Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation

Journal of Neuroscience

Volumn 25, Issue 8, 2005, Pages 1904-1913

  Ramírez, Belén G ^a   Blázquez, Cristina ^b   Gómez Del Pulgar, Teresa ^b   Guzmán, Manuel ^b   De Ceballos, María L ^a  

^a INSTITUTO CAJAL   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

amyloid; Alzheimer's disease; Cannabinoids; Microglia; Neuroprotection; Neurotoxicity

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; AMYLOID BETA PROTEIN; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; DEXANABINOL; GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; CELL ACTIVATION; CELL COUNT; CELL STRUCTURE; COCULTURE; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG RECEPTOR BINDING; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROGLIA; MITOCHONDRION; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENILE PLAQUE;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CANNABINOIDS; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; HUMANS; INJECTIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; MICROGLIA; MIDDLE AGED; MORPHOLINES; MOTOR ACTIVITY; NAPHTHALENES; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SENILE PLAQUES; SIGNAL TRANSDUCTION; TETRAHYDROCANNABINOL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 14244264502     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4540-04.2005     Document Type: Article

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