메뉴 건너뛰기




Volumn 8, Issue , 2011, Pages

Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: An intravital microscopy study

Author keywords

[No Author keywords available]

Indexed keywords

CANNABIDIOL; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE;

EID: 78651456305     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-8-5     Document Type: Article
Times cited : (90)

References (43)
  • 1
    • 0042165861 scopus 로고    scopus 로고
    • Current epidemiology of septic shock: the CUB-Rea Network
    • 10.1164/rccm.2201087, 12851245
    • Annane D, Aegerter P, Jars-Guincestre MC, Guidet B. Current epidemiology of septic shock: the CUB-Rea Network. Am J Respir Crit Care Med 2003, 168:165-172. 10.1164/rccm.2201087, 12851245.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 165-172
    • Annane, D.1    Aegerter, P.2    Jars-Guincestre, M.C.3    Guidet, B.4
  • 2
    • 33750047495 scopus 로고    scopus 로고
    • Management of sepsis
    • 10.1056/NEJMra043632, 17050894
    • Russel JA. Management of sepsis. New Eng J Med 2006, 355:1699-1713. 10.1056/NEJMra043632, 17050894.
    • (2006) New Eng J Med , vol.355 , pp. 1699-1713
    • Russel, J.A.1
  • 3
    • 33846918427 scopus 로고    scopus 로고
    • Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats
    • 10.1159/000097051, 17124395
    • Rosengarten B, Hecht M, Auch D, Ghofrani HA, Schermuly RT, Grimminger F, Kaps M. Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats. Cerebrovasc Dis 2007, 23:140-147. 10.1159/000097051, 17124395.
    • (2007) Cerebrovasc Dis , vol.23 , pp. 140-147
    • Rosengarten, B.1    Hecht, M.2    Auch, D.3    Ghofrani, H.A.4    Schermuly, R.T.5    Grimminger, F.6    Kaps, M.7
  • 4
    • 9744227112 scopus 로고    scopus 로고
    • Modulation of cerebral vascular tone by activated glia: involvement of nitric oxide
    • 10.1111/j.1471-4159.2004.02782.x, 15569260
    • Chisari M, Salomone S, Laureanti F, Copani A, Sortino MA. Modulation of cerebral vascular tone by activated glia: involvement of nitric oxide. J Neurochem 2004, 91:1171-1179. 10.1111/j.1471-4159.2004.02782.x, 15569260.
    • (2004) J Neurochem , vol.91 , pp. 1171-1179
    • Chisari, M.1    Salomone, S.2    Laureanti, F.3    Copani, A.4    Sortino, M.A.5
  • 5
    • 34249830124 scopus 로고    scopus 로고
    • Role of nitric oxide in the brain during lipopolysaccharide-evoked systemic inflammation
    • 10.1002/jnr.21294, 17465018
    • Czapski GA, Cakala M, Chalimoniuk M, Gajkowska B, Strosznajder JB. Role of nitric oxide in the brain during lipopolysaccharide-evoked systemic inflammation. J Neurosci Res 2007, 85:1694-703. 10.1002/jnr.21294, 17465018.
    • (2007) J Neurosci Res , vol.85 , pp. 1694-1703
    • Czapski, G.A.1    Cakala, M.2    Chalimoniuk, M.3    Gajkowska, B.4    Strosznajder, J.B.5
  • 6
    • 58149136406 scopus 로고    scopus 로고
    • Autoregulative function in the brain in an endotoxic rat shock model
    • 10.1007/s00011-008-7199-2, 19109748
    • Rosengarten B, Hecht M, Wolff S, Kaps M. Autoregulative function in the brain in an endotoxic rat shock model. Inflamm Res 2008, 57:542-6. 10.1007/s00011-008-7199-2, 19109748.
    • (2008) Inflamm Res , vol.57 , pp. 542-546
    • Rosengarten, B.1    Hecht, M.2    Wolff, S.3    Kaps, M.4
  • 9
    • 29344445590 scopus 로고    scopus 로고
    • Cannabinoids in neurodegeneration and neuroprotection
    • Birkhäuser Verlag/Switzerland, Mechoulam R
    • Fernandez-Ruiz JJ, Gonzalez S, Romero J, Ramos JA. Cannabinoids in neurodegeneration and neuroprotection. Cannabinoids as Therapeutics 2005, 79-109. Birkhäuser Verlag/Switzerland, Mechoulam R.
    • (2005) Cannabinoids as Therapeutics , pp. 79-109
    • Fernandez-Ruiz, J.J.1    Gonzalez, S.2    Romero, J.3    Ramos, J.A.4
  • 10
    • 30344486638 scopus 로고    scopus 로고
    • Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
    • 10.2353/ajpath.2006.050500, 1592672, 16400026
