T.L.3
  • 32
    • 71749113619 scopus 로고    scopus 로고
    • T cell receptor CDR3 sequence but not recognition characteristics distinguish autoreactive effector and Foxp3(+) regulatory T cells
    • Liu X., Nguyen P., Liu W., Cheng C., Steeves M., Obenauer J.C., et al. T cell receptor CDR3 sequence but not recognition characteristics distinguish autoreactive effector and Foxp3(+) regulatory T cells. Immunity 2009, 31:909-920.
    • (2009) Immunity , vol.31 , pp. 909-920
    • Liu, X.1    Nguyen, P.2    Liu, W.3    Cheng, C.4    Steeves, M.5    Obenauer, J.C.6
  • 33
    • 33747099523 scopus 로고    scopus 로고
    • Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells
    • Pacholczyk R., Ignatowicz H., Kraj P., Ignatowicz L. Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity 2006, 25:249-259.
    • (2006) Immunity , vol.25 , pp. 249-259
    • Pacholczyk, R.1    Ignatowicz, H.2    Kraj, P.3    Ignatowicz, L.4
  • 34
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh C.S., Zheng Y., Liang Y., Fontenot J.D., Rudensky A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol 2006, 7:401-410.
    • (2006) Nat Immunol , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 35
    • 0037083523 scopus 로고    scopus 로고
    • Preferential recognition of self antigens despite normal thymic deletion of CD4(+)CD25(+) regulatory T cells
    • Romagnoli P., Hudrisier D., van Meerwijk J.P. Preferential recognition of self antigens despite normal thymic deletion of CD4(+)CD25(+) regulatory T cells. J Immunol 2002, 168:1644-1648.
    • (2002) J Immunol , vol.168 , pp. 1644-1648
    • Romagnoli, P.1    Hudrisier, D.2    van Meerwijk, J.P.3
  • 36
    • 60549084941 scopus 로고    scopus 로고
    • + T-cell development in a mouse expressing a transgenic TCR derived from a Treg
    • + T-cell development in a mouse expressing a transgenic TCR derived from a Treg. Eur J Immunol 2009, 39:234-240.
    • (2009) Eur J Immunol , vol.39 , pp. 234-240
    • Dipaolo, R.J.1    Shevach, E.M.2
  • 37
    • 78649722883 scopus 로고    scopus 로고
    • How specificity for self-peptides shapes the development and function of regulatory T cells
    • Simons D.M., Picca C.C., Oh S., Perng O.A., Aitken M., Erikson J., et al. How specificity for self-peptides shapes the development and function of regulatory T cells. J Leukoc Biol 2010, 88:1099-1107.
    • (2010) J Leukoc Biol , vol.88 , pp. 1099-1107
    • Simons, D.M.1    Picca, C.C.2    Oh, S.3    Perng, O.A.4    Aitken, M.5    Erikson, J.6
  • 38
    • 77955498156 scopus 로고    scopus 로고
    • Regulatory T cells: roles of T cell receptor for their development and function
    • Ohkura N., Sakaguchi S. Regulatory T cells: roles of T cell receptor for their development and function. Semin Immunopathol 2010, 32:95-106.
    • (2010) Semin Immunopathol , vol.32 , pp. 95-106
    • Ohkura, N.1    Sakaguchi, S.2
  • 39
    • 55449084935 scopus 로고    scopus 로고
    • The T-cell receptor repertoire of regulatory T cells
    • Pacholczyk R., Kern J. The T-cell receptor repertoire of regulatory T cells. Immunology 2008, 125:450-458.
    • (2008) Immunology , vol.125 , pp. 450-458
    • Pacholczyk, R.1    Kern, J.2
  • 40
    • 77958124875 scopus 로고    scopus 로고
    • Thymic selection and lineage commitment of CD4(+)Foxp3(+) regulatory T lymphocytes
    • Romagnoli P., van Meerwijk J.P. Thymic selection and lineage commitment of CD4(+)Foxp3(+) regulatory T lymphocytes. Prog Mol Biol Transl Sci 2010, 92:251-277.
