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Volumn 79, Issue 6, 2011, Pages 964-973

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: Relevance to alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 [4 (1,1 DIMETHYLHEPTYL) 2,6 DIMETHOXYPHENYL] 6,6 DIMETHYLBICYCLO[3.1.1]HEPT 2 EN 2 YLMETHANOL; ADENOSINE A2A RECEPTOR; ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; CALCIUM; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR AGONIST; CYTOKINE; LIPOPOLYSACCHARIDE; NITRITE;

EID: 79956293339     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.071290     Document Type: Article
Times cited : (298)

References (40)
  • 2
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression
    • Carrier EJ, Auchampach JA, and Hillard CJ (2006) Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA 103:7895-7900.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 3
    • 0035866060 scopus 로고    scopus 로고
    • beta-amyloid stimulation of microglia anti monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • Combs CK, Karlo JC, Kao SC, and Landreth GE (2001) beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 21:1179-1188. (Pubitemid 32128763)
    • (2001) Journal of Neuroscience , vol.21 , Issue.4 , pp. 1179-1188
    • Combs, C.K.1    Colleen, K.J.2    Kao, S.-C.3    Landreth, G.E.4
  • 4
    • 1642268380 scopus 로고    scopus 로고
    • Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
    • DOI 10.1007/s00210-004-0871-3
    • Costa B, Colleoni M, Conti S, Parolaro D, Franke C, Trovato AE, and Giagnoni G (2004) Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw. Naunyn Schmiedebergs Arch Pharmacol 369:294-299. (Pubitemid 38372934)
    • (2004) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.369 , Issue.3 , pp. 294-299
    • Costa, B.1    Colleoni, M.2    Conti, S.3    Parolaro, D.4    Franke, C.5    Trovato, A.E.6    Giagnoni, G.7
  • 5
    • 0036135610 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells
    • Cui YH, Le Y, Gong W, Proost P, Van Damme J, Murphy WJ, and Wang JM (2002) Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells. J Immunol 168:434-442. (Pubitemid 34014146)
    • (2002) Journal of Immunology , vol.168 , Issue.1 , pp. 434-442
    • Cui, Y.-H.1    Le, Y.2    Gong, W.3    Proost, P.4    Van Damme, J.5    Murphy, W.J.6    Ji, M.W.7
  • 6
    • 34547380216 scopus 로고    scopus 로고
    • Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells
    • DOI 10.1016/j.yexcr.2007.05.012, PII S0014482707002212
    • De Petrocellis L, Marini P, Matias I, Moriello AS, Starowicz K, Cristino L, Nigam S, and Di Marzo V (2007) Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells. Exp Cell Res 313:2993-3004. (Pubitemid 47135571)
    • (2007) Experimental Cell Research , vol.313 , Issue.14 , pp. 2993-3004
    • De Petrocellis, L.1    Marini, P.2    Matias, I.3    Moriello, A.S.4    Starowicz, K.5    Cristino, L.6    Nigam, S.7    Di, M.V.8
  • 8
    • 33344456093 scopus 로고    scopus 로고
    • The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    • DOI 10.1007/s00109-005-0025-1
    • Esposito G, De Filippis D, Carnuccio R, Izzo AA, and Iuvone T (2006a) The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J Mol Med 84:253-258. (Pubitemid 43291014)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.3 , pp. 253-258
    • Esposito, G.1    De Filippis, D.2    Carnuccio, R.3    Izzo, A.A.4    Iuvone, T.5
  • 9
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, and Iuvone T (2006b) Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci Lett 399:91-95.