    • El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou GI. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol 2006, 168:235-244. 10.2353/ajpath.2006.050500, 1592672, 16400026.
    • (2006) Am J Pathol , vol.168 , pp. 235-244
    • El-Remessy, A.B.1    Al-Shabrawey, M.2    Khalifa, Y.3    Tsai, N.T.4    Caldwell, R.B.5    Liou, G.I.6
  • 12
    • 62449330864 scopus 로고    scopus 로고
    • Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
    • 10.1124/jpet.108.147181, 2682269, 19074681
    • Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Haskó G, Pacher P. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. J Pharmacol Exp Ther 2009, 328:708-714. 10.1124/jpet.108.147181, 2682269, 19074681.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 708-714
    • Pan, H.1    Mukhopadhyay, P.2    Rajesh, M.3    Patel, V.4    Mukhopadhyay, B.5    Gao, B.6    Haskó, G.7    Pacher, P.8
  • 14
    • 0028798203 scopus 로고
    • Mechanisms of endotoxin-induced dilatation of cerebral arterioles
    • Brian JE, Heistad DD, Faraci FM. Mechanisms of endotoxin-induced dilatation of cerebral arterioles. Am J Physiol 1995, 269:H783-H788.
    • (1995) Am J Physiol , vol.269
    • Brian, J.E.1    Heistad, D.D.2    Faraci, F.M.3
  • 15
    • 0031800817 scopus 로고    scopus 로고
    • Role of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Endotoxin-Induced Cerebral Hyperemia
    • Okamoto H, Ito O, Roman RJ, Hudetz AG. Role of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Endotoxin-Induced Cerebral Hyperemia. Stroke 1998, 29:1209-1218.
    • (1998) Stroke , vol.29 , pp. 1209-1218
    • Okamoto, H.1    Ito, O.2    Roman, R.J.3    Hudetz, A.G.4
  • 16
    • 67049171321 scopus 로고    scopus 로고
    • Pathogenesis of septic encephalopathy
    • 10.1097/WCO.0b013e32832b3101, 19387342
    • Pytel P, Alexander J. Pathogenesis of septic encephalopathy. Curr Opin Neurol 2009, 22:283-287. 10.1097/WCO.0b013e32832b3101, 19387342.
    • (2009) Curr Opin Neurol , vol.22 , pp. 283-287
    • Pytel, P.1    Alexander, J.2
  • 18
    • 1642417657 scopus 로고    scopus 로고
    • The pharmacology and therapeutic potential of cannabidiol
    • Kluwer Academic Plenum Publishers, Di Marzo V
    • Pertwee RG. The pharmacology and therapeutic potential of cannabidiol. Cannabinoids 2004, 32-83. Kluwer Academic Plenum Publishers, Di Marzo V.
    • (2004) Cannabinoids , pp. 32-83
    • Pertwee, R.G.1
  • 19
    • 0033496026 scopus 로고    scopus 로고
    • Dynamic in vivo measurement of erythrocyte velocity and flow in capillaries and of microvessel diameter in the rat brain by confocal laser microscopy
    • 10.1097/00004647-199908000-00005, 10458593
    • Seylaz J, Charbonné R, Nanri K, Von Euw D, Borredon J, Kacem K, Méric P, Pinard E. Dynamic in vivo measurement of erythrocyte velocity and flow in capillaries and of microvessel diameter in the rat brain by confocal laser microscopy. J Cereb Blood Flow Metab 1999, 19:863-870. 10.1097/00004647-199908000-00005, 10458593.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 863-870
    • Seylaz, J.1    Charbonné, R.2    Nanri, K.3    Von Euw, D.4    Borredon, J.5    Kacem, K.6    Méric, P.7    Pinard, E.8
  • 20
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
    • 10.1084/jem.20070304, 2118680, 17664291
    • Paul J, Strickland S, Melchor JP. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med 2007, 204:1999-2008. 10.1084/jem.20070304, 2118680, 17664291.
    • (2007) J Exp Med , vol.204 , pp. 1999-2008
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 21
    • 38849195673 scopus 로고    scopus 로고
    • The encephalopathy in sepsis
    • 10.1016/j.ccc.2007.10.001, 18241779
    • Siami S, Annane D, Sharshar T. The encephalopathy in sepsis. Crit Care Clin 2008, 24:67-82. 10.1016/j.ccc.2007.10.001, 18241779.
    • (2008) Crit Care Clin , vol.24 , pp. 67-82
    • Siami, S.1    Annane, D.2    Sharshar, T.3
  • 23
    • 70349189518 scopus 로고    scopus 로고
    • Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    • 10.1016/j.tips.2009.07.006, 19729208
    • Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 2009, 30:515-527. 10.1016/j.tips.2009.07.006, 19729208.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 515-527
    • Izzo, A.A.1    Borrelli, F.2    Capasso, R.3    Di Marzo, V.4    Mechoulam, R.5
  • 24
    • 34547100965 scopus 로고    scopus 로고
    • Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
    • 10.1152/ajpheart.00236.2007, 2228254, 17384130
    • Rajesh M, Mukhopadhyay P, Batkai S, Hasko G, Liaudet L, Drel VR, Obrosova IG, Pacher P. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am J Physiol Heart Circ Physiol 2007, 293:H610-H619. 10.1152/ajpheart.00236.2007, 2228254, 17384130.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Rajesh, M.1    Mukhopadhyay, P.2    Batkai, S.3    Hasko, G.4    Liaudet, L.5    Drel, V.R.6    Obrosova, I.G.7    Pacher, P.8
  • 25
    • 38449109178 scopus 로고    scopus 로고
    • 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
    • 10.1111/j.1471-4159.2007.05073.x, 18028339
    • Massi P, Valenti M, Vaccani A, Gasperi V, Perletti G, Marras E, Fezza F, Maccarrone M, Parolaro D. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 2008, 104:1091-1100. 10.1111/j.1471-4159.2007.05073.x, 18028339.
    • (2008) J Neurochem , vol.104 , pp. 1091-1100
    • Massi, P.1    Valenti, M.2    Vaccani, A.3    Gasperi, V.4    Perletti, G.5    Marras, E.6    Fezza, F.7    Maccarrone, M.8    Parolaro, D.9
  • 26
    • 1642268380 scopus 로고    scopus 로고
    • Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
    • Costa B, Colleoni M, Conti S, Parolaro D, Franke C, Trovato AE, Giagnoni G. Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw. Naun Schm Arch Pharmacol 2004, 369:294-299.
    • (2004) Naun Schm Arch Pharmacol , vol.369 , pp. 294-299
    • Costa, B.1    Colleoni, M.2    Conti, S.3    Parolaro, D.4    Franke, C.5    Trovato, A.E.6    Giagnoni, G.7
  • 27
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • 10.1124/pr.58.3.2, 2241751, 16968947
    • Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006, 58:389-462. 10.1124/pr.58.3.2, 2241751, 16968947.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 28
    • 3543091441 scopus 로고    scopus 로고
    • How does peripheral lipopolysaccharide induce gene expression in the brain of rats?
    • 10.1016/j.tox.2004.04.015, 15297033
    • Singh AK, Jiang Y. How does peripheral lipopolysaccharide induce gene expression in the brain of rats?. Toxicology 2004, 201:197-207. 10.1016/j.tox.2004.04.015, 15297033.
    • (2004) Toxicology , vol.201 , pp. 197-207
    • Singh, A.K.1    Jiang, Y.2
  • 29
    • 73849115110 scopus 로고    scopus 로고
    • Central cannabinoid-1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area
    • 10.1097/SHK.0b013e3181a4fd8f, 19295473
    • Villanueva A, Yilmaz MS, Millington WR, Cutrera RA, Stouffer DG, Parsons LH, Cheer JF, Feleder C. Central cannabinoid-1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. Shock 2009, 32:614-620. 10.1097/SHK.0b013e3181a4fd8f, 19295473.
    • (2009) Shock , vol.32 , pp. 614-620
    • Villanueva, A.1    Yilmaz, M.S.2    Millington, W.R.3    Cutrera, R.A.4    Stouffer, D.G.5    Parsons, L.H.6    Cheer, J.F.7    Feleder, C.8
  • 30
    • 38048998959 scopus 로고    scopus 로고
    • TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1
    • Alexander JJ, Jacob A, Cunningham, Hensley L, Quigg RJ. TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1. Neurochem Intl 2008, 52:447-456.
    • (2008) Neurochem Intl , vol.52 , pp. 447-456
    • Alexander, J.J.1    Jacob, A.2    Cunningham3    Hensley, L.4    Quigg, R.J.5
  • 31
    • 33746903601 scopus 로고    scopus 로고
    • Nitric Oxide synthase as a target for the prevention of hypoxic-ischemic newborn brain damage
    • Martínez-Orgado J, Fernández-López D, Moro MA, Lizasoain I. Nitric Oxide synthase as a target for the prevention of hypoxic-ischemic newborn brain damage. Curr Enzym Inhib 2006, 2:219-229.
