Accelerated telomere shortening the human inactive X chromosome

American Journal of Human Genetics

Volumn 65, Issue 6, 1999, Pages 1617-1622

  Surrallés, Jordi ^a   Hande, M Prakash ^b   Marcos, Ricard ^a   Lansdorp, Peter M ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANEUPLOIDY; ARTICLE; AUTOSOME; CENTROMERE; CHROMOSOME SEGREGATION; FEMALE; GENETIC STABILITY; HUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TELOMERE; X CHROMOSOME INACTIVATION;

EUKARYOTA;

EID: 0033362027     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302665     Document Type: Article

References (30)

1. Biessman H, Mason JM (1997) Telomere maintenance without telomerase. Chromosoma 106:63-69
2. Blasco MA, Lee H-W, Hande P, Samper E, Lansdorp P, De-Pinho R, Greider CW (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34
3. Colgin LM, Reddel RR (1999) Telomere maintenance mechanisms and cellular immortalization. Curr Opin Genet Dev 9:97-103
4. d'Adda di Fagagna F, Hande MP, Tong W-M, Lansdorp PM, Wang Z-Q, Jackson SP (1999) Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet 23:76-80
5. Dietzel S, Eils R, Sätzler K, Bornfleth H, Jauch A, Cremer C, Cremer T (1998) Evidence agaist a looped structure of the inactive human X-chromosome territory. Exp Cell Res 240: 187-196
6. Fitzgerald PH, McEwan CM (1977) Total aneuploidy and age-related sex chromosome aneuploidy in cultured lymphocytes of normal men and women. Hum Genet 39:329-337
7. Greider CW (1996) Telomere length regulation. Annu Rev Biochem 65:337-365
8. Greider CW, Blackburn EH (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43:405-413
9. Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, de Lange T (1999) Mammalian telomeres end in a large duplex loop. Cell 97:503-514
10. Hande MP, Samper E, Lansdorp P, Blasco MA (1999) Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol 144:589-601
11. Harley CB (1995) Telomeres and aging. In: Blackburn EH, Greider CW (eds) Telomeres, Cold Spring Harbor, NY: Cold Spring Harbor Press, pp 247-263
12. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC (1990) Telomere reduction in human colorectal carcinoma and with ageing. Nature 346:866-868
13. Heard E, Clerc P, Avner P (1997) X-chromosome inactivation in mammals. Annu Rev Genet 31:571-610
14. Jacobs PA, Brunton M, Court Brown WM, Doll R (1963) Change in human chromosome count with age: evidence for a sex difference. Nature 197:1080-1081
15. Jacobs PA, Court Brown WM, Doll R (1961) Distribution of human chromosome counts in relation to age. Nature 191: 1178-1180
16. Jeppesen P, Turner BM (1993) The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Cell 74:281-289
17. Kirk KE, Harmon BP, Reichardt IK, Sedat JW, Blackburn EH (1997) Block in anaphase chromosome separation caused by telomerase template mutation. Science 275:1478-1481
18. Lansdorp PM, Verwoerd NP, van de Rijke FM, Dragowska V, Little M-T, Dirks RW, Raap AK, et al ( 1996) Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 5:685-691
19. Lyon MF (1961) Gene action in the X chromosome of the mouse (Mus musculus). Nature 190:372-373
20. Martens UMM, Zijlmans MJP, Poon SSS, Dragowska W, Yui J, Chavez EA, Ward RK, et al (1998) Short telomeres on human chromosome 17p. Nat Genet 18:76-80
21. Rufer N, Brümmendorf TH, Kolvraa S, Bischoff C, Christensen K, Wadsworth L, Schulzer M, et al (1999) Telomere fluorescence measurements in granulocytes and T lymphocytes subsets points to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med 190: 157-167
22. Sandell LL, Zakian VA (1993) Loss of a yeast telomere: arrest, recovery, and chromosome loss. Cell 75:729-739
23. Slijepcevic P (1998) Telomere length regulation: a view from the individual chromosome perspective. Fxp Cell Res 244: 268-274
24. Slijepcevic P, Hande MP, Bouffler SD, Lansdorp PM (1997) Telomere length, chromatin structure and chromosome fusigenic potential. Chromosoma 106:413-421
25. Surrallés J, Jeppesen P, Morrison H, Natarajan AT (1996) Analysis of loss of inactive X chromosome in interphase cells. Am J Hum Genet 59:1091-1096
26. Surrallés J, Natarajan AT (1998a) Position effect of translocations involving the inactive X chromosome: physical linkage to XIC/XIST does not lead to de novo inactivation in human differentiated cells. Cytogenet Cell Genet 82:58-66
27. _ (1998b) Radiosensitivity and repair of the inactive X-chromosome: insights from FISH and immunocytogenetics. Mutat Res 414:117-124
28. Willard HF (1996) X-chromosome inactivation, XIST, and pursuit of the X-inactivation center. Cell 86:5-7
29. Willard HF, Latt SA (1976) Analysis of deoxyribonucleic acid replication in human X chromosomes by fluorescence microscopy. Am J Hum Genet 28:213-227
30. 3 repeats. Proc Natl Acad Sci USA 94:7423-7428