In vitro micronucleus scoring by flow cytometry: Differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

Environmental and Molecular Mutagenesis

Volumn 47, Issue 1, 2006, Pages 56-66

  Avlasevich, Svetlana L ^a   Bryce, Steven M ^a   Cairns, Siân E ^a   Dertinger, Stephen D ^a  

^a LITRON LABORATORIES   (United States)

Author keywords

Ethidium monoazide; Flow cytometry; Genotoxicity testing; High throughput; Micronuclei

Indexed keywords

BENZO[A]PYRENE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DYE; ETHIDIUM; ETHIDIUM AZIDE; ETOPOSIDE; HYDROXYUREA; MESYLIC ACID METHYL ESTER; RIBONUCLEASE; SUCROSE; TRIBUTYLTIN; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LABELING; CELL MEMBRANE; CHROMATIN; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SAFETY; FLOW CYTOMETRY; GENOTOXICITY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MICRONUCLEUS; MOUSE; NONHUMAN; RELIABILITY; SCORING SYSTEM; TOXICITY TESTING;

ANIMALS; APOPTOSIS; AZIDES; BIOLOGICAL ASSAY; CELL CYCLE; CELL LINE, TUMOR; CHROMATIN; FLOW CYTOMETRY; FLUORESCENT DYES; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MICROSCOPY, FLUORESCENCE; MUTAGENS; NECROSIS; ORGANIC CHEMICALS; REPRODUCIBILITY OF RESULTS;

ANIMALIA;

EID: 32544457702     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.20170     Document Type: Article

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