-
1
-
-
0023664272
-
Genistein, a specific inhibitor of tyrosine-specific protein kinases
-
Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M. and Fukami, Y. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem., 262, 5592-5595.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 5592-5595
-
-
Akiyama, T.1
Ishida, J.2
Nakagawa, S.3
Ogawara, H.4
Watanabe, S.5
Itoh, N.6
Shibuya, M.7
Fukami, Y.8
-
2
-
-
0028978525
-
Genotoxicity of 17 gyrase and 4 mammalian topoisomerases II-poisons in prokaryotic and eukaryotic test systems
-
Albertini, S., Chatelat, A.-A., Miller, B., Muster, W., Pujadas, E., Strobel, R. and Gocke, E. (1995) Genotoxicity of 17 gyrase and 4 mammalian topoisomerases II-poisons in prokaryotic and eukaryotic test systems. Mutagenesis, 10, 343-351.
-
(1995)
Mutagenesis
, vol.10
, pp. 343-351
-
-
Albertini, S.1
Chatelat, A.-A.2
Miller, B.3
Muster, W.4
Pujadas, E.5
Strobel, R.6
Gocke, E.7
-
3
-
-
0025060317
-
Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells
-
Applegate, M.L., Moore, M.M., Broder, C.B., Burrell, A., Juhn, G., Kasweck, K.L., Lin, P.F., Wadhams, A. and Hozier, J.C. (1990) Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells. Proc. Natl Acad. Sci. USA, 87, 51-55.
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 51-55
-
-
Applegate, M.L.1
Moore, M.M.2
Broder, C.B.3
Burrell, A.4
Juhn, G.5
Kasweck, K.L.6
Lin, P.F.7
Wadhams, A.8
Hozier, J.C.9
-
4
-
-
0028068277
-
Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: Comparison to Salmonella responses
-
Ashby, J., Tinwell, H., Glover, P., Poorman-Allen, P., Krehl, R., Callander, R.D. and Clive, D. (1994) Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses. Environ. Mol. Mutat., 35, 12-31.
-
(1994)
Environ. Mol. Mutat.
, vol.35
, pp. 12-31
-
-
Ashby, J.1
Tinwell, H.2
Glover, P.3
Poorman-Allen, P.4
Krehl, R.5
Callander, R.D.6
Clive, D.7
-
5
-
-
0018886507
-
Lack of mutagenicity of some phytoestrogens in the Salmonella/mammalian microsome assay
-
Bartholomew, R.M. and Ryan, D.S. (1980) Lack of mutagenicity of some phytoestrogens in the Salmonella/mammalian microsome assay. Mutat. Res., 78, 317-321.
-
(1980)
Mutat. Res.
, vol.78
, pp. 317-321
-
-
Bartholomew, R.M.1
Ryan, D.S.2
-
6
-
-
0032189963
-
Mutagenic properties of topoisomerase-targeted drugs
-
1400
-
Baguley, B.C. and Ferguson, L.R. (1998) Mutagenic properties of topoisomerase-targeted drugs. Biochim. Biophys. Acta, 1400, 213-222.
-
(1998)
Biochim. Biophys. Acta
, pp. 213-222
-
-
Baguley, B.C.1
Ferguson, L.R.2
-
7
-
-
0032189653
-
Structure of DNA topoisomerases
-
1400
-
Berger, J.M. (1998) Structure of DNA topoisomerases. Biochim. Biophys. Acta, 1400, 3-18.
-
(1998)
Biochim. Biophys. Acta
, pp. 3-18
-
-
Berger, J.M.1
-
8
-
-
0032190561
-
Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme
-
1400
-
Burden, D.A. and Osheroff, N. (1998) Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme. Biochim. Biophys. Acta, 1400, 139-154.
