메뉴 건너뛰기




Volumn 153, Issue 2, 2008, Pages 199-215

The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9-tetrahydrocannabinol, cannabidiol and Δ 9-tetrahydrocannabivarin

Author keywords

9 tetrahydrocannabinol; 9 tetrahydrocannabivarin; Cannabidiol; Cannabinoid receptor agonism; Cannabinoid receptor antagonism; Cannabis; CB 2 receptors; CB 1 receptors; Clinical applications

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANANDAMIDE; CANNABIDIOL; CANNABIGEROL; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR; CANNABINOL; CANNABIS; CAPSAICIN; CLONIDINE; DELTA 9 TETRAHYDROCANNABIVARIN; DELTA8 TETRAHYDROCANNABINOL; DEXANABINOL; DRONABINOL; METHANANDAMIDE; MORPHINE; NABILONE; O 4394; RIMONABANT; UNCLASSIFIED DRUG; DRUG DERIVATIVE; TETRAHYDROCANNABINOL; TETRAHYDROCANNABIVARIN 9;

EID: 38349158960     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707442     Document Type: Review
Times cited : (1489)

References (184)
  • 1
    • 34250323489 scopus 로고    scopus 로고
    • Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    • Aguado T, Carracedo A, Julien B, Velasco G, Milman G, Mechoulam R et al. (2007). Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis. J Biol Chem 282: 6854-6862.
    • (2007) J Biol Chem , vol.282 , pp. 6854-6862
    • Aguado, T.1    Carracedo, A.2    Julien, B.3    Velasco, G.4    Milman, G.5    Mechoulam, R.6
  • 7
    • 0035452419 scopus 로고    scopus 로고
    • 1 receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis
    • 1 receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Synapse 41: 195-202.
    • (2001) Synapse , vol.41 , pp. 195-202
    • Berrendero, F.1    Sánchez, A.2    Cabranes, A.3    Puerta, C.4    Ramos, J.A.5    García-Merino, A.6
  • 8
    • 34249933789 scopus 로고    scopus 로고
    • Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)
    • Bifulco M, Laezza C, Gazzerro P, Pentimalli F (2007). Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review). Oncol Rep 17: 813-816.
    • (2007) Oncol Rep , vol.17 , pp. 813-816
    • Bifulco, M.1    Laezza, C.2    Gazzerro, P.3    Pentimalli, F.4
  • 9
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I et al. (2001). Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 134: 845-852.
    • (2001) Br J Pharmacol , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3    Tchilibon, S.4    Ponde, D.E.5    Brandi, I.6
  • 11
    • 9644255633 scopus 로고    scopus 로고
    • 9- Tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats
    • 9- Tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats. Eur J Pharmacol 506: 63-69.
    • (2004) Eur J Pharmacol , vol.506 , pp. 63-69
    • Braida, D.1    Iosuè, S.2    Pegorini, S.3    Sala, M.4
  • 12
    • 33846014230 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats
    • 9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats. Eur J Pharmacol 555: 156-163.
    • (2007) Eur J Pharmacol , vol.555 , pp. 156-163
    • Braida, D.1    Limonta, V.2    Malabarba, L.3    Zani, A.4    Sala, M.5
  • 14
    • 0034948614 scopus 로고    scopus 로고
    • Evidence for a new G protein-coupled cannabinoid receptor in mouse brain
    • Breivogel CS, Griffin G, Di Marzo V, Martin BR (2001). Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. Mol Pharmacol 60: 155-163.
    • (2001) Mol Pharmacol , vol.60 , pp. 155-163
    • Breivogel, C.S.1    Griffin, G.2    Di Marzo, V.3    Martin, B.R.4
  • 15
    • 0023852829 scopus 로고
    • In vivo metabolism of the n-propyl homologues of delta-8- and delta-9-tetrahydrocannabinol in the mouse
    • Brown N, Harvey D (1988). In vivo metabolism of the n-propyl homologues of delta-8- and delta-9-tetrahydrocannabinol in the mouse. Biomed Environ Mass Spectrom 15: 403-410.
    • (1988) Biomed Environ Mass Spectrom , vol.15 , pp. 403-410
    • Brown, N.1    Harvey, D.2
  • 17
    • 84859047666 scopus 로고    scopus 로고
    • Effects on the immune system
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Cabral GA, Staab A (2005). Effects on the immune system. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, vol. 168. Springer-Verlag: Heidelberg. pp 385-423.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 385-423
    • Cabral, G.A.1    Staab, A.2
  • 18
    • 33746964933 scopus 로고    scopus 로고
    • 1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice
    • 1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice. Brain Res 1107: 199-205.
    • (2006) Brain Res , vol.1107 , pp. 199-205
    • Cabranes, A.1    Pryce, G.2    Baker, D.3    Fernández-Ruiz, J.4
  • 19
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    • Carracedo A, Gironella M, Lorente M, Garcia S, Guzmán M, Velasco G et al. (2006). Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 66: 6748-6755.
    • (2006) Cancer Res , vol.66 , pp. 6748-6755
    • Carracedo, A.1    Gironella, M.2    Lorente, M.3    Garcia, S.4    Guzmán, M.5    Velasco, G.6
  • 20
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression
    • Carrier EJ, Auchampach JA, Hillard CJ (2006). Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA 103: 7895-7900.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 21
    • 38349185106 scopus 로고    scopus 로고
    • The CB-1 antagonist, delta-9-tetrahydrocannabivarin (THCV) has antiobesity activity in dietary-induced obese (DIO) mice
    • Burlington, Vermont, USA. International Cannabinoid Research Society, p
    • Cawthorne MA, Wargent E, Zaibi M, Stott C, Wright S (2007). The CB-1 antagonist, delta-9-tetrahydrocannabivarin (THCV) has antiobesity activity in dietary-induced obese (DIO) mice. Symposium on the Cannabinoids. Burlington, Vermont, USA. International Cannabinoid Research Society, p 141.
