-
1
-
-
36249024247
-
Regulatory T cells - A brief history and perspective
-
1:CAS:528:DC%2BD2sXhsVSgur7J 17972355 10.1002/eji.200737593
-
S Sakaguchi K Wing M Miyara 2007 Regulatory T cells-a brief history and perspective Eur J Immunol 37 Suppl 1 S116 S123 1:CAS:528:DC%2BD2sXhsVSgur7J 17972355 10.1002/eji.200737593
-
(2007)
Eur J Immunol
, vol.37
, Issue.SUPPL. 1
-
-
Sakaguchi, S.1
Wing, K.2
Miyara, M.3
-
2
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
1:CAS:528:DC%2BD3sXhtFarsbw%3D 12522256 10.1126/science.1079490
-
S Hori T Nomura S Sakaguchi 2003 Control of regulatory T cell development by the transcription factor Foxp3 Science 299 5609 1057 1061 1:CAS:528:DC%2BD3sXhtFarsbw%3D 12522256 10.1126/science.1079490
-
(2003)
Science
, vol.299
, Issue.5609
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
3
-
-
0037385330
-
Foxp3 programs the development and function of CD4∈+∈CD25+ regulatory T cells
-
1:CAS:528:DC%2BD3sXitlyqs74%3D 12612578 10.1038/ni904
-
JD Fontenot MA Gavin AY Rudensky 2003 Foxp3 programs the development and function of CD4∈+∈CD25+ regulatory T cells Nat Immunol 4 4 330 336 1:CAS:528:DC%2BD3sXitlyqs74%3D 12612578 10.1038/ni904
-
(2003)
Nat Immunol
, vol.4
, Issue.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
4
-
-
0037385314
-
An essential role for Scurfin in CD4∈+∈CD25+ T regulatory cells
-
1:CAS:528:DC%2BD3sXitlyqs7s%3D 12612581 10.1038/ni909
-
R Khattri T Cox SA Yasayko F Ramsdell 2003 An essential role for Scurfin in CD4∈+∈CD25+ T regulatory cells Nat Immunol 4 4 337 342 1:CAS:528:DC%2BD3sXitlyqs7s%3D 12612581 10.1038/ni909
-
(2003)
Nat Immunol
, vol.4
, Issue.4
, pp. 337-342
-
-
Khattri, R.1
Cox, T.2
Yasayko, S.A.3
Ramsdell, F.4
-
5
-
-
0035162560
-
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
-
1:CAS:528:DC%2BD3MXis1yktQ%3D%3D 11138001 10.1038/83784
-
ME Brunkow EW Jeffery KA Hjerrild B Paeper LB Clark SA Yasayko JE Wilkinson D Galas SF Ziegler F Ramsdell 2001 Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse Nat Genet 27 1 68 73 1:CAS:528: DC%2BD3MXis1yktQ%3D%3D 11138001 10.1038/83784
-
(2001)
Nat Genet
, vol.27
, Issue.1
, pp. 68-73
-
-
Brunkow, M.E.1
Jeffery, E.W.2
Hjerrild, K.A.3
Paeper, B.4
Clark, L.B.5
Yasayko, S.A.6
Wilkinson, J.E.7
Galas, D.8
Ziegler, S.F.9
Ramsdell, F.10
-
6
-
-
13144261691
-
FOXP3 acts as a rheostat of the immune response
-
1:CAS:528:DC%2BD2MXhvFyns7Y%3D 15661028 10.1111/j.0105-2896.2005.00231.x
-
HD Ochs SF Ziegler TR Torgerson 2005 FOXP3 acts as a rheostat of the immune response Immunol Rev 203 156 164 1:CAS:528:DC%2BD2MXhvFyns7Y%3D 15661028 10.1111/j.0105-2896.2005.00231.x
-
(2005)
Immunol Rev
, vol.203
, pp. 156-164
-
-
Ochs, H.D.1
Ziegler, S.F.2
Torgerson, T.R.3
-
7
-
-
33646168597
-
FOXP3: Of mice and men
-
1:CAS:528:DC%2BD28XkvFSqt7s%3D 16551248 10.1146/annurev.immunol.24. 021605.090547
-
SF Ziegler 2006 FOXP3: of mice and men Annu Rev Immunol 24 209 226 1:CAS:528:DC%2BD28XkvFSqt7s%3D 16551248 10.1146/annurev.immunol.24.021605.090547
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 209-226
-
-
Ziegler, S.F.1
-
8
-
-
65549136983
-
Mechanisms of foxp3+ T regulatory cell-mediated suppression
-
1:CAS:528:DC%2BD1MXosVCks7g%3D 19464986 10.1016/j.immuni.2009.04.010
-
EM Shevach 2009 Mechanisms of foxp3+ T regulatory cell-mediated suppression Immunity 30 5 636 645 1:CAS:528:DC%2BD1MXosVCks7g%3D 19464986 10.1016/j.immuni.2009.04.010
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 636-645
-
-
Shevach, E.M.1
-
9
-
-
70349512606
-
Regulatory T cells: How do they suppress immune responses?
-
1:CAS:528:DC%2BD1MXhtFygs7vL 19737784 10.1093/intimm/dxp095
-
S Sakaguchi K Wing Y Onishi P Prieto-Martin T Yamaguchi 2009 Regulatory T cells: how do they suppress immune responses? Int Immunol 21 10 1105 1111 1:CAS:528:DC%2BD1MXhtFygs7vL 19737784 10.1093/intimm/dxp095
-
(2009)
Int Immunol
, vol.21
, Issue.10
, pp. 1105-1111
-
-
Sakaguchi, S.1
Wing, K.2
Onishi, Y.3
Prieto-Martin, P.4
Yamaguchi, T.5
-
10
-
-
0031647622
-
Immunologic self-tolerance maintained by CD25∈+∈CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
-
1:CAS:528:DyaK1MXmtFehtQ%3D%3D 9885918 10.1093/intimm/10.12.1969
-
T Takahashi Y Kuniyasu M Toda N Sakaguchi M Itoh M Iwata J Shimizu S Sakaguchi 1998 Immunologic self-tolerance maintained by CD25∈+∈CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state Int Immunol 10 12 1969 1980 1:CAS:528:DyaK1MXmtFehtQ%3D%3D 9885918 10.1093/intimm/10.12.1969
-
(1998)
Int Immunol
, vol.10
, Issue.12
, pp. 1969-1980
-
-
Takahashi, T.1
Kuniyasu, Y.2
Toda, M.3
Sakaguchi, N.4
Itoh, M.5
Iwata, M.6
Shimizu, J.7
Sakaguchi, S.8
-
11
-
-
0031821875
-
CD4∈+∈CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
-
1:CAS:528:DyaK1cXkvVaqt7g%3D 9670041 10.1084/jem.188.2.287
-
AM Thornton EM Shevach 1998 CD4∈+∈CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production J Exp Med 188 2 287 296 1:CAS:528:DyaK1cXkvVaqt7g%3D 9670041 10.1084/jem.188.2.287
-
(1998)
J Exp Med
, vol.188
, Issue.2
, pp. 287-296
-
-
Thornton, A.M.1
Shevach, E.M.2
-
12
-
-
13544271161
-
Cutting edge: Contact-mediated suppression by CD4∈+∈CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
-
1:CAS:528:DC%2BD2MXhtV2ku7w%3D 15699103
-
DC Gondek LF Lu SA Quezada S Sakaguchi RJ Noelle 2005 Cutting edge: contact-mediated suppression by CD4∈+∈CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism J Immunol 174 4 1783 1786 1:CAS:528:DC%2BD2MXhtV2ku7w%3D 15699103
-
(2005)
J Immunol
, vol.174
, Issue.4
, pp. 1783-1786
-
-
Gondek, D.C.1
Lu, L.F.2
Quezada, S.A.3
Sakaguchi, S.4
Noelle, R.J.5
-
13
-
-
35449006679
-
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
-
1:CAS:528:DC%2BD2sXht1ygurzJ 17919943 10.1016/j.immuni.2007.08.014
-
X Cao SF Cai TA Fehniger J Song LI Collins DR Piwnica-Worms TJ Ley 2007 Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance Immunity 27 4 635 646 1:CAS:528:DC%2BD2sXht1ygurzJ 17919943 10.1016/j.immuni.2007.08.014
-
(2007)
Immunity
, vol.27
, Issue.4
, pp. 635-646
-
-
Cao, X.1
Cai, S.F.2
Fehniger, T.A.3
Song, J.4
Collins, L.I.5
Piwnica-Worms, D.R.6
Ley, T.J.7
-
14
-
-
34250376423
-
Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression
-
1:CAS:528:DC%2BD2sXms1akt78%3D 17502663 10.1084/jem.20062129
-
T Bopp C Becker M Klein S Klein-Hessling A Palmetshofer E Serfling V Heib M Becker J Kubach S Schmitt S Stoll H Schild MS Staege M Stassen H Jonuleit E Schmitt 2007 Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression J Exp Med 204 6 1303 1310 1:CAS:528: DC%2BD2sXms1akt78%3D 17502663 10.1084/jem.20062129
-
(2007)
J Exp Med
, vol.204
, Issue.6
, pp. 1303-1310
-
-
Bopp, T.1
Becker, C.2
Klein, M.3
Klein-Hessling, S.4
Palmetshofer, A.5
Serfling, E.6
Heib, V.7
Becker, M.8
Kubach, J.9
Schmitt, S.10
Stoll, S.11
Schild, H.12
Staege, M.S.13
Stassen, M.14
Jonuleit, H.15
Schmitt, E.16
-
15
-
-
36248976097
-
CD4∈+∈CD25∈+∈Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
-
1:CAS:528:DC%2BD2sXhtlajtr7E 17982458 10.1038/ni1536
-
P Pandiyan L Zheng S Ishihara J Reed MJ Lenardo 2007 CD4∈+∈ CD25∈+∈Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells Nat Immunol 8 12 1353 1362 1:CAS:528:DC%2BD2sXhtlajtr7E 17982458 10.1038/ni1536
-
(2007)
Nat Immunol
, vol.8
, Issue.12
, pp. 1353-1362
-
-
Pandiyan, P.1
Zheng, L.2
Ishihara, S.3
Reed, J.4
Lenardo, M.J.5
-
16
-
-
33646578505
-
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression
-
1:CAS:528:DC%2BD28XmsVOht7g%3D 16771859 10.1111/j.1365-2567.2006.02362.x
