Genetic polymorphisms of genes involved in DNA repair and metabolism influence micronucleus frequencies in human peripheral blood lymphocytes

Mutagenesis

Volumn 26, Issue 1, 2011, Pages 33-42

  Dhillon, Varinderpal S ^a   Thomas, Philip ^a   Iarmarcovai, G ^b   Kirsch Volders, Micheline ^c   Bonassi, Stefano ^d   Fenech, Michael ^a  

^a CSIRO   (Australia)

^b AIX MARSEILLE UNIVERSITY   (France)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA REPAIR; GENETIC POLYMORPHISM; GENOTOXICITY; GENOTYPE; HUMAN; METABOLISM; MICRONUCLEUS; NONHUMAN; NUTRIENT; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REVIEW; VITAMIN METABOLISM;

CYTOCHROME P-450 CYP2E1; DNA REPAIR; DNA-BINDING PROTEINS; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENS; POLYMORPHISM, GENETIC; REDUCED FOLATE CARRIER PROTEIN; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 78650664538     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/geq076     Document Type: Review

References (79)

1. Iarmarcovai, G., Bonassi, S., Botta, A., Baan, R. A. and Orsière, T. (2008) Genetic polymorphisms and micronucleus formation: a review of the literature. Mutat. Res., 658, 215-233.
2. Fenech, M. (2007) Cytokinesis-block micronucleus cytome assay. Nat. Protoc., 2, 1084-1104.
3. Bonassi, S., Znaor, A., Ceppi, M. et al. (2007) An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis, 28, 625-631.
4. Fenech, M. (2003) Nutritional treatment of genome instability: a paradigm shift in disease prevention and in the setting of recommended dietary allowances. Nutr. Res. Rev., 16, 109-122.
5. Fenech, M. F. (2010) Dietary reference values of individual micronutrients and nutriomes for genome damage prevention: current status and a road map to the future. Am. J. Clin. Nutr., 91, 1438S-1454S.
6. Bonassi, S., Ugolini, D., Kirsch-Volders, M., Stromberg, U., Vermeulen, R. and Tucker, J. D. (2005) Human population studies with cytogenetic biomarkers: review of the literature and future prospectives. Environ. Mol. Mutagen., 45, 258-270.
7. Fenech, M. (2005) The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis. Mutagenesis, 20, 255-269.
8. Fenech, M. and Morley, A. A. (1985) Measurement of micronuclei in lymphocytes. Mutat. Res., 147, 29-36.
9. Fenech, M. and Morley, A. A. (1987) Ageing in vivo does not influence micronucleus induction in human lymphocytes by X-irradiation. Mech. Ageing Dev., 39, 113-119.
10. Fenech, M. (2000) The in vitro micronucleus technique. Mutat. Res., 455, 81-95.
11. Wang, Q., Wang, A. H., Tan, H. S., Feng, N. N., Ye, Y. J., Feng, X. Q., Liu, G., Zheng, Y. X. and Xia, Z. L. (2010) Genetic polymorphisms of DNA repair genes and chromosomal damage in workers exposed to, 1, 3-butadiene. Carcinogenesis, 31, 858-863.
12. Wen-Bin, M., Wei, W., Yu-Lan, Q., Fang, J. and Zhao-Lin, X. (2009) Micronucleus occurrence related to base excision repair gene polymorphisms in Chinese workers occupationally exposed to vinyl chloride monomer. J. Occup. Environ. Med., 51, 578-585.
13. Rohr, P., da Silva, J., Erdtmann, B., Saffi, J., Guecheva, T. N., Henriques, J. A. and Kvitko, K. (2010) BER gene polymorphisms (OGG1 Ser326Cys and XRCC1 Arg194Trp) and modulation of DNA damage due to pesticides exposure. Environ. Mol. Mutagen., March 7, 2010. [Epub ahead of print].
14. Wang, Q., Ji, F., Sun, Y. et al. (2010) Genetic polymorphisms of XRCC1, HOGG1 and MGMT and micronucleus occurrence in Chinese vinyl chloride-exposed workers. Carcinogenesis., 31, 1068-1073.
15. Qiu, L., Leng, S., Wang, Z., Dai, Y., Zheng, Y. and Wang, Z. (2007) Path analysis of biomarkers of exposure and early biological effects among coke-oven workers exposed to polycyclic aromatic hydrocarbons. Cancer Epidemiol. Biomarkers Prev., 16, 1193-1199.
16. Leng, S., Cheng, J., Zhang, L. et al. (2005) The association of XRCC1 haplotypes and chromosomal damage levels in peripheral blood lymphocyte among coke-oven workers. Cancer Epidemiol. Biomarkers Prev., 14, 1295-1301.
17. Pérez-Cadah́ia, B., Laffon, B., Valdiglesias, V., Pásaro, E. and Méndez, J. (2008) Cytogenetic effects induced by Prestige oil on human populations: the role of polymorphisms in genes involved in metabolism and DNA repair. Mutat. Res., 653, 117-123.
