메뉴 건너뛰기




Volumn 134, Issue 1, 2004, Pages 48-56

Methylenetetrahydrofolate Reductase C677T Polymorphism, Folic Acid and Riboflavin Are Important Determinants of Genome Stability in Cultured Human Lymphocytes

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HOMOCYSTEINE; METHIONINE; RIBOFLAVIN;

EID: 0346726185     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.1.48     Document Type: Article
Times cited : (156)

References (53)
  • 1
    • 0004187982 scopus 로고    scopus 로고
    • Folic acid
    • (Ziegler, E. E. & Filer, L. J., eds.) 7th ed. ILSI Press, Washington, D.C.
    • Selhub, J. & Rosenberg, I. H. (1996) Folic acid. In: Present Knowledge in Nutrition (Ziegler, E. E. & Filer, L. J., eds.), 7th ed., pp. 206-219. ILSI Press, Washington, D.C.
    • (1996) Present Knowledge in Nutrition , pp. 206-219
    • Selhub, J.1    Rosenberg, I.H.2
  • 2
    • 0036328028 scopus 로고    scopus 로고
    • Folate status: Effects on pathways of colorectal carcinogenesis
    • Choi, S. & Mason, J. B. (2002) Folate status: effects on pathways of colorectal carcinogenesis. J. Nutr. 132: 2413S-2418S.
    • (2002) J. Nutr. , vol.132
    • Choi, S.1    Mason, J.B.2
  • 3
    • 0035906327 scopus 로고    scopus 로고
    • The role of folic acid and vitamin B12 in genomic stability of human cells
    • Fenech, M. (2001) The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat. Res. 475: 56-67.
    • (2001) Mutat. Res. , vol.475 , pp. 56-67
    • Fenech, M.1
  • 4
    • 0036719572 scopus 로고    scopus 로고
    • Are vitamin and mineral deficiencies a major cancer risk?
    • Ames, B. N. & Wakimoto, P. (2002) Are vitamin and mineral deficiencies a major cancer risk? Nature Rev. Cancer 2: 694-704.
    • (2002) Nature Rev. Cancer , vol.2 , pp. 694-704
    • Ames, B.N.1    Wakimoto, P.2
  • 5
    • 0009435122 scopus 로고    scopus 로고
    • Riboflavin
    • (Ziegler, E. E. & Filer, L. J., eds.), 7th ed. ILSI Press, Washington, D.C.
    • Rivlin, R. S. (1996) Riboflavin. In: Present Knowledge in Nutrition (Ziegler, E. E. & Filer, L. J., eds.), 7th ed., pp. 206-219. ILSI Press, Washington, D.C.
    • (1996) Present Knowledge in Nutrition , pp. 206-219
    • Rivlin, R.S.1
  • 6
    • 0033869703 scopus 로고    scopus 로고
    • Riboflavin as a determinant of plasma total homocysteine: Effect of modification by the methylenetetrahydrofolate reductase C677T polymorphism
    • Hustad S., Ueland, P. M., Vollset, S. E., Zhang, Y., Bjorke-Monsen, A. L. & Schneede, J. (2000) Riboflavin as a determinant of plasma total homocysteine: effect of modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin. Chem. 46(8): 1065-1071.
    • (2000) Clin. Chem. , vol.46 , Issue.8 , pp. 1065-1071
    • Hustad, S.1    Ueland, P.M.2    Vollset, S.E.3    Zhang, Y.4    Bjorke-Monsen, A.L.5    Schneede, J.6
  • 9
    • 0033607241 scopus 로고    scopus 로고
    • Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukaemia in adults
    • Skibola, C. F., Smith, M. T., Kane, E., Roman, E., Rollinson, S., Cartwright R. A. & Morgan, G. (1999) Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukaemia in adults. Proc. Natl. Acad. Sci. U.S.A. 96: 12810-12815.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 12810-12815
    • Skibola, C.F.1    Smith, M.T.2    Kane, E.3    Roman, E.4    Rollinson, S.5    Cartwright, R.A.6    Morgan, G.7
  • 11
    • 0036324027 scopus 로고    scopus 로고
    • Epidemiological studies of folate and colorectal neoplasia: A review
    • Giovannucci, E. (2002) Epidemiological studies of folate and colorectal neoplasia: a review. J. Nutr. 132: 2350S-2355S.
    • (2002) J. Nutr. , vol.132
    • Giovannucci, E.1
  • 16
    • 0034936018 scopus 로고    scopus 로고
    • MTHFR C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro
    • Crott, J. W., Mashiyama, S. T., Ames, B. N. & Fenech, M. (2001) MTHFR C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis 22: 1019-1025.