-
C Oderup L Cederbom A Makowska CM Cilio F Ivars 2006 Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression Immunology 118 2 240 249 1:CAS:528:DC%2BD28XmsVOht7g%3D 16771859 10.1111/j.1365-2567.2006. 02362.x
-
(2006)
Immunology
, vol.118
, Issue.2
, pp. 240-249
-
-
Oderup, C.1
Cederbom, L.2
Makowska, A.3
Cilio, C.M.4
Ivars, F.5
-
17
-
-
0036852170
-
CTLA-4-Ig regulates tryptophan catabolism in vivo
-
1:CAS:528:DC%2BD38Xot1Chs7Y%3D 12368911 10.1038/ni846
-
U Grohmann C Orabona F Fallarino C Vacca F Calcinaro A Falorni P Candeloro ML Belladonna R Bianchi MC Fioretti P Puccetti 2002 CTLA-4-Ig regulates tryptophan catabolism in vivo Nat Immunol 3 11 1097 1101 1:CAS:528:DC%2BD38Xot1Chs7Y%3D 12368911 10.1038/ni846
-
(2002)
Nat Immunol
, vol.3
, Issue.11
, pp. 1097-1101
-
-
Grohmann, U.1
Orabona, C.2
Fallarino, F.3
Vacca, C.4
Calcinaro, F.5
Falorni, A.6
Candeloro, P.7
Belladonna, M.L.8
Bianchi, R.9
Fioretti, M.C.10
Puccetti, P.11
-
18
-
-
33646567156
-
Activated CD4∈+∈CD25+ T cells selectively kill B lymphocytes
-
1:CAS:528:DC%2BD28XkvFWhurY%3D 16418326 10.1182/blood-2005-11-4502
-
DM Zhao AM Thornton RJ DiPaolo EM Shevach 2006 Activated CD4∈+∈CD25+ T cells selectively kill B lymphocytes Blood 107 10 3925 3932 1:CAS:528:DC%2BD28XkvFWhurY%3D 16418326 10.1182/blood-2005-11-4502
-
(2006)
Blood
, vol.107
, Issue.10
, pp. 3925-3932
-
-
Zhao, D.M.1
Thornton, A.M.2
Dipaolo, R.J.3
Shevach, E.M.4
-
19
-
-
39449126502
-
The Foxp3+ regulatory T cell: A jack of all trades, master of regulation
-
1:CAS:528:DC%2BD1cXitVOjt7o%3D 18285775 10.1038/ni1572
-
Q Tang JA Bluestone 2008 The Foxp3+ regulatory T cell: a jack of all trades, master of regulation Nat Immunol 9 3 239 244 1:CAS:528: DC%2BD1cXitVOjt7o%3D 18285775 10.1038/ni1572
-
(2008)
Nat Immunol
, vol.9
, Issue.3
, pp. 239-244
-
-
Tang, Q.1
Bluestone, J.A.2
-
20
-
-
46249101518
-
How regulatory T cells work
-
1:CAS:528:DC%2BD1cXns1ehs7g%3D 18566595 10.1038/nri2343
-
DA Vignali LW Collison CJ Workman 2008 How regulatory T cells work Nat Rev Immunol 8 7 523 532 1:CAS:528:DC%2BD1cXns1ehs7g%3D 18566595 10.1038/nri2343
-
(2008)
Nat Rev Immunol
, vol.8
, Issue.7
, pp. 523-532
-
-
Vignali, D.A.1
Collison, L.W.2
Workman, C.J.3
-
21
-
-
0033523607
-
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
-
1:CAS:528:DyaK1MXmsVClt7s%3D 10510089 10.1084/jem.190.7.995
-
C Asseman S Mauze MW Leach RL Coffman F Powrie 1999 An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation J Exp Med 190 7 995 1004 1:CAS:528:DyaK1MXmsVClt7s%3D 10510089 10.1084/jem.190.7.995
-
(1999)
J Exp Med
, vol.190
, Issue.7
, pp. 995-1004
-
-
Asseman, C.1
Mauze, S.2
Leach, M.W.3
Coffman, R.L.4
Powrie, F.5
-
22
-
-
0034679567
-
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
-
1:CAS:528:DC%2BD3cXkvFGiu7Y%3D 10899916 10.1084/jem.192.2.295
-
S Read V Malmstrom F Powrie 2000 Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation J Exp Med 192 2 295 302 1:CAS:528:DC%2BD3cXkvFGiu7Y%3D 10899916 10.1084/jem.192.2.295
-
(2000)
J Exp Med
, vol.192
, Issue.2
, pp. 295-302
-
-
Read, S.1
Malmstrom, V.2
Powrie, F.3
-
23
-
-
36549030784
-
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
-
1:CAS:528:DC%2BD2sXhtlCrtbzI 18033300 10.1038/nature06306
-
LW Collison CJ Workman TT Kuo K Boyd Y Wang KM Vignali R Cross D Sehy RS Blumberg DA Vignali 2007 The inhibitory cytokine IL-35 contributes to regulatory T-cell function Nature 450 7169 566 569 1:CAS:528:DC%2BD2sXhtlCrtbzI 18033300 10.1038/nature06306
-
(2007)
Nature
, vol.450
, Issue.7169
, pp. 566-569
-
-
Collison, L.W.1
Workman, C.J.2
Kuo, T.T.3
Boyd, K.4
Wang, Y.5
Vignali, K.M.6
Cross, R.7
Sehy, D.8
Blumberg, R.S.9
Vignali, D.A.10
-
24
-
-
70349249977
-
Dynamics of peripheral tolerance and immune regulation mediated by Treg
-
1:CAS:528:DC%2BD1MXhtVKrtr3P 19662638 10.1002/eji.200939688
-
S Sakaguchi K Wing T Yamaguchi 2009 Dynamics of peripheral tolerance and immune regulation mediated by Treg Eur J Immunol 39 9 2331 2336 1:CAS:528:DC%2BD1MXhtVKrtr3P 19662638 10.1002/eji.200939688
-
(2009)
Eur J Immunol
, vol.39
, Issue.9
, pp. 2331-2336
-
-
Sakaguchi, S.1
Wing, K.2
Yamaguchi, T.3
-
25
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
1:CAS:528:DC%2BD1cXht1Slu7%2FJ 18845758 10.1126/science.1160062
-
K Wing Y Onishi P Prieto-Martin T Yamaguchi M Miyara Z Fehervari T Nomura S Sakaguchi 2008 CTLA-4 control over Foxp3+ regulatory T cell function Science 322 5899 271 275 1:CAS:528:DC%2BD1cXht1Slu7%2FJ 18845758 10.1126/science.1160062
-
(2008)
Science
, vol.322
, Issue.5899
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
Fehervari, Z.6
Nomura, T.7
Sakaguchi, S.8
-
26
-
-
0033136302
-
Thymus and autoimmunity: Production of CD25∈+∈CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
-
1:CAS:528:DyaK1MXislGgu7Y%3D 10228007
-
M Itoh T Takahashi N Sakaguchi Y Kuniyasu J Shimizu F Otsuka S Sakaguchi 1999 Thymus and autoimmunity: production of CD25∈+∈CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance J Immunol 162 9 5317 5326 1:CAS:528: DyaK1MXislGgu7Y%3D 10228007
-
(1999)
J Immunol
, vol.162
, Issue.9
, pp. 5317-5326
-
-
Itoh, M.1
Takahashi, T.2
Sakaguchi, N.3
Kuniyasu, Y.4
Shimizu, J.5
Otsuka, F.6
Sakaguchi, S.7
-
27
-
-
0034679560
-
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
-
1:CAS:528:DC%2BD3cXkvFGiu7c%3D 10899917 10.1084/jem.192.2.303
-
T Takahashi T Tagami S Yamazaki T Uede J Shimizu N Sakaguchi TW Mak S Sakaguchi 2000 Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4 J Exp Med 192 2 303 310 1:CAS:528:DC%2BD3cXkvFGiu7c%3D 10899917 10.1084/jem.192.2.303
-
(2000)
J Exp Med
, vol.192
, Issue.2
, pp. 303-310
-
-
Takahashi, T.1
Tagami, T.2
Yamazaki, S.3
Uede, T.4
Shimizu, J.5
Sakaguchi, N.6
Mak, T.W.7
Sakaguchi, S.8
-
28
-
-
34447643405
-
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor
-
1:CAS:528:DC%2BD2sXosFeqt74%3D 17613255 10.1016/j.immuni.2007.04.017
-
T Yamaguchi K Hirota K Nagahama K Ohkawa T Takahashi T Nomura S Sakaguchi 2007 Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor Immunity 27 1 145 159 1:CAS:528: DC%2BD2sXosFeqt74%3D 17613255 10.1016/j.immuni.2007.04.017
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 145-159
-
-
Yamaguchi, T.1
Hirota, K.2
Nagahama, K.3
Ohkawa, K.4
Takahashi, T.5
Nomura, T.6
Sakaguchi, S.7
-
29
-
-
48249103057
-
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
-
1:CAS:528:DC%2BD1cXptFOhurw%3D 18635688 10.1073/pnas.0711106105
-
Y Onishi Z Fehervari T Yamaguchi S Sakaguchi 2008 Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation Proc Natl Acad Sci U S A 105 29 10113 10118 1:CAS:528:DC%2BD1cXptFOhurw%3D 18635688 10.1073/pnas.0711106105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.29
, pp. 10113-10118
-
-
Onishi, Y.1
Fehervari, Z.2
Yamaguchi, T.3
Sakaguchi, S.4
-
30
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
1:CAS:528:DyaK2MXntFWnurs%3D 7636184
-
S Sakaguchi N Sakaguchi M Asano M Itoh M Toda 1995 Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 3 1151 1164 1:CAS:528: DyaK2MXntFWnurs%3D 7636184
-
(1995)
J Immunol
, vol.155
, Issue.3
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
31
-
-
15444374646
-
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
-
1:CAS:528:DC%2BD2MXitl2rt78%3D 15753206 10.1084/jem.20041982
-
R Setoguchi S Hori T Takahashi S Sakaguchi 2005 Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization J Exp Med 201 5 723 735 1:CAS:528:DC%2BD2MXitl2rt78%3D 15753206 10.1084/jem.20041982
