Flow cytometry peripheral blood micronucleus test in vivo: determination of potential thresholds for aneuploidy induced by spindle poisons

Environmental and Molecular Mutagenesis

Volumn 51, Issue 4, 2010, Pages 278-284

  Cammerer, Zoryana ^a,b   Schumacher, Martin M ^a   Kirsch Volders, Micheline ^b   Suter, Willi ^a   Elhajouji, Azeddine ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Aneugens; Flow cytometry; In vivo; Micronucleus test; MN RETs; Reticulocytes; Statistical modeling; Thresholds

Indexed keywords

ANEUGEN; COLCHICINE; CYCLOPHOSPHAMIDE; TUBULIN; VINBLASTINE; VINCRISTINE; MUTAGENIC AGENT;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME BREAKAGE; CHROMOSOME LOSS; CONTROLLED STUDY; DOSE RESPONSE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; IN VIVO STUDY; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; RAT; RETICULOCYTE; ANIMAL; CHEMICALLY INDUCED DISORDER; METHODOLOGY; MICRONUCLEUS;

MUS; RATTUS;

ANEUGENS; ANEUPLOIDY; ANIMALS; COLCHICINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; MALE; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENS; VINBLASTINE; VINCRISTINE;

EID: 77951641899     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20542     Document Type: Article

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