Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition

British Journal of Cancer

Volumn 87, Issue 12, 2002, Pages 1379-1385

  Baeyens, A ^a   Thierens, H ^a   Claes, K ^a   Poppe, B ^a   Messiaen, L ^a   De Ridder, L ^a   Vral, Anne ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Breast cancer; Chromosomal radiosensitivity; G2 assay; Genetic predisposition; Micronucleus (MN) assay; Peripheral blood lymphocytes

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; CELL ASSAY; CELL CULTURE; CHROMATID; CHROMOSOME; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENETIC PREDISPOSITION; HUMAN; HUMAN TISSUE; INCUBATION TIME; IRRADIATION; LYMPHOCYTE; MAJOR CLINICAL STUDY; METAPHASE; MICRONUCLEUS; MICRONUCLEUS TEST; POPULATION; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY;

ADULT; AGED; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CHROMOSOME ABERRATIONS; FEMALE; G0 PHASE; G2 PHASE; GAMMA RAYS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LYMPHOCYTES; MICRONUCLEUS TESTS; MIDDLE AGED; MUTATION; RADIATION TOLERANCE; X-RAYS;

EID: 0037011657     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600628     Document Type: Article

References (37)

1. Abbott DW, Freeman ML, Holt JT (1998) Double-Strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J Natl Cancer Inst 90: 978-985
2. Baria K, Warren C, Roberts SA, West CM, Scott D (2001a) Chromosomal radiosensitivity as a marker of predisposition to common cancers? Br J Cancer 84: 892-896
3. Baria K, Warren C, Roberts SA, West CM, Evans DGR, Varley JM, Scott D (2001b) Letters to the Editor, Correspondence re: A. Rothfuss et al, Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. (Cancer Res 60: 390-394). Cancer Res 61: 5948-5949
4. Boei JJWA, Vermeulen S, Natarajan AT (2000) Technical report. Analysis of radiation-induced chromosomal aberrations using telomeric and centromeric PNA probes. Int J Radiat Biol 76: 163-167
5. Bryant PE (1998) The signal model: A possible explanation for the conversion of DNA double-strand breaks into chromatid breaks. Int J Radiat Biol 73: 243-251
6. Burrill W, Barber JBP, Roberts SA, Bulman B, Scott D (2000) Heritability of chromosomal radiosensitivity in breast cancer patients: A pilot study with the lymphocyte micronucleus assay. Int J Radiat Biol 76: 1617-1619
7. Chen JJ, Silver D, Cantor S, Livingston DM, Scully R (1999) BRCA1, BRCA2, and RAD 51 operate in a common DNA damage response pathway. Cancer Res 59: 1752-1756
8. Claes K, Machackova E, De Vos M, Poppe B, De Paepe A, Messiaen L (1999a) Mutation analysis of the BRCA1 and BRCA2 genes in the belgian patient population and identification of a belgian founder mutation BRCA1 IVS5+3A>G. Disease Markers 15: 69-73
9. Claes K, Machackova E, De Vos M, Mortier G, De Paepe A, Messiaen L (1999b) Mutation analysis of the BRCA1 and BRCA2 genes results in the identification of novel and recurrent mutations in 6/16 flemish families with breast and/or ovarian cancer but not in 12 sporadic patients with early-onset disease. Mutation in brief no. 224.Online. Hum Mutat 13: 256
10. Fenech M (1993) The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations. Murat Res 285: 35-44
11. Fomina J, Darroudi F, Boei JJWA, Natarajan AT (2000) Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe. Int J Radiat Biol 76: 807-813
12. Gentile M, Olsen K, Dufmats M, Wingren S (1999) Frequent allelic losses at 11q24.1-q25 in young women with breast cancer: Association with poor survival. Br J Cancer 80: 843-849
13. Jeggo PA (1998) Identification of genes involved in the repair of DNA double-strand breaks in mammalian cells. Radiat Res 150 (Suppl): S80-S91
14. Jones LA, Scott D, Cowan R, Roberts SA (1995) Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: Chromosome aberrations after low dose-rate irradiation. Int J Radiat Biol 67: 519-528
15. Kanaar R, Hoeijmakers JHJ, Van Gent DC (1998) Molecular mechanisms of DNA double-strand break repair. Cell Biol 8: 483-489