-
(2005)
J Exp Med
, vol.201
, Issue.5
, pp. 723-735
-
-
Setoguchi, R.1
Hori, S.2
Takahashi, T.3
Sakaguchi, S.4
-
32
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2
-
1:CAS:528:DC%2BD2cXntFCmt7c%3D 15343366 10.1038/nri1435
-
TR Malek AL Bayer 2004 Tolerance, not immunity, crucially depends on IL-2 Nat Rev Immunol 4 9 665 674 1:CAS:528:DC%2BD2cXntFCmt7c%3D 15343366 10.1038/nri1435
-
(2004)
Nat Rev Immunol
, vol.4
, Issue.9
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
33
-
-
33846805925
-
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes
-
1:CAS:528:DC%2BD2sXhs1Chsrk%3D 17196245 10.1016/j.jaci.2006.10.007
-
AA Caudy ST Reddy T Chatila JP Atkinson JW Verbsky 2007 CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes J Allergy Clin Immunol 119 2 482 487 1:CAS:528:DC%2BD2sXhs1Chsrk%3D 17196245 10.1016/j.jaci.2006.10.007
-
(2007)
J Allergy Clin Immunol
, vol.119
, Issue.2
, pp. 482-487
-
-
Caudy, A.A.1
Reddy, S.T.2
Chatila, T.3
Atkinson, J.P.4
Verbsky, J.W.5
-
34
-
-
27544481941
-
A function for interleukin 2 in Foxp3-expressing regulatory T cells
-
1:CAS:528:DC%2BD2MXhtFamsb%2FI 16227984 10.1038/ni1263
-
JD Fontenot JP Rasmussen MA Gavin AY Rudensky 2005 A function for interleukin 2 in Foxp3-expressing regulatory T cells Nat Immunol 6 11 1142 1151 1:CAS:528:DC%2BD2MXhtFamsb%2FI 16227984 10.1038/ni1263
-
(2005)
Nat Immunol
, vol.6
, Issue.11
, pp. 1142-1151
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Gavin, M.A.3
Rudensky, A.Y.4
-
35
-
-
51549104932
-
IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4∈+∈Foxp3+ regulatory T cell development
-
1:CAS:528:DC%2BD1cXhtVSiu7nM 18714000
-
KB Vang J Yang SA Mahmud MA Burchill AL Vegoe MA Farrar 2008 IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4∈+∈Foxp3+ regulatory T cell development J Immunol 181 5 3285 3290 1:CAS:528:DC%2BD1cXhtVSiu7nM 18714000
-
(2008)
J Immunol
, vol.181
, Issue.5
, pp. 3285-3290
-
-
Vang, K.B.1
Yang, J.2
Mahmud, S.A.3
Burchill, M.A.4
Vegoe, A.L.5
Farrar, M.A.6
-
36
-
-
33746365086
-
The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells
-
1:CAS:528:DC%2BD28XpvFegtro%3D 16903906 10.1111/j.0105-2896.2006.00415.x
-
EM Shevach RA DiPaolo J Andersson DM Zhao GL Stephens AM Thornton 2006 The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells Immunol Rev 212 60 73 1:CAS:528:DC%2BD28XpvFegtro%3D 16903906 10.1111/j.0105-2896.2006.00415.x
-
(2006)
Immunol Rev
, vol.212
, pp. 60-73
-
-
Shevach, E.M.1
Dipaolo, R.A.2
Andersson, J.3
Zhao, D.M.4
Stephens, G.L.5
Thornton, A.M.6
-
37
-
-
65549123867
-
Natural and adaptive foxp3+ regulatory T cells: More of the same or a division of labor?
-
1:CAS:528:DC%2BD1MXosVCks7s%3D 19464985 10.1016/j.immuni.2009.05.002
-
MA Curotto de Lafaille JJ Lafaille 2009 Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30 5 626 635 1:CAS:528:DC%2BD1MXosVCks7s%3D 19464985 10.1016/j.immuni.2009.05.002
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 626-635
-
-
Curotto De Lafaille, M.A.1
Lafaille, J.J.2
-
38
-
-
34247555353
-
Differentiation and function of Th17 T cells
-
1:CAS:528:DC%2BD2sXlt1agsLg%3D 17433650 10.1016/j.coi.2007.04.005
-
B Stockinger M Veldhoen 2007 Differentiation and function of Th17 T cells Curr Opin Immunol 19 3 281 286 1:CAS:528:DC%2BD2sXlt1agsLg%3D 17433650 10.1016/j.coi.2007.04.005
-
(2007)
Curr Opin Immunol
, vol.19
, Issue.3
, pp. 281-286
-
-
Stockinger, B.1
Veldhoen, M.2
-
39
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
1:CAS:528:DC%2BD28XitVOks7s%3D 16473830 10.1016/j.immuni.2006.01.001
-
M Veldhoen RJ Hocking CJ Atkins RM Locksley B Stockinger 2006 TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Immunity 24 2 179 189 1:CAS:528:DC%2BD28XitVOks7s%3D 16473830 10.1016/j.immuni.2006.01.001
-
(2006)
Immunity
, vol.24
, Issue.2
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
40
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
1:CAS:528:DC%2BD28XksVGns7g%3D 16648838 10.1038/nature04753
-
E Bettelli Y Carrier W Gao T Korn TB Strom M Oukka HL Weiner VK Kuchroo 2006 Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 7090 235 238 1:CAS:528: DC%2BD28XksVGns7g%3D 16648838 10.1038/nature04753
-
(2006)
Nature
, vol.441
, Issue.7090
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
Weiner, H.L.7
Kuchroo, V.K.8
-
41
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
1:CAS:528:DC%2BD2sXjvVSnsL8%3D 17363300 10.1016/j.immuni.2007.02.009
-
A Laurence CM Tato TS Davidson Y Kanno Z Chen Z Yao RB Blank F Meylan R Siegel L Hennighausen EM Shevach JJ O'Shea 2007 Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation Immunity 26 3 371 381 1:CAS:528:DC%2BD2sXjvVSnsL8%3D 17363300 10.1016/j.immuni.2007.02.009
-
(2007)
Immunity
, vol.26
, Issue.3
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
Kanno, Y.4
Chen, Z.5
Yao, Z.6
Blank, R.B.7
Meylan, F.8
Siegel, R.9
Hennighausen, L.10
Shevach, E.M.11
O'Shea, J.J.12
-
42
-
-
31344480633
-
LAT-mediated signaling in CD4∈+∈CD25+ regulatory T cell development
-
1:CAS:528:DC%2BD28XhtVyru7w%3D 16380508 10.1084/jem.20050903
-
S Koonpaew S Shen L Flowers W Zhang 2006 LAT-mediated signaling in CD4∈+∈CD25+ regulatory T cell development J Exp Med 203 1 119 129 1:CAS:528:DC%2BD28XhtVyru7w%3D 16380508 10.1084/jem.20050903
-
(2006)
J Exp Med
, vol.203
, Issue.1
, pp. 119-129
-
-
Koonpaew, S.1
Shen, S.2
Flowers, L.3
Zhang, W.4
-
43
-
-
0035320679
-
Thymic selection of CD4∈+∈CD25+ regulatory T cells induced by an agonist self-peptide
-
1:CAS:528:DC%2BD3MXis1aktLg%3D 11276200 10.1038/86302
-
MS Jordan A Boesteanu AJ Reed AL Petrone AE Holenbeck MA Lerman A Naji AJ Caton 2001 Thymic selection of CD4∈+∈CD25+ regulatory T cells induced by an agonist self-peptide Nat Immunol 2 4 301 306 1:CAS:528: DC%2BD3MXis1aktLg%3D 11276200 10.1038/86302
-
(2001)
Nat Immunol
, vol.2
, Issue.4
, pp. 301-306
-
-
Jordan, M.S.1
Boesteanu, A.2
Reed, A.J.3
Petrone, A.L.4
Holenbeck, A.E.5
Lerman, M.A.6
Naji, A.7
Caton, A.J.8
-
44
-
-
0036568942
-
Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
-
1:CAS:528:DC%2BD38Xjt12jtr4%3D 11970982
-
K Kawahata Y Misaki M Yamauchi S Tsunekawa K Setoguchi J Miyazaki K Yamamoto 2002 Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression J Immunol 168 9 4399 4405 1:CAS:528:DC%2BD38Xjt12jtr4%3D 11970982
-
(2002)
J Immunol
, vol.168
, Issue.9
, pp. 4399-4405
-
-
Kawahata, K.1
Misaki, Y.2
Yamauchi, M.3
Tsunekawa, S.4
Setoguchi, K.5
Miyazaki, J.6
Yamamoto, K.7
-
45
-
-
68949105350
-
Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking
-
19668367 10.1371/journal.pone.0006580 1:CAS:528:DC%2BD1MXhtVWmt7rN
-
JK Kim M Klinger J Benjamin Y Xiao DJ Erle DR Littman N Killeen 2009 Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking PLoS ONE 4 8 e6580 19668367 10.1371/journal.pone.0006580 1:CAS:528:DC%2BD1MXhtVWmt7rN
-
(2009)
PLoS ONE
, vol.4
, Issue.8
, pp. 6580
-
-
Kim, J.K.1
Klinger, M.2
Benjamin, J.3
Xiao, Y.4
Erle, D.J.5
Littman, D.R.6
Killeen, N.7
-
46
-
-
13944260538
-
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
-
1:CAS:528:DC%2BD2MXlvVKmtg%3D%3D 15640801 10.1038/ni1160
-
X Tai M Cowan L Feigenbaum A Singer 2005 CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 Nat Immunol 6 2 152 162 1:CAS:528: DC%2BD2MXlvVKmtg%3D%3D 15640801 10.1038/ni1160
-
(2005)
Nat Immunol
, vol.6
, Issue.2
, pp. 152-162
-
-
Tai, X.1
Cowan, M.2
Feigenbaum, L.3
Singer, A.4
-
47
-
-
0033682056
-