    • (2010) Prog Mol Biol Transl Sci , vol.92 , pp. 251-277
    • Romagnoli, P.1    van Meerwijk, J.P.2
  • 41
    • 76249084410 scopus 로고    scopus 로고
    • Cutting edge: normal regional lymph node enrichment of antigen-specific regulatory T cells with autoimmune disease-suppressive capacity
    • Wheeler K.M., Samy E.T., Tung K.S. Cutting edge: normal regional lymph node enrichment of antigen-specific regulatory T cells with autoimmune disease-suppressive capacity. J Immunol 2009, 183:7635-7638.
    • (2009) J Immunol , vol.183 , pp. 7635-7638
    • Wheeler, K.M.1    Samy, E.T.2    Tung, K.S.3
  • 42
    • 59649118664 scopus 로고    scopus 로고
    • Antigen-specific peripheral shaping of the natural regulatory T cell population
    • Lathrop S.K., Santacruz N.A., Pham D., Luo J., Hsieh C.S. Antigen-specific peripheral shaping of the natural regulatory T cell population. J Exp Med 2008, 205:3105-3117.
    • (2008) J Exp Med , vol.205 , pp. 3105-3117
    • Lathrop, S.K.1    Santacruz, N.A.2    Pham, D.3    Luo, J.4    Hsieh, C.S.5
  • 43
    • 77958134780 scopus 로고    scopus 로고
    • Discrete TCR repertoires and CDR3 features distinguish effector and Foxp3+ regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis
    • Nguyen P., Liu W., Ma J., Manirarora J.N., Liu X., Cheng C., et al. Discrete TCR repertoires and CDR3 features distinguish effector and Foxp3+ regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis. J Immunol 2010, 185:3895-3904.
    • (2010) J Immunol , vol.185 , pp. 3895-3904
    • Nguyen, P.1    Liu, W.2    Ma, J.3    Manirarora, J.N.4    Liu, X.5    Cheng, C.6
  • 44
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    • Korn T., Reddy J., Gao W., Bettelli E., Awasthi A., Petersen T.R., et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 2007, 13:423-431.
    • (2007) Nat Med , vol.13 , pp. 423-431
    • Korn, T.1    Reddy, J.2    Gao, W.3    Bettelli, E.4    Awasthi, A.5    Petersen, T.R.6
  • 45
    • 34548680545 scopus 로고    scopus 로고
    • Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells
    • Pacholczyk R., Kern J., Singh N., Iwashima M., Kraj P., Ignatowicz L. Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity 2007, 27:493-504.
    • (2007) Immunity , vol.27 , pp. 493-504
    • Pacholczyk, R.1    Kern, J.2    Singh, N.3    Iwashima, M.4    Kraj, P.5    Ignatowicz, L.6
  • 46
    • 70350440009 scopus 로고    scopus 로고
    • TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes
    • Leung M.W., Shen S., Lafaille J.J. TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J Exp Med 2009, 206:2121-2130.
    • (2009) J Exp Med , vol.206 , pp. 2121-2130
    • Leung, M.W.1    Shen, S.2    Lafaille, J.J.3
  • 47
    • 65749120321 scopus 로고    scopus 로고
    • Intraclonal competition limits the fate determination of regulatory T cells in the thymus
    • Bautista J.L., Lio C.W., Lathrop S.K., Forbush K., Liang Y., Luo J., et al. Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat Immunol 2009, 10:610-617.
    • (2009) Nat Immunol , vol.10 , pp. 610-617
    • Bautista, J.L.1    Lio, C.W.2    Lathrop, S.K.3    Forbush, K.4    Liang, Y.5    Luo, J.6
  • 48
    • 77951897845 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus
    • Hanabuchi S., Ito T., Park W.R., Watanabe N., Shaw J.L., Roman E., et al. Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus. J Immunol 2010, 184:2999-3007.