16. Knight RD, Parshad R, Price FM, Tarone RE, Sanford KK (1993) X-ray induced chromatid damage in relation to DNA repair and cancer incidence in family members. Int J Cancer 54: 589-593
17. Parkin DM, Läära E, Muir CS (1988) Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer 41: 184-197
18. Parshad R, Price FM, Bohr VA, Cowans KH, Zujewski JA, Sanford KK (1996) Deficient DNA repair capacity, a predisposing factor in breast cancer. Br J Cancer 74: 1-5
19. Patel RK, Trivedi AH, Arora DC, Bhatavdekar JM, Patel DD (1997) DNA repair proficiency in breast cancer patients and their first-degree relatives. Int J Cancer 73: 20-24
20. Peto J, Collins N, Barfoot R, Seal S, Warren W, Rahman N, Easton DF, Evans C, Deacon J, Stratton MR (1999) Prevalence of BRCA1 and BRCA2 Gene Mutations in patients with early-Onset breast cancer. J Natl Cancer Inst 91: 943-949
21. Peto J, Houlston RS (2001) Genetics and the common cancers. Eur J Cancer 37: S88-S96
22. Riches AC, Bryant PE, Steel CM, Gleig A, Robertson AJ, Preece PE, Thompson AM (2001) Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics. Br J Cancer 85: 1157-1161
23. Roberts SA, Spreadborough AR, Bulman B, Barber JBP, Evans DGR, Scott D (1999) Heritability of cellular radiosensitivity: A marker of Low-Penetrance Predisposition genes in breast cancer? Am J Hum Genet 65: 784-794
24. Rothfuß A, Schutz P, Bochum S, Volm T, Eberhardt E, Kreienberg R, Vogel W, Speit G (2000) Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res 60: 390-394
25. Rothkamm K, Kühne M, Jeggo PA, Löbrich M (2001) Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res 61: 3886-3893
26. Sanford KK, Parshad R, Gantt R, Tarone RE, Jones GM, Price FM (1989) Factors affecting and significance of G2 chromatin radiosensitivity in predisposition to cancer. Int J Radiat Biol 55: 963-981
27. Scott D, Spreadborough A, Levine EL, Roberts SA (1994) Genetic predisposition in breast cancer. Lancet 344: 1444
28. Scott D, Barber JBP, Levine EL, Burrill W, Roberts SA (1998) Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: A test for predisposition? Br J Cancer 77: 614-620
29. Scott D, Barber JBP, Spreadborough AR, Burrill W, Roberts SA (1999) Increased chromosomal radiosensitivity in breast cancer patients: A comparison of two assays. Int J Radiat Biol 75: 1-10
30. Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A, Takeda S (1998) Homologous recombination and nonhomologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 17: 5497-5508
31. Teare MD, Wallace SA, Harris M, Howell A, Birch JM (1994) Cancer experience in the relatives of an unselected series of breast cancer patients. Br J Cancer 70: 102-111
32. Terzoudi GI, Jung T, Hain J, Vrouvas J, Margaritis K, Donta-Bakoyiannis C, Makropoulos V, Angelakis PH, Pantelias GE (2000) Increased chromosomal radiosensitivity in cancer patients: The role of cdk1/cyclin-B activity level in the mechanisms involved. Int J Radiat Biol 76: 607-615
33. Thierens H, Vral A, Morthier R, Aousalah B, De Ridder L (2000) Cytogenetic monitoring of hospital workers occupationally exposed to ionising radiation using the micronucleus centromere assay. Mutagenesis 15: 245-249
34. Vral A, Verhaegen F, Thierens H, De Ridder L (1994) The in vitro cytokinesis-block micronucleus assay: A detailed description of an improved slide preparation technique for the automated detection of micronuclei in human lymphocytes. Mutagenesis 9: 439-443
35. Vral A, Thierens H, Baeyens A, De Ridder L (2002) How reliable are chromosomal aberration assays as biomarkers of individual sensitivity, towards ionising radiation? Radiat Res 157: 472-477
36. Wang H, Zeng ZC, Bui TA, Dibiase SJ, Qin W, Xia F, Powell SN, Iliakis G (2001) Nonhomologous endjoining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. Cancer Res 61: 270-277
37. Wu H, Durante M, George K, Goodwin EH, Yang TC (1996) Rejoining and misrejoining of radiation-induced chromatin breaks. II. Biophysical Model Radiat Res 145: 281-288