Do dose response thresholds exist for genotoxic alkylating agents?

Mutagenesis

Volumn 20, Issue 6, 2005, Pages 389-398

  Jenkins, G J S ^a   Doak, S H ^a   Johnson, G E ^a   Quick, E ^a   Waters, E M ^a   Parry, J M ^b  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; ALKYLATING AGENT; DNA; ETHYLNITROSOUREA; GUANINE DERIVATIVE; ISOENZYME; MESYLIC ACID METHYL ESTER; TRANSFERASE;

ADDUCTION; CELL ACTIVITY; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CONCENTRATION RESPONSE; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; EXPOSURE; GENOTOXICITY; IN VITRO STUDY; MISMATCH REPAIR; MUTAGENESIS; MUTATION; POINT MUTATION; PRIORITY JOURNAL; REVIEW; WILD TYPE;

ALKYLATING AGENTS; CHROMOSOME ABERRATIONS; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MUTAGENS; MUTATION; SUBSTRATE SPECIFICITY;

EID: 29144476683     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gei054     Document Type: Review

References (75)

1. Schneiderman,M.A., Decoufle,P. and Brown,C.C. (1979) Thresholds for environmental cancer: biologic and statistical considerations. Ann. N. Y. Acad. Sci., 329, 92-130.
2. Lutz,W.K. (1998) Dose response relationships in chemical carcinogenesis, super-position of different mechanisms of activation, resulting in linear-nonlinear curves, practical thresholds, J shapes. Mutat. Res., 405, 117-124.
3. Parry,J.M., Jenkins,G.J.S., Haddad,F., Bourner,R. and Parry,E.M. (2000) In vitro and in vivo extrapolations of genotoxin exposures: consideration of factors which influence dose response thresholds. Mutat. Res., 464, 53-63.
4. Crebelli,R. (2000). Threshold-mediated mechanisms in mutagenesis: implications in the classification and regulation of chemical mutagens. Mutat. Res., 464, 129-135.
5. Speit,G., Autrup,H., Crebelli,R., Henderson,L., Kirsch-Volders,M., Madle,S., Parry,J.M., Sarrif,A.M. and Vrijhof,H. (2000) Thresholds in genetic toxicology - concluding remarks. Mutat. Res., 464, 149-153.
6. Sofuni,T., Hayashi,M., Nohmi,T., Matsuoka,A., Yamada,M. and Kamata,E. (2000) Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity. Mutat. Res., 464, 97-104.
7. Lynch,A., Harvey,J., Aylott,M., Nicholas,E., Burman,M., Siddiqui,A., Walker,S. and Rees,R. (2003) Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity. Mutagenesis, 18, 345-353.
8. Bolt,H.M., Foth,H., Hengstler,J.G. and Degen,G.H. (2004) Carcinogenicity categorization of chemicals: new aspects to be considered in a European perspective. Toxicol. Lett., 151, 29-41.
9. Parry,J.M., Fowler,P., Quick,E. and Parry,E.M. (2004) Investigations into the biological relevance of in vitro clastogenic and aneugenic activity. Cytogenet. Genome Res., 104, 283-288.
10. Lutz,W.K. (2000) A true dose in chemical carcinogenesis, cannot be defined for a population, irrespective of the mode of action. Hum. Exp. Toxicol., 19, 566-568.
11. Henderson,L., Alberini,S. and Aardema,M. (2000) Thresholds in genotoxicity responses. Mutat. Res., 464, 123-128.
12. Muller,L. and Kasper,P. (2000) Human biological relevance and the use of threshold arguments in regulatory genotoxicicty assessment: experience with pharmaceuticals. Mutat. Res., 464, 19-34.
13. Kirsch-Volders,M., Vanhauwaert,A., Eichenlaub-Ritter,U. and Decordier,I. (2003) Indirect mechanisms of genotoxicity. Toxicol. Lett., 140-141, 63-74.
14. Lutz,W.K., Tiedge,O., Lutz,R.W. and Stopper,H. (2005) Different types of combination effects for the induction of micronuclei in mouse lymphoma cells by binary mixtures of the genotoxic agents MMS, MNU and genistein. Toxicol. Sci., 86, 318-323.
