Evidence that the plant cannabinoid Δ 9- tetrahydrocannabivarin is a cannabinoid CB 1 and CB 2 receptor antagonist

British Journal of Pharmacology

Volumn 146, Issue 7, 2005, Pages 917-926

  Thomas, Adèle ^a   Stevenson, Lesley A ^a   Wease, Kerrie N ^a   Price, Martin R ^a   Baillie, Gemma ^a   Ross, Ruth A ^a   Pertwee, Roger G ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

9 tetrahydrocannabinol; 9 Tetrahydrocannabivarin; Anandamide; Cannabinoids; CB 2 receptor antagonist; CB 1 receptor antagonist; CP55940; Methanandamide; Mouse vas deferens; R (+) WIN55212

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANANDAMIDE; BETA,GAMMA METHYLENEADENOSINE TRIPHOSPHATE; CANNABIDIOL DERIVATIVE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CAPSAICIN; CLONIDINE; DELTA9 TETRAHYDROCANNABIVARIN; DRONABINOL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); METHANANDAMIDE; PHENYLEPHRINE; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN; CELL MEMBRANE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; VAS DEFERENS;

ANIMALS; ARACHIDONIC ACIDS; CANNABINOIDS; CANNABIS; CHO CELLS; CLONIDINE; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MICE; MORPHOLINES; MUSCLE CONTRACTION; NAPHTHALENES; POLYUNSATURATED ALKAMIDES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; TETRAHYDROCANNABINOL; VAS DEFERENS;

EID: 28444433385     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706414     Document Type: Article

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