    • (2007) Symposium on the Cannabinoids , pp. 141
    • Cawthorne, M.A.1    Wargent, E.2    Zaibi, M.3    Stott, C.4    Wright, S.5
  • 23
    • 33645088405 scopus 로고    scopus 로고
    • Activation of G-proteins in brain by endogenous and exogenous cannabinoids
    • Childers SR (2006). Activation of G-proteins in brain by endogenous and exogenous cannabinoids. AAPS J 8: E112-E117.
    • (2006) AAPS J , vol.8
    • Childers, S.R.1
  • 26
    • 0020083061 scopus 로고
    • Effects of marihuana cannabinoids on seizure in cobalt-epileptic rats
    • Colasanti BK, Lindamood C, Craig CR (1982). Effects of marihuana cannabinoids on seizure in cobalt-epileptic rats. Pharmacol Biochem Behav 16: 573-578.
    • (1982) Pharmacol Biochem Behav , vol.16 , pp. 573-578
    • Colasanti, B.K.1    Lindamood, C.2    Craig, C.R.3
  • 27
    • 12344262003 scopus 로고    scopus 로고
    • 3 receptor agonists in the least shrew (Cryptotis parva)
    • 3 receptor agonists in the least shrew (Cryptotis parva). Pharmacol Biochem Behav 80: 35-44.
    • (2005) Pharmacol Biochem Behav , vol.80 , pp. 35-44
    • Darmani, N.A.1    Crim, J.L.2
  • 28
    • 1642303039 scopus 로고    scopus 로고
    • Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis
    • Darmani NA, Johnson JC (2004). Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis. Eur J Pharmacol 488: 201-212.
    • (2004) Eur J Pharmacol , vol.488 , pp. 201-212
    • Darmani, N.A.1    Johnson, J.C.2
  • 29
    • 1242272173 scopus 로고    scopus 로고
    • Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development
    • De Vry J, Jentzsch KR, Kuhl E, Eckel G (2004). Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development. Behav Pharmacol 15: 1-12.
    • (2004) Behav Pharmacol , vol.15 , pp. 1-12
    • De Vry, J.1    Jentzsch, K.R.2    Kuhl, E.3    Eckel, G.4
  • 31
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G et al. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258: 1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3    Pertwee, R.G.4    Stevenson, L.A.5    Griffin, G.6
  • 32
    • 0022509199 scopus 로고
    • Cannabinoid pharmacology
    • Dewey WL (1986). Cannabinoid pharmacology. Pharmacol Rev 38: 151-178.
    • (1986) Pharmacol Rev , vol.38 , pp. 151-178
    • Dewey, W.L.1
  • 34
    • 33645794041 scopus 로고    scopus 로고
    • The biosynthesis, fate and pharmacological properties of endocannabinoids
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Di Marzo V, De Petrocellis L, Bisogno T (2005). The biosynthesis, fate and pharmacological properties of endocannabinoids. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, Vol 168. Springer-Verlag: Heidelberg. pp 147-185.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 147-185
    • Di Marzo, V.1    De Petrocellis, L.2    Bisogno, T.3
  • 37
    • 0020537267 scopus 로고
    • Convulsant-anticonvulsant properties of delta-9-tetrahydrocannabinol in rabbits
    • Fish BS, Consroe P, Fox RR (1983). Convulsant-anticonvulsant properties of delta-9-tetrahydrocannabinol in rabbits. Behav Genet 13: 205-211.
    • (1983) Behav Genet , vol.13 , pp. 205-211
    • Fish, B.S.1    Consroe, P.2    Fox, R.R.3
  • 38
    • 21244478975 scopus 로고    scopus 로고
    • Therapeutic potential of cannabinoid receptor agonists as analgesic agents
    • Fox A, Bevan S (2005). Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert Opin Investig Drugs 14: 695-703.
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 695-703
    • Fox, A.1    Bevan, S.2
  • 39
    • 20444398090 scopus 로고    scopus 로고
    • Endocannabinoid signaling system and brain reward: Emphasis on dopamine
    • Gardner EL (2005). Endocannabinoid signaling system and brain reward: emphasis on dopamine. Pharmacol Biochem Behav 81: 263-284.
    • (2005) Pharmacol Biochem Behav , vol.81 , pp. 263-284
    • Gardner, E.L.1
  • 41
    • 0014940443 scopus 로고
    • Preliminary experiments on the chemistry and pharmacology of cannabis
    • Gill EW, Paton WDM, Pertwee RG (1970). Preliminary experiments on the chemistry and pharmacology of cannabis. Nature 228: 134-136.
    • (1970) Nature , vol.228 , pp. 134-136
    • Gill, E.W.1    Paton, W.D.M.2    Pertwee, R.G.3
  • 43
    • 0032770197 scopus 로고    scopus 로고
    • Presynaptic imidazoline receptors: New developments in characterization and classification
    • Göthert M, Brüss M, Bönisch H, Molderings GJ (1999). Presynaptic imidazoline receptors: new developments in characterization and classification. Ann NY Acad Sci 881: 171-184.
    • (1999) Ann NY Acad Sci , vol.881 , pp. 171-184
    • Göthert, M.1    Brüss, M.2    Bönisch, H.3    Molderings, G.J.4
  • 44
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: Potential anticancer agents
    • Guzmán M (2003). Cannabinoids: potential anticancer agents. Nat Rev Cancer 3: 745-755.
    • (2003) Nat Rev Cancer , vol.3 , pp. 745-755
    • Guzmán, M.1
  • 45
    • 84855339807 scopus 로고    scopus 로고
    • Effects on cell viability
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Guzmán M (2005). Effects on cell viability. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, vol. 168. Springer-Verlag: Heidelberg. pp 627-642.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 627-642
    • Guzmán, M.1
  • 47
    • 0036753757 scopus 로고    scopus 로고
    • Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers
    • Hájos N, Freund TF (2002). Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers. Neuropharmacology 43: 503-510.