B7/CD28 costimulation is essential for the homeostasis of the CD4∈+∈CD25+ immunoregulatory T cells that control autoimmune diabetes
-
1:CAS:528:DC%2BD3cXivFyrsbg%3D 10795741 10.1016/S1074-7613(00)80195-8
-
B Salomon DJ Lenschow L Rhee N Ashourian B Singh A Sharpe JA Bluestone 2000 B7/CD28 costimulation is essential for the homeostasis of the CD4∈+∈CD25+ immunoregulatory T cells that control autoimmune diabetes Immunity 12 4 431 440 1:CAS:528:DC%2BD3cXivFyrsbg%3D 10795741 10.1016/S1074-7613(00)80195-8
-
(2000)
Immunity
, vol.12
, Issue.4
, pp. 431-440
-
-
Salomon, B.1
Lenschow, D.J.2
Rhee, L.3
Ashourian, N.4
Singh, B.5
Sharpe, A.6
Bluestone, J.A.7
-
48
-
-
16044371193
-
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
-
1:CAS:528:DyaK28XmtVGmtLw%3D 8808683 10.1016/S1074-7613(00)80323-4
-
DJ Lenschow KC Herold L Rhee B Patel A Koons HY Qin E Fuchs B Singh CB Thompson JA Bluestone 1996 CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes Immunity 5 3 285 293 1:CAS:528: DyaK28XmtVGmtLw%3D 8808683 10.1016/S1074-7613(00)80323-4
-
(1996)
Immunity
, vol.5
, Issue.3
, pp. 285-293
-
-
Lenschow, D.J.1
Herold, K.C.2
Rhee, L.3
Patel, B.4
Koons, A.5
Qin, H.Y.6
Fuchs, E.7
Singh, B.8
Thompson, C.B.9
Bluestone, J.A.10
-
49
-
-
2942642383
-
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
-
1:CAS:528:DC%2BD2cXkvV2jsLg%3D 15184499 10.1084/jem.20040139
-
Q Tang KJ Henriksen M Bi EB Finger G Szot J Ye EL Masteller H McDevitt M Bonyhadi JA Bluestone 2004 In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes J Exp Med 199 11 1455 1465 1:CAS:528: DC%2BD2cXkvV2jsLg%3D 15184499 10.1084/jem.20040139
-
(2004)
J Exp Med
, vol.199
, Issue.11
, pp. 1455-1465
-
-
Tang, Q.1
Henriksen, K.J.2
Bi, M.3
Finger, E.B.4
Szot, G.5
Ye, J.6
Masteller, E.L.7
McDevitt, H.8
Bonyhadi, M.9
Bluestone, J.A.10
-
50
-
-
16444377660
-
Dependence of self-tolerance on TRAF6-directed development of thymic stroma
-
1:CAS:528:DC%2BD2MXivFCgsLo%3D 15705807 10.1126/science.1105677
-
T Akiyama S Maeda S Yamane K Ogino M Kasai F Kajiura M Matsumoto J Inoue 2005 Dependence of self-tolerance on TRAF6-directed development of thymic stroma Science 308 5719 248 251 1:CAS:528:DC%2BD2MXivFCgsLo%3D 15705807 10.1126/science.1105677
-
(2005)
Science
, vol.308
, Issue.5719
, pp. 248-251
-
-
Akiyama, T.1
Maeda, S.2
Yamane, S.3
Ogino, K.4
Kasai, M.5
Kajiura, F.6
Matsumoto, M.7
Inoue, J.8
-
51
-
-
10744226628
-
NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner
-
1:CAS:528:DC%2BD2cXpslWgtA%3D%3D 14764671
-
F Kajiura S Sun T Nomura K Izumi T Ueno Y Bando N Kuroda H Han Y Li A Matsushima Y Takahama S Sakaguchi T Mitani M Matsumoto 2004 NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner J Immunol 172 4 2067 2075 1:CAS:528:DC%2BD2cXpslWgtA%3D%3D 14764671
-
(2004)
J Immunol
, vol.172
, Issue.4
, pp. 2067-2075
-
-
Kajiura, F.1
Sun, S.2
Nomura, T.3
Izumi, K.4
Ueno, T.5
Bando, Y.6
Kuroda, N.7
Han, H.8
Li, Y.9
Matsushima, A.10
Takahama, Y.11
Sakaguchi, S.12
Mitani, T.13
Matsumoto, M.14
-
52
-
-
34547151992
-
A decade of AIRE
-
1:CAS:528:DC%2BD2sXotFahtLc%3D 17641664 10.1038/nri2136
-
D Mathis C Benoist 2007 A decade of AIRE Nat Rev Immunol 7 8 645 650 1:CAS:528:DC%2BD2sXotFahtLc%3D 17641664 10.1038/nri2136
-
(2007)
Nat Rev Immunol
, vol.7
, Issue.8
, pp. 645-650
-
-
Mathis, D.1
Benoist, C.2
-
53
-
-
0037062420
-
Specificity requirements for selection and effector functions of CD25∈+∈4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice
-
1:CAS:528:DC%2BD38XkvVGht7k%3D 12034883 10.1073/pnas.122224799
-
S Hori M Haury A Coutinho J Demengeot 2002 Specificity requirements for selection and effector functions of CD25∈+∈4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice Proc Natl Acad Sci U S A 99 12 8213 8218 1:CAS:528:DC%2BD38XkvVGht7k%3D 12034883 10.1073/pnas. 122224799
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.12
, pp. 8213-8218
-
-
Hori, S.1
Haury, M.2
Coutinho, A.3
Demengeot, J.4
-
54
-
-
33645102841
-
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
-
1:CAS:528:DC%2BD28Xis1Gmur8%3D 16532000 10.1038/ni1318
-
CS Hsieh Y Zheng Y Liang JD Fontenot AY Rudensky 2006 An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires Nat Immunol 7 4 401 410 1:CAS:528:DC%2BD28Xis1Gmur8%3D 16532000 10.1038/ni1318
-
(2006)
Nat Immunol
, vol.7
, Issue.4
, pp. 401-410
-
-
Hsieh, C.S.1
Zheng, Y.2
Liang, Y.3
Fontenot, J.D.4
Rudensky, A.Y.5
-
55
-
-
34548680545
-
Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells
-
1:CAS:528:DC%2BD2sXhtFWmu7fK 17869133 10.1016/j.immuni.2007.07.019
-
R Pacholczyk J Kern N Singh M Iwashima P Kraj L Ignatowicz 2007 Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells Immunity 27 3 493 504 1:CAS:528:DC%2BD2sXhtFWmu7fK 17869133 10.1016/j.immuni. 2007.07.019
-
(2007)
Immunity
, vol.27
, Issue.3
, pp. 493-504
-
-
Pacholczyk, R.1
Kern, J.2
Singh, N.3
Iwashima, M.4
Kraj, P.5
Ignatowicz, L.6
-
56
-
-
70349246628
-
TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cells
-
1:CAS:528:DC%2BD1MXhtVWrs73I 19648277 10.4049/jimmunol.0900514
-
M Kuczma I Pawlikowska M Kopij R Podolsky GA Rempala P Kraj 2009 TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cells J Immunol 183 5 3118 3129 1:CAS:528:DC%2BD1MXhtVWrs73I 19648277 10.4049/jimmunol.0900514
-
(2009)
J Immunol
, vol.183
, Issue.5
, pp. 3118-3129
-
-
Kuczma, M.1
Pawlikowska, I.2
Kopij, M.3
Podolsky, R.4
Rempala, G.A.5
Kraj, P.6
-
57
-
-
4143066714
-
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
-
1:CAS:528:DC%2BD2cXnsVKlt7c%3D 15308106 10.1016/j.immuni.2004.07.009
-
CS Hsieh Y Liang AJ Tyznik SG Self D Liggitt AY Rudensky 2004 Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors Immunity 21 2 267 277 1:CAS:528:DC%2BD2cXnsVKlt7c%3D 15308106 10.1016/j.immuni.2004.07.009
-
(2004)
Immunity
, vol.21
, Issue.2
, pp. 267-277
-
-
Hsieh, C.S.1
Liang, Y.2
Tyznik, A.J.3
Self, S.G.4
Liggitt, D.5
Rudensky, A.Y.6
-
58
-
-
34047117869
-
CD4∈+∈CD25+ regulatory T cells are activated in vivo by recognition of self
-
1:CAS:528:DC%2BD2sXjslers7o%3D 17369190 10.1093/intimm/dxm021
-
J Andersson I Stefanova GL Stephens EM Shevach 2007 CD4∈+∈CD25+ regulatory T cells are activated in vivo by recognition of self Int Immunol 19 4 557 566 1:CAS:528:DC%2BD2sXjslers7o%3D 17369190 10.1093/intimm/dxm021
-
(2007)
Int Immunol
, vol.19
, Issue.4
, pp. 557-566
-
-
Andersson, J.1
Stefanova, I.2
Stephens, G.L.3
Shevach, E.M.4
-
59
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
1:CAS:528:DC%2BD2sXhslSqs74%3D 17220874 10.1038/nature05543
-
MA Gavin JP Rasmussen JD Fontenot V Vasta VC Manganiello JA Beavo AY Rudensky 2007 Foxp3-dependent programme of regulatory T-cell differentiation Nature 445 7129 771 775 1:CAS:528:DC%2BD2sXhslSqs74%3D 17220874 10.1038/nature05543
-
(2007)
Nature
, vol.445
, Issue.7129
, pp. 771-775
-
-
Gavin, M.A.1
Rasmussen, J.P.2
Fontenot, J.D.3
Vasta, V.4
Manganiello, V.C.5
Beavo, J.A.6
Rudensky, A.Y.7
-
60
-
-
77954166341
-
Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice
-
1:CAS:528:DC%2BD1MXht1ymtbrF 19812199 10.4049/jimmunol.0803762
-
K Lahl CT Mayer T Bopp J Huehn C Loddenkemper G Eberl G Wirnsberger K Dornmair R Geffers E Schmitt J Buer T Sparwasser 2009 Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice J Immunol 183 9 5662 5672 1:CAS:528:DC%2BD1MXht1ymtbrF 19812199 10.4049/jimmunol.0803762
-
(2009)
J Immunol
, vol.183
, Issue.9
, pp. 5662-5672
-
-
Lahl, K.1
Mayer, C.T.2
Bopp, T.3
Huehn, J.4
Loddenkemper, C.5
