Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT 1A receptor activation

British Journal of Pharmacology

Volumn 159, Issue 4, 2010, Pages 950-957

  Magen, I ^a   Avraham, Y ^a   Ackerman, Z ^b   Vorobiev, L ^a   Mechoulam, R ^a   Berry, E M ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Activity; Bile duct ligation; Cognition; Gene expression; Inflammation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CANNABIDIOL; CANNABIS; CYTOKINE RECEPTOR; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PROTEIN TNFRSF1A; SEROTONIN 1A RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT; BILIRUBIN BLOOD LEVEL; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HEPATIC ENCEPHALOPATHY; HIPPOCAMPUS; LIGATION; LIVER FUNCTION; LOCOMOTION; MAZE TEST; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CANNABIDIOL; CHOLESTASIS, EXTRAHEPATIC; COGNITION; COMMON BILE DUCT; DISEASE MODELS, ANIMAL; DOPAMINE ANTAGONISTS; FEMALE; HEPATIC ENCEPHALOPATHY; HIPPOCAMPUS; LIGATION; LIVER; LIVER FUNCTION TESTS; MICE; MOTOR ACTIVITY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RNA, MESSENGER; SEROTONIN AGONISTS;

EID: 77249134168     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00589.x     Document Type: Article

References (53)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. Apelqvist G, Bergqvist PB, Larsson B, Bugge M, Bengtsson F (1998). Regional brain serotonin receptor changes in portacaval shunted rats. Acta Physiol Scand 162 : 509 516.
3. Avraham Y, Israeli E, Gabbay E, Okun A, Zolotarev O, Silberman I et al. (2006). Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice. Neurobiol Dis 21 : 237 245.
4. Avraham Y, Zolotarev O, Grigoriadis NC, Poutahidis T, Magen I, Vorobiav L et al. (2008). Cannabinoids and capsaicin improve liver function following thioacetamide-induced acute injury in mice. Am J Gastroenterol 103 : 3047 3056.
5. Barde YA, Edgar D, Thoenen H (1982). Purification of a new neurotrophic factor from mammalian brain. EMBO J 1 : 549 553.
6. Barnes NM, Sharp T (1999). A review of central 5-HT receptors and their function. Neuropharmacology 38 : 1083 1152. Review.
7. Benito C, Tolón RM, Pazos MR, Núñez E, Castillo AI, Romero J (2008). Cannabinoid CB2 receptors in human brain inflammation. Br J Pharmacol 153 : 277 285. Review.
8. Ben-Shabat S, Hanuš LO, Katzavian G, Gallily R (2006). New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity. J Med Chem 49 : 1113 1117.
9. Butterworth RF, Giguere JF, Michaud J, Lavoie J, Layrargues GP (1987). Ammonia: key factor in the pathogenesis of hepatic encephalopathy. Neurochem Pathol 6 : 1 12. Review.
10. Campos AC, Guimarães FS (2008). Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology (Berl) 199 : 223 230.
11. Carrier EJ, Auchampach JA, Hillard CJ (2006). Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA 103 : 7895 7900.
12. Çelik T, Gören MZ, Çinar K, Gürdal H, Onder FO, Tan A et al. (2005). Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat. Hepatology 41 : 731 737.
13. Chan JP, Cordeira J, Calderon G, Iyer LK, Rios M (2008). Depletion of central BDNF in mice impedes terminal differentiation of new granule neurons in the adult hippocampus. Mol Cell Neurosci 39 : 372 383.
14. Dagon Y, Avraham Y, Ilan Y, Mechoulam R, Berry EM (2007). Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase. FASEB J 21 : 2431 2441.
15. Devane WA, Hanuš L, Breuer A, Pertwee RG, Stevenson LA, Griffin G et al. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 : 1946 1949.
16. Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T (2006). Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci Lett 399 : 91 95.
17. Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M et al. (2001). Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 32 : 911 926.
18. Gaoni Y, Mechoulam R (1971). The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish. J Am Chem Soc 93 : 217 224.
19. Hanuš L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, Horowitz M (1999). HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. Proc Natl Acad Sci USA 96 : 14228 14233.
20. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA et al. (2002). International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54 : 161 202. Review.
21. Huang LT, Hsieh CS, Chou MH, Chuang JH, Liou CW, Tiao MM et al. (2004). Obstructive jaundice in rats: cause of spatial memory deficits with recovery after biliary decompression. World J Surg 28 : 283 287.
22. Iosif RE, Ekdahl CT, Ahlenius H, Pronk CJ, Bonde S, Kokaia Z et al. (2006). Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci 26 : 9703 9712.
23. Nomenclature of Organic Chemistry, Sections A, B, C, D, E, and F, Pergamon Press, Oxford, 1979.