    • (2010) J Immunol , vol.184 , pp. 2999-3007
    • Hanabuchi, S.1    Ito, T.2    Park, W.R.3    Watanabe, N.4    Shaw, J.L.5    Roman, E.6
  • 50
    • 34250216635 scopus 로고    scopus 로고
    • A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta
    • Selvaraj R.K., Geiger T.L. A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta. J Immunol 2007, 178:7667-7677.
    • (2007) J Immunol , vol.178 , pp. 7667-7677
    • Selvaraj, R.K.1    Geiger, T.L.2
  • 51
    • 33947644716 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
    • Davidson T.S., Dipaolo R.J., Andersson J., Shevach E.M. Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J Immunol 2007, 178:4022-4026.
    • (2007) J Immunol , vol.178 , pp. 4022-4026
    • Davidson, T.S.1    Dipaolo, R.J.2    Andersson, J.3    Shevach, E.M.4
  • 53
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation
    • Kim H.P., Leonard W.J. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med 2007, 204:1543-1551.
    • (2007) J Exp Med , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 54
    • 78650309487 scopus 로고    scopus 로고
    • Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3
    • Maruyama T., Li J., Vaque J.P., Konkel J.E., Wang W., Zhang B., et al. Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol 2011, 12:86-95.
    • (2011) Nat Immunol , vol.12 , pp. 86-95
    • Maruyama, T.1    Li, J.2    Vaque, J.P.3    Konkel, J.E.4    Wang, W.5    Zhang, B.6
  • 55
    • 34547788180 scopus 로고    scopus 로고
    • + DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • + DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007, 204:1757-1764.
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Cárcamo, C.V.3
  • 56
    • 38949164425 scopus 로고    scopus 로고
    • Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
    • Elias K.M., Laurence A., Davidson T.S., Stephens G., Kanno Y., Shevach E.M., et al. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 2008, 111:1013-1020.
    • (2008) Blood , vol.111 , pp. 1013-1020
    • Elias, K.M.1    Laurence, A.2    Davidson, T.S.3    Stephens, G.4    Kanno, Y.5    Shevach, E.M.6
  • 57
    • 42649095378 scopus 로고    scopus 로고
    • Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    • Quintana F.J., Basso A.S., Iglesias A.H., Korn T., Farez M.F., Bettelli E., et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008, 453:65-71.
    • (2008) Nature , vol.453 , pp. 65-71
    • Quintana, F.J.1    Basso, A.S.2    Iglesias, A.H.3    Korn, T.4    Farez, M.F.5    Bettelli, E.6
  • 58
    • 77958151145 scopus 로고    scopus 로고
    • The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    • Liu G., Yang K., Burns S., Shrestha S., Chi H. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat Immunol 2010, 11:1047-1056.
    • (2010) Nat Immunol , vol.11 , pp. 1047-1056
    • Liu, G.1    Yang, K.2    Burns, S.3    Shrestha, S.4    Chi, H.5
  • 60
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco L.M., Salinas V.H., Brown K.E., Vanguri V.K., Freeman G.J., Kuchroo V.K., et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009, 206:3015-3029.
    • (2009) J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3    Vanguri, V.K.4    Freeman, G.J.5    Kuchroo, V.K.6
  • 61
    • 35748956420 scopus 로고    scopus 로고
    • Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
    • Kopf H., de la Rosa G.M., Howard O.M., Chen X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int Immunopharmacol 2007, 7:1819-1824.
    • (2007) Int Immunopharmacol , vol.7 , pp. 1819-1824
    • Kopf, H.1    de la Rosa, G.M.2    Howard, O.M.3    Chen, X.4
  • 63
    • 77953811224 scopus 로고    scopus 로고
    • Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
    • Ouyang W., Beckett O., Ma Q., Paik J.H., DePinho R.A., Li M.O. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol 2010, 11:618-627.