Eberl, G.6
Wirnsberger, G.7
Dornmair, K.8
Geffers, R.9
Schmitt, E.10
Buer, J.11
Sparwasser, T.12
-
61
-
-
33748460087
-
Foxp3-dependent and -independent molecules specific for CD25∈+∈CD4+ natural regulatory T cells revealed by DNA microarray analysis
-
1:CAS:528:DC%2BD28Xot1CmsLo%3D 16772372 10.1093/intimm/dxl060
-
N Sugimoto T Oida K Hirota K Nakamura T Nomura T Uchiyama S Sakaguchi 2006 Foxp3-dependent and -independent molecules specific for CD25∈+∈CD4+ natural regulatory T cells revealed by DNA microarray analysis Int Immunol 18 8 1197 1209 1:CAS:528:DC%2BD28Xot1CmsLo%3D 16772372 10.1093/intimm/dxl060
-
(2006)
Int Immunol
, vol.18
, Issue.8
, pp. 1197-1209
-
-
Sugimoto, N.1
Oida, T.2
Hirota, K.3
Nakamura, K.4
Nomura, T.5
Uchiyama, T.6
Sakaguchi, S.7
-
62
-
-
36048978911
-
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
-
1:CAS:528:DC%2BD2sXhsVWjurjN 18024188 10.1016/j.immuni.2007.09.010
-
JA Hill M Feuerer K Tash S Haxhinasto J Perez R Melamed D Mathis C Benoist 2007 Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature Immunity 27 5 786 800 1:CAS:528:DC%2BD2sXhsVWjurjN 18024188 10.1016/j.immuni.2007.09.010
-
(2007)
Immunity
, vol.27
, Issue.5
, pp. 786-800
-
-
Hill, J.A.1
Feuerer, M.2
Tash, K.3
Haxhinasto, S.4
Perez, J.5
Melamed, R.6
Mathis, D.7
Benoist, C.8
-
63
-
-
38349095578
-
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
-
1:CAS:528:DC%2BD1cXovV2muw%3D%3D 18157133 10.1038/ni1549
-
Y Tone K Furuuchi Y Kojima ML Tykocinski MI Greene M Tone 2008 Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer Nat Immunol 9 2 194 202 1:CAS:528:DC%2BD1cXovV2muw%3D%3D 18157133 10.1038/ni1549
-
(2008)
Nat Immunol
, vol.9
, Issue.2
, pp. 194-202
-
-
Tone, Y.1
Furuuchi, K.2
Kojima, Y.3
Tykocinski, M.L.4
Greene, M.I.5
Tone, M.6
-
64
-
-
34447265236
-
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
-
1:CAS:528:DC%2BD2sXnslylsr4%3D 17591856
-
HP Kim WJ Leonard 2007 CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation J Exp Med 204 7 1543 1551 1:CAS:528:DC%2BD2sXnslylsr4%3D 17591856
-
(2007)
J Exp Med
, vol.204
, Issue.7
, pp. 1543-1551
-
-
Kim, H.P.1
Leonard, W.J.2
-
65
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
1:CAS:528:DC%2BD2sXnsFaqt78%3D 17569825 10.1126/science.1145697
-
D Mucida Y Park G Kim O Turovskaya I Scott M Kronenberg H Cheroutre 2007 Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid Science 317 5835 256 260 1:CAS:528:DC%2BD2sXnsFaqt78%3D 17569825 10.1126/science.1145697
-
(2007)
Science
, vol.317
, Issue.5835
, pp. 256-260
-
-
Mucida, D.1
Park, Y.2
Kim, G.3
Turovskaya, O.4
Scott, I.5
Kronenberg, M.6
Cheroutre, H.7
-
66
-
-
34547757390
-
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
-
1:CAS:528:DC%2BD2sXptVyjs7c%3D 17620362 10.1084/jem.20070602
-
CM Sun JA Hall RB Blank N Bouladoux M Oukka JR Mora Y Belkaid 2007 Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid J Exp Med 204 8 1775 1785 1:CAS:528: DC%2BD2sXptVyjs7c%3D 17620362 10.1084/jem.20070602
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1775-1785
-
-
Sun, C.M.1
Hall, J.A.2
Blank, R.B.3
Bouladoux, N.4
Oukka, M.5
Mora, J.R.6
Belkaid, Y.7
-
67
-
-
34547769253
-
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
-
1:CAS:528:DC%2BD2sXptVyjs7Y%3D 17620363 10.1084/jem.20070719
-
MJ Benson K Pino-Lagos M Rosemblatt RJ Noelle 2007 All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation J Exp Med 204 8 1765 1774 1:CAS:528:DC%2BD2sXptVyjs7Y%3D 17620363 10.1084/jem.20070719
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1765-1774
-
-
Benson, M.J.1
Pino-Lagos, K.2
Rosemblatt, M.3
Noelle, R.J.4
-
68
-
-
54349095059
-
CD103+ GALT DCs promote Foxp3+ regulatory T cells
-
1:CAS:528:DC%2BD1cXht1CmsLbJ 19079226 10.1038/mi.2008.43
-
KR Siddiqui F Powrie 2008 CD103+ GALT DCs promote Foxp3+ regulatory T cells Mucosal Immunol 1 Suppl 1 S34 S38 1:CAS:528:DC%2BD1cXht1CmsLbJ 19079226 10.1038/mi.2008.43
-
(2008)
Mucosal Immunol
, vol.1
, Issue.SUPPL. 1
-
-
Siddiqui, K.R.1
Powrie, F.2
-
69
-
-
33847220736
-
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
-
1:CAS:528:DC%2BD2sXhvFGitLY%3D 17237761 10.1038/nature05563
-
Y Zheng SZ Josefowicz A Kas TT Chu MA Gavin AY Rudensky 2007 Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells Nature 445 7130 936 940 1:CAS:528:DC%2BD2sXhvFGitLY%3D 17237761 10.1038/nature05563
-
(2007)
Nature
, vol.445
, Issue.7130
, pp. 936-940
-
-
Zheng, Y.1
Josefowicz, S.Z.2
Kas, A.3
Chu, T.T.4
Gavin, M.A.5
Rudensky, A.Y.6
-
70
-
-
33847242598
-
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
-
1:CAS:528:DC%2BD2sXhvFGit74%3D 17237765 10.1038/nature05478
-
A Marson K Kretschmer GM Frampton ES Jacobsen JK Polansky KD MacIsaac SS Levine E Fraenkel H von Boehmer RA Young 2007 Foxp3 occupancy and regulation of key target genes during T-cell stimulation Nature 445 7130 931 935 1:CAS:528:DC%2BD2sXhvFGit74%3D 17237765 10.1038/nature05478
-
(2007)
Nature
, vol.445
, Issue.7130
, pp. 931-935
-
-
Marson, A.1
Kretschmer, K.2
Frampton, G.M.3
Jacobsen, E.S.4
Polansky, J.K.5
MacIsaac, K.D.6
Levine, S.S.7
Fraenkel, E.8
Von Boehmer, H.9
Young, R.A.10
-
71
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
1:CAS:528:DC%2BD1MXltlSrsbY%3D 19412181 10.1038/ni.1731
-
MA Koch G Tucker-Heard NR Perdue JR Killebrew KB Urdahl DJ Campbell 2009 The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation Nat Immunol 10 6 595 602 1:CAS:528:DC%2BD1MXltlSrsbY%3D 19412181 10.1038/ni.1731
-
(2009)
Nat Immunol
, vol.10
, Issue.6
, pp. 595-602
-
-
Koch, M.A.1
Tucker-Heard, G.2
Perdue, N.R.3
Killebrew, J.R.4
Urdahl, K.B.5
Campbell, D.J.6
-
72
-
-
62649165369
-
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
-
1:CAS:528:DC%2BD1MXht1ehsLg%3D 19182775 10.1038/nature07674
-
Y Zheng A Chaudhry A Kas P deRoos JM Kim TT Chu L Corcoran P Treuting U Klein AY Rudensky 2009 Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses Nature 458 7236 351 356 1:CAS:528:DC%2BD1MXht1ehsLg%3D 19182775 10.1038/nature07674
-
(2009)
Nature
, vol.458
, Issue.7236
, pp. 351-356
-
-
Zheng, Y.1
Chaudhry, A.2
Kas, A.3
Deroos, P.4
Kim, J.M.5
Chu, T.T.6
Corcoran, L.7
Treuting, P.8
Klein, U.9
Rudensky, A.Y.10
-
73
-
-
70049113279
-
CD4+ regulatory T cells control TH17 responses in a stat3-dependent manner
-
1:CAS:528:DC%2BD1MXhtlyls7bE 19797626 10.1126/science.1172702
-
A Chaudhry D Rudra P Treuting RM Samstein Y Liang A Kas AY Rudensky 2009 CD4+ regulatory T cells control TH17 responses in a stat3-dependent manner Science 326 986 991 1:CAS:528:DC%2BD1MXhtlyls7bE 19797626 10.1126/science. 1172702
-
(2009)
Science
, vol.326
, pp. 986-991
-
-
Chaudhry, A.1
Rudra, D.2
Treuting, P.3
Samstein, R.M.4
Liang, Y.5
Kas, A.6
Rudensky, A.Y.7
-
74
-
-
37149018400
-
FOXP3 actively represses transcription by recruiting the HAT/HDAC complex
-
1:CAS:528:DC%2BD2sXhtVaks7rP 17592252
-
B Li MI Greene 2007 FOXP3 actively represses transcription by recruiting the HAT/HDAC complex Cell Cycle 6 12 1432 1436 1:CAS:528:DC%2BD2sXhtVaks7rP 17592252
-
(2007)
Cell Cycle
, vol.6
, Issue.12
, pp. 1432-1436
-
-
Li, B.1
Greene, M.I.2
-
75
-
-
17044393922
-
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
-
1:CAS:528:DC%2BD2MXjsFemtLg%3D 15790681 10.1073/pnas.0501675102
-
E Bettelli M Dastrange M Oukka 2005 Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells Proc Natl Acad Sci U S A 102 14 5138 5143 1:CAS:528:DC%2BD2MXjsFemtLg%3D 15790681 10.1073/pnas.0501675102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.14