-
(1998)
Biochim. Biophys. Acta
, pp. 139-154
-
-
Burden, D.A.1
Osheroff, N.2
-
9
-
-
0024602758
-
Role of DNA breakage in cytotoxicity of doxorubicin, 9-deoxydoxorubicin and 4-demethyl-6-deoxydoxorubicin in murine leukaemia P388 cells
-
Capranico, G., De Isabella, P., Penco, S., Tinelli, S. and Zunino, F. (1989) Role of DNA breakage in cytotoxicity of doxorubicin, 9-deoxydoxorubicin and 4-demethyl-6-deoxydoxorubicin in murine leukaemia P388 cells. Cancer Res., 49, 2022-2027.
-
(1989)
Cancer Res.
, vol.49
, pp. 2022-2027
-
-
Capranico, G.1
De Isabella, P.2
Penco, S.3
Tinelli, S.4
Zunino, F.5
-
10
-
-
0017059028
-
The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes
-
Countryman, P. and Heddle, J. (1976) The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res., 41, 321-332.
-
(1976)
Mutat. Res.
, vol.41
, pp. 321-332
-
-
Countryman, P.1
Heddle, J.2
-
11
-
-
0025898722
-
The molecular pharmacology of doxorubicin in vivo
-
Cummings, J., Anderson, L., Willmott, N. and Smyth, J.F. (1991) The molecular pharmacology of doxorubicin in vivo. Eur. J. Cancer, 27, 532-535.
-
(1991)
Eur. J. Cancer
, vol.27
, pp. 532-535
-
-
Cummings, J.1
Anderson, L.2
Willmott, N.3
Smyth, J.F.4
-
12
-
-
0032456061
-
Genistein-induced upregulation of p21WAF1, downregulation of cyclin B and induction of apoptosis in prostate cancer cells
-
Davis, J.N., Singh, B., Bhuiyan, M. and Sarkar, F.H. (1998) Genistein-induced upregulation of p21WAF1, downregulation of cyclin B and induction of apoptosis in prostate cancer cells. Nutr. Cancer, 32, 123-131.
-
(1998)
Nutr. Cancer
, vol.32
, pp. 123-131
-
-
Davis, J.N.1
Singh, B.2
Bhuiyan, M.3
Sarkar, F.H.4
-
13
-
-
0001852505
-
Anthracyclines and anthracenediones
-
Chabner, B.A. and Longo, D.L. (eds), 2nd Edn. Lippincott-Raven, Philadelphia, PA
-
Doroshow, J.H. (1996) Anthracyclines and anthracenediones. In Chabner, B.A. and Longo, D.L. (eds), Cancer Chemotherapy and Biotherapy: Principles and Practise, 2nd Edn. Lippincott-Raven, Philadelphia, PA, pp. 409-434.
-
(1996)
Cancer Chemotherapy and Biotherapy: Principles and Practise
, pp. 409-434
-
-
Doroshow, J.H.1
-
15
-
-
0032552567
-
Statistical models for low dose exposure
-
Edler, L. and Kopp-Schneider, A. (1998) Statistical models for low dose exposure. Mutat. Res., 402, 227-236.
-
(1998)
Mutat. Res.
, vol.402
, pp. 227-236
-
-
Edler, L.1
Kopp-Schneider, A.2
-
16
-
-
0029590246
-
Indications for a threshold of chemically induced aneuploidy in-vitro in human lymphocytes
-
Elhajouji, A., Van Hummelen, P. and Kirsch-Volders, M. (1995) Indications for a threshold of chemically induced aneuploidy in-vitro in human lymphocytes. Environ. Mol. Mutat., 26, 292-304.
-
(1995)
Environ. Mol. Mutat.
, vol.26
, pp. 292-304
-
-
Elhajouji, A.1
Van Hummelen, P.2
Kirsch-Volders, M.3
-
17
-
-
0030985954
-
Indications for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vivo in human lymphocytes
-
Elhajouji, A., Tibaldi, F. and Kirsch-Volders, M. (1997) Indications for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vivo in human lymphocytes. Mutagenesis, 12, 133-140.
-
(1997)
Mutagenesis
, vol.12
, pp. 133-140
-
-
Elhajouji, A.1
Tibaldi, F.2
Kirsch-Volders, M.3
-
18
-
-
0033628701
-
Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
-
Fortune, J.M. and Osheroff, N. (2000) Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog. Nucleic Acid Res. Mal. Biol., 64, 221-523.
