메뉴 건너뛰기




Volumn 88, Issue 11, 2006, Pages 1515-1531

Chromosomal changes: induction, detection methods and applicability in human biomonitoring

Author keywords

Chromosomal aberration; Fluorescence in situ hybridization; Genetic polymorphisms; Micronuclei

Indexed keywords

CARCINOGEN;

EID: 33751119273     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2006.07.004     Document Type: Review
Times cited : (281)

References (121)
  • 4
    • 0029590246 scopus 로고
    • Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes
    • Elhajouji A., Van Hummelen P., and Kirsch-Volders M. Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ. Mol. Mutagen. 26 (1995) 292-304
    • (1995) Environ. Mol. Mutagen. , vol.26 , pp. 292-304
    • Elhajouji, A.1    Van Hummelen, P.2    Kirsch-Volders, M.3
  • 5
    • 0030985954 scopus 로고    scopus 로고
    • Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes
    • Elhajouji A., Tibaldi F., and Kirsch-Volders M. Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes. Mutagenesis 12 (1997) 133-140
    • (1997) Mutagenesis , vol.12 , pp. 133-140
    • Elhajouji, A.1    Tibaldi, F.2    Kirsch-Volders, M.3
  • 6
    • 0036020643 scopus 로고    scopus 로고
    • Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules
    • Decordier I., Dillen L., Cundari E., and Kirsch-Volders M. Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules. Mutagenesis 17 (2002) 337-344
    • (2002) Mutagenesis , vol.17 , pp. 337-344
    • Decordier, I.1    Dillen, L.2    Cundari, E.3    Kirsch-Volders, M.4
  • 7
    • 0037173425 scopus 로고    scopus 로고
    • Importance of detecting numerical versus structural chromosome aberrations
    • Kirsch-Volders M., Vanhauwaert A., De Boeck M., and Decordier I. Importance of detecting numerical versus structural chromosome aberrations. Mutat. Res. 504 (2002) 137-148
    • (2002) Mutat. Res. , vol.504 , pp. 137-148
    • Kirsch-Volders, M.1    Vanhauwaert, A.2    De Boeck, M.3    Decordier, I.4
  • 8
    • 33751105784 scopus 로고    scopus 로고
    • Chromosomal mutations
    • Cummings B. (Ed), Pearson Education Inc, San Francisco
    • Russell P.J. Chromosomal mutations. In: Cummings B. (Ed). Genetics (2002), Pearson Education Inc, San Francisco 595-621
    • (2002) Genetics , pp. 595-621
    • Russell, P.J.1
  • 10
    • 1542720377 scopus 로고    scopus 로고
    • Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts
    • Hagmar L., Stromberg U., Bonassi S., Hansteen I.-L., Knudsen L.E., Lindholm C., and Norppa H. Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts. Cancer Res. 64 (2004) 2258-2263
    • (2004) Cancer Res. , vol.64 , pp. 2258-2263
    • Hagmar, L.1    Stromberg, U.2    Bonassi, S.3    Hansteen, I.-L.4    Knudsen, L.E.5    Lindholm, C.6    Norppa, H.7
  • 12
    • 0031409634 scopus 로고    scopus 로고
    • Selective elimination of human lymphoid cells with unstable chromosome aberrations by p53-dependent apoptosis
    • Schwartz J.L., and Jordan R. Selective elimination of human lymphoid cells with unstable chromosome aberrations by p53-dependent apoptosis. Carcinogenesis 18 (1997) 201-205
    • (1997) Carcinogenesis , vol.18 , pp. 201-205
    • Schwartz, J.L.1    Jordan, R.2
  • 13
    • 0001885499 scopus 로고
    • Assays for the detection of Chemically-induced chromosome damage in cultured mammalian cells
    • Venitt S., and Parry J.M. (Eds), IRL Press, Oxford
    • Dean B.J., and Danford N. Assays for the detection of Chemically-induced chromosome damage in cultured mammalian cells. In: Venitt S., and Parry J.M. (Eds). Mutagenicity Testing-a Practical Approach (1984), IRL Press, Oxford 187-232
    • (1984) Mutagenicity Testing-a Practical Approach , pp. 187-232
    • Dean, B.J.1    Danford, N.2
  • 14
    • 0031017437 scopus 로고    scopus 로고
    • In vitro micronucleus-centromere assay to detect radiation-damage induced by low doses in human lymphocytes
    • Vral A., Thierens H., and De Ridder L. In vitro micronucleus-centromere assay to detect radiation-damage induced by low doses in human lymphocytes. Int. J. Radiat. Biol. 71 1 (1997) 61-68
    • (1997) Int. J. Radiat. Biol. , vol.71 , Issue.1 , pp. 61-68
    • Vral, A.1    Thierens, H.2    De Ridder, L.3
  • 15
    • 0036001288 scopus 로고    scopus 로고
    • Assessment of genotoxic effects related to chronic low level exposure to ionizing radiation using biomarkers for DNA damage and repair