, pp. 5138-5143
-
-
Bettelli, E.1
Dastrange, M.2
Oukka, M.3
-
76
-
-
34247215187
-
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
-
1:CAS:528:DC%2BD2sXjslOlsb8%3D 17377532 10.1038/nature05673
-
M Ono H Yaguchi N Ohkura I Kitabayashi Y Nagamura T Nomura Y Miyachi T Tsukada S Sakaguchi 2007 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 Nature 446 7136 685 689 1:CAS:528: DC%2BD2sXjslOlsb8%3D 17377532 10.1038/nature05673
-
(2007)
Nature
, vol.446
, Issue.7136
, pp. 685-689
-
-
Ono, M.1
Yaguchi, H.2
Ohkura, N.3
Kitabayashi, I.4
Nagamura, Y.5
Nomura, T.6
Miyachi, Y.7
Tsukada, T.8
Sakaguchi, S.9
-
77
-
-
47749124186
-
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
-
1:CAS:528:DC%2BD1cXntFSnsbY%3D 18434325 10.1074/jbc.M801286200
-
K Ichiyama H Yoshida Y Wakabayashi T Chinen K Saeki M Nakaya G Takaesu S Hori A Yoshimura T Kobayashi 2008 Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat J Biol Chem 283 25 17003 17008 1:CAS:528:DC%2BD1cXntFSnsbY%3D 18434325 10.1074/jbc.M801286200
-
(2008)
J Biol Chem
, vol.283
, Issue.25
, pp. 17003-17008
-
-
Ichiyama, K.1
Yoshida, H.2
Wakabayashi, Y.3
Chinen, T.4
Saeki, K.5
Nakaya, M.6
Takaesu, G.7
Hori, S.8
Yoshimura, A.9
Kobayashi, T.10
-
78
-
-
69549120242
-
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells
-
1:CAS:528:DC%2BD1MXhtVersrzN 19696312 10.1126/science.1176077
-
F Pan H Yu EV Dang J Barbi X Pan JF Grosso D Jinasena SM Sharma EM McCadden D Getnet CG Drake JO Liu MC Ostrowski DM Pardoll 2009 Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells Science 325 5944 1142 1146 1:CAS:528:DC%2BD1MXhtVersrzN 19696312 10.1126/science.1176077
-
(2009)
Science
, vol.325
, Issue.5944
, pp. 1142-1146
-
-
Pan, F.1
Yu, H.2
Dang, E.V.3
Barbi, J.4
Pan, X.5
Grosso, J.F.6
Jinasena, D.7
Sharma, S.M.8
McCadden, E.M.9
Getnet, D.10
Drake, C.G.11
Liu, J.O.12
Ostrowski, M.C.13
Pardoll, D.M.14
-
79
-
-
33846016948
-
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
-
1:CAS:528:DC%2BD28Xht1eltrbN 17028180 10.1074/jbc.M608848200
-
C Chen EA Rowell RM Thomas WW Hancock AD Wells 2006 Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation J Biol Chem 281 48 36828 36834 1:CAS:528: DC%2BD28Xht1eltrbN 17028180 10.1074/jbc.M608848200
-
(2006)
J Biol Chem
, vol.281
, Issue.48
, pp. 36828-36834
-
-
Chen, C.1
Rowell, E.A.2
Thomas, R.M.3
Hancock, W.W.4
Wells, A.D.5
-
80
-
-
2442453767
-
Calcineurin: A central controller of signalling in eukaryotes
-
1:CAS:528:DC%2BD2cXis1Krt74%3D 15060569 10.1038/sj.embor.7400133
-
J Aramburu J Heitman GR Crabtree 2004 Calcineurin: a central controller of signalling in eukaryotes EMBO Rep 5 4 343 348 1:CAS:528:DC%2BD2cXis1Krt74%3D 15060569 10.1038/sj.embor.7400133
-
(2004)
EMBO Rep
, vol.5
, Issue.4
, pp. 343-348
-
-
Aramburu, J.1
Heitman, J.2
Crabtree, G.R.3
-
81
-
-
0032039075
-
Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT
-
1:CAS:528:DyaK1cXivFyqur8%3D 9660947 10.1016/S1097-2765(00)80063-5
-
J Aramburu F Garcia-Cozar A Raghavan H Okamura A Rao PG Hogan 1998 Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT Mol Cell 1 5 627 637 1:CAS:528:DyaK1cXivFyqur8%3D 9660947 10.1016/S1097-2765(00)80063-5
-
(1998)
Mol Cell
, vol.1
, Issue.5
, pp. 627-637
-
-
Aramburu, J.1
Garcia-Cozar, F.2
Raghavan, A.3
Okamura, H.4
Rao, A.5
Hogan, P.G.6
-
82
-
-
0033634846
-
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
-
1:CAS:528:DC%2BD3cXntVyhs7g%3D 11030334 10.1016/S1097-2765(00)00053-8
-
H Okamura J Aramburu C Garcia-Rodriguez JP Viola A Raghavan M Tahiliani X Zhang J Qin PG Hogan A Rao 2000 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity Mol Cell 6 3 539 550 1:CAS:528:DC%2BD3cXntVyhs7g%3D 11030334 10.1016/S1097-2765(00)00053-8
-
(2000)
Mol Cell
, vol.6
, Issue.3
, pp. 539-550
-
-
Okamura, H.1
Aramburu, J.2
Garcia-Rodriguez, C.3
Viola, J.P.4
Raghavan, A.5
Tahiliani, M.6
Zhang, X.7
Qin, J.8
Hogan, P.G.9
Rao, A.10
-
83
-
-
0030973579
-
Transcription factors of the NFAT family: Regulation and function
-
1:CAS:528:DyaK2sXisVCmtLc%3D 9143705 10.1146/annurev.immunol.15.1.707
-
A Rao C Luo PG Hogan 1997 Transcription factors of the NFAT family: regulation and function Annu Rev Immunol 15 707 747 1:CAS:528:DyaK2sXisVCmtLc%3D 9143705 10.1146/annurev.immunol.15.1.707
-
(1997)
Annu Rev Immunol
, vol.15
, pp. 707-747
-
-
Rao, A.1
Luo, C.2
Hogan, P.G.3
-
84
-
-
33746228122
-
FOXP3 controls regulatory T cell function through cooperation with NFAT
-
1:CAS:528:DC%2BD28Xot1OntLs%3D 16873067 10.1016/j.cell.2006.05.042
-
Y Wu M Borde V Heissmeyer M Feuerer AD Lapan JC Stroud DL Bates L Guo A Han SF Ziegler D Mathis C Benoist L Chen A Rao 2006 FOXP3 controls regulatory T cell function through cooperation with NFAT Cell 126 2 375 387 1:CAS:528:DC%2BD28Xot1OntLs%3D 16873067 10.1016/j.cell.2006.05.042
-
(2006)
Cell
, vol.126
, Issue.2
, pp. 375-387
-
-
Wu, Y.1
Borde, M.2
Heissmeyer, V.3
Feuerer, M.4
Lapan, A.D.5
Stroud, J.C.6
Bates, D.L.7
Guo, L.8
Han, A.9
Ziegler, S.F.10
Mathis, D.11
Benoist, C.12
Chen, L.13
Rao, A.14
-
85
-
-
0032212631
-
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
-
1:CAS:528:DyaK1cXnvFWksbk%3D 9846484 10.1016/S1074-7613(00)80660-3
-
AM Ranger M Oukka J Rengarajan LH Glimcher 1998 Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development Immunity 9 5 627 635 1:CAS:528:DyaK1cXnvFWksbk%3D 9846484 10.1016/S1074-7613(00)80660-3
-
(1998)
Immunity
, vol.9
, Issue.5
, pp. 627-635
-
-
Ranger, A.M.1
Oukka, M.2
Rengarajan, J.3
Glimcher, L.H.4
-
86
-
-
36348962321
-
RUNX genes in development and cancer: Regulation of viral gene expression and the discovery of RUNX family genes
-
1:CAS:528:DC%2BD1cXitlGqur4%3D 18037406 10.1016/S0065-230X(07)99002-8
-
Y Ito 2008 RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes Adv Cancer Res 99 33 76 1:CAS:528:DC%2BD1cXitlGqur4%3D 18037406 10.1016/S0065-230X(07)99002-8
-
(2008)
Adv Cancer Res
, vol.99
, pp. 33-76
-
-
Ito, Y.1
-
87
-
-
18744398397
-
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
-
1:CAS:528:DC%2BD38XptlGrtbo%3D 12464175 10.1016/S0092-8674(02)01111-X
-
I Taniuchi M Osato T Egawa MJ Sunshine SC Bae T Komori Y Ito DR Littman 2002 Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development Cell 111 5 621 633 1:CAS:528:DC%2BD38XptlGrtbo%3D 12464175 10.1016/S0092-8674(02)01111-X
-
(2002)
Cell
, vol.111
, Issue.5
, pp. 621-633
-
-
Taniuchi, I.1
Osato, M.2
Egawa, T.3
Sunshine, M.J.4
Bae, S.C.5
Komori, T.6
Ito, Y.7
Littman, D.R.8
-
88
-
-
18344389720
-
Causal relationship between the loss of RUNX3 expression and gastric cancer
-
1:CAS:528:DC%2BD38XjtVOntLs%3D 11955451 10.1016/S0092-8674(02)00690-6
-
QL Li K Ito C Sakakura H Fukamachi K Inoue XZ Chi KY Lee S Nomura CW Lee SB Han HM Kim WJ Kim H Yamamoto N Yamashita T Yano T Ikeda S Itohara J Inazawa T Abe A Hagiwara H Yamagishi A Ooe A Kaneda T Sugimura T Ushijima SC Bae Y Ito 2002 Causal relationship between the loss of RUNX3 expression and gastric cancer Cell 109 1 113 124 1:CAS:528:DC%2BD38XjtVOntLs%3D 11955451 10.1016/S0092- 8674(02)00690-6
-
(2002)
Cell
, vol.109
, Issue.1
, pp. 113-124
-
-
Li, Q.L.1
Ito, K.2
Sakakura, C.3
Fukamachi, H.4
Inoue, K.5
Chi, X.Z.6
Lee, K.Y.7
Nomura, S.8
Lee, C.W.9
Han, S.B.10
Kim, H.M.11
Kim, W.J.12
Yamamoto, H.13
Yamashita, N.14
Yano, T.15
Ikeda, T.16
Itohara, S.17
Inazawa, J.18
Abe, T.19
Hagiwara, A.20
Yamagishi, H.21
Ooe, A.22
Kaneda, A.23
Sugimura, T.24
Ushijima, T.25
Bae, S.C.26
Ito, Y.27
more..