-
(2000)
Prog. Nucleic Acid Res. Mal. Biol.
, vol.64
, pp. 221-523
-
-
Fortune, J.M.1
Osheroff, N.2
-
19
-
-
0033006172
-
A critical evaluation of the mechanisms of action proposed for the antitumour effects of the anthracycline antibiotics adriamycin and daunorubicin
-
Gerwitz, D.A. (1999) A critical evaluation of the mechanisms of action proposed for the antitumour effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol., 57, 727-741.
-
(1999)
Biochem. Pharmacol.
, vol.57
, pp. 727-741
-
-
Gerwitz, D.A.1
-
20
-
-
0002634316
-
Chemistry and mechanism of action of the quinolone antibacterials
-
Andriole, V.T. (ed.), 2nd Edn. Academic Press, San Diego, CA
-
Gootz, T.D. and Brightly, K.E. (1998) Chemistry and mechanism of action of the quinolone antibacterials. In Andriole, V.T. (ed.), The Quinolones, 2nd Edn. Academic Press, San Diego, CA, pp. 27-80.
-
(1998)
The Quinolones
, pp. 27-80
-
-
Gootz, T.D.1
Brightly, K.E.2
-
21
-
-
0035889630
-
Ciprofloxacin: In vivo genotoxicity studies
-
Herbold, B.A., Brendler-Schwaab, S.Y. and Ahr, H.J. (2001) Ciprofloxacin: in vivo genotoxicity studies. Mutat. Res., 498, 193-205.
-
(2001)
Mutat. Res.
, vol.498
, pp. 193-205
-
-
Herbold, B.A.1
Brendler-Schwaab, S.Y.2
Ahr, H.J.3
-
22
-
-
0024353277
-
Evidence for the reversibility of cellular DNA lesions induced by mammalian topoisomerase II poisons
-
Hsiang, Y.H. and Liu, L.F. (1998) Evidence for the reversibility of cellular DNA lesions induced by mammalian topoisomerase II poisons. J. Biol. Chem. 264, 9713-9715.
-
(1998)
J. Biol. Chem.
, vol.264
, pp. 9713-9715
-
-
Hsiang, Y.H.1
Liu, L.F.2
-
23
-
-
0031741785
-
Mechanisms of action of the soy isoflavone genistein: Emerging role for its effects via transforming growth factor beta signaling pathways
-
Kim, H., Peterson, T.G. and Barnes, S. (1998) Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways. Am. J. Clin. Nutr., 68 (suppl. 6), 1418S-1425S.
-
(1998)
Am. J. Clin. Nutr.
, vol.68
, pp. 1418S-1425S
-
-
Kim, H.1
Peterson, T.G.2
Barnes, S.3
-
24
-
-
0033960141
-
Concepts of threshold in mutagenesis and carcinogenesis
-
Kirsch-Volders, M., Aardema, M. and Elhajouji, A. (2000) Concepts of threshold in mutagenesis and carcinogenesis. Mutat. Res., 464, 3-11.
-
(2000)
Mutat. Res.
, vol.464
, pp. 3-11
-
-
Kirsch-Volders, M.1
Aardema, M.2
Elhajouji, A.3
-
25
-
-
0030994869
-
Induction of micronuclei, DNA strand breaks and HPRT mutations in cultured Chinese hamster V79 cells by the phytoestogen cumoestrol
-
Kulling, S.E. and Metzler, M. (1997) Induction of micronuclei, DNA strand breaks and HPRT mutations in cultured Chinese hamster V79 cells by the phytoestogen cumoestrol. Food Chem. Toxicol., 35, 605-613.
-
(1997)
Food Chem. Toxicol.
, vol.35
, pp. 605-613
-
-
Kulling, S.E.1
Metzler, M.2
-
26
-
-
0033982904
-
Dose-response and thresholds-mediated mechanisms in mutagenesis: Statistical models and study design
-
Lovell, D.P. (2000) Dose-response and thresholds-mediated mechanisms in mutagenesis: statistical models and study design. Mutat. Res., 464, 87-95.