    • Touil N., Aka P.V., Buchet J.P., Thierens H., and Kirsch-Volders M. Assessment of genotoxic effects related to chronic low level exposure to ionizing radiation using biomarkers for DNA damage and repair. Mutagenesis 17 3 (2002) 223-232
    • (2002) Mutagenesis , vol.17 , Issue.3 , pp. 223-232
    • Touil, N.1    Aka, P.V.2    Buchet, J.P.3    Thierens, H.4    Kirsch-Volders, M.5
  • 16
    • 0032439244 scopus 로고    scopus 로고
    • Chromosomal damage rate, aging, and diet
    • Fenech M. Chromosomal damage rate, aging, and diet. Ann. N. Y. Acad. Sci. 854 (1998) 23-36
    • (1998) Ann. N. Y. Acad. Sci. , vol.854 , pp. 23-36
    • Fenech, M.1
  • 17
    • 1842766408 scopus 로고    scopus 로고
    • Cytogenetic biomarkers and genetic polymorphisms
    • Norppa H. Cytogenetic biomarkers and genetic polymorphisms. Toxicol. Lett. 149 (2004) 309-334
    • (2004) Toxicol. Lett. , vol.149 , pp. 309-334
    • Norppa, H.1
  • 19
    • 0002876016 scopus 로고    scopus 로고
    • Cytogenetic biomarkers in occupational exposure to dii socyanates: influence of genetic polymorphisms of metabolic enzymes
    • Norppa H., Bemardini S., Wikman H., Järventaus H., Rosenberg C., Bolognesi C., and Hirvonen A. Cytogenetic biomarkers in occupational exposure to dii socyanates: influence of genetic polymorphisms of metabolic enzymes. Environ. Mol. Mutag. 35 Suppl. 31 (2000) 45
    • (2000) Environ. Mol. Mutag. , vol.35 , Issue.SUPPL. 31 , pp. 45
    • Norppa, H.1    Bemardini, S.2    Wikman, H.3    Järventaus, H.4    Rosenberg, C.5    Bolognesi, C.6    Hirvonen, A.7
  • 21
    • 4344654838 scopus 로고    scopus 로고
    • Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations
    • Tuimala J., Szekely G., Wikman H., Jarventaus H., Hirvonen A., Gundy S., and Norppa H. Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations. Mutat. Res. 554 (2004) 319-333
    • (2004) Mutat. Res. , vol.554 , pp. 319-333
    • Tuimala, J.1    Szekely, G.2    Wikman, H.3    Jarventaus, H.4    Hirvonen, A.5    Gundy, S.6    Norppa, H.7
  • 22
    • 0032426246 scopus 로고    scopus 로고
    • Individual sensitivity to cytogenetic effects of 1,2:3,4-diepoxybutane in cultured human lymphocytes: influence of glutathione S-transferase M1, P1 and T1 genotypes
    • Landi S., Norppa H., Frenzilli G., Cipollini G., Ponzanelli I., Barale R., and Hirvonen A. Individual sensitivity to cytogenetic effects of 1,2:3,4-diepoxybutane in cultured human lymphocytes: influence of glutathione S-transferase M1, P1 and T1 genotypes. Pharmacogenetics 8 (1998) 461-471
    • (1998) Pharmacogenetics , vol.8 , pp. 461-471
    • Landi, S.1    Norppa, H.2    Frenzilli, G.3    Cipollini, G.4    Ponzanelli, I.5    Barale, R.6    Hirvonen, A.7
  • 28
    • 0034673259 scopus 로고    scopus 로고
    • Role of maternal exposures and newborn genotypes on newborn chromosome aberration frequencies
    • Pluth J.M., Ramsey M.J., and Tucker J.D. Role of maternal exposures and newborn genotypes on newborn chromosome aberration frequencies. Mutat. Res. 465 (2000) 101-111
    • (2000) Mutat. Res. , vol.465 , pp. 101-111
    • Pluth, J.M.1    Ramsey, M.J.2    Tucker, J.D.3
  • 29
    • 0034007880 scopus 로고    scopus 로고
    • Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes
    • Abdel-Rahman S.Z., Salama S.A., Au W.W., and Hamada F.A. Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes. Pharmacogenetics 10 (2000) 239-249
    • (2000) Pharmacogenetics , vol.10 , pp. 239-249
    • Abdel-Rahman, S.Z.1    Salama, S.A.2    Au, W.W.3    Hamada, F.A.4
  • 31
    • 3242772932 scopus 로고    scopus 로고
    • Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK
    • Affatato A.A., Wolfe K.J., Lopez M.S., Hallberg C., Ammenheuser M.M., and Abdel-Rahman S.Z. Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK. Environ. Mol. Mutagen. 44 (2004) 65-73
    • (2004) Environ. Mol. Mutagen. , vol.44 , pp. 65-73
    • Affatato, A.A.1    Wolfe, K.J.2    Lopez, M.S.3    Hallberg, C.4    Ammenheuser, M.M.5    Abdel-Rahman, S.Z.6
  • 32
    • 9644252940 scopus 로고    scopus 로고
    • Genotoxicity of tobacco smoke and tobacco smoke condensate: a review
    • DeMarini D.M. Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. Mutat. Res. 567 (2004) 447-474
    • (2004) Mutat. Res. , vol.567 , pp. 447-474
    • DeMarini, D.M.1
  • 33
    • 0023928522 scopus 로고
    • Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample
    • Bender M.A., Preston R.J., Leonard R.C., Pyatt B.E., Gooch P.C., and Shelby M.D. Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. Mutat. Res. 204 (1988) 421-433
    • (1988) Mutat. Res. , vol.204 , pp. 421-433
