Cannabis constituents modulate δ9- tetrahydrocannabinolinduced hyperphagia in rats

Psychopharmacology

Volumn 210, Issue 1, 2010, Pages 97-106

  Farrimond, Jonathan A ^a   Hill, Andrew J ^a   Whalley, Benjamin J ^a   Williams, Claire M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

9THC; Behavior; Cannabis; Dronabinol; Feeding; Phytocannabinoids

Indexed keywords

CANNABICHROMENE; CANNABIS; DRONABINOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG MECHANISM; FEEDING BEHAVIOR; FOOD INTAKE; HYPERPHAGIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY;

ANIMALS; CANNABIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; HYPERPHAGIA; MALE; RATS; REACTION TIME; TETRAHYDROCANNABINOL;

EID: 77955570050     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-1821-z     Document Type: Article

References (48)

1. Akbas F, Gasteyger C, Sjödin A, Astrup A, Larsen TM (2008) A critical review of the cannabinoid receptor as a drug target for obesity management. Obes Rev 10:58-67
2. Beal JA (1994) Appetite effect of dronabinol. J Clin Oncol 12:1524-1525
3. Ben Amar M (2006) Cannabinoids in medicine: a review of their therapeutic potential. J Ethnopharmacol 105:1-25
4. Blundell JE, McArthur RA (1978) Behavioural flux and feeding: continuous monitoring of food intake and food selection, and the video-recording of appetitive and satiety sequences for the analysis of drug action. Anorectic agents: mechanism of action and tolerance. Raven Press, New York, pp 19-43
5. Brown AJ (2007) Novel cannabinoid receptors. Brit J Pharmacol 152:567-575
6. 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. Eur J Pharmacol 323: R3-R4
7. Carr TP, Jesch ED, Brown AW (2008) Endocannabinoids, metabolic regulation, and the role of diet. Nutr Res 28:641-650
8. 9- tetrahydrocannabivarin on [35S] GTP. S binding in mouse brain cerebellum and piriform cortex membranes. Brit J Pharmacol 154:1349-1358
9. De Petrocellis L, Vellani V, Schiano-Moriello A, Marini P, Magherini PC, Orlando P, Di Marzo V (2008) Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J Pharmacol Exp Ther 325:1007-1015
10. Dewey WL, Martin BR, May EL (1984) Cannabinoid stereoisomers: pharmacological effects. Handbook of stereoisomers: drugs in psychopharmacology. CPC Press, Boca Raton, pp 317-326
11. Di Marzo V, Bifulco M, De Petrocellis L (2004) The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 3:771-784
12. 1 receptors selectively stimulates feeding of palatable foods in rats. J Neurosci 28:9702-9709
13. Elsohly MA, Slade D (2005) Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci 78:539-548
14. 2 by cannabinoids. Lack of correlation with CNS effects. FEBS Lett 211:119-122
15. Gallate JE, McGregor IS (1999) The motivation for beer in rats: effects of ritanserin, naloxone and SR141716. Psychopharmacology 142:302-308
16. 1 receptor agonist. Eur J Pharmacol 370:233-240
17. Grotenhermen F (2006) Cannabinoids and the endocannabinoid system. Cannabinoids 1:10-14
18. Haney M, Rabkin J, Gunderson E, Foltin RW (2005) Dronabinol and marijuana in HIV+marijuana smokers: acute effects on caloric intake and mood. Psychopharmacology 181:170-178
19. Hao S, Avraham Y, Mechoulam R, Berry EM (2000) Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice. Eur J Pharmacol 392:147-156
20. Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 11:563-583
21. Holland ML, Allen JD, Arnold JC (2008) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol 591:128-131
22. Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R (2009) Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 30:515-527
23. Jones D (2008) End of the line for cannabinoid receptor 1 as an antiobesity target? Nat Rev Drug Discov 7:961-962
24. Kirkham TC, Blundell JE (1984) Dual action of naloxone on feeding revealed by behavioural analysis: separate effects on initiation and termination of eating. Appetite 5:45
25. Kirkham TC, Williams CM (2001) Endogenous cannabinoids and appetite. Nutr Res 14:65-86
26. 1 receptor-independent effects. Cell Calcium 46:154-162
27. 9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum. Brit J Pharmacol 154:204-215
28. 2. Mol Pharmacol 73:441-450
29. 1-tetrahydrocannabinol, the major active constituent of hashish. Tetrahedron Lett 12:1109-1111
30. Moore THM, Zammit S, Lingford-Hughes A, Barnes TRE, Jones PB, Burke M, Lewis G (2007) Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 370:319-328
31. Neovius M, Teixeira-Pinto A, Rasmussen F (2007) Shift in the composition of obesity in young adult men in Sweden over a third of a century. Int J Obes 32:832-836
32. 9- tetrahydrocannabivarin. Brit J Pharmacol 153:199-215
33. 9- tetrahydrocannabivarin. Brit J Pharmacol 153:199-215
34. Pertwee RG (2008b) Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addict Biol 13:147-159
35. Rao GK, Kaminski NE (2006) Cannabinoid-mediated elevation of intracellular calcium: a structure-activity relationship. J Pharmacol Exp Ther 317:820-829
36. Riedel G, Fadda P, McKillop-Smith PRG, Platt B, Robinson L (2009) Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice. Brit J Pharmacol 156:1154-1166
37. 2+ levels. J Neurosci 29:2053
38. Takeda S, Misawa K, Yamamoto I, Watanabe K (2008) Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis. Drug Metab Dispos 36:1917-1921
39. 2 receptor antagonist. Brit J Pharmacol 7:917-926
40. Weston SE, Williamson EM, Constanti A, Stephens GJ, Whalley BJ (2006) Tetrahydrocannabivarin exhibits anticonvulsant effects in a piriform cortical brain slice model of epileptiform activity. Proceedings of the BPS at http://www.pa2online.org/abstract/abstract.jsp?abid=28533
41. Whalley BJ, Wilkinson JD, Williamson EM, Constanti A (2004) A novel component of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in vitro. Neurosci Lett 365:58-63
42. 1 receptors. Psychopharmacology 143:315-317
43. 9-THC and anandamide. Physiol Behav 76:241-250
44. Williams CM, Kirkham TC (in press) Accumbens shell infusion of the endocannabinoid 2-AG increases food intake by advancing mealonset in free-feeding rats. Psychopharmacology
45. 9-THC. Physiol Behav 65:343-346
46. Williamson EM, Evans FJ (2000) Cannabinoids in clinical practice. Drugs 60:1303-1314
47. Wirth PW, Watson ES, ElSohly M, Turner CE, Murphy JC (1980) Anti-inflammatory properties of cannabichromene. Life Sci 26:1991-1995
48. Zhu HJ, Wang JS, Markowitz JS, Donovan JL, Gibson BB, Gefroh HA, Devane CL (2006) Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana. J Pharmacol Exp Ther 317:850-857