Cannabinoids protect cells from oxidative cell death: A receptor- independent mechanism

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 3, 2000, Pages 807-812

  Chen, Yanqiu ^a   Buck, Jochen ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABIDIOL; CANNABINOID; CANNABINOL; CELL RECEPTOR; DELTA8 TETRAHYDROCANNABINOL; DRONABINOL; RECOMBINANT PLATELET DERIVED GROWTH FACTOR; RETINOL DERIVATIVE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; B LYMPHOCYTE; CELL DEATH; CELL GROWTH; CELL PROTECTION; CELL SURVIVAL; DRUG RECEPTOR BINDING; FIBROBLAST; HUMAN; HUMAN CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SERUM;

ANTIOXIDANTS; CELL DEATH; HUMANS; MORPHOLINES; NAPHTHALENES; NITRIC OXIDE; OXIDATIVE STRESS; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

EID: 0034046970     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Babior BM (1978) Oxygen-dependent microbial killing by phagocytes. N Engl J Med 298:659-668, 721-725.
2. Baier-Bitterlich G, Wachter H and Fuchs D (1996) Oxidative stress and apoptosis in HIV infection. Science (Wash DC) 271:582-583.
3. Bayewitch M, Avidor-Resis T, Levy R, Barg J, Mechoulam R and Vogel Zvi (1995) The peripheral cannabinoid receptor: Adenylate cyclase inhibition and G protein coupling. FEBS Lett 374:143-147.
4. Bouaboula M, Poinot-Chazel C, Marchand J, Canat X, Bourrie B, Rinaldi-Carmona M, Calandra B, Le Fur G and Casellas P (1996) Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor: Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. Eur J Biochem 237:704-711.
5. Bouaboula M, Rinaldi M, Carayon P, Carillon C, Delpech B, Shire D, Le Fur G and Casellas P (1993) Cannabinoid-receptor expression in human leukocytes. Eur J Biochem 214:173-180.
6. Buck J, Grün F, Derguini F, Chen Y, Kimura S, Noy N and Hämmerling U (1993) Anhydroretinol: A natural occurring inhibitor of lymphocyte physiology. J Exp Med 178:675-680.
7. Buck J, Ritter G, Dannecker L, Katta V, Cohen SL, Chait BT and Hämmerling U (1990) Retinol is essential for growth of activated human B cells. J Exp Med 171:1613-1624.
8. Busciglio J and Yankner BA (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature (Lond) 378:776-779.
9. Chen Y, Buck J and Derguini F (1999) Anhydroretinol induces oxidative stress and cell death. Cancer Res 59:3985-3990.
10. Chen Y, Derguini F and Buck J (1997) Vitamin A in serum is a survival factor for fibroblasts. Proc Natl Acad Sci USA 94:10205-10208.
11. Cerutti PA (1985) Prooxidant states and tumor promotion. Science (Wash DC) 227:375-381.
12. Coffey RG, Yamamoto Y, Snella E and Pross S (1996) Tetrahydrocannabinol inhibition of macrophage nitric oxide production. Biochem Pharmacol 52:743-751.
13. Coyle JT and Puttfarcken P (1993) Oxidative stress, glutamate, and neurogenerative disorders. Science (Wash DC) 262:689-695.
14. Derocq J-M, Segui M, Matchand J, Le Fur G and Casellas P (1995) Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS Lett 369: 177-182.
15. Dewey WL (1986) Cannabinoid pharmacology. Pharmacol Rev 38:151-178.
16. Dulbecco R (1970) Topoinhibition and serum requirement of transformed and untransformed cells. Nature (Lond) 227:802-806.
17. Emanuel D, Gold J, Colacino J, Lopez C and Hämmerling U (1984) A human monoclonal antibody to cytomegalovirus (CMV). J Immunol 133:2202-2205.
18. Frei B, Stocker R and Ames BN (1992) Small molecular antioxidant defenses in human extracellular fluids, in Molecular Biology of Free Radical Scavenging Systems (Scandalios JG ed) pp 23-46, Cold Spring Harbor Laboratory Press, New York.
19. Galiegue S, Mary S, Marchand J, Dussossoy D, Carriere D, Carayon P, Bouaboula M, Shire D, Le Fur G and Casellas P (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232:54-61.
20. Grün F, Hämmerling U and Buck J (1997) Purification, cloning, and bacterial expression of retinol dehydratase from Spodoptera frugiperda. J Biol Chem 271: 16135-16138.
21. 9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 95:8268-8273.
22. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL and Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251.
23. 9-tetrahydrocannabinol is mediated through the inibition of nuclear factor-κB/REL activation. Mol Pharmacol 50:334-341.
24. Johnson TM, Yu Z, Ferrans VJ, Lowenstein EA and Finkel T (1996) Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc Natl Acad Sci USA 93:11848-11852.
25. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC and Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (Lond) 346:561-564.
26. Munro S, Thomas KL and Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature (Lond) 365:61-65.
27. Nahas G (1984) Marihuana in Science and Medicine. Raven Press, New York.
28. Nakao N, Grasbon-Frodl EM, Widner H and Brundin P (1996) Antioxidant treatment protects striatal neurons against excitotoxic insults. Neuroscience 73:185-200.
29. Rinaldi-Carmona M, Batth F, Millan J, Derocq J-M, Casellas P, Congy C, Oustric D, Sappan M, Bouaboula M, Calandra B, Portier M, Shire D, Berliere J-C and Le Fur G (1998) SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor. J Pharmacol Exp Ther 284:644-650.
30. Scandalios JG (1997) Oxidative Stress and the Molecular Biology of Antioxidant Defenses. CSHL Press, New York.
31. Schatz AR, Lee M, Condie RB, Pulaski JT and Kaminski NE (1997) Cannabinoid receptors CB1 and CB2: A characterization of expression and adenylate cyclase modulation within the immune system. Toxicol Appl Pharmacol 142:278-287.
32. Schwarz H, Blanco FJ and Lotz M (1994) Anandamide, an endogeneous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. J Neuroimmunol 55:107-115.
33. Shapiro BM (1991) The control of oxidant stress at fertilization. Science (Wash DC) 252:533-536.
34. Showalter VM, Compton DR, Martin BR and Abood ME (1996) Evaluation a binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 264:463-468.
35. Slipetz DM, O'Neill GP, Favreau L, Dufresne C, Gallant M, Gareau Y, Guay D. Labelle M and Metters KM (1995) Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Mol Pharmacol 48:352-361.
36. Sohal RS and Weindruch R (1996) Oxidative stress, caloric restriction, and aging. Science (Wash DC) 273:59-63.
37. Stefano GB, Liu Y and Goligorsky MS (1996) Cannabinoid receptors are coupled to nitric oxide release in invertibrate immunocytes, misroglia, and human monocytes. J Biol Chem 271:19238-19242.
38. Thomas WK, Friedman H and Specter S (1998) Marijuana, immunity and infection. J Neuroimmunol 83:102-115.
39. Turner CT, Elsohly MA and Boeren EG (1980) Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod (Lloydia) 43:169-234.
40. 9-Tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: Involvement of Bcl-2 and Caspase-1. J Pharmacol Exp Ther 286:1103-1109.