    • (2002) Neuropharmacology , vol.43 , pp. 503-510
    • Hájos, N.1    Freund, T.F.2
  • 48
    • 34247281666 scopus 로고    scopus 로고
    • Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission
    • Haller J, Mátyas F, Soproni K, Varga B, Barsy B, Németh B et al. (2007). Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission. Eur J Neurosci 25: 2445-2456.
    • (2007) Eur J Neurosci , vol.25 , pp. 2445-2456
    • Haller, J.1    Mátyas, F.2    Soproni, K.3    Varga, B.4    Barsy, B.5    Németh, B.6
  • 49
    • 33748457916 scopus 로고    scopus 로고
    • 2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice
    • 2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice. Eur J Pharmacol 546: 60-68.
    • (2006) Eur J Pharmacol , vol.546 , pp. 60-68
    • Haller, V.L.1    Cichewicz, D.L.2    Welch, S.P.3
  • 50
    • 33644835159 scopus 로고    scopus 로고
    • 9-Tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors
    • 9-Tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Mol Pharmacol 69: 991-997.
    • (2006) Mol Pharmacol , vol.69 , pp. 991-997
    • Hejazi, N.1    Zhou, C.2    Oz, M.3    Sun, H.4    Ye, J.H.5    Zhang, L.6
  • 54
  • 58
    • 27644567089 scopus 로고    scopus 로고
    • Cannabinoids and the digestive tract
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Izzo AA, Coutts AA (2005). Cannabinoids and the digestive tract. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, Vol 168. Springer-Verlag: Heidelberg. pp 573-598.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 573-598
    • Izzo, A.A.1    Coutts, A.A.2
  • 61
    • 0033863179 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor induction in experimental stroke
    • Jin KL, Mao XO, Goldsmith PC, Greenberg DA (2000). CB1 cannabinoid receptor induction in experimental stroke. Ann Neurol 48: 257-261.
    • (2000) Ann Neurol , vol.48 , pp. 257-261
    • Jin, K.L.1    Mao, X.O.2    Goldsmith, P.C.3    Greenberg, D.A.4
  • 62
    • 20444419001 scopus 로고    scopus 로고
    • Self-administration of cannabinoids by experimental animals and human marijuana smokers
    • Justinova Z, Goldberga SR, Heishman SJ, Tanda G (2005). Self-administration of cannabinoids by experimental animals and human marijuana smokers. Pharmacol Biochem Behav 81: 285-299.
    • (2005) Pharmacol Biochem Behav , vol.81 , pp. 285-299
    • Justinova, Z.1    Goldberga, S.R.2    Heishman, S.J.3    Tanda, G.4
  • 64
    • 1442299855 scopus 로고    scopus 로고
    • 9-Tetrahydrocannabinol antagonizes endocannabinoid modulation of synaptic transmission between hippocampal neurons in culture
    • 9-Tetrahydrocannabinol antagonizes endocannabinoid modulation of synaptic transmission between hippocampal neurons in culture. Neuropharmacology 46: 709-715.
    • (2004) Neuropharmacology , vol.46 , pp. 709-715
    • Kelley, B.G.1    Thayer, S.A.2
  • 65
    • 33746261289 scopus 로고    scopus 로고
    • 2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis
    • 2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. Eur J Pharmacol 542: 100-105.
    • (2006) Eur J Pharmacol , vol.542 , pp. 100-105
    • Kim, K.1    Moore, D.H.2    Makriyannis, A.3    Abood, M.E.4
  • 66
    • 33745783119 scopus 로고    scopus 로고
    • Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium
    • Kimball ES, Schneider CR, Wallace NH, Hornby PJ (2006). Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. Am J Physiol Gastrointest Liver Physiol 291: G364-G371.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291
    • Kimball, E.S.1    Schneider, C.R.2    Wallace, N.H.3    Hornby, P.J.4
  • 67
    • 17044390454 scopus 로고    scopus 로고
    • Endogenous cannabinoid receptor ligand induces themigration of human natural killer cells
    • Kishimoto S, Muramatsu M, Gokoh M, Oka S, Waku K, Sugiura T (2005). Endogenous cannabinoid receptor ligand induces themigration of human natural killer cells. J Biochem 137: 217-223.
    • (2005) J Biochem , vol.137 , pp. 217-223
    • Kishimoto, S.1    Muramatsu, M.2    Gokoh, M.3    Oka, S.4    Waku, K.5    Sugiura, T.6
  • 68
    • 33745086856 scopus 로고    scopus 로고
    • Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors
    • Koch M, Dehghani F, Habazettl I, Schomerus C, Korf H-W (2006). Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. J Neurochem 98: 267-278.
    • (2006) J Neurochem , vol.98 , pp. 267-278
    • Koch, M.1    Dehghani, F.2    Habazettl, I.3    Schomerus, C.4    Korf, H.-W.5
  • 69
    • 22744444334 scopus 로고    scopus 로고
    • Neurotransmission: Emerging roles of endocannabinoids
    • Kreitzer AC (2005). Neurotransmission: emerging roles of endocannabinoids. Curr Biol 15: R549-R551.
    • (2005) Curr Biol , vol.15
    • Kreitzer, A.C.1
  • 70
    • 18144379186 scopus 로고    scopus 로고
    • Characterization and comparison of recombinant human and rat TRPV1 receptors: Effects of exo- and endocannabinoids
    • Lam PMW, McDonald J, Lambert DG (2005). Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids. Br J Anaesth 94: 649-656.