15. Hengstler,J.G., Bogdanffy,M.S., Bolt,H.M. and Oesch,F. (2003) Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate. Annu. Rev. Pharmacol., 43, 485-520.
16. Elhajouji,A., VanHummelen,P. and KirschVolders,M. (1995) Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ. Mol. Mutagen., 26, 292-304.
17. Elhajouji,A., Tibaldi,F. and KirschVolders,M. (1997) Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes. Mutagenesis, 12. 133-140.
18. Touil,N., Elhajouji,A., Thierens,H. and Kirsch-Volders,M. (2000) Analysis of chromosome loss and chromosome segregation in cytokinesis-blocked human lymphocytes: non-disjunction is the prevalent mistake in chromosome segregation produced by low dose exposure to ionizing radiation. Mutagenesis, 15, 1-7.
19. Perera,F.P. (1988) The significance of DNA and protein adducts in human biomonitoring studies. Mutat. Res., 205, 255-269.
20. Zito,R. (2001) Low doses and thresholds in genotoxicity: from theories to experiments. J. Exp. Clin. Cancer Res., 20, 315-325.
21. Lovell,D.P. (2000) Dose response and threshold mediated mechanisms in mutagenesis: statistical models and study design. Mutat. Res., 464, 87-95.
22. Swenberg,J.A., Ham,A., Koc,H., Morinello,E., Ranasinghe,A., Tretyakova,N., Upton,P.B. and Wu,K.Y. (2000) DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene. Mutat. Res., 464, 77-86.
23. Rossiter,B.I.F and Caskey,C.T. (1990) Molecular scanning methods of mutation detection. J. Biol. Chem., 265, 12753-12756.
24. Jenkins,G.J.S., Suzen,H.S., Sueiro,R.A. and Parry,J.M. (1999) The Restriction Site Mutation (RSM) assay. A review of the methodology development and the current status of the technique. Mutagenesis, 14, 439-448.
25. McKinzie,P.B., Delongchamp,R.R., Heflich,R.H. and Parsons,P.L. (2001) Prospects for applying genotypic selection of somatic oncomutation to chemical risk assessment. Mutat. Res., 489, 47-78.
26. Fenech,M. and Morley,A.A. (1985) Measurement of micronuclei in lymphocytes. Mutat. Res., 147, 29-36.
27. Grawe,J., Abramsson-Zetterberg,L. and Zetterberg,G. (1998) Low dose effects of chemicals as assessed by the flow cytometric in vivo micronucleus assay. Mutat. Res., 405, 199-208.
28. Bentley,K.S., Kirkland,D., Murphy,M. and Marshall,R. (2000) Evaluation of thresholds for benomyl- and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybridisation. Mutat. Res., 464, 41-51.
29. Bonacker,D., Stoiber,T., Bohm,K.J., Unger,E., Degen,G.H., Their,R. and Bolt,H.M. (2004) Chromosomal genotoxicity of nitrobenzene and benzonitrile. Arch. Toxicol., 78, 49-57.
30. Friedberg,E.C., Walker,G.C. and Siede,W. (eds) (1995) DNA Repair and Mutagenesis. American Society for Microbiology (ASM) Press, Washington DC, pp. 32-33.
31. Shibuya,T. and Morimoto,K. (1993) A review of the genotoxicity of 1-ethyl-1-nitrosourea. Mutat. Res. 297, 3-38.
32. Harris,C. (1987) Biochemical and molecular effects of N-nitroso compounds in human cultured cells: an overview. In The Relevance of N-Nitroso Compounds to Human Cancer. IARC Scientific Publication Number 84, Lyon, France, pp. 20-25.
33. Bartsch,H., Ohshima,H., Shuker,D.E.G., Pignatelli,B. and Calmels,S. (1990) Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology. Mutat. Res., 238, 255-267.
34. Beranek,D.T. (1990) Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res., 231, 11-30.
35. Burns,P.A., Gorden,A.J.E., Kunsmann,G.K. and Glickman,B.W. (1988) Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea induced lesions in E. Coli. Cancer Res., 48, 4455-4458.
