Neuroscience: Identification and functional characterization of brainstem cannabinoid CB2 receptors

Science

Volumn 310, Issue 5746, 2005, Pages 329-332

  Van Sickle, Marja D ^a   Duncan, Marnie ^a   Kingsley, Philip J ^b   Mouihate, Abdeslam ^a   Urbani, Paolo ^c   Mackie, Ken ^d   Stella, Nephi ^d   Makriyannis, Alexandros ^e   Piomelli, Daniele ^f   Davison, Joseph S ^a   Marnett, Lawrence J ^b   Di Marzo, Vincenzo ^c   Pittman, Quentin J ^a   Patel, Kamala D ^a   Sharkey, Keith A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CNR   (Italy)

^d UNIVERSITY OF WASHINGTON   (United States)

^e NORTHEASTERN UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLOGY; PROTEINS; RNA;

CENTRAL NERVOUS SYSTEM (CNS); ENDOCANNABINOID; PROTEIN LOCALIZATION;

BRAIN;

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARACHIDONOYLGLYCEROL; AMI 241; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; ENDOCANNABINOID; MESSENGER RNA; UNCLASSIFIED DRUG; AMIDE; ANANDAMIDE; ARACHIDONIC ACID DERIVATIVE; CANNABINOID;

MEDICINE;

ANIMAL CELL; ARTICLE; BINDING SITE; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; ANIMAL; BRAIN CORTEX; CEREBELLUM; DRUG ANTAGONISM; DRUG POTENTIATION; FERRET; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VOMITING; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; ARACHIDONIC ACIDS; BLOTTING, WESTERN; BRAIN STEM; CANNABINOIDS; CEREBELLUM; CEREBRAL CORTEX; ENDOCANNABINOIDS; FERRETS; IMMUNOHISTOCHEMISTRY; MICE; POLYUNSATURATED ALKAMIDES; RATS; RECEPTOR, CANNABINOID, CB2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VOMITING;

EID: 26844504226     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1115740     Document Type: Article

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31. We thank L. Oland, W. Ho, and N. Shariat for excellent technical support and animal care. Q.J.P., J.S.D., and K.A.S. were supported by the Canadian Institutes of Health Research (CIHR); K.D.P. by a CIHR group grant in leukocyte trafficking; L.J.M. by GM1S431; and K.M., N.S., A.M., and D.P. by U.S. National Institutes of Health. M.D.V.S. is an Alberta Heritage Foundation for Medical Research (AHFMR) graduate student; M.D. is an AHFMR and Canadian Association of Gastroenterology/CIHR/Janssen-Ortho postdoctoral fellow; K.D.P. holds a Canada research chair and is an AHFMR senior scholar; and Q.J.P. and K.A.S. are AHFMR medical scientists.