    • Bender, M.A.1    Preston, R.J.2    Leonard, R.C.3    Pyatt, B.E.4    Gooch, P.C.5    Shelby, M.D.6
  • 34
    • 0028784814 scopus 로고
    • Influence of smoking habits on the frequencies of structural and numerical chromosomal aberrations in human peripheral blood lymphocytes using the fluorescence in situ hybridization (FISH) technique
    • van Diemen P.C., Maasdam D., Vermeulen S., Darroudi F., and Natarajan A.T. Influence of smoking habits on the frequencies of structural and numerical chromosomal aberrations in human peripheral blood lymphocytes using the fluorescence in situ hybridization (FISH) technique. Mutagenesis 10 (1995) 487-495
    • (1995) Mutagenesis , vol.10 , pp. 487-495
    • van Diemen, P.C.1    Maasdam, D.2    Vermeulen, S.3    Darroudi, F.4    Natarajan, A.T.5
  • 35
    • 0025338913 scopus 로고
    • A Nordic data base on somatic chromosome damage in humans
    • Nordic Study Group on the Health Risk of Chromosome Damage
    • Nordic Study Group on the Health Risk of Chromosome Damage. A Nordic data base on somatic chromosome damage in humans. Mutat. Res. 241 (1990) 325-337
    • (1990) Mutat. Res. , vol.241 , pp. 325-337
  • 36
    • 0029166930 scopus 로고
    • The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting
    • Ramsey M.J., Moore II D.H., Briner J.F., Lee D.A., Olsen L., Senft J.R., and Tucker J.D. The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat. Res. 338 (1995) 95-106
    • (1995) Mutat. Res. , vol.338 , pp. 95-106
    • Ramsey, M.J.1    Moore II, D.H.2    Briner, J.F.3    Lee, D.A.4    Olsen, L.5    Senft, J.R.6    Tucker, J.D.7
  • 37
    • 0022452193 scopus 로고
    • Analysis of chromosome aberrations in lymphocytes of long-term heavy smokers
    • Littlefield L.G., and Joiner E.E. Analysis of chromosome aberrations in lymphocytes of long-term heavy smokers. Mutat. Res. 170 (1986) 145-150
    • (1986) Mutat. Res. , vol.170 , pp. 145-150
    • Littlefield, L.G.1    Joiner, E.E.2
  • 38
    • 0025265981 scopus 로고
    • Chromosome aberrations and urinary thioethers in smokers
    • Sinues B., Izquierdo M., and Perez Viguera J. Chromosome aberrations and urinary thioethers in smokers. Mutat. Res. 240 (1990) 289-293
    • (1990) Mutat. Res. , vol.240 , pp. 289-293
    • Sinues, B.1    Izquierdo, M.2    Perez Viguera, J.3
  • 39
    • 0035916431 scopus 로고    scopus 로고
    • Frequencies of chromosome aberrations in a control population determined by G banding
    • Tawn E.J., and Whitehouse C.A. Frequencies of chromosome aberrations in a control population determined by G banding. Mutat. Res. 490 (2001) 171-177
    • (2001) Mutat. Res. , vol.490 , pp. 171-177
    • Tawn, E.J.1    Whitehouse, C.A.2
  • 41
    • 9644269056 scopus 로고    scopus 로고
    • Genotoxicity of environmental tobacco smoke: a review
    • Husgafvel-Pursiainen K. Genotoxicity of environmental tobacco smoke: a review. Mutat. Res. 567 (2004) 427-445
    • (2004) Mutat. Res. , vol.567 , pp. 427-445
    • Husgafvel-Pursiainen, K.1
  • 42
    • 0024382578 scopus 로고
    • Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption
    • Chen A.T., Reidy J.A., Annest J.L., Welty T.K., and Zhou H.G. Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption. Environ. Mol. Mutagen. 13 (1989) 319-324
    • (1989) Environ. Mol. Mutagen. , vol.13 , pp. 319-324
    • Chen, A.T.1    Reidy, J.A.2    Annest, J.L.3    Welty, T.K.4    Zhou, H.G.5
  • 45
    • 0023475508 scopus 로고
    • Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers
    • Kao-Shan C.S., Fine R.L., Whang-Peng J., Lee E.C., and Chabner B.A. Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers. Cancer Res. 47 (1987) 6278-6282
    • (1987) Cancer Res. , vol.47 , pp. 6278-6282
    • Kao-Shan, C.S.1    Fine, R.L.2    Whang-Peng, J.3    Lee, E.C.4    Chabner, B.A.5
  • 47
    • 0036129318 scopus 로고    scopus 로고
    • Biomarkers in molecular epidemiology studies for health risk prediction
    • Bonassi S., and Au W.W. Biomarkers in molecular epidemiology studies for health risk prediction. Mutat. Res. 511 (2002) 73-86
    • (2002) Mutat. Res. , vol.511 , pp. 73-86
    • Bonassi, S.1    Au, W.W.2
  • 48
    • 0032530829 scopus 로고    scopus 로고
    • Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH)
    • Hagmar L., Bonassi S., Strömberg U., Brøgger A., Knudsen L.S., Norppa H., and Reuterwall C. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 58 (1998) 4117-4121
    • (1998) Cancer Res. , vol.58 , pp. 4117-4121