24. Jalan R, Turjanski N, Taylor-Robinson SD, Koepp MJ, Richardson MP, Wilson JA et al. (2000). Increased availability of central benzodiazepine receptors in patients with chronic hepatic encephalopathy and alcohol related disease. Gut 46 : 546 552.
25. Jiang W, Desjardins P, Butterworth RF (2009). Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. J Neurochem 109 : 485 493.
26. Kerfoot SM, D'Mello C, Nguyen H, Ajuebor MN, Kubes P, Le T et al. (2006). TNF- secreting monocytes are recruited into the brain of cholestatic mice. Hepatology 43 : 154 162.
27. Kountouras J, Billing BH, Scheuer PJ (1984). Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol 65 : 305 311.
28. Leibrock J, Lottspeich F, Hohn A, Hofer M, Hengerer B, Masiakowski P (1989). Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341 : 149 152.
29. Liu KZ, Man A, Shaw RA, Liang B, Xu Z, Gong Y (2006). Molecular determination of liver fibrosis by synchrotron infrared microspectroscopy. Biochim Biophys Acta 158 : 960 967.
30. Magen I, Avraham Y, Ackerman Z, Vorobiev L, Mechoulam R, Berry EM (2009). Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. J Hepatol 51 : 528 534.
31. Malfait AM, Gallily R, Sumariwalla PF, Malik AS, Andreakos E, Mechoulam R et al. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA 97 : 9561 9566.
32. Mallat A, Lotersztajn S (2008). Endocannabinoids and liver disease. I. Endocannabinoids and their receptors in the liver. Am J Physiol Gastrointest Liver Physiol 294 : G9 G12. Review.
33. Mechoulam R, Ben-Shabat S, Hanuš L, Ligumsky M, Kaminski NE, Schatz AR et al. (1995). Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50 : 83 90.
34. Mechoulam R, Peters M, Murillo-Rodriguez E, Hanuš LO (2007). Cannabidiol - recent advances. Chem Biodivers 4 : 1678 1692. Review.
35. Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K et al. (2005). Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke 36 : 1077 1082.
36. Mizuno M, Yamada K, Takei N, Tran MH, He J, Nakajima A et al. (2003). Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Mol Psychiatry 8 : 217 224.
37. Monje ML, Toda H, Palmer TD (2003). Inflammatory blockade restores adult hippocampal neurogenesis. Science 302 : 1760 1765.
38. Mousseau DD, Baker GB, Butterworth RF (1997). Increased density of catalytic sites and expression of brain monoamine oxidase A in humans with hepatic encephalopathy. J Neurochem 68 : 1200 1208.
39. Odeh M, Sabo E, Srugo I, Oliven A (2004). Serum levels of tumor necrosis factor- correlate with severity of hepatic encephalopathy due to chronic liver failure. Liver Int 24 : 110 116.
40. Pacher P, Bátkai S, Kunos G (2006). The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58 : 389 462. Review.
41. Parker LA, Kwiatkowska M, Burton P, Mechoulam R (2004). Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew). Psychopharmacology (Berl) 171 : 156 161.
42. Pick CG, Yanai J (1983). Eight arm maze for mice. Int J Neurosci 21 : 63 66.
43. Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS (2009). 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol 156 : 181 188.
44. Russo EB, Burnett A, Hall B, Parker KK (2005). Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 30 : 1037 1043.
45. Ryberg E, Larsson N, Sjögren S, Hjorth S, Hermansson NO, Leonova J et al. (2007). The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 152 : 1092 1101.
46. Schiller L, Donix M, Jähkel M, Oehler J (2006). Serotonin 1A and 2A receptor densities, neurochemical and behavioural characteristics in two closely related mice strains after long-term isolation. Prog Neuropsychopharmacol Biol Psychiatry 30 : 492 503.
47. Shawcross DL, Davies NA, Williams R, Jalan R (2004). Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 40 : 247 254.
48. Stella N (2004). Cannabinoid signaling in glial cells. Glia 48 : 267 277. Review.
49. Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K et al. (1995). 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 215 : 89 97.
50. Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG (2007). Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol 150 : 613 623.
51. Van der Stelt M, Di Marzo V (2005). Anandamide as an intracellular messenger regulating ion channel activity. Prostaglandins Other Lipid Mediat 77 : 111 122. Review.
52. Wu CW, Chen YC, Yu L, Chen HI, Jen CJ, Huang AM et al. (2007). Treadmill exercise counteracts the suppressive effects of peripheral lipopolysaccharide on hippocampal neurogenesis and learning and memory. J Neurochem 103 : 2471 2481.
53. Yurdaydin C, Karavelioglu D, Onaran O, Celik T, Yaşa MH, Uzunalimoglu O (1998). Opioid receptor ligands in human hepatic encephalopathy. J Hepatol 29 : 796 801.