    • (2005) Br J Anaesth , vol.94 , pp. 649-656
    • Lam, P.M.W.1    McDonald, J.2    Lambert, D.G.3
  • 71
    • 14344259844 scopus 로고    scopus 로고
    • 1 receptor antagonists as promising new medications for drug dependence
    • 1 receptor antagonists as promising new medications for drug dependence. J Pharmacol Exp Ther 312: 875-883.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 875-883
    • Le Foll, B.1    Goldberg, S.R.2
  • 73
    • 33645794039 scopus 로고    scopus 로고
    • Cannabinoid tolerance and dependence
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Lichtman AH, Martin BR (2005). Cannabinoid tolerance and dependence. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, Vol 168. Springer-Verlag: Heidelberg. pp 691-717.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 691-717
    • Lichtman, A.H.1    Martin, B.R.2
  • 74
    • 0141738711 scopus 로고    scopus 로고
    • Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats
    • Lim G, Sung B, Ji R-R, Mao J (2003). Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. Pain 105: 275-283.
    • (2003) Pain , vol.105 , pp. 275-283
    • Lim, G.1    Sung, B.2    Ji, R.-R.3    Mao, J.4
  • 75
    • 33746217173 scopus 로고    scopus 로고
    • Exposure to a lithium-paired context elicits gaping in rats: A model of anticipatory nausea
    • Limebeer CL, Hall G, Parker LA (2006). Exposure to a lithium-paired context elicits gaping in rats: a model of anticipatory nausea. Physiol Behav 88: 398-403.
    • (2006) Physiol Behav , vol.88 , pp. 398-403
    • Limebeer, C.L.1    Hall, G.2    Parker, L.A.3
  • 76
    • 31144468211 scopus 로고    scopus 로고
    • A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo
    • Lunn CA, Fine JS, Rojas-Triana A, Jackson JV, Fan X, Kung TT et al. (2006). A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther 316: 780-788.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 780-788
    • Lunn, C.A.1    Fine, J.S.2    Rojas-Triana, A.3    Jackson, J.V.4    Fan, X.5    Kung, T.T.6
  • 77
    • 84858999012 scopus 로고    scopus 로고
    • 9-tetrahydrocannabivarin modulates synaptic transmission at central inhibitory synapses. Proc Br Pharmacol Soc at http://www.pa2online.org/abstract/abstract.jsp?abid=28558&author= Whalley&cat=7&period=29.
    • 9-tetrahydrocannabivarin modulates synaptic transmission at central inhibitory synapses. Proc Br Pharmacol Soc at http://www.pa2online.org/abstract/abstract.jsp?abid=28558&author= Whalley&cat=7&period=29.
  • 80
    • 33645982868 scopus 로고    scopus 로고
    • Involvement of the endocannabinoid system in drug addiction
    • Maldonado R, Valverde O, Berrendero F (2006). Involvement of the endocannabinoid system in drug addiction. Trends Neurosci 29: 225-232.
    • (2006) Trends Neurosci , vol.29 , pp. 225-232
    • Maldonado, R.1    Valverde, O.2    Berrendero, F.3
  • 81
    • 33847171461 scopus 로고    scopus 로고
    • Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases
    • Mallat A, Teixeira-Clerc F, Deveaux V, Lotersztajn S (2007). Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases. Expert Opin Ther Targets 11: 403-409.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 403-409
    • Mallat, A.1    Teixeira-Clerc, F.2    Deveaux, V.3    Lotersztajn, S.4
  • 87
    • 33845673559 scopus 로고    scopus 로고
    • Endocannabinoids and the control of energy balance
    • Matias I, Di Marzo V (2007). Endocannabinoids and the control of energy balance. Trends Endocrinol Metab 18: 27-37.
    • (2007) Trends Endocrinol Metab , vol.18 , pp. 27-37
    • Matias, I.1    Di Marzo, V.2
  • 88
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 89
    • 23944437209 scopus 로고    scopus 로고
    • Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
    • McAllister SD, Chan C, Taft RJ, Luu T, Abood ME, Moore DH et al. (2005). Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. J Neurooncol 74: 31-40.
    • (2005) J Neurooncol , vol.74 , pp. 31-40
    • McAllister, S.D.1    Chan, C.2    Taft, R.J.3    Luu, T.4    Abood, M.E.5    Moore, D.H.6
  • 90
    • 38349165639 scopus 로고    scopus 로고
    • Endocannabinoids and phytocannabinoids inhibit human neutrophil migration
    • Burlington, Vermont, USA. International Cannabinoid Research Society. p
    • McHugh D, Ross RA (2005). Endocannabinoids and phytocannabinoids inhibit human neutrophil migration. Symposium on the Cannabinoids. Burlington, Vermont, USA. International Cannabinoid Research Society. p 38.
    • (2005) Symposium on the Cannabinoids , pp. 38
    • McHugh, D.1    Ross, R.A.2
  • 91
    • 0037100312 scopus 로고    scopus 로고
    • Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
    • McKallip RJ, Lombard C, Fisher M, Martin BR, Ryu SH, Grant S et al. (2002). Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100: 627-634.
    • (2002) Blood , vol.100 , pp. 627-634
    • McKallip, R.J.1    Lombard, C.2    Fisher, M.3    Martin, B.R.4    Ryu, S.H.5    Grant, S.6
  • 92
    • 28444487445 scopus 로고    scopus 로고
    • Plant cannabinoids: A neglected pharmacological treasure trove
    • Mechoulam R (2005). Plant cannabinoids: a neglected pharmacological treasure trove. Br J Pharmacol 146: 913-915.
    • (2005) Br J Pharmacol , vol.146 , pp. 913-915
    • Mechoulam, R.1
  • 93
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR et al. (1995). Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50: 83-90.
    • (1995) Biochem Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3    Ligumsky, M.4    Kaminski, N.E.5    Schatz, A.R.6
  • 94
    • 34250213868 scopus 로고    scopus 로고
    • Cannabinoids as therapeutic agents in cardiovascular disease: A tale of passions and illusions
    • Mendizábal VE, Adler-Graschinsky E (2007). Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions. Br J Pharmacol 151: 427-440.
