Defective cell cycle induction by IL-2 in naive T-cells antigen stimulated in the presence of refractory T-lymphocytes

International Immunology

Volumn 18, Issue 7, 2006, Pages 1043-1054

  Inaba, Hiroto ^a   Geiger, Terrence L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Apoptosis; Cytokine; Proliferation; Signal transduction; Suppression; T cell

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MYC PROTEIN; PROTEIN BCL XL; PROTEIN KINASE B; STAT5 PROTEIN; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL CYCLE; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DOWN REGULATION; IMMUNE RESPONSE; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; ANTIGENS; APOPTOSIS; BCL-X PROTEIN; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; CELLS, CULTURED; CLONAL ANERGY; COCULTURE TECHNIQUES; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; ONCOGENE PROTEIN V-AKT; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY; UP-REGULATION;

EID: 33745263084     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl038     Document Type: Article

References (54)

1. Smyth, M. J., Krasovskis, E. and Johnstone, R. W. 1998. Fas ligand-mediated lysis of self bystander targets by human papillomavirus-specific CD8+ cytotoxic T lymphocytes. J. Virol. 72:5948.
2. Zarozinski, C. C., McNally, J. M., Lohman, B. L., Daniels, K. A. and Welsh, R. M. 2000. Bystander sensitization to activation-induced cell death as a mechanism of virus-induced immune suppression. J. Virol. 74:3650.
3. Burrows, S. R., Fernan, A., Argaet, V. and Suhrbier, A. 1993. Bystander apoptosis induced by CD8+ cytotoxic T cell (CTL) clones: Implications for CTL lytic mechanisms. Int. Immunol. 5:1049.
4. Thornton, A. M. and Shevach, E. M. 1998. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
5. Thornton, A. M. and Shevach, E. M. 2000. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J. Immunol. 164:183.
6. Jonuleit, H., Schmitt, E., Kakirman, H., Stassen, M., Knop, J. and Enk, A. H. 2002. Infectious tolerance: Human CD25(+) regulatory Tcells convey suppressor activity to conventional CD4(+) T helper cells. J. Exp. Med. 196:255.
7. Fontenot, J. D. and Rudensky, A. Y. 2005. A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6:331.
8. Duthoit, C. T., Mekala, D. J., Alli, R. S. and Geiger, T. L. 2005. Uncoupling of IL-2 signaling from cell cycle progression in naive CD4+ T cells by regulatory CD4+CD25+ T lymphocytes. J. Immunol. 174:155.
9. Taams, L. S. and Wauben, M. H. 2000. Anergic T cells as active regulators of the immune response. Hum. Immunol. 61:633.
10. Taams, L. S., Boot, E. P., van Eden, W. and Wauben, M. H. 2000. 'Anergic' T cells modulate the T-cell activating capacity of antigen-presenting cells. J. Autoimmun. 14:335.
11. Chai, J. G., Bartok, I., Chandler, P. et al. 1999. Anergic T cells act as suppressor cells in vitro and in vivo. Eur. J. Immunol. 29:686.
12. Wilde, D. B., Prystowsky, M. B., Ely, J. M., Vogel, S. N., Dialynas, D. P. and Fitch, F. W. 1984. Antigen-reactive cloned helper T cells. II. Exposure of murine cloned helper T cells to IL 2-containing supernatant induces unresponsiveness to antigenic restimulation and inhibits lymphokine production after antigenic stimulation. J. Immunol. 133:636.
13. Wilde, D. B. and Fitch, F. W. 1984. Antigen-reactive cloned helper T cells. I. Unresponsiveness to antigenic restimulation develops after stimulation of cloned helper T cells. J. Immunol. 132: 1632.
14. Duthoit, C. T., Nguyen, P. and Geiger, T. L. 2004. Antigen nonspecific suppression of T cell responses by activated stimulation-refractory CD4+ T cells. J. Immunol. 172:2238.
15. Iazzi, G., Karjalainen, K. and Lanzavecchia, A. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8:89.
16. Schrum, A. G. and Turka, L. A. 2002. The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering. J. Exp. Med. 196:793.
17. Nelson, B. H. and Willerford, D. M. 1998. Biology of the interleukin-2 receptor. Adv. Immunol. 70:1.
18. Lin, J. X. and Leonard, W. J. 1997. Signaling from the IL-2 receptor to the nucleus. Cytokine Growth Factor Rev. 8:313.
19. Schorle, H., Holtschke, T., Hunig, T., Schimpl, A. and Horak, I. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621.
20. de la Rosa, M., Rutz, S., Dorninger, H. and Scheffold, A. 2004. Interleukin-2 is essential for CD4+CD25+ regulatory Tcell function. Eur. J. Immunol. 34:2480.
21. Barthlott, T., Moncrieffe, H., Veldhoen, M. et al. 2005. CD25+ CD4+ Tcells compete with naive CD4+ Tcells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 17:279.
22. Wan, Y. Y. and Flavell, R. A. 2005. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl Acad. Sci. USA 102:5126.
23. Rao, P. E., Petrone, A. L. and Ponath, P. D. 2005. Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}. J. Immunol. 174:1446.
