Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL- 2H3 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 292, Issue 3, 2000, Pages 960-967

  Rakhshan, Fariborz ^a   Day, Theresa A ^a   Blakely, Randy D ^b   Barker, Eric L ^a  

^a PURDUE UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANANDAMIDE; CANNABINOID;

ACTIVE TRANSPORT; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL LEVEL; CELL MEMBRANE TRANSPORT; FATTY ACID METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT;

AMIDOHYDROLASES; ARACHIDONIC ACIDS; BIOLOGICAL TRANSPORT; CANNABINOIDS; CARRIER PROTEINS; CELL LINE; MAST CELLS; POLYUNSATURATED ALKAMIDES; TETRAHYDROCANNABINOL;

EID: 0034054679     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Abumrad NA, El-Maghrabi MR, Amri EZ, Lopez E and Grimaldi PA (1993) Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol Chem 268:17665-17668.
2. Barker EL, Perlman MA, Adkins EM, Houlihan WJ, Pristupa ZB, Niznik HB and Blakely RD (1998) High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis - An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. J Biol Chem 273:19459-19468.
3. Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A and Piomelli D (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science (Wash DC) 277:1094-1097.
4. Berk PD, Bradbury MW, Zhou SL, Stump D and Handler JS (1996) Characterization of membrane transport processes: Lessons from the study of BSP, bilirubin, and fatty acid uptake. Semin Liver Dis 16:107-120.
5. Bisogno T, Maurelli S, Melck D, De Petrocellis L and Di Marzo V (1997) Biosynthesis, uptake and degradation of anandamide and palmitoylethanolamide in leukocytes. J Biol Chem 272:3315-3323.
6. Cadas H. Di Tomaso E and Piomelli D (1997) Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. J Neurosci 17:1226-1242.
7. Calignano A, Larana G, Beltramo M, Makriyannis A and Piomelli D (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM404. Eur J Pharmacol 337:R1-R2.
8. Cheng Y and Prusoff WH (1973) Relationship between the inhibition constant and the concentration of inhibitor that causes 50 percent inhibition of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
9. Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA and Gilula NB (1996) Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature (Lond) 384:83-87.
10. Crawley JN, Corwin RL, Robinson JK, Felder CC, Devane WA and Axelrod J (1993) Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents. Pharmacol Biochem Behav 46:967-972.
11. De Petrocellis L, Melck D, Ueda N, Maurelli S, Kurahashi Y, Yamamoto S, Marino G and Di Marzo V (1997) Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem Biophys Res Commun 231:82-88.
12. Deutsch DG and Chin SA (1993) Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem Pharmacol 46:791-796.
13. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A and Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (Wash DC) 258:1946-1949.
14. Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC and Piomelli D (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature (Lond) 372:686-691.
15. Facci L, Dal Toso R, Romanello S, Buriani A, Skaper SD and Leon A (1995) Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc Natl Acad Sci USA 92:3376-3380.
16. Felder CC, Briley EM, Axelrod J, Simpson JT, Mackie K and Devane WA (1993) Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci USA 90:7656-7660.
17. Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, Lai Y, Ma AL and Mitchell RL (1995) Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48:443-450.
18. Fride E and Mechoulam R (1993) Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent. Eur J Pharmacol 231:313-314.
19. Garcia CK, Goldstein JL, Pathak RK, Anderson RG and Brown MS (1994) Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle. Cell 76:865-873.
20. Goparaju SK, Ueda N, Yamaguchi H and Yamamoto S (1998) Anandamide amidohydrolase reacting with 2-arachidonoylglycerol another cannabinoid receptor ligand. FEBS Lett 422:69-73.
21. Hamilton JA (1998) Fatty acid transport: Difficult or easy? J Lipid Res 39:467-481.
22. +/glucose co-transporter. Nature (Lond) 330:379-381.
23. Hillard CJ, Edgemond WS, Jarrahian A and Campbell WB (1997) Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. J Neurochem 69:631-638.
24. Hirsch D, Stahl A and Lodish HF (1998) A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci USA 95:8625-8629.
25. Hirst RA, Lambert DG and Notcutt WG (1998) Pharmacology and potential therapeutic uses of cannabis. Br J Anaesth 81:77-84.
26. Howlett AC (1995) Pharmacology of cannabinoid receptors. Annu Rev Pharmacol Toxicol 35:607-634.
27. Isola LM, Zhou SL, Kiang CL, Stump DD, Bradbury MW and Berk PD (1995) 3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptake. Proc Natl Acad Sci USA 92:9866-9870.
28. Kamp F and Hamilton JA (1993) Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry 32:11074-11086.
29. Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW and Schuster VL (1995) Identification and characterization of a prostaglandin transporter. Science (Wash DC) 268:866-869.
30. Klein TW, Newton C and Friedman H (1998) Cannabinoid receptors and immunity. Immunol Today 19:373-381.
31. Natarajan V, Reddy PV, Schmid PC and Schmid HO (1982) N-acylation of ethanolamine phospholipids in canine myocardium. Biochim Biophys Acta 712:342-355.
32. +/Cl neurotransmitter transporters. J Neurochem 71:1785-1803.
33. 14C] as a substrate for anandamide amidase. Life Sci 56:1999-2005.
34. Piomelli D, Beltramo M, Glasnapp S, Lin SY, Goutopoulos A, Xie XQ and Makriyannis A (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc Natl Acad Sci USA 96:5802-5807.
35. Schaffer JE and Lodish HF (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79:427-436.
36. Skaper SD, Buriani A, Dal Toso R, Petrelli L, Romanello S, Facci L and Leon A (1996) The aliamide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Natl Acad Sci USA 93:3984-3989.
37. Smith PB, Compton DR, Welch SP, Razdan RK, Mechoulam R and Martin BR (1994) The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice. J Pharmacol Exp Ther 270:219-227.
38. Stein WD (1986) Transport and Diffusion across Cell Membranes, pp 363-474, Academic Press, San Diego.
39. Stella N, Schweitzer P and Piomelli D (1997) A second endogenous cannabinoid that modulates long-term potentiation. Nature (Lond) 388:773-778.
40. Takata K, Kasahara M, Oka Y and Hirano H (1993) Mammalian sugar transporters: Their localization and link to cellular functions. Acta Histochem Cytochem 26:165-178