    • Hagmar, L.1    Bonassi, S.2    Strömberg, U.3    Brøgger, A.4    Knudsen, L.S.5    Norppa, H.6    Reuterwall, C.7
  • 52
    • 0033118454 scopus 로고    scopus 로고
    • Increased chromosome-type chromosome aberration frequencies as biomarkers of cancer risk in a blackfoot endemic area
    • Liou S.H., Lung J.C., Chen Y.H., Yang T., Hsieh L.L., Chen C.J., and Wu T.N. Increased chromosome-type chromosome aberration frequencies as biomarkers of cancer risk in a blackfoot endemic area. Cancer Res. 59 (1999) 1481-1484
    • (1999) Cancer Res. , vol.59 , pp. 1481-1484
    • Liou, S.H.1    Lung, J.C.2    Chen, Y.H.3    Yang, T.4    Hsieh, L.L.5    Chen, C.J.6    Wu, T.N.7
  • 53
    • 0021987630 scopus 로고
    • Measurement of micronuclei in lymphocytes
    • Fenech M., and Morley A.A. Measurement of micronuclei in lymphocytes. Mutat. Res. 147 (1985) 29-36
    • (1985) Mutat. Res. , vol.147 , pp. 29-36
    • Fenech, M.1    Morley, A.A.2
  • 54
    • 24044508252 scopus 로고    scopus 로고
    • The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis
    • Fenech M. The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis. Mutagenesis 20 (2005) 255-269
    • (2005) Mutagenesis , vol.20 , pp. 255-269
    • Fenech, M.1
  • 55
    • 0037340936 scopus 로고    scopus 로고
    • Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay
    • Thomas P., Umegaki K., and Fenech M. Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay. Mutagenesis 18 (2003) 187-194
    • (2003) Mutagenesis , vol.18 , pp. 187-194
    • Thomas, P.1    Umegaki, K.2    Fenech, M.3
  • 56
    • 19844378446 scopus 로고    scopus 로고
    • Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability-results from a dietary intake and micronucleus index survey in South Australia
    • Fenech M., Baghurst P., Luderer W., Turner J., Record S., Ceppi M., and Bonassi S. Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability-results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 26 (2005) 991-999
    • (2005) Carcinogenesis , vol.26 , pp. 991-999
    • Fenech, M.1    Baghurst, P.2    Luderer, W.3    Turner, J.4    Record, S.5    Ceppi, M.6    Bonassi, S.7
  • 57
    • 0037112246 scopus 로고    scopus 로고
    • Chromosomal biomarkers of genomic instability relevant to cancer
    • Fenech M. Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov. Today 7 (2002) 1128-1137
    • (2002) Drug Discov. Today , vol.7 , pp. 1128-1137
    • Fenech, M.1
  • 58
    • 23744443826 scopus 로고    scopus 로고
    • Aneuploidy: a matter of bad connections
    • Cimini D., and Degrassi F. Aneuploidy: a matter of bad connections. Trends Cell Biol. 15 (2005) 442-451
    • (2005) Trends Cell Biol. , vol.15 , pp. 442-451
    • Cimini, D.1    Degrassi, F.2
  • 59
    • 4344663928 scopus 로고    scopus 로고
    • Micronuclei with multiple copies of the X chromosome: do chromosomes replicate in micronuclei?
    • Leach N.T., and Jackson-Cook C. Micronuclei with multiple copies of the X chromosome: do chromosomes replicate in micronuclei?. Mutat. Res. 554 (2004) 89-94
    • (2004) Mutat. Res. , vol.554 , pp. 89-94
    • Leach, N.T.1    Jackson-Cook, C.2
  • 60
    • 0031885745 scopus 로고    scopus 로고
    • Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay
    • Elhajouji A., Cunha M., and Kirsch-Volders M. Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay. Mutagenesis 13 (1998) 193-198
    • (1998) Mutagenesis , vol.13 , pp. 193-198
    • Elhajouji, A.1    Cunha, M.2    Kirsch-Volders, M.3
  • 61
    • 0035170551 scopus 로고    scopus 로고
    • Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes
    • Kirsch-Volders M., and Fenech M. Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis 16 (2001) 51-58
    • (2001) Mutagenesis , vol.16 , pp. 51-58
    • Kirsch-Volders, M.1    Fenech, M.2
  • 64
    • 0032785259 scopus 로고    scopus 로고
    • The Human MicroNucleus project-an international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans
    • Fenech M., Holland N., Chang W.P., Zeiger E., and Bonassi S. The Human MicroNucleus project-an international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutat. Res. 428 (1999) 271-283
    • (1999) Mutat. Res. , vol.428 , pp. 271-283
    • Fenech, M.1    Holland, N.2    Chang, W.P.3    Zeiger, E.4    Bonassi, S.5
  • 65
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech M. The in vitro micronucleus technique. Mutat. Res. 455 (2000) 81-95
    • (2000) Mutat. Res. , vol.455 , pp. 81-95
    • Fenech, M.1
  • 66
    • 0038393167 scopus 로고    scopus 로고
    • What do human micronuclei contain?