    • (2007) Br J Pharmacol , vol.151 , pp. 427-440
    • Mendizábal, V.E.1    Adler-Graschinsky, E.2
  • 95
    • 0015234020 scopus 로고
    • Cannabivarin and tetrahydrocannabivarin, two new constituents of hashish
    • Merkus FWHM (1971). Cannabivarin and tetrahydrocannabivarin, two new constituents of hashish. Nature 232: 579-580.
    • (1971) Nature , vol.232 , pp. 579-580
    • Merkus, F.W.H.M.1
  • 96
    • 33751244807 scopus 로고    scopus 로고
    • Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain
    • Mitrirattanakul S, Ramakul N, Guerrero AV, Matsuka Y, Ono T, Iwase H et al. (2006). Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain. Pain 126: 102-114.
    • (2006) Pain , vol.126 , pp. 102-114
    • Mitrirattanakul, S.1    Ramakul, N.2    Guerrero, A.V.3    Matsuka, Y.4    Ono, T.5    Iwase, H.6
  • 98
    • 33746913292 scopus 로고    scopus 로고
    • The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    • Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R et al. (2006). The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51: 455-466.
    • (2006) Neuron , vol.51 , pp. 455-466
    • Monory, K.1    Massa, F.2    Egertová, M.3    Eder, M.4    Blaudzun, H.5    Westenbroek, R.6
  • 100
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S, Thomas KL, Abu-Shaar M (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 103
    • 33646872652 scopus 로고    scopus 로고
    • Receptor-independent actions of cannabinoids on cell membranes: Focus on endocannabinoids
    • Oz M (2006). Receptor-independent actions of cannabinoids on cell membranes: focus on endocannabinoids. Pharmacol Ther 111: 114-144.
    • (2006) Pharmacol Ther , vol.111 , pp. 114-144
    • Oz, M.1
  • 104
    • 33749132194 scopus 로고    scopus 로고
    • Cannabinoids: Effects on vomiting and nausea in animal models
    • Mechoulam R ed, Birkhaüser Verlag: Basel. pp
    • Parker LA, Limebeer CL, Kwiatkowska M (2005). Cannabinoids: effects on vomiting and nausea in animal models. In: Mechoulam R (ed). Cannabinoids as Therapeutics. Birkhaüser Verlag: Basel. pp 183-200.
    • (2005) Cannabinoids as Therapeutics , pp. 183-200
    • Parker, L.A.1    Limebeer, C.L.2    Kwiatkowska, M.3
  • 105
    • 0037337169 scopus 로고    scopus 로고
    • Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea
    • Parker LA, Mechoulam R, Schlievert C, Abbott L, Fudge ML, Burton P (2003). Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea. Psychopharmacology 166: 156-162.
    • (2003) Psychopharmacology , vol.166 , pp. 156-162
    • Parker, L.A.1    Mechoulam, R.2    Schlievert, C.3    Abbott, L.4    Fudge, M.L.5    Burton, P.6
  • 106
    • 33745261630 scopus 로고    scopus 로고
    • Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: Further evidence for an anxiolytic role for endogenous cannabinoid signaling
    • Patel S, Hillard CJ (2006). Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. J Pharmacol Exp Ther 318: 304-311.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 304-311
    • Patel, S.1    Hillard, C.J.2
  • 107
    • 0023840294 scopus 로고
    • The central neuropharmacology of psychotropic cannabinoids
    • Pertwee RG (1988). The central neuropharmacology of psychotropic cannabinoids. Pharmacol Ther 36: 189-261.
    • (1988) Pharmacol Ther , vol.36 , pp. 189-261
    • Pertwee, R.G.1
  • 109
    • 0032802188 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid receptor ligands
    • Pertwee RG (1999). Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6: 635-664.
    • (1999) Curr Med Chem , vol.6 , pp. 635-664
    • Pertwee, R.G.1
  • 110
    • 16444368192 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol and cannabidiol
    • 9-tetrahydrocannabinol and cannabidiol. Euphytica 140: 73-82.
    • (2004) Euphytica , vol.140 , pp. 73-82
    • Pertwee, R.G.1
  • 111
    • 1642417657 scopus 로고    scopus 로고
    • The pharmacology and therapeutic potential of cannabidiol
    • Di Marzo V ed, Kluwer Academic/Plenum Publishers: New York. pp
    • Pertwee RG (2004b). The pharmacology and therapeutic potential of cannabidiol. In: Di Marzo V (ed). Cannabinoids. Kluwer Academic/Plenum Publishers: New York. pp 32-83.
    • (2004) Cannabinoids , pp. 32-83
    • Pertwee, R.G.1
  • 112
    • 2342587090 scopus 로고    scopus 로고
    • Novel pharmacological targets for cannabinoids
    • Pertwee RG (2004c). Novel pharmacological targets for cannabinoids. Curr Neuropharmacol 2: 9-29.
    • (2004) Curr Neuropharmacol , vol.2 , pp. 9-29
    • Pertwee, R.G.1
  • 113
    • 84884474728 scopus 로고    scopus 로고
    • Pharmacological actions of cannabinoids
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Pertwee RG (2005a). Pharmacological actions of cannabinoids. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, Vol. 168. Springer-Verlag: Heidelberg. pp 1-51.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 1-51
    • Pertwee, R.G.1
  • 114
    • 33644804271 scopus 로고    scopus 로고
    • The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
    • Pertwee RG (2005b). The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J 7: E625-E654.
    • (2005) AAPS J , vol.7
    • Pertwee, R.G.1
  • 115
    • 28444482024 scopus 로고    scopus 로고
    • Cannabidiol as a potential medicine
    • Mechoulam R ed, Birkhaüser Verlag: Basel. pp
    • Pertwee RG (2005c). Cannabidiol as a potential medicine. In: Mechoulam R (ed). Cannabinoids as Therapeutics. Birkhaüser Verlag: Basel. pp 47-65.