    • (2010) Nat Immunol , vol.11 , pp. 618-627
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Paik, J.H.4    DePinho, R.A.5    Li, M.O.6
  • 64
    • 77954395996 scopus 로고    scopus 로고
    • Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
    • Harada Y., Harada Y., Elly C., Ying G., Paik J.H., DePinho R.A., et al. Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med 2010, 207:1381-1391.
    • (2010) J Exp Med , vol.207 , pp. 1381-1391
    • Harada, Y.1    Harada, Y.2    Elly, C.3    Ying, G.4    Paik, J.H.5    DePinho, R.A.6
  • 65
    • 78650085394 scopus 로고    scopus 로고
    • Foxo transcription factors control regulatory T cell development and function
    • Kerdiles Y.M., Stone E.L., Beisner D.R., McGargill M.A., et al. Foxo transcription factors control regulatory T cell development and function. Immunity 2010, 33:890-904.
    • (2010) Immunity , vol.33 , pp. 890-904
    • Kerdiles, Y.M.1    Stone, E.L.2    Beisner, D.R.3    McGargill, M.A.4
  • 66
    • 77955391804 scopus 로고    scopus 로고
    • TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
    • Gottschalk R.A., Corse E., Allison J.P. TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J Exp Med 2010, 207:1701-1711.
    • (2010) J Exp Med , vol.207 , pp. 1701-1711
    • Gottschalk, R.A.1    Corse, E.2    Allison, J.P.3
  • 67
    • 79952915024 scopus 로고    scopus 로고
    • Sub-optimal CD4 T cell activation triggers autonomous TGF-beta-dependent conversion to Foxp3(+) regulatory T cells
    • Oliveira V.G., Caridade M., Paiva R.S., Demengeot J., Graca L. Sub-optimal CD4 T cell activation triggers autonomous TGF-beta-dependent conversion to Foxp3(+) regulatory T cells. Eur J Immunol 2011, 41:1249-1255.
    • (2011) Eur J Immunol , vol.41 , pp. 1249-1255
    • Oliveira, V.G.1    Caridade, M.2    Paiva, R.S.3    Demengeot, J.4    Graca, L.5
  • 68
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai X., Cowan M., Feigenbaum L., Singer A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol 2005, 6:152-162.
    • (2005) Nat Immunol , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 69
    • 53149092106 scopus 로고    scopus 로고
    • CD28 costimulation is essential for human T regulatory expansion and function
    • Golovina T.N., Mikheeva T., Suhoski M.M., Aqui N.A., Tai V.C., Shan X., et al. CD28 costimulation is essential for human T regulatory expansion and function. J Immunol 2008, 181:2855-2868.
    • (2008) J Immunol , vol.181 , pp. 2855-2868
    • Golovina, T.N.1    Mikheeva, T.2    Suhoski, M.M.3    Aqui, N.A.4    Tai, V.C.5    Shan, X.6
  • 70
    • 79953073879 scopus 로고    scopus 로고
    • Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling
    • Semple K., Nguyen A., Yu Y., Wang H., Anasetti C., Yu X.Z. Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling. Blood 2011, 117:3096-3103.
    • (2011) Blood , vol.117 , pp. 3096-3103
    • Semple, K.1    Nguyen, A.2    Yu, Y.3    Wang, H.4    Anasetti, C.5    Yu, X.Z.6
  • 72
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive T cells
    • Apostolou I., von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med 2004, 199:1401-1408.
    • (2004) J Exp Med , vol.199 , pp. 1401-1408
    • Apostolou, I.1    von Boehmer, H.2
  • 73
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    • Tsuji M., Komatsu N., Kawamoto S., Suzuki K., Kanagawa O., Honjo T., et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 2009, 323:1488-1492.