    • Norppa H., and Falck G.C. What do human micronuclei contain?. Mutagenesis 18 (2003) 221-233
    • (2003) Mutagenesis , vol.18 , pp. 221-233
    • Norppa, H.1    Falck, G.C.2
  • 67
    • 0346726185 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes
    • Kimura M., Umegaki K., Higuchi M., Thomas P., and Fenech M. Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J. Nutr. 134 (2004) 48-56
    • (2004) J. Nutr. , vol.134 , pp. 48-56
    • Kimura, M.1    Umegaki, K.2    Higuchi, M.3    Thomas, P.4    Fenech, M.5
  • 68
    • 0030805031 scopus 로고    scopus 로고
    • The in vitro micronucleus test: a multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction
    • Kirsch-Volders M., Elhajouji A., Cundari E., and Van Hummelen P. The in vitro micronucleus test: a multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction. Mutat. Res. 392 (1997) 19-30
    • (1997) Mutat. Res. , vol.392 , pp. 19-30
    • Kirsch-Volders, M.1    Elhajouji, A.2    Cundari, E.3    Van Hummelen, P.4
  • 70
    • 0027930347 scopus 로고
    • Sex is an important variable affecting spontaneous micronucleus frequency in cytokinesis-blocked lymphocytes
    • Fenech M., Neville S., and Rinaldi J. Sex is an important variable affecting spontaneous micronucleus frequency in cytokinesis-blocked lymphocytes. Mutat. Res. 313 (1994) 203-207
    • (1994) Mutat. Res. , vol.313 , pp. 203-207
    • Fenech, M.1    Neville, S.2    Rinaldi, J.3
  • 72
    • 0033362027 scopus 로고    scopus 로고
    • Accelerated telomere shortening in the human inactive X chromosome
    • Surralles J., Hande M.P., Marcos R., and Lansdorp P.M. Accelerated telomere shortening in the human inactive X chromosome. Am. J. Hum. Genet. 65 (1999) 1617-1622
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 1617-1622
    • Surralles, J.1    Hande, M.P.2    Marcos, R.3    Lansdorp, P.M.4
  • 73
    • 0028225730 scopus 로고
    • Sex chromosomes, micronuclei and aging in women
    • Hando J., Nath J., and Tucker J. Sex chromosomes, micronuclei and aging in women. Chromosoma 103 (1994) 186-192
    • (1994) Chromosoma , vol.103 , pp. 186-192
    • Hando, J.1    Nath, J.2    Tucker, J.3
  • 74
    • 0028982807 scopus 로고
    • Y chromosome aneuploidy, micronuclei, kinetochores and aging in men
    • Nath J., Tucker J., and Hando J. Y chromosome aneuploidy, micronuclei, kinetochores and aging in men. Chromosoma 103 (1995) 725-731
    • (1995) Chromosoma , vol.103 , pp. 725-731
    • Nath, J.1    Tucker, J.2    Hando, J.3
  • 76
    • 0031411471 scopus 로고    scopus 로고
    • X chromosome inactivation and micronuclei in normal and Turner individuals
    • Hando J.C., Tucker J.D., Davenport M., Tepperberg J., and Nath J. X chromosome inactivation and micronuclei in normal and Turner individuals. Hum. Genet. 5-6 (1997) 624-628
    • (1997) Hum. Genet. , vol.5-6 , pp. 624-628
    • Hando, J.C.1    Tucker, J.D.2    Davenport, M.3    Tepperberg, J.4    Nath, J.5
  • 77
    • 0029968510 scopus 로고    scopus 로고
    • Activation status of the X chromosome in human micronucleated lymphocytes
    • Tucker J., Nath J., and Hando J. Activation status of the X chromosome in human micronucleated lymphocytes. Hum. Genet. 97 (1996) 471-475
    • (1996) Hum. Genet. , vol.97 , pp. 471-475
    • Tucker, J.1    Nath, J.2    Hando, J.3
  • 81
    • 1642481251 scopus 로고    scopus 로고
    • Evidence of association of the CYP2E1 genetic polymorphism with micronuclei frequency in human peripheral blood
    • Ishikawa H., Yamamoto H., Tian Y., Kawano M., Yamauchi T., and Yokoyama K. Evidence of association of the CYP2E1 genetic polymorphism with micronuclei frequency in human peripheral blood. Mutat. Res. 546 (2004) 45-53
    • (2004) Mutat. Res. , vol.546 , pp. 45-53
    • Ishikawa, H.1    Yamamoto, H.2    Tian, Y.3    Kawano, M.4    Yamauchi, T.5    Yokoyama, K.6
  • 82
    • 0030016899 scopus 로고    scopus 로고
    • Cytogenetic monitoring of occupational exposure to pesticides: characterization of GSTM1, GSTT1, and NAT2 genotypes
    • Scarpato R., Migliore L., Hirvonen A., Falck G., and Norppa H. Cytogenetic monitoring of occupational exposure to pesticides: characterization of GSTM1, GSTT1, and NAT2 genotypes. Environ. Mol. Mutagen. 27 (1996) 263-269
    • (1996) Environ. Mol. Mutagen. , vol.27 , pp. 263-269
    • Scarpato, R.1    Migliore, L.2    Hirvonen, A.3    Falck, G.4    Norppa, H.5
  • 83
    • 5644268143 scopus 로고    scopus 로고
    • Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations?