18. Cheng, J., Leng, S., Li, H., Huang, C., Niu, Y., Zhang, L., Liang, X., Lin, H. and Zheng, Y. (2009) Suboptimal DNA repair capacity predisposes coke-oven workers to accumulate more chromosomal damages in peripheral lymphocytes. Cancer Epidemiol. Biomarkers Prev., 18, 987-993.
19. Ji, F., Wang, W., Xia, Z. L. et al. (2010) Prevalence and persistence of chromosomal damage, and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers. Carcinogenesis, 31, 648-653.
20. Ishikawa, H., Ishikawa, T., Miyatsu, Y., Kurihara, K., Fukao, A. and Yokoyama, K. (2006) A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers. Mutat. Res., 599, 135-143.
21. Guven, M., Guven, G. S., Oz, E., Ozaydin, A., Batar, B., Ulutin, T., Hacihanefioglu, S. and Domanic, N. (2007) DNA repair gene XRCC1 and XPD polymorphisms and their association with coronary artery disease risks and micronucleus frequency. Heart Vessels, 22, 355-360.
22. Cornetta, T., Padua, L., Testa, A., Ievoli, E., Festa, F., Tranfo, G., Baccelliere, L. and Cozzi, R. (2008) Molecular biomonitoring of a population of nurses handling antineoplastic drugs. Mutat. Res., 638, 75-82.
23. Mateuca, R. A., Roelants, M., Iarmarcovai, G. et al. (2008) hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo. Mutagenesis, 23, 35-41.
24. Kaziḿirová, A., Barancoková, M., Dzupinková, Z., Wsólová, L. and Dusinská, M. (2009) Micronuclei and chromosomal aberrations, important markers of ageing: possible association with XPC and XPD polymorphisms. Mutat. Res., 661, 35-40.
25. Cheng, J., Leng, S., Dai, Y., Huang, C., Pan, Z., Niu, Y., Li, B. and Zheng, Y. (2007) Association between nucleotide excision repair gene polymorphisms and chromosomal damage in coke-oven workers. Biomarkers, 12, 76-86.
26. Qiu, Y. L., Wang, W., Wang, T., Liu, J., Sun, P., Qian, J., Jin, L. and Xia, Z. L. (2008) Genetic polymorphisms, messenger RNA expression of p53, p21, and CCND1, and possible links with chromosomal aberrations in Chinese vinyl chloride-exposed workers. Cancer Epidemiol. Biomarkers Prev., 17, 2578-2584.
27. Manfredi, S., Masetti, S., Botto, N., Colombo, M. G., Terrazzi, M., Vassalle, C., Biagini, A. and Andreassi, M. G. (2002) P53 codon 72 polymorphism in coronary artery disease: no evidence for association with increased risk or micronucleus frequency. Environ. Mol. Mutagen., 40, 110-115.
28. Wang, Y., Duan, H., Dai, Y., Bin, P., Cheng, J., Pan, Z., Huang, C., Leng, S. and Zheng, Y. (2009) Antaxia-telangiectasia mutated gene polymorphisms and susceptibility to chromosomal damage among poly-cyclic aromatic hydrocarbons exposed workers. Sci. Total Environ., 407, 2615-2620.
29. da Silva, J., Moraes, C. R., Heuser, V. D. et al. (2008) Evaluation of genetic damage in a Brazilian population occupationally exposed to pesticides and its correlation with polymorphisms in metabolizing genes. Mutagenesis, 23, 415-422.
30. Migliore, L., Naccarati, A., Coppedè, F. et al. (2006) Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene. Pharmacogenet. Genomics, 16, 87-99.
31. Neri, M., Filiberti, R., Taioli, E. et al. (2005) Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure. Mutat. Res., 592, 36-44.
32. Wang, W., Qiu, Y. L., Ji, F., Liu, J., Wu, F., Miao, W. B., Li, Y., Brandt-Rauf, P. W. and Xia, Z. L. (2010) Genetic polymorphisms in metabolizing enzymes and susceptibility of chromosomal damage induced by vinyl chloride monomer in a Chinese worker population. J. Occup. Environ. Med., 52, 163-168.
33. Leng, S., Dai, Y., Niu, Y., Pan, Z., Li, X., Cheng, J., He, F. and Zheng, Y. (2004) Effects of genetic polymorphisms of metabolic enzymes on cytokinesis-block micronucleus in peripheral blood lymphocyte among coke-oven workers. Cancer Epidemiol. Biomarkers Prev., 13, 1631-1639.
34. Jiang, S., Yu, L., Cheng, J. et al. (2010) Genomic damages in peripheral blood lymphocytes and association with polymorphisms of three glutathione S-transferases in workers exposed to formaldehyde. Mutat. Res., 695, 9-15.