    • (2005) Cannabinoids as Therapeutics , pp. 47-65
    • Pertwee, R.G.1
  • 116
    • 30444457225 scopus 로고    scopus 로고
    • Cannabinoid pharmacology: The first 66 years
    • Pertwee RG (2006). Cannabinoid pharmacology: the first 66 years. Br J Pharmacol 147: S163-S171.
    • (2006) Br J Pharmacol , vol.147
    • Pertwee, R.G.1
  • 117
    • 38349156729 scopus 로고    scopus 로고
    • Cannabinoids and multiple sclerosis
    • in press
    • Pertwee RG (2007a). Cannabinoids and multiple sclerosis. Mol Neurobiol (in press).
    • (2007) Mol Neurobiol
    • Pertwee, R.G.1
  • 118
    • 36448995830 scopus 로고    scopus 로고
    • GPR55: A new member of the cannabinoid receptor clan?
    • in press
    • Pertwee RG (2007b). GPR55: a new member of the cannabinoid receptor clan? Br J Pharmacol (in press).
    • (2007) Br J Pharmacol
    • Pertwee, R.G.1
  • 120
    • 0037027935 scopus 로고    scopus 로고
    • Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens
    • Pertwee RG, Ross RA, Craib SJ, Thomas A (2002). Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. Eur J Pharmacol 456: 99-106.
    • (2002) Eur J Pharmacol , vol.456 , pp. 99-106
    • Pertwee, R.G.1    Ross, R.A.2    Craib, S.J.3    Thomas, A.4
  • 125
    • 33645961913 scopus 로고    scopus 로고
    • 9THC-induced increase of cortical and hippocampal acetylcholine release by mu opioid and D-1 dopamine receptors
    • 9THC-induced increase of cortical and hippocampal acetylcholine release by mu opioid and D-1 dopamine receptors. Neuropharmacology 50: 661-670.
    • (2006) Neuropharmacology , vol.50 , pp. 661-670
    • Pisanu, A.1    Acquas, E.2    Fenu, S.3    Di Chiara, G.4
  • 126
    • 0037032111 scopus 로고    scopus 로고
    • 9-Tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: An in vivo microdialysis study
    • 9-Tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study. Brain Res 948: 155-158.
    • (2002) Brain Res , vol.948 , pp. 155-158
    • Pistis, M.1    Ferraro, L.2    Pira, L.3    Flore, G.4    Tanganelli, S.5    Gessa, G.L.6
  • 128
    • 0034054679 scopus 로고    scopus 로고
    • Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells
    • Rakhshan F, Day TA, Blakely RD, Barker EL (2000). Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells. J Pharmacol Exp Ther 292: 960-967.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 960-967
    • Rakhshan, F.1    Day, T.A.2    Blakely, R.D.3    Barker, E.L.4
  • 129
    • 0030756533 scopus 로고    scopus 로고
    • Cannabinol derivatives: Binding to cannabinoid receptors and inhibition of adenylylcyclase
    • Rhee M-H, Vogel Z, Barg J, Bayewitch M, Levy R, Hanus L et al. (1997). Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase. J Med Chem 40: 3228-3233.
    • (1997) J Med Chem , vol.40 , pp. 3228-3233
    • Rhee, M.-H.1    Vogel, Z.2    Barg, J.3    Bayewitch, M.4    Levy, R.5    Hanus, L.6
  • 130
  • 132
    • 33645786113 scopus 로고    scopus 로고
    • Human studies of cannabinoids and medicinal cannabis
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Robson P (2005). Human studies of cannabinoids and medicinal cannabis. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, vol. 168. Springer-Verlag: Heidelberg. pp 719-756.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 719-756
    • Robson, P.1
  • 133
  • 134
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • Russo EB, Burnett A, Hall B, Parker KK (2005). Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 30: 1037-1043.
    • (2005) Neurochem Res , vol.30 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3    Parker, K.K.4
  • 136
    • 12344250051 scopus 로고    scopus 로고
    • The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro
    • Sacerdote P, Martucci C, Vaccani A, Bariselli F, Panerai AE, Colombo A et al. (2005). The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro. J Neuroimmunol 159: 97-105.
    • (2005) J Neuroimmunol , vol.159 , pp. 97-105
    • Sacerdote, P.1    Martucci, C.2    Vaccani, A.3    Bariselli, F.4    Panerai, A.E.5    Colombo, A.6
  • 137
    • 33748509092 scopus 로고    scopus 로고
    • Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats
    • Sanson M, Bueno L, Fioramonti J (2006). Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats. Neurogastroenterol Motil 18: 949-956.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 949-956
    • Sanson, M.1    Bueno, L.2    Fioramonti, J.3
  • 138
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • Sarfaraz S, Afaq F, Adhami VM, Mukhtar H (2005). Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 65: 1635-1641.
    • (2005) Cancer Res , vol.65 , pp. 1635-1641
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 140
    • 0032589801 scopus 로고    scopus 로고
    • 9-Tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture
    • 9-Tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture. Mol Pharmacol 55: 8-13.
    • (1999) Mol Pharmacol , vol.55 , pp. 8-13
    • Shen, M.1    Thayer, S.A.2
  • 141
    • 33947278309 scopus 로고    scopus 로고
    • The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
    • Shoemaker JL, Seely KA, Reed RL, Crow JP, Prather PL (2007). The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset. J Neurochem 101: 87-98.
    • (2007) J Neurochem , vol.101 , pp. 87-98
    • Shoemaker, J.L.1    Seely, K.A.2    Reed, R.L.3    Crow, J.P.4    Prather, P.L.5
  • 142
    • 0030425575 scopus 로고    scopus 로고
    • Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
    • Showalter VM, Compton DR, Martin BR, Abood ME (1996). Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278: 989-999.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 989-999
    • Showalter, V.M.1    Compton, D.R.2    Martin, B.R.3    Abood, M.E.4
  • 145
    • 0742271034 scopus 로고    scopus 로고
    • Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids
    • Sim-Selley LJ (2003). Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids. Crit Rev Neurobiol 15: 91-119.