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1    Komatsu, N.2    Kawamoto, S.3    Suzuki, K.4    Kanagawa, O.5    Honjo, T.6
  • 76
    • 79955680455 scopus 로고    scopus 로고
    • Antigen-specific induction of regulatory T cells in vivo and in vitro
    • 173-185
    • Daniel C., Ploegh H., von Boehmer H. Antigen-specific induction of regulatory T cells in vivo and in vitro. Methods Mol Biol 2011, 707:173-185. 173-185.
    • (2011) Methods Mol Biol , vol.707 , pp. 173-185
    • Daniel, C.1    Ploegh, H.2    von Boehmer, H.3
  • 77
    • 77950628840 scopus 로고    scopus 로고
    • A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells
    • Getnet D., Grosso J.F., Goldberg M.V., Harris T.J., Yen H.R., Bruno T.C., et al. A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells. Mol Immunol 2010, 47:1595-1600.
    • (2010) Mol Immunol , vol.47 , pp. 1595-1600
    • Getnet, D.1    Grosso, J.F.2    Goldberg, M.V.3    Harris, T.J.4    Yen, H.R.5    Bruno, T.C.6
  • 78
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton A.M., Korty P.E., Tran D.Q., Wohlfert E.A., Murray P.E., Belkaid Y., et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 2010, 184:3433-3441.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6
  • 79
    • 78650636296 scopus 로고    scopus 로고
    • Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells."
    • Verhagen J., Wraith D.C. Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.". J Immunol 2010, 185:7129.
    • (2010) J Immunol , vol.185 , pp. 7129
    • Verhagen, J.1    Wraith, D.C.2
  • 80
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill J.A., Feuerer M., Tash K., Haxhinasto S., Perez J., Melamed R., et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 2007, 27:786-800.
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3    Haxhinasto, S.4    Perez, J.5    Melamed, R.6
  • 83
    • 33745263084 scopus 로고    scopus 로고
    • Defective cell cycle induction by IL-2 in naive T-cells antigen stimulated in the presence of refractory T-lymphocytes
    • Inaba H., Geiger T.L. Defective cell cycle induction by IL-2 in naive T-cells antigen stimulated in the presence of refractory T-lymphocytes. Int Immunol 2006, 18:1043-1054.
    • (2006) Int Immunol , vol.18 , pp. 1043-1054
    • Inaba, H.1    Geiger, T.L.2
  • 84
    • 51549104749 scopus 로고    scopus 로고
    • In vivo suppression of naive CD4 T cell responses by IL-2- and antigen-stimulated T lymphocytes in the absence of APC competition
    • Inaba H., Steeves M., Nguyen P., Geiger T.L. In vivo suppression of naive CD4 T cell responses by IL-2- and antigen-stimulated T lymphocytes in the absence of APC competition. J Immunol 2008, 181:3323-3335.
    • (2008) J Immunol , vol.181 , pp. 3323-3335
    • Inaba, H.1    Steeves, M.2    Nguyen, P.3    Geiger, T.L.4
  • 88
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz S.Z., Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 90
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim J.M., Rasmussen J.P., Rudensky A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007, 8:191-197.
    • (2007) Nat Immunol , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 91
    • 79551504156 scopus 로고    scopus 로고
    • Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of foxp3 expression and Treg function
    • Lal G., Yin N., Xu J., Lin M., Schroppel S., Ding Y., et al. Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of foxp3 expression and Treg function. Am J Transplant 2011, 11:203-214.
    • (2011) Am J Transplant , vol.11 , pp. 203-214
    • Lal, G.1    Yin, N.2    Xu, J.3    Lin, M.4    Schroppel, S.5    Ding, Y.6
  • 92
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    • Burchill M.A., Yang J., Vogtenhuber C., Blazar B.R., Farrar M.A. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 2007, 178:280-290.