-
(2000)
Mutat. Res.
, vol.464
, pp. 87-95
-
-
Lovell, D.P.1
-
27
-
-
0032552522
-
Dose-response relationship in chemical carcinogenesis; superposition of different mechanisms of action, resulting in linear nonlinear curves, practical thresholds, J-shapes
-
Lutz, W. (1998) Dose-response relationship in chemical carcinogenesis; superposition of different mechanisms of action, resulting in linear nonlinear curves, practical thresholds, J-shapes. Mutat. Res., 405, 117-124.
-
(1998)
Mutat. Res.
, vol.405
, pp. 117-124
-
-
Lutz, W.1
-
28
-
-
0024431747
-
Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II
-
Markovits, J., Linassier, C., Fosse, P., Couprie, J., Pierre, J., Jacquemin-Sablon, A., Saucier, J.M., Le Pecq, J.B. and Larsen, A.K. (1989) Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res., 49, 5111-5117.
-
(1989)
Cancer Res.
, vol.49
, pp. 5111-5117
-
-
Markovits, J.1
Linassier, C.2
Fosse, P.3
Couprie, J.4
Pierre, J.5
Jacquemin-Sablon, A.6
Saucier, J.M.7
Le Pecq, J.B.8
Larsen, A.K.9
-
29
-
-
0002028597
-
Mutations and apoptosis in genistein-exposed human lymphoblastoid cells
-
Morris, S.M., Chen, J.J., Domon, O.E., McGarrity, L.J., Bishop, M.E., Manjanatha, M.G. and Casciano, D.A. (1998) Mutations and apoptosis in genistein-exposed human lymphoblastoid cells. Mutat. Res., 405, 41-56.
-
(1998)
Mutat. Res.
, vol.405
, pp. 41-56
-
-
Morris, S.M.1
Chen, J.J.2
Domon, O.E.3
McGarrity, L.J.4
Bishop, M.E.5
Manjanatha, M.G.6
Casciano, D.A.7
-
30
-
-
0342316476
-
Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: Experience with pharmaceuticals
-
Müller, L. and Kasper, P. (2000) Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals. Mutat. Res., 464, 19-34.
-
(2000)
Mutat. Res.
, vol.464
, pp. 19-34
-
-
Müller, L.1
Kasper, P.2
-
31
-
-
0029411277
-
Induction of micronucleus formation in mouse splenocytes by the soy isoflavone genistein in vitro but not in vivo
-
Record, I.R., Jannes, M., Dreosti, I.E. and King, R.A. (1995) Induction of micronucleus formation in mouse splenocytes by the soy isoflavone genistein in vitro but not in vivo. Food Chem. Toxicol., 33, 919-922.
-
(1995)
Food Chem. Toxicol.
, vol.33
, pp. 919-922
-
-
Record, I.R.1
Jannes, M.2
Dreosti, I.E.3
King, R.A.4
-
32
-
-
0018614461
-
Thresholds for environmental cancer: Biologic and statistical considerations
-
Schneiderman, M.A., Decoufle, P. and Brown, C.C. (1979) Thresholds for environmental cancer: biologic and statistical considerations. Ann. N. Y. Acad. Sci., 329, 92-130.
-
(1979)
Ann. N. Y. Acad. Sci.
, vol.329
, pp. 92-130
-
-
Schneiderman, M.A.1
Decoufle, P.2
Brown, C.C.3
-
33
-
-
0033763830
-
1 cell-cycle arrest in human prostate cancer cells
-
1 cell-cycle arrest in human prostate cancer cells. Mol. Carcinog., 29, 92-102.
-
(2000)
Mol. Carcinog.
, vol.29
, pp. 92-102
-
-
Shen, J.-C.1
Klein, R.D.2
Wei, Q.3
Guan, Y.4
Contois, J.H.5
Wang, T.T.Y.6
Chang, C.7
Hursting, S.D.8
-
34
-
-
0033982309
-
Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity
-
Sofuni, T., Hayashi, M., Nohmi, T., Matsuoka, A., Yamada, M. and Kamata, E. (2000) Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity. Mutat. Res., 464, 97-104.
