Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men

Carcinogenesis

Volumn 18, Issue 7, 1997, Pages 1329-1336

  Fenech, Michael F ^a   Dreosti, Ivor E ^a   Rinaldi, Josephine R ^a  

^a CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADULT; AGED; ARTICLE; CHROMOSOME DAMAGE; CLINICAL TRIAL; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FOLIC ACID DEFICIENCY; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS; PREVALENCE; PRIORITY JOURNAL;

AGED; CHROMOSOME ABERRATIONS; DNA DAMAGE; FOLIC ACID; HOMOCYSTEINE; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MIDDLE AGED; VITAMIN B 12;

EID: 0031410993     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.7.1329     Document Type: Article

References (38)

1. Holliday, R. (1994) Understanding Ageing. Cambridge University Press.
2. Harris, C.C. (1991) Chemical and physical carcinogenesis: advances and perspectives for the 1990s. Cancer Res., 51 (Suppl.), 5023S-5044S.
3. Ames, B.N., Gold, L.S. and Willett, W.C. (1995) The causes and prevention of cancer. Proc. Natl Acad. Sci. USA, 92, 5258-5265.
4. Mendelsohn, M.L. (1991) An introduction to biological dosimetry. In Gledhill, B.L. and Mauro, F. (eds), New Horizons in Biological Dosimetry Progress in Clinical and Biological Research, Wiley-Liss Publications, New York, vol. 372, pp. 1-10.
5. MacGregor, J.T. (1990) Dietary factors affecting spontaneous chromosomal damage in man. In Pariza, M.W., Aeschbacher, H.U., Felton, J.S. and Sato, S. (eds), Mutagens and Carcinogens in the Diet. Progress in Clinical and Biological Research, vol. 347, pp. 139-153.
6. Holliday, R. (1987) The inheritance of epigenetic defects. Science, 238, 163-170.
7. Pancharuniti, N., Lewis, C.A., Sauberlich, H.E. et al. (1994) Plasma homocysteine, folate and vitamin B-12 concentrations and risk for early-onset coronary artery disease. Am. J. Clin. Nutr., 59, 940-948.
8. Giovannucci, E., Stampfer, M.J., Colditz, G.A., Rimm, E.B., Trichopoulos, D., Rosner, B.A., Speizer, F.E. and Willett, W.C. (1993) Folate, methionine and alcohol intake and risk of colorectal adenoma. J. Natl Cancer Inst., 85, 875-882.
9. Krumdieck, C.L. (1991) Localised folate deficiency and cancer. In Laidlaw, S.A. and Swendseid, M.E. (eds) Vitamins and Cancer Prevention. Wiley-Liss Publications. New York, pp. 39-49.
10. Wald, N. (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin study. Lancet, 338, 131-137.
11. Green, G. and Jacobsen, D.W. (1995) Clinical implications of hyperhomocysteinemia. In Bailey, L.E. (ed.), Folate in Health and Disease. Marcel Dekker, New York, pp. 75-122.
12. Fenech, M. and Morley, A.A. (1985) Measurement of micronuclei in lymphocytes. Mutat. Res., 147, 29-36.
13. Fenech, M. (1993) The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Env. Hlth Persp., 101 (Suppl. 3), 101-107.
14. Fenech, M. and Rinaldi, J. (1994) The relationship between micronuclei in human lymphocytes and plasma levels of vitamin-C, vitamin-E, vitamin B-12 and folic acid. Carcinogenesis, 15, 1405-1411.
15. Fenech, M. and Rinaldi, J. (1995) A comparison of lymphocyte micronuclei and plasma micronutrients in vegetarians and non-vegetarians. Carcinogenesis, 16, 223-230.
16. Bonassi, S., Abbondandolo, A., Camurri, L. et al. (1995) Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Cancer Genet. Cytogenet., 79, 133-135.
17. Hagmar, L., Brogger, A., Hansteen, I. et al. (1994) Cancer risk in humans predicted by increased level of chromosomal aberrations in lymphocytes: Nordic Study Group on the Health Risk of Chromosome Damage. Cancer Res., 54, 2919-2922.
18. Micale, M.A., Visscher, D.W., Gulino, S.E. and Wolman, S.R. (1994) Chromosomal aneuploidy in proliferative breast disease. Hum. Pathol., 25, 29-35.
