Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells

Nature Medicine

Volumn 13, Issue 4, 2007, Pages 492-497

  Maresz, Katarzyna ^a   Pryce, Gareth ^b,i   Ponomarev, Eugene D ^a   Marsicano, Giovanni ^c   Croxford, J Ludovic ^b,d   Shriver, Leah P ^a,e   Ledent, Catherine ^f   Cheng, Xiaodong ^a   Carrier, Erica J ^e   Mann, Monica K ^a,e   Giovannoni, Gavin ^b,i   Pertwee, Roger G ^g   Yamamura, Takashi ^d   Buckley, Nancy E ^h   Hillard, Cecilia J ^e   Lutz, Beat ^c   Baker, David ^b,i   Dittel, Bonnie N ^a,e  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^e MEDICAL COLLEGE OF WISCONSIN   (United States)

^f UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^g UNIVERSITY OF ABERDEEN   (United Kingdom)

^h CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

ⁱ QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; RIMONABANT; TETRAHYDROCANNABINOL;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALIA;

EID: 34147165471     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1561     Document Type: Article

References (30)

1. Hickey, W.F., Hsu, B.L. & Kimura, H. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28, 254-260 (1991).
2. Sospedra, M. & Martin, R. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23, 683-747 (2005).
3. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C. & Bonner, T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564 (1990).
4. Munro, S., Thomas, K.L. & Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365, 61-65 (1993).
5. Kaminski, N.E., Abood, M.E., Kessler, F.K., Martin, B.R. & Schatz, A.R. Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol. Pharmacol. 42, 736-742 (1992).
6. Klein, T.W. et al. The cannabinoid system and immune modulation. J. Leukoc. Biol. 74, 486-496 (2003).
7. 2 receptors. Science 310, 329-332 (2005).
8. Salzet, M., Breton, C., Bisogno, T. & Di Marzo, V. Comparative biology of the endocannabinoid system possible role in the immune response. Eur. J. Biochem. 267, 4917-4927 (2000).
9. Pertwee, R.G. Cannabinoids and multiple sclerosis. Pharmacol. Ther. 95, 165-174 (2002).
10. 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. J. Neuroimmunol. 23, 73-81 (1989).
11. Wirguin, I. et al. Suppression of experimental autoimmune encephalomyelitis by cannabinoids. Immunopharmacology 28, 209-214 (1994).
12. Arévalo-Martín, A., Vela, J.M., Molina-Holgado, E., Borrell, J. & Guaza, C. Therapeutic action of cannabinoids in a murine model of multiple sclerosis. J. Neurosci. 23, 2511-2516 (2003).
13. Pryce, G. et al. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 126, 2191-2202 (2003).
14. Rinaldi-Carmona, M. et al. SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor. J. Pharmacol. Exp. Ther. 284, 644-650 (1998).
15. Rinaldi-Carmona, M. et al. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350, 240-244 (1994).
16. Do, Y., McKallip, R.J., Nagarkatti, M. & Nagarkatti, P.S. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-κB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. J. Immunol. 173, 2373-2382 (2004).
17. Parolaro, D., Massi, P., Rubino, T. & Monti, E. Endocannabinoids in the immune system and cancer. Prostaglandins Leukot. Essent. Fatty Acids 66, 319-332 (2002).
18. Ponomarev, E.D. et al. γδ T cell regulation of IFN-γ production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J. Immunol. 173, 1587-1595 (2004).
19. Ponomarev, E.D. et al. GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J. Immunol. 178, 39-48 (2007).
20. Sugiura, T. & Waku, K. 2-Arachidonoylglycerol and the cannabinoid receptors. Chem. Phys. Lipids 108, 89-106 (2000).
21. 2 receptor in microglial cells in response to inflammatory stimuli. J. Neurochem. 95, 437-445 (2005).
22. 7 receptors control 2-arachidonoylglycerol production by microglial cells. Proc. Natl. Acad. Sci. USA 101, 3214-3219 (2004).
23. Witting, A. et al. Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection. Proc. Natl. Acad. Sci. USA 103, 6362-6367 (2006).
24. Marsicano, G. et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302, 84-88 (2003).
25. Tronche, F. et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23, 99-103 (1999).
26. Hennet, T., Hagen, F.K., Tabak, L.A. & Marth, J.D. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc. Natl. Acad. Sci. USA 92, 12070-12074 (1995).
27. Dittel, B.N., Merchant, R.M. & Janeway, C.A., Jr Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis. J. Immunol. 162, 6392-6400 (1999).
28. 2 receptor. Eur. J. Pharmacol. 396, 141-149 (2000).
29. Ponomarev, E.D. & Dittel, B.N. γδ T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism. J. Immunol. 174, 4678-4687 (2005).
30. 2 receptor. Bioorg. Med. Chem. 7, 2905-2914 (1999).