Preferential recognition of self antigens despite normal thymic deletion of CD4+CD25+ regulatory T cells

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1644-1648

  Romagnoli, Paola ^a   Hudrisier, Denis ^a   Van Meerwijk, Joost P M ^a  

^a CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN; SUPERANTIGEN;

ANIMAL CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CLONAL ANERGY; CONTROLLED STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; ONTOGENY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROLYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS FUNCTION;

EID: 0037083523     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1644     Document Type: Article

References (44)

1. T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms
2. Quantitative impact of thymic clonal deletion on the T cell repertoire
3. A nondeletional mechanism of thymic self tolerance
4. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
5. Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo
6. Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells
7. Animal models of autoimmunity and their relevance to human diseases
8. Regulatory T cells: Key controllers of immunologic self-tolerance
9. Regulatory T cells in autoimmmunity
10. Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells
11. How do monoclonal antibodies induce tolerance? A role for infectious tolerance?
12. Induction of diabetes in PVG/c strain rats by manipulation of the immune system
13. + T cell subset that inhibits this autoimmune potential
14. low subset
15. + T cells are important for the balance between protective and pathogenic cell-mediated immunity
16. + T cells
17. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
18. + regulatory cells that control intestinal inflammation
19. + T cells: A common basis between tumor immunity and autoimmunity
20. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
21. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
22. The physiological role of regulatory T cells in the prevention of autoimmunity; the function of the thymus in the generation of the regulatory T cell subset
23. Regulatory CD4 T cells: Expression of IL-2R α chain, resistance to clonal deletion and IL-2 dependency
24. + regulatory T cells induced by an agonist self-peptide
25. Another view of the selective model of thymocyte selection
26. Cloned T lymphocytes and monoclonal antibodies as probes for cell surface molecules active in T cell-mediated cytolysis
27. Establishment of monoclonal anti-Nk-1.1 antibody
28. Structural differences in cell surface T25 polypeptides from thymocytes and cloned T cells
29. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens
30. A shared alloantigenic determinant on Ia antigens encoded by the 1-A and 1-E subregions: Evidence for 1 region gene duplication
31. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: Similarity of L3T4 to the human Leu-3/T4 molecule
32. Thymoma production of T cell growth factor (IL-2)
33. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis
34. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
35. + pre-CTL and induce less clonal expansion than matching B lymphoblastoid cells: Development of a novel limiting dilution analysis method based on CFSE labeling of lymphocytes
36. Mouse mammary tumor virus: Immunological interplays between virus and host
37. Cellular interactions in thymocyte development
38. Studies on T cell maturation on defined thymic stromal cell populations in vitro
39. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
40. + immunoregulatory T cells is antigen nonspecific
41. Dual T cell receptor α chain T cells in autoimmunity
42. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function
43. Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cells
44. + immunoregulatory T cells