    • (2007) J Immunol , vol.178 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 93
    • 33947667310 scopus 로고    scopus 로고
    • Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells
    • Bayer A.L., Yu A., Malek T.R. Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. J Immunol 2007, 178:4062-4071.
    • (2007) J Immunol , vol.178 , pp. 4062-4071
    • Bayer, A.L.1    Yu, A.2    Malek, T.R.3
  • 94
    • 77953267301 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    • Ouyang W., Beckett O., Ma Q., Li M.O. Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity 2010, 32:642-653.
    • (2010) Immunity , vol.32 , pp. 642-653
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Li, M.O.4
  • 96
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang X.O., Nurieva R., Martinez G.J., Kang H.S., Chung Y., Pappu B.P., et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008, 29:44-56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3    Kang, H.S.4    Chung, Y.5    Pappu, B.P.6
  • 97
    • 51049120236 scopus 로고    scopus 로고
    • Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
    • Zhou X., Jeker L.T., Fife B.T., Zhu S., Anderson M.S., McManus M.T., et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med 2008, 205:1983-1991.
    • (2008) J Exp Med , vol.205 , pp. 1983-1991
    • Zhou, X.1    Jeker, L.T.2    Fife, B.T.3    Zhu, S.4    Anderson, M.S.5    McManus, M.T.6
  • 98
    • 65449125930 scopus 로고    scopus 로고
    • Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
    • Duarte J.H., Zelenay S., Bergman M.L., Martins A.C., Demengeot J. Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol 2009, 39:948-955.
    • (2009) Eur J Immunol , vol.39 , pp. 948-955
    • Duarte, J.H.1    Zelenay, S.2    Bergman, M.L.3    Martins, A.C.4    Demengeot, J.5
  • 99
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X., Bailey-Bucktrout S.L., Jeker L.T., Penaranda C., Martínez-Llordella M., Ashby M., et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009, 10:1000-1007.
    • (2009) Nat Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3    Penaranda, C.4    Martínez-Llordella, M.5    Ashby, M.6
  • 102
    • 31544467631 scopus 로고    scopus 로고
    • Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient
    • Zheng S.G., Meng L., Wang J.H., Watanabe M., Barr M.L., Cramer D.V., et al. Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient. Int Immunol 2006, 18:279-289.
    • (2006) Int Immunol , vol.18 , pp. 279-289
    • Zheng, S.G.1    Meng, L.2    Wang, J.H.3    Watanabe, M.4    Barr, M.L.5    Cramer, D.V.6
  • 103
    • 33645786794 scopus 로고    scopus 로고
    • Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo
    • Weber S.E., Harbertson J., Godebu E., Mros G.A., Padrick R.C., Carson B.D., et al. Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo. J Immunol 2006, 176:4730-4739.
    • (2006) J Immunol , vol.176 , pp. 4730-4739
    • Weber, S.E.1    Harbertson, J.2    Godebu, E.3    Mros, G.A.4    Padrick, R.C.5    Carson, B.D.6
  • 105
    • 48249143387 scopus 로고    scopus 로고
    • Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance
    • Selvaraj R.K., Geiger T.L. Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance. J Immunol 2008, 180:2830-2838.
    • (2008) J Immunol , vol.180 , pp. 2830-2838
    • Selvaraj, R.K.1    Geiger, T.L.2
  • 106
    • 34548381245 scopus 로고    scopus 로고
    • TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
    • Wong J., Mathis D., Benoist C. TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med 2007, 204:2039-2045.
    • (2007) J Exp Med , vol.204 , pp. 2039-2045
    • Wong, J.1    Mathis, D.2    Benoist, C.3
  • 107
    • 79551521901 scopus 로고    scopus 로고
    • Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors
    • Hindley J.P., Ferreira C., Jones E., Lauder S.N., Ladell K., Wynn K.K., et al. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Res 2011, 71:736-746.