36. Richardsen,F.C. and Richardsen,K.K. (1990) Sequence dependent formation of alkylDNA adducts: a review of methods, results and biological correlates. Mutat. Res., 233, 127-138.
37. Sendowski,K. and Rajewsky,M.F. (1991) DNA-sequence dependence of Guanine O-6 alkylation by the N-nitroso carcinogens N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea. Mutat. Res., 250, 153-160.
38. Ye,N., Holmquist,G.P. and O'Connor,T.R. (1998) Heterogeneous repair of N-methylpurines at the nucleotide level in normal human cells J. Mol. Biol., 284, 269-285.
39. van Zeeland, A.A., de Groot,A. and Neuhauser-Klaus,A. (1990) DNA adduct formation in mouse testis by ethylating agents: a comparison with germ cell mutagenesis. Mutat. Res., 231, 55-62.
40. 4-ethylthymine and the ethylphosphotriesters dTp(Et)dT are highly persistent DNA modifications in slowly dividing tissues of the ethylnitrosourea treated rat. Carcinogenesis, 8, 751-757.
41. 6-alkylguanine-DNA-alkyltransferase. Cancer Res., 44, 3806-3811.
42. Lawley,P.D., Orr,D.J., Shah,S.A., Farmer,P.B. and Jarman,M. (1973) Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues: synthesis and idetification of a new methylation product O-4-methylthymidine. Biochem. J., 135, 193-201.
43. 2-ethylthymidine. Biochemistry, 31, 4181-4188.
44. Safhill,R., Margison,G.P. and O'Conner,P.J. (1985) Mechanism of carcinogenesis, induced by alkylating agents. Biochim. Biophys. Acta, 823, 111-145.
45. 6-ethylguanine in DNA by a chromatin fraction from rat liver: transfer of the ethyl group to an acceptor protein. Proc. Natl Acad. Sci. USA, 78, 6766-6770.
46. 6-alkylguanine-DNA alkyltransferase. In The Relevance of N-Nitroso Compounds to Human Cancer. IARC Scientific Publication Number 84, Lyon, France, pp. 26-29.
47. 6-methylguanine-DNA transferase in cell survival, mutagenesis and carcinogenesis. Mutat. Res., 145, 1-16.
48. den Engelse,L., Menkveld,G.J., de Brij,R.J. and Tates,A.D. (1986) Formation and stability of alkylated pyrimidines and purines (including imidiazole ring opened 7-alkylguanine) and alkylphosphotriesters in liver DNA of adult rats treated with ethylnitrosourea or dimethylnitrosamine. Carcinogenesis, 7, 393-403.
49. Bronstein,S.M., Cochrane,J.E., Craft,T.R., Swenberg,J.A. and Skopek,T.R. (1991) Toxicity, mutagenicity and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different repair phenotypes. Cancer Res., 51, 5188-5197.
50. Guttenplan,J.B. (1990) Mutagenesis by N-nitroso compounds: relationships to DNA adducts, DNA repair and mutational efficiencies. Mutat. Res., 233, 177-187.
51. 2 by N-methyl-N- and N-ethyl-N-nitrosourea. Mutat. Res., 7, 1-12.
52. Vogel,E. and Natarajan,A.T. (1979) The relationship between reaction kinetics and mutagenic action of monofunctional alkylating agents in higher eukaryotic systems. Recessive lethal mutations and translocations in Drosophilia. Mutat. Res., 62, 51-100.
53. Cabral Neto,J.B., Cabral Caseira,R.E., LePage,A.M.F., Sarasin,A. and Gentil,A. (1994) Coding properties of a unique apurinic/apyrimidinic site replicated in mammalian cells. J. Mol. Biol., 240, 416-420.
54. Fishbein,L. (1970) Chapter 7. In Chemical Mutagens: Environmental Effects On Biological Systems. Academic Press Inc., New York, pp. 142-234.
55. Moore,M.M., Parker,L., Huston,J., HarringtonBrock,K. and Dearfield,K.L. (1991) Comparison of mutagenicity results for 9 compounds evaluated by HGPRT locus in standard and suspension CHO assays. Mutagenesis, 6, 77-85.