35. Kirsch-Volders, M., Mateuca, R. A., Roelants, M. et al. (2006) The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo. Cancer Epidemiol. Biomarkers Prev., 15, 1038-1042.
36. Chen, L., Guo, H., Yuan, J. et al. (2010) Polymorphisms of GSTT1 and GSTM1 and increased micronucleus frequencies in peripheral blood lymphocytes in residents at an e-waste dismantling site in China. J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng., 45, 490-497.
37. Montero, R., Serrano, L., Araujo, A., Dávila, V., Ponce, J., Camacho, R., Morales, E. and Méndez, A. (2006) Increased cytogenetic damage in a zone in transition from agricultural to industrial use: comprehensive analysis of the micronucleus test in peripheral blood lymphocytes. Mutagenesis, 21, 335-342.
38. Masetti, S., Botto, N., Manfredi, S., Colombo, M. G., Rizza, A., Vassalle, C., Clerico, A., Biagini, A. and Andreassi, M. G. (2003) Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk. J. Mol. Med., 81, 488-494.
39. Leopardi, P., Zijno, A., Marcon, F. et al. (2003) Analysis of micronuclei in peripheral blood lymphocytes of traffic wardens: effects of exposure, metabolic genotypes, and inhibition of excision repair in vitro by ARA-C. Environ. Mol. Mutagen., 41, 126-130.
40. Wang, Y., Duan, H., Dai, Y. et al. (2009) Uridine diphosphoglucuronosyl- transferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers. J. Occup. Environ. Med., 51, 682-689.
41. Ishikawa, H., Ishikawa, T., Yamamoto, H., Fukao, A. and Yokoyama, K. (2007) Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms. Mutat. Res., 615, 134-142.
42. Dhillon, V., Thomas, P. and Fenech, M. (2009) Effect of common olymorphisms in folate uptake and metabolism genes on frequency of micronucleated lymphocytes in a South Australian cohort. Mutat. Res., 665, 1-6.
43. Coppedè, F., Migheli, F., Bargagna, S., Siciliano, G., Antonucci, I., Stuppia, L., Palka, G. and Migliore, L. (2009) Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring. Neurosci. Lett., 449, 15-19.
44. Ishikawa, H., Tian, Y., Piao, F. et al. (2006) Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China. Cancer Lett., 240, 29-35.
45. Botto, N., Andreassi, M. G., Manfredi, S., Masetti, S., Cocci, F., Colombo, M. G., Storti, S., Rizza, A. and Biagini, A. (2003) Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage. Eur. J. Hum. Genet., 11, 671-678.
46. Zijno, A., Andreoli, C., Leopardi, P. et al. (2003) Folate status, metabolic genotype, and biomarkers of genotoxicity in healthy subjects. Carcino-genesis, 24, 1097-1103.
47. Andreassi, M. G., Botto, N., Cocci, F. et al. (2003) Methylenetetrahy- drofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease. Hum. Genet., 112, 171-177.
48. Brem, R., Cox, D. G., Chapot, B., Moullan, N., Romestaing, P., Gérard, J. P., Pisani, P. and Hall, J. (2006) The XRCC1 -77T-.C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage. Carcinogenesis, 27, 2469-2474.
49. Kalapila, A. G., Loktionova, N. A. and Pegg, A. E. (2008) Alkyltransfer-ase-mediated toxicity of 1,3-butadiene diepoxide. Chem. Res. Toxicol., 21, 1851-1861.
50. Nazarkina, Z. K., Khodyreva, S. N., Marsin, S., Lavrik, O. I. and Radicella, J. P. (2007) XRCC1 interactions with base excision repair DNA intermediates. DNA Repair (Amst.), 6, 254-264.
51. Kiuru, A., Lindholm, C., Heilimo, I., Ceppi, M., Koivistoinen, A., Ilus, T., Hirvonen, A., Norppa, H. and Salomaa, S. (2005) Influence of DNA repair gene polymorphisms on the yield of chromosomal aberrations. Environ. Mol. Mutagen., 46, 198-205.
52. Tuimala, J., Szekely, G., Wikman, H., Järventaus, H., Hirvonen, A., Gundy, S. and Norppa, H. (2004) Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations. Mutat. Res., 554, 319-333.
53. El Ghissassi, F., Barbin, A. and Bartsch, H. (1998) Metabolic activation of vinyl chloride by rat liver microsomes: low-dose kinetics and involvement of cytochrome P450 2E1. Biochem. Pharmacol., 55, 1445-1452.
54. Guengerich, F. P. (1992) Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases. Chem. Res. Toxicol., 5, 2-5.