    • (2006) Neurosci Lett , vol.399 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 11
    • 0037440415 scopus 로고    scopus 로고
    • Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide
    • DOI 10.1002/glia.10177
    • Facchinetti F, Del Giudice E, Furegato S, Passarotto M, and Leon A (2003) Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lipopolysaccharide. Glia 41:161-168. (Pubitemid 36262193)
    • (2003) GLIA , vol.41 , Issue.2 , pp. 161-168
    • Facchinetti, F.1    Del, G.E.2    Furegato, S.3    Passarotto, M.4    Leon, A.5
  • 12
    • 33750305578 scopus 로고    scopus 로고
    • Functional role of calcium signals for microglial function
    • DOI 10.1002/glia.20412
    • Färber K and Kettenmann H (2006) Functional role of calcium signals for microglial function. Glia 54:656-665. (Pubitemid 44629629)
    • (2006) GLIA , vol.54 , Issue.7 , pp. 656-665
    • Farber, K.1    Kettenmann, H.2
  • 15
    • 0033381793 scopus 로고    scopus 로고
    • 3-(1′,1′-Dimethylbutyl)-1-deoxy-delta-8-THC and related compounds: Synthesis and selective ligands for the CB2 receptor
    • Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, and Martin BR (1999) 3-(1′,1′-Dimethylbutyl)-1-deoxy-delta-8-THC and related compounds: synthesis and selective ligands for the CB2 receptor. Bioorg Med Chem 7:2905-2914.
    • (1999) Bioorg Med Chem , vol.7 , pp. 2905-2914
    • Huffman, J.W.1    Liddle, J.2    Yu, S.3    Aung, M.M.4    Abood, M.E.5    Wiley, J.L.6    Martin, B.R.7
  • 16
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, and Izzo AA (2004) Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 89:134-141. (Pubitemid 38420682)
    • (2004) Journal of Neurochemistry , vol.89 , Issue.1 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di, R.M.5    Izzo, A.A.6
  • 17
    • 0037088914 scopus 로고    scopus 로고
    • Microglial activation and β-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
    • Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, and Gordon MN (2002) Microglial activation and β-amyloid deposit reduction caused by nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J Neurosci 22:2246-2254. (Pubitemid 35386524)
    • (2002) Journal of Neuroscience , vol.22 , Issue.6 , pp. 2246-2254
    • Jantzen, P.T.1    Connor, K.E.2    DiCarlo, G.3    Wenk, G.L.4    Wallace, J.L.5    Rojiani, A.M.6    Coppola, D.7    Morgan, D.8    Gordon, M.N.9
  • 18
    • 0027343512 scopus 로고
    • Electrophysiological behavior of microglia
    • Kettenmann H, Banati R, and Walz W (1993) Electrophysiological behavior of microglia. Glia 7:93-101.
    • (1993) Glia , vol.7 , pp. 93-101
    • Kettenmann, H.1    Banati, R.2    Walz, W.3
  • 20
    • 33645532270 scopus 로고    scopus 로고
    • Purinergic receptors activating rapid intracellular Ca increases in microglia
    • Light AR, Wu Y, Hughen RW, and Guthrie PB (2006) Purinergic receptors activating rapid intracellular Ca increases in microglia. Neuron Glia Biol 2:125-138.
    • (2006) Neuron Glia Biol , vol.2 , pp. 125-138
    • Light, A.R.1    Wu, Y.2    Hughen, R.W.3    Guthrie, P.B.4
  • 22
    • 0029813177 scopus 로고    scopus 로고
    • Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F/beta-amyloid precursor protein and Alzheimer's disease
    • Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, and Games D (1996) Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci 16:5795-5811. (Pubitemid 26293401)
    • (1996) Journal of Neuroscience , vol.16 , Issue.18 , pp. 5795-5811
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Mucke, L.4    Schenk, D.5    Games, D.6
  • 23
    • 65849418702 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes
    • Mato S, Alberdi E, Ledent C, Watanabe M, and Matute C (2009) CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. Glia 57:295-306.