19. Bandyk, M.G., Zhao, L., Troncoso, P., Pisters, L.L., Palmer, J.L., von Eschenbach, A.C., Chung, L.W. and Liang, J.C. (1994) Trisomy 7: a potential cytogenetic marker of human prostate cancer progression. Genes, Chromosomes Cancer, 9, 19-27.
20. Fenech, M. (1993) The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res., 285, 35-44.
21. Vester, B. and Rasmussen, K. (1991) High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur. J. Clin. Chem. Clin. Biochem., 29, 549-554.
22. Lentner, C. (ed.) (1981) Geigy Scientific Tables, Vol. 3. Ciba-Geigy Publishers, Basle, Switzerland.
23. Boushey, C.J., Beresford, S.A.A., Omenn, G.S. and Motulsky, A.G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J. Am. Med. Assoc., 274, 1049-1057.
24. Eto, I. and Krumdieck, C.L. (1986) Role of vitamin B-12 and folate deficiencies in Carcinogenesis. In Poirier, L.A., Newbeme, P.M. and Pariza, M.W. (eds) Essential Nutrients in Carcinogenesis. Plenum Press, USA, pp. 313-331.
25. Wagner, C. (1995) Biochemical role of folate in cellular metabolism. In Bailey, L.B. (ed.), Folate in Health and Disease. Marcel Dekker Inc., New York, pp. 23-42.
26. Scott, J., Kirke, P., Molloy, A., Daly, L. and Weir, D. (1994) The role of folate in the prevention of neural-tube defects. Proc. Nutr. Soc., 53, 631-636.
27. Everson, R.B., Wehr, C.M., Erexson, G.L. and MacGregor, J.T. (1988) Association of marginal folate depletion with increased human chromosomal damage in vivo: demonstration by analysis of micronucleated erythrocytes. J. Natl Cancer Inst., 80, 525-529.
28. Branda, R.F., O'Neill, J.P., Sullivan, L.M. and Albertini, R.J. (1991) Factors influencing mutation at the HPRT locus in T-lymphocytes: women treated for breast cancer. Cancer Res., 51, 6603-6607.
29. Li, Y.N., Gulati, S., Baker, P.J., Brody, L.C., Banerjee, R. and Kruger, W.D. (1996) Cloning, mapping and RNA analysis of the human methionine synthetase gene. Hum. Mol. Genet., 5, 1851-1858.
30. Colman, N., Green, R. and Metz, J. (1975) Prevention of folate deficiency by food fortification II. Absorption of folic acid from fortified staple foods. Am. J. Clin. Nutr., 28, 459-464.
31. Keagy, P.M., Shane, B. and Oace, S.M. 91988) Folate bioavailability in humans: effect of wheat bran and beans. Am. J. Clin. Nutr., 47, 80-88.
32. Bailey, L.B., Barton, L.E., Hiller, S.E. and Cerda, J.J. (1988) Bioavailability of mono and polyglutamylfolate in human subjects. Nutr. Rep. Int., 38, 509-518.
33. Frosst, P. Blom, H.J., Milos, R. et al. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet., 10, 111-113.
34. Rasmussen, K., Moller, J., Lyngbak, M., Holm-Pedersen, A. and Dybkjaer, L. (1996) Age-and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin. Chem., 42, 630-636.
35. Anderson, R.G.W., Kamen, B.A., Rothberg, K.G. and Lacey, S.W. (1992) Potocytosis: sequestration and transport of small molecules by caveolae. Science. 225, 410-411.
36. Fort, D.W., Lark, R.H., Smith, A.K., Marling-Cason, M., Weitman, S.D., Shane, B. and Kamen, B.A. (1993) Accumulation of 5-methyltetrahydrofolic acid and folylpolyglutamate synthetase expression by mitogen-stimulated human lymphocytes. Br. J. Haematol., 84, 595-601.
37. Natarajan, A.T. and Obe, G. (1982) Mutagenicity testing with cultured mammalian cells. In Hedle, J.A. (ed.) Mutagenicity: New Horizons in Genetic Toxicology. Academic Press, London, pp. 171-213.
38. Das, K.C. and Herbert, V. (1976) The lymphocyte as a marker of past nutritional status: persistence of abnormal lymphocyte deoxyuridine (dU) suppression test and chromosomes in patients with past deficiency of folate and vitamin B12. Br. J. Haematol., 38, 219-233.