55. Asami, S., Manabe, H., Miyake, J., Tsurudome, Y., Hirano, T., Yamaguchi, R., Itoh, H. and Kasai, H. (1997) Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung. Carcinogenesis, 18, 1763-1766.
56. Ura, K. and Hayes, J. J. (2002) Nucleotide excision repair and chromatin remodeling. Eur. J. Biochem., 269, 2288-2293.
57. Yu, J. J., Mu, C., Lee, K. B., Okamoto, A., Reed, E. L., Bostick-Bruton, F., Mitchell, K. C. and Reed, E. (1997) A nucleotide polymorphism in ERCC1 in human ovarian cancer cell lines and tumor tissues. Mutat. Res., 382, 13-20.
58. Lee, K. M., Choi, J. Y., Kang, C. et al. (2005) Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. Clin. Cancer Res., 11, 4620-4626.
59. Fenech, M. (2002) Biomarkers of genetic damage for cancer epidemiology. Toxicology, 181-182, 411-466.
60. Winsey, S. L., Haldar, N. A., Marsh, H. P., Bunce, M., Marshall, S. E., Harris, A. L., Wojnarowska, F. and Welsh, K. I. (2000) A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. Cancer Res., 60, 5612-5616.
61. Strassburg, C. P., Vogel, A., Kneip, S., Tukey, R. H. and Manns, M. P. (2002) Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut, 50, 851-856.
62. Shimada, T. (2006) Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. Drug Metab. Pharmacokinet., 21, 257-276.
63. Sheweita, S. A. and Tilmisany, A. K. (2003) Cancer and phase II drug-metabolizing enzymes. Curr. Drug Metab., 4, 45-58.
64. Tompkins, L. M. and Wallace, A. D. (2007) Mechanisms of cytochrome P450 induction. J. Biochem. Mol. Toxicol., 21, 176-181.
65. Singh, M. S. and Michael, M. (2009) Role of xenobiotic metabolic enzymes in cancer epidemiology. Methods Mol. Biol., 472, 243-264.
66. Parl, F. F. (2005) Glutathione S-transferase genotypes and cancer risk. Cancer Lett., 221, 123-129.
67. Goedde, H. W., Agarwal, D. P., Fritze, G. et al. (1992) Distribution of ADH2 and ALDH2 genotypes in different populations. Hum. Genet., 88, 344-346.
68. Herbert, V. (1999) Folic acid. In Shils, M., Olson, J., Shike, M. and Ross, A. C. (eds), Nutrition in Health and Disease. Williams & Wilkins, Baltimore, MD, USA.
69. Melse-Boonstra, A., de Bree, A., Verhoef, P., Bjørke-Monsen, A. L. and Verschuren, W. M. (2002) Dietary monoglutamate and polyglutamate folate are associated with plasma folate concentrations in Dutch men and women aged 20-65 years. J. Nutr., 132, 1307-1312.
70. Mashiyama, S. T., Courtemanche, C., Elson-Schwab, I., Crott, J., Lee, B. L., Ong, C. N., Fenech, M. and Ames, B. N. (2004) Uracil in DNA, determined by an improved assay, is increased when deoxynucleo sides are added to folate-deficient cultured human lymphocytes. Anal. Biochem., 330, 58-69.
71. Beetstra, S., Thomas, P., Salisbury, C., Turner, J. and Fenech, M. (2005) Folic acid deficiency increases chromosomal instability, chromosome 21aneuploidy and sensitivity to radiation-induced micronuclei. Mutat. Res., 578, 317-326.
72. Blount, B. C., Mack, M. M., Wehr, C. M., MacGregor, J. T., Hiatt, R. A., Wang, G., Wickramasinghe, S. N., Everson, R. B. and Ames, B. N. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl Acad. Sci. USA, 94, 3290-3295.
73. Fenech, M. (2001) The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat. Res., 475, 57-67.
74. Crott, J. W., Mashiyama, S. T., Ames, B. N. and Fenech, M. (2001) The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol. Biomarkers Prev., 10, 1089-1096.
75. Kimura, M., Umegaki, K., Higuchi, M., Thomas, P. and Fenech, M. (2004) Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J. Nutr., 134, 48-56.
76. Fenech, M. and Ferguson, L. R. (2001) Vitamins/minerals and genomic stability in humans. Mutat. Res., 475, 1-6.
77. Fenech, M. F., Dreosti, I. E. and Rinaldi, J. R. (1997) Folate, Vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis, 18, 1329-1336.
78. Tyson, J., Caple, F., Spiers, A., Burtle, B., Daly, A. K., Williams, E. A., Hesketh, J. E. and Mathers, J. C. (2009) Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype. Br. J. Nutr., 101, 1316-1323.
79. Ishikawa, H., Tian, Y. and Yamauchi, T. (2003) Influence of gender, age and lifestyle factors on micronuclei frequency in healthy Japanese populations. J. Occup. Health, 45, 179-181.