    • (2001) Carcinogenesis , vol.22 , pp. 1019-1025
    • Crott, J.W.1    Mashiyama, S.T.2    Ames, B.N.3    Fenech, M.4
  • 17
    • 0034792891 scopus 로고    scopus 로고
    • The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytesin vitro
    • Crott, J. W., Mashiyama, S. T., Ames, B. N. & Fenech, M. (2001) The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytesin vitro. Cancer Epidemiol. Biomark. Prev. 10: 1089-1096.
    • (2001) Cancer Epidemiol. Biomark. Prev. , vol.10 , pp. 1089-1096
    • Crott, J.W.1    Mashiyama, S.T.2    Ames, B.N.3    Fenech, M.4
  • 18
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech, M. (2000) The in vitro micronucleus technique. Mutat. Res. 455: 81-95.
    • (2000) Mutat. Res. , vol.455 , pp. 81-95
    • Fenech, M.1
  • 19
    • 0037112246 scopus 로고    scopus 로고
    • Chromosomal biomarkers of genomic instability relevant to cancer
    • Fenech, M. (2002) Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov. Today 7(22): 1128-1137.
    • (2002) Drug Discov. Today , vol.7 , Issue.22 , pp. 1128-1137
    • Fenech, M.1
  • 20
    • 0031410993 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of old men
    • Fenech, M., Dreosti, I. E. & Rinaldi, J. R. (1997) Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of old men. Carcinogenesis 18: 1329-1336.
    • (1997) Carcinogenesis , vol.18 , pp. 1329-1336
    • Fenech, M.1    Dreosti, I.E.2    Rinaldi, J.R.3
  • 21
    • 0031903189 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults
    • Fenech, M., Aitken, C. & Rinaldi, J. (1998) Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 19: 1163-1171.
    • (1998) Carcinogenesis , vol.19 , pp. 1163-1171
    • Fenech, M.1    Aitken, C.2    Rinaldi, J.3
  • 22
    • 0037173452 scopus 로고    scopus 로고
    • Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay
    • Fenech, M. & Crott, J. W. (2002) Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay. Mutat. Res. 504(1-2): 131-136.
    • (2002) Mutat. Res. , vol.504 , Issue.1-2 , pp. 131-136
    • Fenech, M.1    Crott, J.W.2
  • 25
    • 10544249877 scopus 로고    scopus 로고
    • Human methionine synthase: cDNA cloning and identification of mutations in patients of the cbIG complementation group of folic acid/cobalamin disorders
    • Leclerc, D., Campeau, E., Goyette, P., Adjalla, C. E., Christensen, B., Ross, M., Eydoux, P., Rosenblatt, D. S., Rozen, R. & Gravel, R. A. (1996) Human methionine synthase: cDNA cloning and identification of mutations in patients of the cbIG complementation group of folic acid/cobalamin disorders. Hum. Mol. Genet. 5: 1867-1874.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1867-1874
    • Leclerc, D.1    Campeau, E.2    Goyette, P.3    Adjalla, C.E.4    Christensen, B.5    Ross, M.6    Eydoux, P.7    Rosenblatt, D.S.8    Rozen, R.9    Gravel, R.A.10
  • 26
    • 0003084614 scopus 로고
    • Culture media for human cells-RPMI 1603, RPMI 1634, RPMI 1640 and GEM 1717
    • Tissue Culture Association, Rockville, MD
    • Moore, G. E. & Woods, L. K. (1976) Culture media for human cells-RPMI 1603, RPMI 1634, RPMI 1640 and GEM 1717. In: Tissue Culture Association Manual, vol. 3, pp. 503-508. Tissue Culture Association, Rockville, MD.
    • (1976) Tissue Culture Association Manual , vol.3 , pp. 503-508
    • Moore, G.E.1    Woods, L.K.2
  • 27
    • 0036696954 scopus 로고    scopus 로고
    • Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts
    • Suzuki, T., Fuji, M. & Ayusawa, D. (2002) Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts. Exp. Gerontol. 37: 1005-1014.
    • (2002) Exp. Gerontol. , vol.37 , pp. 1005-1014
    • Suzuki, T.1    Fuji, M.2    Ayusawa, D.3
  • 30
    • 0037100745 scopus 로고    scopus 로고
    • Centrosomal abnormalities, multipolar mitoses and chromosomal instability in head and neck tumours with dysfunctional telomeres
    • Gisselson, D., Jonson, T., Martins, C., Mandahl, N., Jin, Y., Mertens, F. & Jin, C. (2002) Centrosomal abnormalities, multipolar mitoses and chromosomal instability in head and neck tumours with dysfunctional telomeres. Br. J. Cancer 87: 202-207.