-
89
-
-
70349741295
-
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells
-
1:CAS:528:DC%2BD1MXhsVChtLrP 19800266 10.1016/j.immuni.2009.09.003
-
A Kitoh M Ono Y Naoe N Ohkura T Yamaguchi H Yaguchi I Kitabayashi T Tsukada T Nomura Y Miyachi I Taniuchi S Sakaguchi 2009 Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells Immunity 31 4 609 620 1:CAS:528:DC%2BD1MXhsVChtLrP 19800266 10.1016/j.immuni.2009.09.003
-
(2009)
Immunity
, vol.31
, Issue.4
, pp. 609-620
-
-
Kitoh, A.1
Ono, M.2
Naoe, Y.3
Ohkura, N.4
Yamaguchi, T.5
Yaguchi, H.6
Kitabayashi, I.7
Tsukada, T.8
Nomura, T.9
Miyachi, Y.10
Taniuchi, I.11
Sakaguchi, S.12
-
90
-
-
0029973591
-
Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta
-
1:CAS:528:DyaK28Xms1Gjtbw%3D 8901586 10.1073/pnas.93.22.12359
-
K Sasaki H Yagi RT Bronson K Tominaga T Matsunashi K Deguchi Y Tani T Kishimoto T Komori 1996 Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta Proc Natl Acad Sci U S A 93 22 12359 12363 1:CAS:528:DyaK28Xms1Gjtbw%3D 8901586 10.1073/pnas.93.22.12359
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.22
, pp. 12359-12363
-
-
Sasaki, K.1
Yagi, H.2
Bronson, R.T.3
Tominaga, K.4
Matsunashi, T.5
Deguchi, K.6
Tani, Y.7
Kishimoto, T.8
Komori, T.9
-
91
-
-
0030588487
-
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo
-
1:CAS:528:DyaK28XntVaqtL0%3D 8929538 10.1016/S0092-8674(00)81389-6
-
Q Wang T Stacy JD Miller AF Lewis TL Gu X Huang JH Bushweller JC Bories FW Alt G Ryan PP Liu A Wynshaw-Boris M Binder M Marin-Padilla AH Sharpe NA Speck 1996 The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo Cell 87 4 697 708 1:CAS:528:DyaK28XntVaqtL0%3D 8929538 10.1016/S0092-8674(00) 81389-6
-
(1996)
Cell
, vol.87
, Issue.4
, pp. 697-708
-
-
Wang, Q.1
Stacy, T.2
Miller, J.D.3
Lewis, A.F.4
Gu, T.L.5
Huang, X.6
Bushweller, J.H.7
Bories, J.C.8
Alt, F.W.9
Ryan, G.10
Liu, P.P.11
Wynshaw-Boris, A.12
Binder, M.13
Marin-Padilla, M.14
Sharpe, A.H.15
Speck, N.A.16
-
92
-
-
70350451993
-
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells
-
1:CAS:528:DC%2BD1MXhtFGjt7vJ 19767756 10.1038/ni.1795
-
D Rudra T Egawa MM Chong P Treuting DR Littman AY Rudensky 2009 Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells Nat Immunol 10 11 1170 1177 1:CAS:528:DC%2BD1MXhtFGjt7vJ 19767756 10.1038/ni.1795
-
(2009)
Nat Immunol
, vol.10
, Issue.11
, pp. 1170-1177
-
-
Rudra, D.1
Egawa, T.2
Chong, M.M.3
Treuting, P.4
Littman, D.R.5
Rudensky, A.Y.6
-
93
-
-
70449706325
-
Runx proteins regulate Foxp3 expression
-
1:CAS:528:DC%2BD1MXhtlCltrjE 19841090 10.1084/jem.20090226
-
L Bruno L Mazzarella M Hoogenkamp A Hertweck BS Cobb S Sauer S Hadjur M Leleu Y Naoe JC Telfer C Bonifer I Taniuchi AG Fisher M Merkenschlager 2009 Runx proteins regulate Foxp3 expression J Exp Med 206 11 2329 2337 1:CAS:528:DC%2BD1MXhtlCltrjE 19841090 10.1084/jem.20090226
-
(2009)
J Exp Med
, vol.206
, Issue.11
, pp. 2329-2337
-
-
Bruno, L.1
Mazzarella, L.2
Hoogenkamp, M.3
Hertweck, A.4
Cobb, B.S.5
Sauer, S.6
Hadjur, S.7
Leleu, M.8
Naoe, Y.9
Telfer, J.C.10
Bonifer, C.11
Taniuchi, I.12
Fisher, A.G.13
Merkenschlager, M.14
-
94
-
-
2442484053
-
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
-
1:CAS:528:DC%2BD2cXktlOgsLo%3D 15032588 10.1146/annurev.immunol.21. 120601.141122
-
S Sakaguchi 2004 Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses Annu Rev Immunol 22 531 562 1:CAS:528:DC%2BD2cXktlOgsLo%3D 15032588 10.1146/annurev. immunol.21.120601.141122
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 531-562
-
-
Sakaguchi, S.1
-
95
-
-
8644220506
-
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia
-
1:CAS:528:DC%2BD2cXhtVGis7%2FI 15514019 10.1073/pnas.0407180101
-
O Brenner D Levanon V Negreanu O Golubkov O Fainaru E Woolf Y Groner 2004 Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia Proc Natl Acad Sci U S A 101 45 16016 16021 1:CAS:528:DC%2BD2cXhtVGis7%2FI 15514019 10.1073/pnas.0407180101
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.45
, pp. 16016-16021
-
-
Brenner, O.1
Levanon, D.2
Negreanu, V.3
Golubkov, O.4
Fainaru, O.5
Woolf, E.6
Groner, Y.7
-
96
-
-
13244277850
-
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
-
1:CAS:528:DC%2BD38XptVShtbg%3D 12402038 10.1038/ng1020
-
L Prokunina C Castillejo-Lopez F Oberg I Gunnarsson L Berg V Magnusson AJ Brookes D Tentler H Kristjansdottir G Grondal AI Bolstad E Svenungsson I Lundberg G Sturfelt A Jonssen L Truedsson G Lima J Alcocer-Varela R Jonsson UB Gyllensten JB Harley D Alarcon-Segovia K Steinsson ME Alarcon-Riquelme 2002 A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans Nat Genet 32 4 666 669 1:CAS:528: DC%2BD38XptVShtbg%3D 12402038 10.1038/ng1020
-
(2002)
Nat Genet
, vol.32
, Issue.4
, pp. 666-669
-
-
Prokunina, L.1
Castillejo-Lopez, C.2
Oberg, F.3
Gunnarsson, I.4
Berg, L.5
Magnusson, V.6
Brookes, A.J.7
Tentler, D.8
Kristjansdottir, H.9
Grondal, G.10
Bolstad, A.I.11
Svenungsson, E.12
Lundberg, I.13
Sturfelt, G.14
Jonssen, A.15
Truedsson, L.16
Lima, G.17
Alcocer-Varela, J.18
Jonsson, R.19
Gyllensten, U.B.20
Harley, J.B.21
Alarcon-Segovia, D.22
Steinsson, K.23
Alarcon-Riquelme, M.E.24
more..