-
(2000)
Mutat. Res.
, vol.464
, pp. 97-104
-
-
Sofuni, T.1
Hayashi, M.2
Nohmi, T.3
Matsuoka, A.4
Yamada, M.5
Kamata, E.6
-
35
-
-
0027973733
-
Genotoxicity studies of grepafloxacin
-
Takahashi, N., Shiahara, T., Kaneko, E., Itoh, T., Shiragiku, T., Awogi, T. and Shibuya, T. (1994) Genotoxicity studies of grepafloxacin. Japn. Pharmacol. Ther., 22, 4567-4577.
-
(1994)
Japn. Pharmacol. Ther.
, vol.22
, pp. 4567-4577
-
-
Takahashi, N.1
Shiahara, T.2
Kaneko, E.3
Itoh, T.4
Shiragiku, T.5
Awogi, T.6
Shibuya, T.7
-
36
-
-
0029028389
-
Toxicity of quinolone antimicrobial agents
-
Takayama, S., Hirohashi, M., Kato, M. and Shimada, H. (1995) Toxicity of quinolone antimicrobial agents. J. Toxicol. Environ. Heath, 45, 1-45.
-
(1995)
J. Toxicol. Environ. Heath
, vol.45
, pp. 1-45
-
-
Takayama, S.1
Hirohashi, M.2
Kato, M.3
Shimada, H.4
-
37
-
-
0021151237
-
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
-
Tewey, K.M., Rowe, T.C., Yang, L., Halligan, B.D. and Liu, L.F. (1994) Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science, 226, 466-468.
-
(1994)
Science
, vol.226
, pp. 466-468
-
-
Tewey, K.M.1
Rowe, T.C.2
Yang, L.3
Halligan, B.D.4
Liu, L.F.5
-
38
-
-
0031847082
-
Etoposide targets topoisomerase II alpha and II beta in leukemic cells: Isoform-specific cleavable complexes visualised and quantified in-situ by a novel immunofluorescence technique
-
Willmore, E., Frank, A.J., Padget, K., Tilby, M.J. and Austin, C.A. (1998) Etoposide targets topoisomerase II alpha and II beta in leukemic cells: isoform-specific cleavable complexes visualised and quantified in-situ by a novel immunofluorescence technique. Mol. Pharmacol., 54, 78-85.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 78-85
-
-
Willmore, E.1
Frank, A.J.2
Padget, K.3
Tilby, M.J.4
Austin, C.A.5
-
39
-
-
0037094408
-
Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells
-
Willmore, E., Errington, F., Tilby, M.J. and Austin, C.A. (2002) Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells. Biochem. Pharmacol., 63, 1807-1815.
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 1807-1815
-
-
Willmore, E.1
Errington, F.2
Tilby, M.J.3
Austin, C.A.4
-
40
-
-
0025189757
-
Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol
-
Yamashita, Y., Kawada, S. and Nakano, H. (1990) Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol. Biochem. Pharmacol., 39, 737-744.
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 737-744
-
-
Yamashita, Y.1
Kawada, S.2
Nakano, H.3
-
41
-
-
0019867969
-
Protein-associated deoxyribonucleic acid intercalating agents 4′-(9-acridinylamino)methanesulfon-m-anisidide and adriamycin
-
Zwelling, L.A., Michaels, S., Erickson, L.C., Ungerleider, M.N., Nichols, M. and Kohn, K. (1981) Protein-associated deoxyribonucleic acid intercalating agents 4′-(9-acridinylamino methanesulfon-m-anisidide and adriamycin. Biochemistry, 20, 6553-6563.
-
(1981)
Biochemistry
, vol.20
, pp. 6553-6563
-
-
Zwelling, L.A.1
Michaels, S.2
Erickson, L.C.3
Ungerleider, M.N.4
Nichols, M.5
Kohn, K.6
|