    • (2002) Br. J. Cancer , vol.87 , pp. 202-207
    • Gisselson, D.1    Jonson, T.2    Martins, C.3    Mandahl, N.4    Jin, Y.5    Mertens, F.6    Jin, C.7
  • 31
    • 0034724312 scopus 로고    scopus 로고
    • Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy
    • Li, R. H., Sonik, A., Rasnick, D. & Duesberg, P. (2000) Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy. Proc. Natl. Acad. Sci. U.S.A. 97(7): 3236-3241.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , Issue.7 , pp. 3236-3241
    • Li, R.H.1    Sonik, A.2    Rasnick, D.3    Duesberg, P.4
  • 33
    • 0037178761 scopus 로고    scopus 로고
    • Connecting chromosomes, crisis and cancer
    • Maser, R. S. & DePinho, R. A. (2002) Connecting chromosomes, crisis and cancer. Science 297: 565-569.
    • (2002) Science , vol.297 , pp. 565-569
    • Maser, R.S.1    DePinho, R.A.2
  • 34
    • 0031416750 scopus 로고    scopus 로고
    • Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis
    • Zingg, J. M. & Jones, P. A. (1997) Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 18: 869-882.
    • (1997) Carcinogenesis , vol.18 , pp. 869-882
    • Zingg, J.M.1    Jones, P.A.2
  • 35
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones, P. A. & Baylin, S. B. (2002) The fundamental role of epigenetic events in cancer. Nature Rev. Genet. 3: 415-428.
    • (2002) Nature Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 36
    • 0035451073 scopus 로고    scopus 로고
    • Recommended dietary allowances for genomic stability
    • Fenech, M. (2001) Recommended dietary allowances for genomic stability. Mutat. Res. 480-481: 51-54.
    • (2001) Mutat. Res. , vol.480-481 , pp. 51-54
    • Fenech, M.1
  • 37
    • 0026354468 scopus 로고
    • Betaine: Homocysteine methyl transferase-a new assay for the liver enzyme and its absence from human skin fibroblasts and peripheral blood lymphocytes
    • Wang, J. A., Dudman, N. P., Lynch, J. & Wilcken, D. E. (1991) Betaine: homocysteine methyl transferase-a new assay for the liver enzyme and its absence from human skin fibroblasts and peripheral blood lymphocytes. Clin. Chim. Acta 204(1-3): 239-249.
    • (1991) Clin. Chim. Acta , vol.204 , Issue.1-3 , pp. 239-249
    • Wang, J.A.1    Dudman, N.P.2    Lynch, J.3    Wilcken, D.E.4
  • 38
    • 0037238069 scopus 로고    scopus 로고
    • A comparison of folic acid and 5-methyl tetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro
    • Wang, X. & Fenech, M. (2003) A comparison of folic acid and 5-methyl tetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro. Mutagenesis 18(1): 81-86.
    • (2003) Mutagenesis , vol.18 , Issue.1 , pp. 81-86
    • Wang, X.1    Fenech, M.2
  • 39
    • 0032559796 scopus 로고    scopus 로고
    • Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase
    • Shimizu, N., Itoh, N., Utiyama, H. & Wahl, G. M. (1998) Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J. Cell Biol. 140: 1307-1320.
    • (1998) J. Cell Biol. , vol.140 , pp. 1307-1320
    • Shimizu, N.1    Itoh, N.2    Utiyama, H.3    Wahl, G.M.4
  • 40
    • 0028242563 scopus 로고
    • Exclusion of specific human chromosomes into micronuclei by 5-azacytidine treatment in lymphocyte cultures
    • Guttenbach, M. & Schmid, M. (1994) Exclusion of specific human chromosomes into micronuclei by 5-azacytidine treatment in lymphocyte cultures. Exp. Cell Res. 211: 127-132.
    • (1994) Exp. Cell Res. , vol.211 , pp. 127-132
    • Guttenbach, M.1    Schmid, M.2
  • 42
    • 0028908387 scopus 로고
    • Chromosome instability in ICF syndrome: Formation of micronuclei from multibranched chromosome 1 demonstrated by fluorescence in situ hybridisation
    • Sawyer, J. R., Swanson, C. M., Wheeler, G. & Cunniff, C. (1995) Chromosome instability in ICF syndrome: formation of micronuclei from multibranched chromosome 1 demonstrated by fluorescence in situ hybridisation. Am. J. Med. Genet. 56(2): 203-209.