    • Aka P., Mateuca R., Buchet J.P., Thierens H., and Kirsch-Volders M. Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations?. Mutat. Res. 556 (2004) 169-181
    • (2004) Mutat. Res. , vol.556 , pp. 169-181
    • Aka, P.1    Mateuca, R.2    Buchet, J.P.3    Thierens, H.4    Kirsch-Volders, M.5
  • 84
    • 14344250052 scopus 로고    scopus 로고
    • Influence of hOGG1, XRCC1 and XRCC3 genotypes on biomarkers of genotoxicity in workers exposed to cobalt or hard metal dusts
    • Mateuca R., Aka P.V., De Boeck M., Hauspie R., Kirsch-Volders M., and Lison D. Influence of hOGG1, XRCC1 and XRCC3 genotypes on biomarkers of genotoxicity in workers exposed to cobalt or hard metal dusts. Toxicol. Lett. 156 (2005) 277-288
    • (2005) Toxicol. Lett. , vol.156 , pp. 277-288
    • Mateuca, R.1    Aka, P.V.2    De Boeck, M.3    Hauspie, R.4    Kirsch-Volders, M.5    Lison, D.6
  • 85
    • 29144455476 scopus 로고    scopus 로고
    • Risk assessment of welders using analysis of eight metals by ICP-MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays; influence of XRCC1 and XRCC3 polymorphisms
    • Iarmarcovai G., Sari-Minodier I., Chaspoul F., Botta C., De Meo M., Orsiere T., Berge-Lefranc J.L., Gallice P., and Botta A. Risk assessment of welders using analysis of eight metals by ICP-MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays; influence of XRCC1 and XRCC3 polymorphisms. Mutagenesis 20 (2005) 425-432
    • (2005) Mutagenesis , vol.20 , pp. 425-432
    • Iarmarcovai, G.1    Sari-Minodier, I.2    Chaspoul, F.3    Botta, C.4    De Meo, M.5    Orsiere, T.6    Berge-Lefranc, J.L.7    Gallice, P.8    Botta, A.9
  • 87
    • 0034792891 scopus 로고    scopus 로고
    • The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro
    • Crott J.W., Mashiyama S.T., Ames B.N., and Fenech M. The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol. Biomarkers Prev. 10 (2001) 1089-1096
    • (2001) Cancer Epidemiol. Biomarkers Prev. , vol.10 , pp. 1089-1096
    • Crott, J.W.1    Mashiyama, S.T.2    Ames, B.N.3    Fenech, M.4
  • 90
    • 0031410993 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men
    • Fenech M.F., Dreosti I.E., and Rinaldi J.R. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 18 (1997) 1329-1336
    • (1997) Carcinogenesis , vol.18 , pp. 1329-1336
    • Fenech, M.F.1    Dreosti, I.E.2    Rinaldi, J.R.3
  • 91
    • 0031903189 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults
    • Fenech M., Aitken C., and Rinaldi J. Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 19 (1998) 1163-1171
    • (1998) Carcinogenesis , vol.19 , pp. 1163-1171
    • Fenech, M.1    Aitken, C.2    Rinaldi, J.3
  • 92
    • 0028895586 scopus 로고
    • A comparison of lymphocyte micronuclei and plasma micronutrients in vegetarians and non-vegetarians
    • Fenech M., and Rinaldi J. A comparison of lymphocyte micronuclei and plasma micronutrients in vegetarians and non-vegetarians. Carcinogenesis 16 (1995) 223-230
    • (1995) Carcinogenesis , vol.16 , pp. 223-230
    • Fenech, M.1    Rinaldi, J.2
  • 93
    • 0031426131 scopus 로고    scopus 로고
    • Vitamin-E supplements and their effect on Vitamin-E status in blood and genetic damage rate in peripheral blood lymphocytes
    • Fenech M., Dreosti I., and Aitken C. Vitamin-E supplements and their effect on Vitamin-E status in blood and genetic damage rate in peripheral blood lymphocytes. Carcinogenesis 18 (1997) 359-364
    • (1997) Carcinogenesis , vol.18 , pp. 359-364
    • Fenech, M.1    Dreosti, I.2    Aitken, C.3
  • 94
    • 0031819173 scopus 로고    scopus 로고
    • Influence of serum micronutrients on the incidence of kinetochore-positive or-negative micronuclei in human peripheral blood lymphocytes
    • Odagiri Y., and Uchida H. Influence of serum micronutrients on the incidence of kinetochore-positive or-negative micronuclei in human peripheral blood lymphocytes. Mutat. Res. 415 (1998) 35-45
    • (1998) Mutat. Res. , vol.415 , pp. 35-45
    • Odagiri, Y.1    Uchida, H.2
  • 95
    • 0031662942 scopus 로고    scopus 로고
    • Micronuclei in lymphocytes and exfoliated buccal cells of postmenopausal women with dietary changes in folate
    • Titenko-Holland N., Jacob R.A., Shang N., Balaraman A., and Smith M.T. Micronuclei in lymphocytes and exfoliated buccal cells of postmenopausal women with dietary changes in folate. Mutat. Res. 417 (1998) 101-114
