Antigen-Specific Induction of Regulatory T Cells In Vivo and In Vitro

Methods in Molecular Biology

Volumn 707, Issue , 2011, Pages 173-185

  Daniel, Carolin ^a   Ploegh, Hidde ^b   von Boehmer, Harald ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c Laboratory of Molecular Biology   (United States)

Author keywords

Antigen; Conversion; DEC205; Foxp3; Regulatory T cells (Tregs); Sortagging

Indexed keywords

ANTIGEN; CELL SURFACE RECEPTOR; DEC 205 RECEPTOR; DEC-205 RECEPTOR; LECTIN; LEUKOCYTE ANTIGEN; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; IMMUNOLOGICAL PROCEDURES; IMMUNOLOGY; METABOLISM; REGULATORY T LYMPHOCYTE;

ANIMALS; ANTIGENS; ANTIGENS, CD; IMMUNOLOGIC TECHNIQUES; LECTINS, C-TYPE; RECEPTORS, CELL SURFACE; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TRETINOIN;

EID: 79955680455     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61737-979-6_11     Document Type: Chapter

References (30)

1. Burnet FM. The Clonal Selection Theory. 200. Cambridge Press, London, 1959.
2. Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987;49(2):273–280.
3. Kisielow P, Bluthmann H, Staerz UD, Steinmetz M, von BH. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 1988;333(6175):742–746.
4. Lederberg J. Genes and antibodies. Science 1959;129(3364):1649–1653.
5. Albert ML, Pearce SF, Francisco LM et al. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 1998;188(7): 1359–1368.
6. Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998;392(6671):86–89.
7. Antonia SJ, Geiger T, Miller J, Flavell RA. Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein. Int Immunol 1995;7(5):715–725.
8. Jolicoeur C, Hanahan D, Smith KM. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc Natl Acad Sci U S A 1994;91(14):6707–6711.
9. Kishimoto H, Sprent J. A defect in central tolerance in NOD mice. Nat Immunol 2001;2(11):1025–1031.
10. Liston A, Hardy K, Pittelkow Y et al. Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling. Genome Biol 2007;8(1):R12.
11. Rocha B, von BH. Peripheral selection of the T cell repertoire. Science 1991;251(4998): 1225–1228.
12. Rocha B, Tanchot C, von BH. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J Exp Med 1993;177(5):1517–1521.
13. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4(4):330–336.
14. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005;6(4):345–352.
15. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008;133(5):775–787.
16. Apostolou I, Sarukhan A, Klein L, von BH. Origin of regulatory T cells with known specificity for antigen. Nat Immunol 2002;3(8):756–763.
17. Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von BH. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005;6(12):1219–1227.
18. Jaeckel E, von BH, Manns MP. Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 2005;54(2):306–310.
19. Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med 2004;199(11): 1467–1477.
20. Rudensky AY, Campbell DJ. In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med 2006;203(3):489–492.
21. Marson A, Kretschmer K, Frampton GM et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007;445(7130):931–935.
22. Chen C, Rowell EA, Thomas RM, Hancock WW, Wells AD. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetyla-tion. J Biol Chem 2006;281(48): 36828–36834.
23. Verginis P, McLaughlin KA, Wucherpfennig KW, von BH, Apostolou I. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A 2008;105(9): 3479–3484.
24. Popp MW, Antos JM, Grotenbreg GM, Spooner E, Ploegh HL. Sortagging: a versatile method for protein labeling. Nat Chem Biol 2007;3(11):707–708.
25. Kretschmer K, Heng TS, von BH. De novo production of antigen-specific suppressor cells in vivo. Nat Protoc 2006;1(2):653–661.
26. Ton-That H, Liu G, Mazmanian SK, Faull KF, Schneewind O. Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif. Proc Natl Acad Sci U S A 1999;96(22):12424–12429.
27. Marraffini LA, Schneewind O. Targeting proteins to the cell wall of sporulating Bacillus anthra-cis. Mol Microbiol 2006;62(5):1402–1417.
28. Hill JA, Hall JA, Sun CM et al. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity 2008;29(5):758–770.
29. Hill JA, Hall JA, Sun CM et al. Response to letter from Mucida et al. Immunity 2009;30:472–473.
30. Mucida D, Pino-Lagos K, Kim G et al. Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells. Immunity 2009;30(4):471–472.