    • (2011) Cancer Res , vol.71 , pp. 736-746
    • Hindley, J.P.1    Ferreira, C.2    Jones, E.3    Lauder, S.N.4    Ladell, K.5    Wynn, K.K.6
  • 109
    • 77953641641 scopus 로고    scopus 로고
    • Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire
    • Fourcade J., Sun Z., Kudela P., Janjic B., Kirkwood J.M., El-Hafnawy T., et al. Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire. J Immunol 2010, 184:6709-6718.
    • (2010) J Immunol , vol.184 , pp. 6709-6718
    • Fourcade, J.1    Sun, Z.2    Kudela, P.3    Janjic, B.4    Kirkwood, J.M.5    El-Hafnawy, T.6
  • 110
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007, 204:1775-1785.
    • (2007) J Exp Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6
  • 111
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • Round J.L., Mazmanian S.K. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A 2010, 107:12204-12209.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 112
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi K., Tanoue T., Shima T., Imaoka A., Kuwahara T., Momose Y., et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011, 331:337-341.
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3    Imaoka, A.4    Kuwahara, T.5    Momose, Y.6
  • 113
    • 77950962146 scopus 로고    scopus 로고
    • Bacterial strain-specific induction of Foxp3+ T regulatory cells is protective in murine allergy models
    • Lyons A., O'Mahony D., O'Brien F., MacSharry J., Sheil B., Ceddia M., et al. Bacterial strain-specific induction of Foxp3+ T regulatory cells is protective in murine allergy models. Clin Exp Allergy 2010, 40:811-819.
    • (2010) Clin Exp Allergy , vol.40 , pp. 811-819
    • Lyons, A.1    O'Mahony, D.2    O'Brien, F.3    MacSharry, J.4    Sheil, B.5    Ceddia, M.6
  • 114
  • 115
  • 116
    • 0346667110 scopus 로고    scopus 로고
    • Structure-function relationship between the human chemokine receptor CXCR3 and its ligands
    • Clark-Lewis I., Mattioli I., Gong J.H., Loetscher P. Structure-function relationship between the human chemokine receptor CXCR3 and its ligands. J Biol Chem 2003, 278:289-295.
    • (2003) J Biol Chem , vol.278 , pp. 289-295
    • Clark-Lewis, I.1    Mattioli, I.2    Gong, J.H.3    Loetscher, P.4
  • 117
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch M.A., Tucker-Heard G., Perdue N.R., Killebrew J.R., Urdahl K.B., Campbell D.J. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009, 10:595-602.
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 118
    • 70449532980 scopus 로고    scopus 로고
    • Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    • Oldenhove G., Bouladoux N., Wohlfert E.A., Hall J.A., Chou D., Dos Santos L., et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 2009, 31:772-786.
    • (2009) Immunity , vol.31 , pp. 772-786
    • Oldenhove, G.1    Bouladoux, N.2    Wohlfert, E.A.3    Hall, J.A.4    Chou, D.5    Dos Santos, L.6
  • 119
    • 78650639173 scopus 로고    scopus 로고
    • Myelin-reactive, TGF-β-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo
    • O'Connor R.A., Leech M.D., Suffner J., Hämmerling G.J., Anderton S.M. Myelin-reactive, TGF-β-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo. J Immunol 2010, 185:7235-7243.
    • (2010) J Immunol , vol.185 , pp. 7235-7243
    • O'Connor, R.A.1    Leech, M.D.2    Suffner, J.3    Hämmerling, G.J.4    Anderton, S.M.5
  • 120
    • 22344434572 scopus 로고    scopus 로고
    • IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
    • Sawitzki B., Kingsley C.I., Oliveira V., Karim M., Herber M., Wood K.J. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med 2005, 201:1925-1935.
