The in vitro MN assay in 2011: Origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance

Archives of Toxicology

Volumn 85, Issue 8, 2011, Pages 873-899

  Kirsch Volders, Micheline ^a   Plas, Gina ^a   Elhajouji, Azeddine ^b   Lukamowicz, Magdalena ^b   Gonzalez, Laetitia ^a   Vande Loock, Kim ^a   Decordier, Ilse ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cytokinesis block micronucleus assay; Genotoxicity; Micronuclei

Indexed keywords

CARCINOGEN; MUTAGENIC AGENT; NANOPARTICLE; TRACE ELEMENT; TUMOR MARKER;

AGE DISTRIBUTION; ANIMAL TESTING ALTERNATIVE; CANCER DIAGNOSIS; CANCER RISK; CELL CYCLE PHASE; CELL FATE; CELL LINE; CELL SURVIVAL; CENTROMERE; CYTOTOXICITY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTOXICITY; GENOTYPE; HAZARD ASSESSMENT; HUMAN; IMAGE ANALYSIS; IN VITRO STUDY; INTERMETHOD COMPARISON; MICRONUCLEUS; MICRONUCLEUS TEST; NANOANALYSIS; NEOPLASM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; SMOKING; VALIDATION PROCESS;

ANIMALS; CARCINOGENS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENS; RISK ASSESSMENT;

EID: 80052762819     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0691-4     Document Type: Review

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