24. Chen, W., Jin, W., Hardegen, N. et al. 2003. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198:1875.
25. Piccirillo, C. A. and Shevach, E. M. 2001. Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol. 167:1137.
26. Moriggl, R., Topham, D. J., Teglund, S. et al. 1999. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10:249.
27. Lin, J. X. and Leonard, W. J. 2000. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19:2566.
28. Moon, J. J. and Nelson, B. H. 2001. Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor. J. Immunol. 167:2714.
29. Moon, J. J., Rubio, E. D., Martino, A., Krumm, A. and Nelson, B. H. 2004. A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor. J. Biol. Chem. 279:5520.
30. Martino, A., Holmes, J. H., Lord, J. D., Moon, J. J. and Nelson, B. H. 2001. Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2. J. Immunol. 166:1723.CD25
31. Nourse, J., Firpo, E., Flanagan, W. M. et al. 1994. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570.
32. Lord, J. D., McIntosh, B. C., Greenberg, P. D. and Nelson, B. H. 2000. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the transactivation domain of Stat5. J. Immunol. 164:2533.
33. Dang, C. V., Resar, L. M., Emison, E. et al. 1999. Function of the c-Myc oncogenic transcription factor. Exp. Cell Res. 253:63.
34. Zhang, S., Lawless, V. A. and Kaplan, M. H. 2000. Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1. J. Immunol. 165:6270.
35. Boussiotis, V. A., Freeman, G. J., Taylor, P. A. et al. 2000. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat. Med. 6:290.
36. Lenardo, M. J. 1991. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 353:858.
37. Plas, D. R., Rathmell, J. C. and Thompson, C. B. 2002. Homeostatic control of lymphocyte survival: Potential origins and implications. Nat. Immunol. 3:515.
38. Iwashima, M. 2003. Kinetic perspectives of T cell antigen receptor signaling. A two-tier model for T cell full activation. Immunol. Rev. 191:196.
39. Kumaki, S., Armitage, R., Ahdieh, M., Park, L. and Cosman, D. 1996. Interleukin-15 up-regulates interleukin-2 receptor alpha chain but down-regulates its own high-affinity binding sites on human T and B cells. Eur. J. Immunol. 26:1235.
40. Chung, I. Y., Dong, H. F., Zhang, X. et al. 2004. Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4(+) cells. Cell. Immunol. 232:57.
41. Plaetinck, G., Combe, M. C., Corthesy, P. et al. 1990. Control of IL-2 receptor-alpha expression by IL-1, tumor necrosis factor, and IL-2. Complex regulation via elements in the 5′ flanking region. J. Immunol. 145:3340.
42. Gerondakis, S., Strasser, A., Metcalf, D., Grigoriadis, G., Scheerlinck, J. Y. and Grumont, R. J. 1996. Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc. Natl Acad. Sci. USA 93:3405.
43. Koike, T., Yamagishi, H., Hatanaka, Y. et al. 2003. A novel ERK-dependent signaling process that regulates interleukin-2 expression in a late phase of T cell activation. J. Biol. Chem. 278:15685.
44. Nelson, B. H., Martyak, T. P., Thompson, L. J., Moon, J. J. and Wang, T. 2003. Uncoupling of promitogenic and antiapoptotic functions of IL-2 by Smad-dependent TGF-beta signaling. J. Immunol. 170:5563.
45. Conrad, D. M., Hanniman, E. A., Watson, C. L., Mader, J. S. and Hoskin, D. W. 2004. Ryanodine receptor signaling is required for anti-CD3-induced T cell proliferation, interleukin-2 synthesis, and interleukin-2 receptor signaling. J. Cell. Biochem. 92:387.
46. Dammermann, W. and Guse, A. H. 2005. Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes. J. Biol. Chem. 280:21394.
47. Gonzalez, J., Harris, T., Childs, G. and Prystowsky, M. B. 2001. Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survival. Blood Cells Mol. Dis. 27:572.
48. Neuhaus, P., Klupp, J. and Langrehr, J. M. 2001. mTOR inhibitors: An overview. Liver Transplant. 7:473.
49. Kreisel, D., Sankaran, D., Wells, A. D. and Turka, L. A. 2002. Interleukin-2-mediated survival and proliferative signals are uncoupled in T lymphocytes that fail to divide after activation. Am. J. Transplant. 2:120.
50. Wells, A. D., Walsh, M. C., Bluestone, J. A. and Turka, L. A. 2001. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J. Clin. Invest. 108:895.
51. Maloy, K. J., Salaun, L., Cahill, R., Dougan, G., Saunders, N. J. and Powrie, F. 2003. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197:111.
52. Zhang, X., Koldzic, D. N., Izikson, L. et al. 2004. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25(+)CD4(+) regulatory T cells. Int. Immunol. 16:249.
53. Wraith, D. C., Nicolson, K. S. and Whitley, N. T. 2004. Regulatory CD4+ T cells and the control of autoimmune disease. Curr. Opin. Immunol. 16:695.
54. Kedl, R. M., Kappler, J. W. and Marrack, P. 2003. Epitope dominance, competition and T cell affinity maturation. Curr. Opin. Immunol. 15:120.