    • (2005) J Exp Med , vol.201 , pp. 1925-1935
    • Sawitzki, B.1    Kingsley, C.I.2    Oliveira, V.3    Karim, M.4    Herber, M.5    Wood, K.J.6
  • 121
    • 60549101976 scopus 로고    scopus 로고
    • Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1
    • Ouaked N., Mantel P.Y., Bassin C., Burgler S., Siegmund K., Akdis C.A., et al. Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1. J Immunol 2009, 182:1041-1049.
    • (2009) J Immunol , vol.182 , pp. 1041-1049
    • Ouaked, N.1    Mantel, P.Y.2    Bassin, C.3    Burgler, S.4    Siegmund, K.5    Akdis, C.A.6
  • 122
    • 77956632634 scopus 로고    scopus 로고
    • Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses
    • Lu L.F., Boldin M.P., Chaudhry A., Lin L.L., Taganov K.D., Hanada T., et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 2010, 142:914-929.
    • (2010) Cell , vol.142 , pp. 914-929
    • Lu, L.F.1    Boldin, M.P.2    Chaudhry, A.3    Lin, L.L.4    Taganov, K.D.5    Hanada, T.6
  • 123
    • 67349114782 scopus 로고    scopus 로고
    • FOXP3 and the regulation of Treg/Th17 differentiation
    • Ziegler S.F., Buckner J.H. FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect 2009, 11:594-598.
    • (2009) Microbes Infect , vol.11 , pp. 594-598
    • Ziegler, S.F.1    Buckner, J.H.2
  • 124
    • 66649115650 scopus 로고    scopus 로고
    • Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t
    • Ayyoub M., Deknuydt F., Raimbaud I., Dousset C., Leveque L., Bioley G., et al. Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. Proc Natl Acad Sci U S A 2009, 106:8635-8640.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8635-8640
    • Ayyoub, M.1    Deknuydt, F.2    Raimbaud, I.3    Dousset, C.4    Leveque, L.5    Bioley, G.6
  • 126
    • 65549088243 scopus 로고    scopus 로고
    • IL-17-producing human peripheral regulatory T cells retain suppressive function
    • Beriou G., Costantino C.M., Ashley C.W., Yang L., Kuchroo V.K., Baecher-Allan C., et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 2009, 113:4240-4249.
    • (2009) Blood , vol.113 , pp. 4240-4249
    • Beriou, G.1    Costantino, C.M.2    Ashley, C.W.3    Yang, L.4    Kuchroo, V.K.5    Baecher-Allan, C.6
  • 128
    • 78649826858 scopus 로고    scopus 로고
    • CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype
    • Kitamura K., Farber J.M., Kelsall B.L. CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype. J Immunol 2010, 185:3295-3304.
    • (2010) J Immunol , vol.185 , pp. 3295-3304
    • Kitamura, K.1    Farber, J.M.2    Kelsall, B.L.3
  • 130
  • 131
    • 68149125188 scopus 로고    scopus 로고
    • IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines
    • Ahyi A.N., Chang H.C., Dent A.L., Nutt S.L., Kaplan M.H. IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol 2009, 183:1598-1606.
    • (2009) J Immunol , vol.183 , pp. 1598-1606
    • Ahyi, A.N.1    Chang, H.C.2    Dent, A.L.3    Nutt, S.L.4    Kaplan, M.H.5
  • 132
    • 0037089575 scopus 로고    scopus 로고
    • Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression
    • Rengarajan J., Mowen K.A., McBride K.D., Smith E.D., Singh H., Glimcher L.H. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med 2002, 195:1003-1012.
    • (2002) J Exp Med , vol.195 , pp. 1003-1012
    • Rengarajan, J.1    Mowen, K.A.2    McBride, K.D.3    Smith, E.D.4    Singh, H.5    Glimcher, L.H.6
  • 133
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    • Zheng Y., Chaudhry A., Kas A., deRoos P., Kim J.M., Chu T.T., et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009, 19:351-356.
    • (2009) Nature , vol.19 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3    deRoos, P.4    Kim, J.M.5    Chu, T.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.