    • (2006) Curr Enzym Inhib , vol.2 , pp. 219-229
    • Martínez-Orgado, J.1    Fernández-López, D.2    Moro, M.A.3    Lizasoain, I.4
  • 32
    • 72749107868 scopus 로고    scopus 로고
    • The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB2 and adenosine receptors
    • 10.1016/j.nbd.2009.10.023, 19900555
    • Castillo AI, Tolón RM, Fernández-Ruiz JJ, Romero J, Martínez-Orgado J. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Neurobiol Dis 2010, 37:434-440. 10.1016/j.nbd.2009.10.023, 19900555.
    • (2010) Neurobiol Dis , vol.37 , pp. 434-440
    • Castillo, A.I.1    Tolón, R.M.2    Fernández-Ruiz, J.J.3    Romero, J.4    Martínez-Orgado, J.5
  • 33
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • 10.1016/j.neulet.2006.01.047, 16490313
    • Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci Lett 2006, 399:91-95. 10.1016/j.neulet.2006.01.047, 16490313.
    • (2006) Neurosci Lett , vol.399 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 34
    • 76249095734 scopus 로고    scopus 로고
    • Cannabinoids delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells
    • 10.1074/jbc.M109.069294, 2804319, 19910459
    • Kozela E, Pietr M, Juknat A, Rimmerman N, Levy R, Vogel Z. Cannabinoids delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells. J Biol Chem 285:1616-1626. 10.1074/jbc.M109.069294, 2804319, 19910459.
    • J Biol Chem , vol.285 , pp. 1616-1626
    • Kozela, E.1    Pietr, M.2    Juknat, A.3    Rimmerman, N.4    Levy, R.5    Vogel, Z.6
  • 35
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • 10.1152/physrev.00029.2006, 2248324, 17237348
    • Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007, 87:315-424. 10.1152/physrev.00029.2006, 2248324, 17237348.
    • (2007) Physiol Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 36
    • 0032528291 scopus 로고    scopus 로고
    • Indicators of glial activation and brain oxidative stress after intraventricular infusion of endotoxin
    • 10.1016/S0169-328X(97)00365-3, 9685567
    • Sugaya K, Chou S, Xu SJ, McKinney M. Indicators of glial activation and brain oxidative stress after intraventricular infusion of endotoxin. Brain Res Mol Brain Res 1998, 58:1-9. 10.1016/S0169-328X(97)00365-3, 9685567.
    • (1998) Brain Res Mol Brain Res , vol.58 , pp. 1-9
    • Sugaya, K.1    Chou, S.2    Xu, S.J.3    McKinney, M.4
  • 37
    • 38349158960 scopus 로고    scopus 로고
    • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
    • 10.1038/sj.bjp.0707442, 2219532, 17828291
    • Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. Br J Pharmacol 2008, 153:199-215. 10.1038/sj.bjp.0707442, 2219532, 17828291.
    • (2008) Br J Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 42
    • 35148900234 scopus 로고    scopus 로고
    • Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery
    • 10.1097/HJH.0b013e3282ef7a0a, 17921818
    • Kozlowska H, Baranowska M, Schilcker E, Kozlowski M, Laudañski J, Malinowska B. Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery. J Hypertens 2007, 25:2240-2248. 10.1097/HJH.0b013e3282ef7a0a, 17921818.
    • (2007) J Hypertens , vol.25 , pp. 2240-2248
    • Kozlowska, H.1    Baranowska, M.2    Schilcker, E.3    Kozlowski, M.4    Laudañski, J.5    Malinowska, B.6
  • 43
    • 56749152412 scopus 로고    scopus 로고
    • Virhodamine relaxes the human pulmonary artery through the endothelial cannabinoid receptor and indirectly through a COX product
    • 10.1038/bjp.2008.371, 2597267, 18806815
    • Kozlowska H, Baranowska M, Schilcker E, Kozlowski M, Laudañski J, Malinowska B. Virhodamine relaxes the human pulmonary artery through the endothelial cannabinoid receptor and indirectly through a COX product. Br J Pharmacol 2008, 155:1034-1042. 10.1038/bjp.2008.371, 2597267, 18806815.
    • (2008) Br J Pharmacol , vol.155 , pp. 1034-1042
    • Kozlowska, H.1    Baranowska, M.2    Schilcker, E.3    Kozlowski, M.4    Laudañski, J.5    Malinowska, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.