56. Tao,K.S., Urlando,C. and Heddle,J.A. (1993) Mutagenicity of methylmethanesulfonate in vivo at the dlb-1 locus and a lac I transgene. Environ. Mol. Mutagen., 22, 293-296.
57. O'Connor,T.R., Boiteax,S. and Laval,J. (1988) Ring opened 7 methylGuanine residues are a block to in vitro DNA synthesis. Nucleic Acids Res., 16, 5879-5894.
58. Lewis,P.D., Harvey,J.S., Waters,E.M. and Parry,J.M. (2000) The mammalian gene mutation database. Mutagenesis, 15, 411-414.
59. Larminat,F., Cambois,G., Zdzienicka,M.Z. and Defais,M. (1998) Lack of correlation between repair of DNA interstrand cross-links and hypersensitivity of hamster cells towards mitomycin C and cisplatin. FEBS Lett., 437, 97-100.
60. Yaghi,B.M., Turner,P.M., Denny,W.A., Turner,P.R., O'Connor,C.J. and Ferguson,L.R. (1998) Comparative mutational spectra of the nitrogen mustard chlorambucil and its half-mustard analogue in Chinese hamster AS52 cells. Mutat. Res., 401, 153-164.
61. Jones,J.C., Zhen,W., Reed,E., Parker,R.J., Sancar,A. and Bohr,V.A. (1991) Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand crosslinks in Chinese hamster ovary cells. J. Biol. Chem., 266, 7101-7107.
62. Reed,E., Yuspa,S.H., Zwelling,L.A., Ozols,R.F. and Poirier,M.C. (1986) Quantitation of cisplatin-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy. J. Clin. Invest., 77, 545-550.
63. 6-alkylguanine-DNA transferase. Mutat. Res., 307, 67-81.
64. Ellison,K.S., Dogliotti,E., Connors,T.D., Basu,A.K. and Essigman,J.M. (1989) Site specific mutagenesis by O-6-alkylGuanines located in the chromosomes of mammalian cells - influence of the mammalian O-6-alkylGuanine-DNA transferase. Proc. Natl Acad. Sci. USA, 86, 8620-8624.
65. 3-methylguanine, induces gene mutations, sister chromatid exchanges and chromosomal aberrations in Chinese hamster cells. Mutat. Res., 108, 279-292.
66. + and methylation-tolerant mismatch repair compromised cells: facts and models. Mutat. Res., 381, 227-241.
67. Galloway,S.M., Greenwood,S.K., Hill,R.B., Bradt,C.I. and Bean,C.L. (1995) A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells. Mutat. Res., 346, 231-245.
68. Armstrong,M.J. and Galloway,S.M. (1997) Mismatch repair provokes chromosome aberrations in hamsters cells treated with methylating agents or 6-thioguanine, but not with ethylating agents. Mutat. Res., 373, 167-178.
69. Johnson,G.E., Parry,J., Parry,L. and Dubrova,Y. (2004) Investigating thresholds of mutagenic activity in cultured cells using the forward mutation assay. Mutagenesis, 19, 6.
70. Newbold,R.F., Warren,W., Medcalf,A.S.C. and Amos,J. (1980) Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification. Nature, 283, 596-598.
71. Galli,A. and Schiestl,R.H. (1996) Effects of Salmonella assay negative and positive carcinogens on intrachromosomal recombination in G1 arrested yeast cells. Mutat. Res., 370, 209-221.
72. Kumar,D., Khan,P.K. and Sinha,S.P. (1995) Cytogenetic toxicity and no effect limit dose of pesticides. Food Chem. Toxicol., 33, 309-314.
73. Hoshi,M., Morimura,K., Wanibuchi,H., Wei,M., Okochi,E., Ushijima,T., Takoaka,K. and Fukushima,S. (2004) No observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen. Toxicol. Sci., 81, 273-279.
74. Koana,T., Takashima,Y., Okada,M.O., Ikehata,M., Miyakoshi,J.J. and Sakai,K. (2004) A threshold exists in the dose response relationship for somatic mutation frequency induced by X irradiation of Drosophila. Radiat. Res., 161, 391-396.
75. Fukushima,S., Wanibuchi,H., Morimura,K. et al. (2004) Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine. Toxicol. Sci., 80, 109-114.