    • (1998) Mutat. Res. , vol.417 , pp. 101-114
    • Titenko-Holland, N.1    Jacob, R.A.2    Shang, N.3    Balaraman, A.4    Smith, M.T.5
  • 96
    • 0037790638 scopus 로고    scopus 로고
    • Nutritional treatment of genome instability: a paradigm shift in disease prevention and in the setting of recommended dietary allowances
    • Fenech M. Nutritional treatment of genome instability: a paradigm shift in disease prevention and in the setting of recommended dietary allowances. Nutr. Res. Rev. 16 (2003) 109-122
    • (2003) Nutr. Res. Rev. , vol.16 , pp. 109-122
    • Fenech, M.1
  • 97
    • 0037339166 scopus 로고    scopus 로고
    • Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project
    • and the HUMN collaborative group
    • Bonassi S., Neri M., Lando C., Ceppi M., Lin Y.-P., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Fenech M., and and the HUMN collaborative group. Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutat. Res. 543 (2003) 155-166
    • (2003) Mutat. Res. , vol.543 , pp. 155-166
    • Bonassi, S.1    Neri, M.2    Lando, C.3    Ceppi, M.4    Lin, Y.-P.5    Chang, W.P.6    Holland, N.7    Kirsch-Volders, M.8    Zeiger, E.9    Fenech, M.10
  • 98
    • 0030789581 scopus 로고    scopus 로고
    • Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience
    • Miller B., Albertini S., Locher F., Thybaud V., and Lorge E. Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience. Mutat. Res. 392 (1997) 187-208
    • (1997) Mutat. Res. , vol.392 , pp. 187-208
    • Miller, B.1    Albertini, S.2    Locher, F.3    Thybaud, V.4    Lorge, E.5
  • 99
    • 0030876092 scopus 로고    scopus 로고
    • Detailed data on in vitro MNT and in vitro CA: industrial experience
    • Albertini S., Miller B., Chetelat A.A., and Locher F. Detailed data on in vitro MNT and in vitro CA: industrial experience. Mutat. Res. 392 (1997) 187-208
    • (1997) Mutat. Res. , vol.392 , pp. 187-208
    • Albertini, S.1    Miller, B.2    Chetelat, A.A.3    Locher, F.4
  • 100
    • 0032006320 scopus 로고    scopus 로고
    • Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM working group on the in vitro micronucleus test
    • Miller B., Pötter-Locher F., Seelbach A., Stopper H., Utesch D., and Madle S. Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM working group on the in vitro micronucleus test. Mutat. Res. 410 (1998) 81-116
    • (1998) Mutat. Res. , vol.410 , pp. 81-116
    • Miller, B.1    Pötter-Locher, F.2    Seelbach, A.3    Stopper, H.4    Utesch, D.5    Madle, S.6
  • 103
    • 1842407141 scopus 로고    scopus 로고
    • Comparison between micronucleated lymphocyte rates observed in healthy subjects and cancer patients
    • Duffaud F., Orsiere T., Villani P., Pelissier A.L., Volot F., Favre R., and Botta A. Comparison between micronucleated lymphocyte rates observed in healthy subjects and cancer patients. Mutagenesis 12 (1997) 227-231
    • (1997) Mutagenesis , vol.12 , pp. 227-231
    • Duffaud, F.1    Orsiere, T.2    Villani, P.3    Pelissier, A.L.4    Volot, F.5    Favre, R.6    Botta, A.7
  • 104
    • 0023759080 scopus 로고
    • Micronucleus assay in human fibroblasts: a measure of spontaneous chromosomal instability and mutagen hypersensitivity
    • Rudd N.L., Hoar D.I., Greentree C.L., Dimnik L.S., and Hennig U.G. Micronucleus assay in human fibroblasts: a measure of spontaneous chromosomal instability and mutagen hypersensitivity. Environ. Mol. Mutagen. 12 (1988) 3-13
    • (1988) Environ. Mol. Mutagen. , vol.12 , pp. 3-13
    • Rudd, N.L.1    Hoar, D.I.2    Greentree, C.L.3    Dimnik, L.S.4    Hennig, U.G.5
  • 105
    • 0022364961 scopus 로고
    • Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells
    • Rosin M.P., and German J. Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells. Hum. Genet. 71 (1985) 187-191
    • (1985) Hum. Genet. , vol.71 , pp. 187-191
    • Rosin, M.P.1    German, J.2
  • 108
  • 109
    • 25844490588 scopus 로고    scopus 로고
    • The new cytogenetics: blurring the boundaries with molecular biology
    • Speicher M.R., and Carter N.P. The new cytogenetics: blurring the boundaries with molecular biology. Nat. Rev. Genet. 6 10 (2005) 782-792
    • (2005) Nat. Rev. Genet. , vol.6 , Issue.10 , pp. 782-792
    • Speicher, M.R.1    Carter, N.P.2
  • 111