    • (2003) Crit Rev Neurobiol , vol.15 , pp. 91-119
    • Sim-Selley, L.J.1
  • 146
    • 0036784515 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol on cannabinoid receptor adaptation in mice
    • 9-tetrahydrocannabinol on cannabinoid receptor adaptation in mice. J Pharmacol Exp Ther 303: 36-44.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 36-44
    • Sim-Selley, L.J.1    Martin, B.R.2
  • 147
    • 0029870716 scopus 로고    scopus 로고
    • The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons
    • Skaper SD, Buriani A, Dal Toso R, Petrelli L, Romanello S, Facci L et al. (1996). The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Natl Acad Sci USA 93: 3984-3989.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3984-3989
    • Skaper, S.D.1    Buriani, A.2    Dal Toso, R.3    Petrelli, L.4    Romanello, S.5    Facci, L.6
  • 148
    • 33748581395 scopus 로고    scopus 로고
    • Cannabinoid receptors in atherosclerosis
    • Steffens S, Mach F (2006). Cannabinoid receptors in atherosclerosis. Curr Opin Lipidol 17: 519-526.
    • (2006) Curr Opin Lipidol , vol.17 , pp. 519-526
    • Steffens, S.1    Mach, F.2
  • 149
    • 17144400758 scopus 로고    scopus 로고
    • Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
    • Steffens S, Veillard NR, Arnaud C, Pelli G, Burger F, Staub C et al. (2005). Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature 434: 782-786.
    • (2005) Nature , vol.434 , pp. 782-786
    • Steffens, S.1    Veillard, N.R.2    Arnaud, C.3    Pelli, G.4    Burger, F.5    Staub, C.6
  • 150
    • 29244449844 scopus 로고    scopus 로고
    • Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones
    • Straiker A, Mackie K (2005). Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. J Physiol 569: 501-517.
    • (2005) J Physiol , vol.569 , pp. 501-517
    • Straiker, A.1    Mackie, K.2
  • 152
    • 18844419446 scopus 로고    scopus 로고
    • Effects of cannabinoids on neurotransmission
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Szabo B, Schlicker E (2005). Effects of cannabinoids on neurotransmission. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, Vol 168. Springer-Verlag: Heidelberg. pp 327-365.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 327-365
    • Szabo, B.1    Schlicker, E.2
  • 153
    • 33745889335 scopus 로고    scopus 로고
    • Ocular hypotensive effects of an intratracheally delivered liposomal delta-9-tetrahydrocannabinol preparation in rats
    • Szczesniak AM, Kelly MEM, Whynot S, Shek PN, Hung O (2006). Ocular hypotensive effects of an intratracheally delivered liposomal delta-9-tetrahydrocannabinol preparation in rats. J Ocul Pharmacol Ther 22: 160-167.
    • (2006) J Ocul Pharmacol Ther , vol.22 , pp. 160-167
    • Szczesniak, A.M.1    Kelly, M.E.M.2    Whynot, S.3    Shek, P.N.4    Hung, O.5
  • 157
    • 33748950459 scopus 로고    scopus 로고
    • Effect of sublingual application of cannabinoids on intraocular pressure: A pilot study
    • Tomida I, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ (2006). Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study. J Glaucoma 15: 349-353.
    • (2006) J Glaucoma , vol.15 , pp. 349-353
    • Tomida, I.1    Azuara-Blanco, A.2    House, H.3    Flint, M.4    Pertwee, R.G.5    Robson, P.J.6
  • 159
    • 0019604278 scopus 로고
    • Electrophysiologic properties of the cannabinoids
    • Turkanis SA, Karler R (1981). Electrophysiologic properties of the cannabinoids. J Clin Pharmacol 21: 449S-463S.
    • (1981) J Clin Pharmacol , vol.21
    • Turkanis, S.A.1    Karler, R.2
  • 163
    • 33645795765 scopus 로고    scopus 로고
    • Retrograde signalling by endocannabinoids
    • Pertwee RG ed, Springer-Verlag: Heidelberg. pp
    • Vaughan CW, Christie MJ (2005). Retrograde signalling by endocannabinoids. In: Pertwee RG (ed). Cannabinoids. Handbook of Experimental Pharmacology, Vol 168. Springer-Verlag: Heidelberg. pp 367-383.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , vol.168 , pp. 367-383
    • Vaughan, C.W.1    Christie, M.J.2
  • 165
    • 33646365073 scopus 로고    scopus 로고
    • Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes
    • Walczak JS, Pichette V, Leblond F, Desbiens K, Beaulieu P (2006). Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes. J Neurosci Res 83: 1310-1322.
    • (2006) J Neurosci Res , vol.83 , pp. 1310-1322
    • Walczak, J.S.1    Pichette, V.2    Leblond, F.3    Desbiens, K.4    Beaulieu, P.5
  • 166
    • 0141742514 scopus 로고    scopus 로고
    • The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy
    • Wallace MJ, Blair RE, Falenski KW, Martin BR, DeLorenzo RJ (2003). The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. J Pharmacol Exp Ther 307: 129-137.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 129-137
    • Wallace, M.J.1    Blair, R.E.2    Falenski, K.W.3    Martin, B.R.4    DeLorenzo, R.J.5
  • 168
    • 0037442829 scopus 로고    scopus 로고
    • Nonpsychotropic cannabinoid receptors regulate microglial cell migration
    • Walter L, Franklin A, Witting A, Wade C, Xie Y, Kunos G et al. (2003). Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J Neurosci 23: 1398-1405.