    • (2009) Glia , vol.57 , pp. 295-306
    • Mato, S.1    Alberdi, E.2    Ledent, C.3    Watanabe, M.4    Matute, C.5
  • 25
    • 38449086056 scopus 로고    scopus 로고
    • Endocannabinoids and traumatic brain injury
    • DOI 10.1007/s12035-007-8008-6
    • Mechoulam R and Shohami E (2007) Endocannabinoids and traumatic brain injury. Mol Neurobiol 36:68-74. (Pubitemid 351360359)
    • (2007) Molecular Neurobiology , vol.36 , Issue.1 , pp. 68-74
    • Mechoulam, R.1    Shohami, E.2
  • 26
    • 0141769473 scopus 로고    scopus 로고
    • Activation of mouse microglial cells affects P2 receptor signaling
    • DOI 10.1016/S0006-8993(99)02244-1, PII S0006899399022441
    • Möller T, Kann O, Verkhratsky A, and Kettenmann H (2000) Activation of mouse microglial cells affects P2 receptor signaling. Brain Res 853:49-59. (Pubitemid 30015998)
    • (2000) Brain Research , vol.853 , Issue.1 , pp. 49-59
    • Moller, T.1    Kann, O.2    Verkhratsky, A.3    Kettenmann, H.4
  • 27
    • 0029414908 scopus 로고
    • 125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor
    • 125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor. Mol Pharmacol 48:970-974.
    • (1995) Mol Pharmacol , vol.48 , pp. 970-974
    • Palmer, T.M.1    Poucher, S.M.2    Jacobson, K.A.3    Stiles, G.L.4
  • 28
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signalling
    • Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873-884.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 873-884
    • Piomelli, D.1
  • 29
    • 0033986604 scopus 로고    scopus 로고
    • Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells
    • DOI 10.1002/(SICI)1098-1136(20000101)29:1<58::AID-GLIA6>3.0.CO;2-W
    • Puffenbarger RA, Boothe AC, and Cabral GA (2000) Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells. Glia 29:58-69. (Pubitemid 30031134)
    • (2000) GLIA , vol.29 , Issue.1 , pp. 58-69
    • Puffenbarger, R.A.1    Boothe, A.C.2    Cabral, G.A.3
  • 30
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
    • DOI 10.1523/JNEUROSCI.4540-04.2005
    • Ramírez BG, Blázquez C, Gómez del Pulgar T, Guzmán M, and de Ceballos ML (2005) Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J Neurosci 25:1904-1913. (Pubitemid 40289395)
    • (2005) Journal of Neuroscience , vol.25 , Issue.8 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    Gomez, D.P.T.3    Guzman, M.4    De Ceballos, M.L.5
  • 32
    • 0028129936 scopus 로고
    • SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
    • DOI 10.1016/0014-5793(94)00773-X
    • Rinaldi-Carmona M, Barth F, Héaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Néliat G, and Caput D (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240-244. (Pubitemid 24268029)
    • (1994) FEBS Letters , vol.350 , Issue.2-3 , pp. 240-244
    • Rinaldi-Carmona, M.1
  • 34
    • 0030425575 scopus 로고    scopus 로고
    • Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
    • Showalter VM, Compton DR, Martin BR, and Abood ME (1996) Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278:989-999. (Pubitemid 27166944)
    • (1996) Journal of Pharmacology and Experimental Therapeutics , vol.278 , Issue.3 , pp. 989-999
    • Showalter, V.M.1    Compton, D.R.2    Martin, B.R.3    Abood, M.E.4
  • 35
    • 0035968272 scopus 로고    scopus 로고
    • Amyloid-beta induces chemotaxis and oxidant stress by acting at formyl-peptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain
    • Tiffany HL, Lavigne MC, Cui YH, Wang JM, Leto TL, Gao JL, and Murphy PM (2002) Amyloid-beta induces chemotaxis and oxidant stress by acting at formyl-peptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. J Biol Chem 276:23645-23652.
    • (2002) J Biol Chem , vol.276 , pp. 23645-23652
    • Tiffany, H.L.1    Lavigne, M.C.2    Cui, Y.H.3    Wang, J.M.4    Leto, T.L.5    Gao, J.L.6    Murphy, P.M.7
  • 40
    • 1842611884 scopus 로고    scopus 로고
    • Cannabinoids and neuroinflammation
    • DOI 10.1038/sj.bjp.0705667
    • Walter L and Stella N (2004) Cannabinoids and neuroinflammation. Br J Pharmacol 141:775-785. (Pubitemid 38446178)
    • (2004) British Journal of Pharmacology , vol.141 , Issue.5 , pp. 775-785
    • Walter, L.1    Stella, N.2


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