    • 0030408338 scopus 로고    scopus 로고
    • The coloring of cytogenetics
    • Speicher M.R., and Ward D.C. The coloring of cytogenetics. Nat. Med. 2 9 (1996) 1046-1048
    • (1996) Nat. Med. , vol.2 , Issue.9 , pp. 1046-1048
    • Speicher, M.R.1    Ward, D.C.2
  • 112
    • 1542579958 scopus 로고    scopus 로고
    • CABAND: classification of aberrations in multicolor banded chromosomes
    • Horstmann M., and Obe G. CABAND: classification of aberrations in multicolor banded chromosomes. Cytogenet. Genome Res. 103 1-2 (2003) 24-27
    • (2003) Cytogenet. Genome Res. , vol.103 , Issue.1-2 , pp. 24-27
    • Horstmann, M.1    Obe, G.2
  • 113
    • 2642564378 scopus 로고    scopus 로고
    • mBAND: a high resolution multicolor banding technique for the detection of complex intrachromosomal aberrations
    • Chudoba I., Hickmann G., Friedrich T., Jauch A., Kozlowski P., and Senger G. mBAND: a high resolution multicolor banding technique for the detection of complex intrachromosomal aberrations. Cytogenet. Genome Res. 104 1-4 (2004) 390-393
    • (2004) Cytogenet. Genome Res. , vol.104 , Issue.1-4 , pp. 390-393
    • Chudoba, I.1    Hickmann, G.2    Friedrich, T.3    Jauch, A.4    Kozlowski, P.5    Senger, G.6
  • 114
    • 0028802056 scopus 로고
    • Automated metaphase finding: an assessment of the efficiency of the METAFER2 system in a routine mutagenicity assay
    • Huber R., Kulka U., Lorch T., Braselmann H., and Bauchinger M. Automated metaphase finding: an assessment of the efficiency of the METAFER2 system in a routine mutagenicity assay. Mutat. Res. 334 (1995) 97-102
    • (1995) Mutat. Res. , vol.334 , pp. 97-102
    • Huber, R.1    Kulka, U.2    Lorch, T.3    Braselmann, H.4    Bauchinger, M.5
  • 116
    • 0037416769 scopus 로고    scopus 로고
    • The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay
    • Abrahamsson-Zetterberg L. The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay. Mutat. Res. 535 2 (2003) 215-222
    • (2003) Mutat. Res. , vol.535 , Issue.2 , pp. 215-222
    • Abrahamsson-Zetterberg, L.1
  • 117
    • 0027949609 scopus 로고
    • Scoring of radiation-induced micronuclei in cytokinesisblocked human lymphocytes by automated image analysis
    • Verhaegen F., Vral A., Seuntjens J., Schipper N.W., de Ridder L., and Thierens H. Scoring of radiation-induced micronuclei in cytokinesisblocked human lymphocytes by automated image analysis. Cytometry 17 (1994) 119-127
    • (1994) Cytometry , vol.17 , pp. 119-127
    • Verhaegen, F.1    Vral, A.2    Seuntjens, J.3    Schipper, N.W.4    de Ridder, L.5    Thierens, H.6
  • 118
    • 2642528557 scopus 로고    scopus 로고
    • New developments in automated cytogenetic imaging: unattended scoring of dicentric chromosomes, micronuclei, single cell gel electrophoresis, and fluorescence signals
    • Schunck C., Johannes T., Varga D., Lorch T., and Plesch A. New developments in automated cytogenetic imaging: unattended scoring of dicentric chromosomes, micronuclei, single cell gel electrophoresis, and fluorescence signals. Cytogenet. Genome Res. 104 (2004) 383-389
    • (2004) Cytogenet. Genome Res. , vol.104 , pp. 383-389
    • Schunck, C.1    Johannes, T.2    Varga, D.3    Lorch, T.4    Plesch, A.5
  • 120
    • 0027171487 scopus 로고
    • Automated detection of cytochalasin-B blocked binucleated lymphocytes for scoring micronuclei
    • Castelain P., Van Hummelen P., Deleener A., and Kirsch-Volders M. Automated detection of cytochalasin-B blocked binucleated lymphocytes for scoring micronuclei. Mutagenesis 8 4 (1993) 285-293
    • (1993) Mutagenesis , vol.8 , Issue.4 , pp. 285-293
    • Castelain, P.1    Van Hummelen, P.2    Deleener, A.3    Kirsch-Volders, M.4
  • 121
    • 0029067552 scopus 로고
    • DNA content of micronuclei measured by image analysis in human lymphocytes can be used to identify aneugens if the cell cycle stage is taken into account
    • Van Hummelen P., Nusse N., Castelain P., and Kirsch-Volders M. DNA content of micronuclei measured by image analysis in human lymphocytes can be used to identify aneugens if the cell cycle stage is taken into account. Environ. Mol. Mutagen. 25 (1995) 269-278
    • (1995) Environ. Mol. Mutagen. , vol.25 , pp. 269-278
    • Van Hummelen, P.1    Nusse, N.2    Castelain, P.3    Kirsch-Volders, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.