    • (1995) Am. J. Med. Genet. , vol.56 , Issue.2 , pp. 203-209
    • Sawyer, J.R.1    Swanson, C.M.2    Wheeler, G.3    Cunniff, C.4
  • 43
    • 0029072603 scopus 로고
    • Micronuclei induced by modulators of methylation: Analogs of 5-azacytidine
    • Stopper, H., Korber, C., Gibis, P., Spencer, D. L. & Caspary W. J. (1995) Micronuclei induced by modulators of methylation: analogs of 5-azacytidine. Carcinogenesis 16(7): 1647-1650.
    • (1995) Carcinogenesis , vol.16 , Issue.7 , pp. 1647-1650
    • Stopper, H.1    Korber, C.2    Gibis, P.3    Spencer, D.L.4    Caspary, W.J.5
  • 45
    • 0036171590 scopus 로고    scopus 로고
    • The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring Cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene
    • Jacques, P. F., Kalmbach, R., Bagley, P. J., Russo, G. T., Rogers, G., Wilson, P.W.F., Rosenberg, I. H. & Selhub, J. (2002) The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring Cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J. Nutr. 132: 282-288.
    • (2002) J. Nutr. , vol.132 , pp. 282-288
    • Jacques, P.F.1    Kalmbach, R.2    Bagley, P.J.3    Russo, G.T.4    Rogers, G.5    Wilson, P.W.F.6    Rosenberg, I.H.7    Selhub, J.8
  • 46
    • 0036890065 scopus 로고    scopus 로고
    • Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease
    • DeBree, A., Verschuren, W. M., Kronhout, D., Kluijtmans, L. A. & Blom, H. J. (2002) Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol. Rev. 54(4): 599-618.
    • (2002) Pharmacol. Rev. , vol.54 , Issue.4 , pp. 599-618
    • DeBree, A.1    Verschuren, W.M.2    Kronhout, D.3    Kluijtmans, L.A.4    Blom, H.J.5
  • 48
    • 0035500597 scopus 로고    scopus 로고
    • Effects of homocysteine on proliferation, necrosis, and apoptosis of vascular smooth muscle cells in culture and influence of folic acid
    • Buemi, M., Marino, D., Di Pasquale, G., Floccari, F., Ruello, A., Aloisi, C., Corica, F., Senatore, M., Romeo, A. & Frisina, N. (2001) Effects of homocysteine on proliferation, necrosis, and apoptosis of vascular smooth muscle cells in culture and influence of folic acid. Thromb. Res. 104(:3): 207-213.
    • (2001) Thromb. Res. , vol.104 , Issue.3 , pp. 207-213
    • Buemi, M.1    Marino, D.2    Di Pasquale, G.3    Floccari, F.4    Ruello, A.5    Aloisi, C.6    Corica, F.7    Senatore, M.8    Romeo, A.9    Frisina, N.10
  • 49
    • 0036263874 scopus 로고    scopus 로고
    • Serum total homocysteine increases with the rapid proliferation rate of tumor cell and decline upon cell death: A potential new tumor marker
    • Sun, C. F., Haven, T. R., Wu, T. L., Tsao, K. C. & Wu, J. T. (2002) Serum total homocysteine increases with the rapid proliferation rate of tumor cell and decline upon cell death: a potential new tumor marker. Clin. Chim. Acta 321(1-2): 55-62.
    • (2002) Clin. Chim. Acta , vol.321 , Issue.1-2 , pp. 55-62
    • Sun, C.F.1    Haven, T.R.2    Wu, T.L.3    Tsao, K.C.4    Wu, J.T.5
  • 50
    • 0036197073 scopus 로고    scopus 로고
    • Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes
    • Zhang, Q., Zeng, X., Guo, J. & Wang, X. (2002) Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes. Cardiovasc. Res. 53(4): 1035-1042.
    • (2002) Cardiovasc. Res. , vol.53 , Issue.4 , pp. 1035-1042
    • Zhang, Q.1    Zeng, X.2    Guo, J.3    Wang, X.4
  • 51
    • 0036294472 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker
    • Wu, L. L. & Wu, J. T. (2002) Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin. Chim. Acta 322: 21-28.
    • (2002) Clin. Chim. Acta , vol.322 , pp. 21-28
    • Wu, L.L.1    Wu, J.T.2
  • 52
    • 0035830288 scopus 로고    scopus 로고
    • Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: A case-control study
    • Thompson, J. R., Fitzgerald, P., Willoughby, M.L.N. & Armstrong, B. K. (2001) Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet 358: 1935-1940.
    • (2001) Lancet , vol.358 , pp. 1935-1940
    • Thompson, J.R.1    Fitzgerald, P.2    Willoughby, M.L.N.3    Armstrong, B.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.