-
97
-
-
0345659216
-
A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis
-
1:CAS:528:DC%2BD3sXpt1Ciu70%3D 14608357 10.1038/ng1268
-
C Helms L Cao JG Krueger EM Wijsman F Chamian D Gordon M Heffernan JA Daw J Robarge J Ott PY Kwok A Menter AM Bowcock 2003 A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis Nat Genet 35 4 349 356 1:CAS:528:DC%2BD3sXpt1Ciu70%3D 14608357 10.1038/ng1268
-
(2003)
Nat Genet
, vol.35
, Issue.4
, pp. 349-356
-
-
Helms, C.1
Cao, L.2
Krueger, J.G.3
Wijsman, E.M.4
Chamian, F.5
Gordon, D.6
Heffernan, M.7
Daw, J.A.8
Robarge, J.9
Ott, J.10
Kwok, P.Y.11
Menter, A.12
Bowcock, A.M.13
-
98
-
-
0344364566
-
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis
-
1:CAS:528:DC%2BD3sXpt1Ciu7w%3D 14608356 10.1038/ng1267
-
S Tokuhiro R Yamada X Chang A Suzuki Y Kochi T Sawada M Suzuki M Nagasaki M Ohtsuki M Ono H Furukawa M Nagashima S Yoshino A Mabuchi A Sekine S Saito A Takahashi T Tsunoda Y Nakamura K Yamamoto 2003 An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis Nat Genet 35 4 341 348 1:CAS:528:DC%2BD3sXpt1Ciu7w%3D 14608356 10.1038/ng1267
-
(2003)
Nat Genet
, vol.35
, Issue.4
, pp. 341-348
-
-
Tokuhiro, S.1
Yamada, R.2
Chang, X.3
Suzuki, A.4
Kochi, Y.5
Sawada, T.6
Suzuki, M.7
Nagasaki, M.8
Ohtsuki, M.9
Ono, M.10
Furukawa, H.11
Nagashima, M.12
Yoshino, S.13
Mabuchi, A.14
Sekine, A.15
Saito, S.16
Takahashi, A.17
Tsunoda, T.18
Nakamura, Y.19
Yamamoto, K.20
more..
-
99
-
-
33750282677
-
The IL-23/Th(17) axis: Therapeutic targets for autoimmune inflammation
-
1:CAS:528:DC%2BD28XhtFens7nM 17010592 10.1016/j.coi.2006.09.008
-
K Kikly L Liu S Na JD Sedgwick 2006 The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation Curr Opin Immunol 18 6 670 675 1:CAS:528:DC%2BD28XhtFens7nM 17010592 10.1016/j.coi.2006.09.008
-
(2006)
Curr Opin Immunol
, vol.18
, Issue.6
, pp. 670-675
-
-
Kikly, K.1
Liu, L.2
Na, S.3
Sedgwick, J.D.4
-
100
-
-
39449127389
-
Th17 cells and mucosal host defense
-
1:CAS:528:DC%2BD1cXisVSrsLk%3D 18054248 10.1016/j.smim.2007.10.009
-
SJ Aujla PJ Dubin JK Kolls 2007 Th17 cells and mucosal host defense Semin Immunol 19 6 377 382 1:CAS:528:DC%2BD1cXisVSrsLk%3D 18054248 10.1016/j.smim.2007.10.009
-
(2007)
Semin Immunol
, vol.19
, Issue.6
, pp. 377-382
-
-
Aujla, S.J.1
Dubin, P.J.2
Kolls, J.K.3
-
101
-
-
37549008775
-
Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer
-
1:CAS:528:DC%2BD2sXhsVCjs7bO 18089828 10.1158/0008-5472.CAN-07-2259
-
T Kottke L Sanchez-Perez RM Diaz J Thompson H Chong K Harrington SK Calderwood J Pulido N Georgopoulos P Selby A Melcher R Vile 2007 Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer Cancer Res 67 24 11970 11979 1:CAS:528: DC%2BD2sXhsVCjs7bO 18089828 10.1158/0008-5472.CAN-07-2259
-
(2007)
Cancer Res
, vol.67
, Issue.24
, pp. 11970-11979
-
-
Kottke, T.1
Sanchez-Perez, L.2
Diaz, R.M.3
Thompson, J.4
Chong, H.5
Harrington, K.6
Calderwood, S.K.7
Pulido, J.8
Georgopoulos, N.9
Selby, P.10
Melcher, A.11
Vile, R.12
-
102
-
-
33646560950
-
Transforming growth factor-beta induces development of the T(H)17 lineage
-
1:CAS:528:DC%2BD28XksVGns7k%3D 16648837 10.1038/nature04754
-
PR Mangan LE Harrington DB O'Quinn WS Helms DC Bullard CO Elson RD Hatton SM Wahl TR Schoeb CT Weaver 2006 Transforming growth factor-beta induces development of the T(H)17 lineage Nature 441 7090 231 234 1:CAS:528: DC%2BD28XksVGns7k%3D 16648837 10.1038/nature04754
-
(2006)
Nature
, vol.441
, Issue.7090
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O'Quinn, D.B.3
Helms, W.S.4
Bullard, D.C.5
Elson, C.O.6
Hatton, R.D.7
Wahl, S.M.8
Schoeb, T.R.9
Weaver, C.T.10
-
103
-
-
0348223787
-
Conversion of peripheral CD4∈+∈CD25- naive T cells to CD4∈+∈CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
1:CAS:528:DC%2BD3sXpvFaktLg%3D 14676299 10.1084/jem.20030152
-
W Chen W Jin N Hardegen KJ Lei L Li N Marinos G McGrady SM Wahl 2003 Conversion of peripheral CD4∈+∈CD25- naive T cells to CD4∈+∈CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3 J Exp Med 198 12 1875 1886 1:CAS:528:DC%2BD3sXpvFaktLg%3D 14676299 10.1084/jem.20030152
-
(2003)
J Exp Med
, vol.198
, Issue.12
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
McGrady, G.7
Wahl, S.M.8
-
104
-
-
0242669199
-
Coordinated histone modifications mediated by a CtBP co-repressor complex
-
1:CAS:528:DC%2BD3sXivFGhsLs%3D 12700765 10.1038/nature01550
-
Y Shi J Sawada G Sui B el Affar JR Whetstine F Lan H Ogawa MP Luke Y Nakatani 2003 Coordinated histone modifications mediated by a CtBP co-repressor complex Nature 422 6933 735 738 1:CAS:528:DC%2BD3sXivFGhsLs%3D 12700765 10.1038/nature01550
-
(2003)
Nature
, vol.422
, Issue.6933
, pp. 735-738
-
-
Shi, Y.1
Sawada, J.2
Sui, G.3
El Affar, B.4
Whetstine, J.R.5
Lan, F.6
Ogawa, H.7
Luke, M.P.8
Nakatani, Y.9
-
105
-
-
0041884743
-
Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state
-
1:CAS:528:DC%2BD3sXntFeqt7s%3D 12939344 10.1084/jem.20030686
-
S Fisson G Darrasse-Jeze E Litvinova F Septier D Klatzmann R Liblau BL Salomon 2003 Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state J Exp Med 198 5 737 746 1:CAS:528:DC%2BD3sXntFeqt7s%3D 12939344 10.1084/jem.20030686
-
(2003)
J Exp Med
, vol.198
, Issue.5
, pp. 737-746
-
-
Fisson, S.1
Darrasse-Jeze, G.2
Litvinova, E.3
Septier, F.4
Klatzmann, D.5
Liblau, R.6
Salomon, B.L.7
-
106
-
-
33846980131
-
Epigenetic control of the foxp3 locus in regulatory T cells
-
17298177 10.1371/journal.pbio.0050038 1:CAS:528:DC%2BD2sXhslOru7k%3D
-
S Floess J Freyer C Siewert U Baron S Olek J Polansky K Schlawe HD Chang T Bopp E Schmitt S Klein-Hessling E Serfling A Hamann J Huehn 2007 Epigenetic control of the foxp3 locus in regulatory T cells PLoS Biol 5 2 e38 17298177 10.1371/journal.pbio.0050038 1:CAS:528:DC%2BD2sXhslOru7k%3D
-
(2007)
PLoS Biol
, vol.5
, Issue.2
, pp. 38
-
-
Floess, S.1
Freyer, J.2
Siewert, C.3
Baron, U.4
Olek, S.5
Polansky, J.6
Schlawe, K.7
Chang, H.D.8
Bopp, T.9
Schmitt, E.10
Klein-Hessling, S.11
Serfling, E.12
Hamann, A.13
Huehn, J.14
-
107
-
-
74949115148
-
Immunomodulatory effect of 5-azacytidine (5-azaC): Potential role in the transplantation setting
-
19887673 10.1182/blood-2009-03-210393 1:CAS:528:DC%2BC3cXnvVyjuw%3D%3D
-
LI Sanchez-Abarca S Gutierrez-Cosio C Santamaria T Caballero-Velazquez B Blanco C Herrero-Sanchez JL Garcia S Carrancio P Hernandez-Campo FJ Gonzalez T Flores L Ciudad E Ballestar C Del Canizo JF San Miguel JA Perez-Simon 2009 Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting Blood 115 107 121 19887673 10.1182/blood-2009-03-210393 1:CAS:528:DC%2BC3cXnvVyjuw%3D%3D
-
(2009)
Blood
, vol.115
, pp. 107-121
-
-
Sanchez-Abarca, L.I.1
Gutierrez-Cosio, S.2
Santamaria, C.3
Caballero-Velazquez, T.4
Blanco, B.5
Herrero-Sanchez, C.6
Garcia, J.L.7
Carrancio, S.8
Hernandez-Campo, P.9
Gonzalez, F.J.10
Flores, T.11
Ciudad, L.12
Ballestar, E.13
Del Canizo, C.14
San Miguel, J.F.15
Perez-Simon, J.A.16
-
108
-
-
65549100376
-
Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1
-
1:CAS:528:DC%2BD1MXmtVKrtro%3D 19454658 10.4049/jimmunol.0803320
-
SZ Josefowicz CB Wilson AY Rudensky 2009 Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1 J Immunol 182 11 6648 6652 1:CAS:528:DC%2BD1MXmtVKrtro%3D 19454658 10.4049/jimmunol.0803320
-
(2009)
J Immunol
, vol.182
, Issue.11
, pp. 6648-6652
-
-
Josefowicz, S.Z.1
Wilson, C.B.2
Rudensky, A.Y.3
|