    • (2003) J Neurosci , vol.23 , pp. 1398-1405
    • Walter, L.1    Franklin, A.2    Witting, A.3    Wade, C.4    Xie, Y.5    Kunos, G.6
  • 169
    • 1842611884 scopus 로고    scopus 로고
    • Cannabinoids and neuroinflammation
    • Walter L, Stella N (2004). Cannabinoids and neuroinflammation. Br J Pharmacol 141: 775-785.
    • (2004) Br J Pharmacol , vol.141 , pp. 775-785
    • Walter, L.1    Stella, N.2
  • 170
    • 0025187245 scopus 로고
    • Comparison of pharmacological effects of tetrahydrocannabinols and their 11-hydroxy-metabolites in mice
    • Watanabe K, Kijima T, Narimatsu S, Nishikami J, Yamamoto I, Yoshimura H (1990). Comparison of pharmacological effects of tetrahydrocannabinols and their 11-hydroxy-metabolites in mice. Chem Pharm Bull 38: 2317-2319.
    • (1990) Chem Pharm Bull , vol.38 , pp. 2317-2319
    • Watanabe, K.1    Kijima, T.2    Narimatsu, S.3    Nishikami, J.4    Yamamoto, I.5    Yoshimura, H.6
  • 171
    • 38349102519 scopus 로고    scopus 로고
    • Weston S, Williamson EM, Constanti A, Stephens G, Whalley B (2006). Tetrahydrocannabivarin exhibits anticonvulsant effects in a piriform cortical brain slice model of epileptiform activity. Proc Br Pharmacol Soc at http://www.pa2online.org/abstract/abstract.jsp?abid=28533&author= Whalley&cat=7&period=29.
    • Weston S, Williamson EM, Constanti A, Stephens G, Whalley B (2006). Tetrahydrocannabivarin exhibits anticonvulsant effects in a piriform cortical brain slice model of epileptiform activity. Proc Br Pharmacol Soc at http://www.pa2online.org/abstract/abstract.jsp?abid=28533&author= Whalley&cat=7&period=29.
  • 172
    • 34247862287 scopus 로고    scopus 로고
    • The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists
    • Whiteside GT, Lee GP, Valenzano KJ (2007). The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists. Curr Med Chem 14: 917-936.
    • (2007) Curr Med Chem , vol.14 , pp. 917-936
    • Whiteside, G.T.1    Lee, G.P.2    Valenzano, K.J.3
  • 176
    • 33846186042 scopus 로고    scopus 로고
    • Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis
    • Wilkinson JD, Williamson EM (2007). Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J Dermatol Sci 45: 87-92.
    • (2007) J Dermatol Sci , vol.45 , pp. 87-92
    • Wilkinson, J.D.1    Williamson, E.M.2
  • 177
    • 0016738676 scopus 로고
    • Analgesic properties of the tetrahydrocannabinols, their metabolites and analogs
    • Wilson RS, May EL (1975). Analgesic properties of the tetrahydrocannabinols, their metabolites and analogs. J Med Chem 18: 700-703.
    • (1975) J Med Chem , vol.18 , pp. 700-703
    • Wilson, R.S.1    May, E.L.2
  • 178
    • 24044458606 scopus 로고    scopus 로고
    • Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons
    • Wotherspoon G, Fox A, McIntyre P, Colley S, Bevan S, Winter J (2005). Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons. Neuroscience 135: 235-245.
    • (2005) Neuroscience , vol.135 , pp. 235-245
    • Wotherspoon, G.1    Fox, A.2    McIntyre, P.3    Colley, S.4    Bevan, S.5    Winter, J.6
  • 179
    • 34548446421 scopus 로고    scopus 로고
    • Anti-inflammatory property of the cannabinoid receptor-2 selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis
    • e-pub ahead of print
    • Xu H, Cheng B, Manivannan A, Cabay L, Pertwee RG, Coutts A et al. (2007). Anti-inflammatory property of the cannabinoid receptor-2 selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. J Leukoc Biol 82 [e-pub ahead of print].
    • (2007) J Leukoc Biol , pp. 82
    • Xu, H.1    Cheng, B.2    Manivannan, A.3    Cabay, L.4    Pertwee, R.G.5    Coutts, A.6
  • 180
    • 33750298256 scopus 로고    scopus 로고
    • Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma
    • Xu X, Liu Y, Huang S, Liu G, Xie C, Zhou J et al. (2006). Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma. Cancer Genet Cytogenet 171: 31-38.
    • (2006) Cancer Genet Cytogenet , vol.171 , pp. 31-38
    • Xu, X.1    Liu, Y.2    Huang, S.3    Liu, G.4    Xie, C.5    Zhou, J.6
  • 181
    • 33645224970 scopus 로고    scopus 로고
    • COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    • at
    • Yiangou Y, Facer P, Durrenberger P, Chessell IP, Naylor A, Bountra C et al. (2006). COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol 6 at http://www.biomedcentral.com/1471-2377/6/12.
    • (2006) BMC Neurol , vol.6
    • Yiangou, Y.1    Facer, P.2    Durrenberger, P.3    Chessell, I.P.4    Naylor, A.5    Bountra, C.6
  • 182
    • 0038684167 scopus 로고    scopus 로고
    • Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models
    • Zhang J, Hoffert C, Vu HK, Groblewski T, Ahmad S, O'Donnell D (2003). Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models. Eur J Neurosci 17: 2750-2754.
    • (2003) Eur J Neurosci , vol.17 , pp. 2750-2754
    • Zhang, J.1    Hoffert, C.2    Vu, H.K.3    Groblewski, T.4    Ahmad, S.5    O'Donnell, D.6
  • 183
    • 0033545866 scopus 로고    scopus 로고
    • Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
    • Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI (1999). Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA 96: 5780-5785.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5780-5785
    • Zimmer, A.1    Zimmer, A.M.2    Hohmann, A.G.3    Herkenham, M.4    Bonner, T.I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.