-
1
-
-
33748891391
-
Cancer stem cells
-
Jordan, C.T.; Guzman, M.L.; Noble, M. Cancer stem cells. N. Engl. J. Med. 2006, 355, 1253-1261.
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 1253-1261
-
-
Jordan, C.T.1
Guzman, M.L.2
Noble, M.3
-
2
-
-
67649939163
-
The increasing complexity of the cancer stem cell paradigm
-
Rosen, J.M.; Jordan, C.T. The increasing complexity of the cancer stem cell paradigm. Science 2009, 324, 1670-1673.
-
(2009)
Science
, vol.324
, pp. 1670-1673
-
-
Rosen, J.M.1
Jordan, C.T.2
-
3
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
Reya, T.; Clevers, H. Wnt signalling in stem cells and cancer. Nature 2005, 434, 843-850.
-
(2005)
Nature
, vol.434
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
4
-
-
0034648848
-
Wnt signalling molecules act in axis formation in the diploblastic metazoan Hydra
-
Hobmayer, B.; Rentzsch, F.; Kuhn, K.; Happel, C.M.; von Laue, C.C.; Snyder, P.; Rothbacher, U.; Holstein, T.W. Wnt signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature 2000, 407, 186-189.
-
(2000)
Nature
, vol.407
, pp. 186-189
-
-
Hobmayer, B.1
Rentzsch, F.2
Kuhn, K.3
Happel, C.M.4
von Laue, C.C.5
Snyder, P.6
Rothbacher, U.7
Holstein, T.W.8
-
5
-
-
21344460054
-
EphB receptor activity suppresses colorectal cancer progression
-
Batlle, E.; Bacani, J.; Begthel, H.; Jonkheer, S.; Gregorieff, A.; van de Born, M.; Malats, N.; Sancho, E.; Boon, E.; Pawson, T.; Gallinger, S.; Pals, S.; Clevers, H. EphB receptor activity suppresses colorectal cancer progression. Nature 2005, 435, 1126-1130.
-
(2005)
Nature
, vol.435
, pp. 1126-1130
-
-
Batlle, E.1
Bacani, J.2
Begthel, H.3
Jonkheer, S.4
Gregorieff, A.5
van de Born, M.6
Malats, N.7
Sancho, E.8
Boon, E.9
Pawson, T.10
Gallinger, S.11
Pals, S.12
Clevers, H.13
-
6
-
-
0034696336
-
Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
-
Li, Y.; Hively, W.P.; Varmus, H.E. Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene 2000, 19, 1002-1009.
-
(2000)
Oncogene
, vol.19
, pp. 1002-1009
-
-
Li, Y.1
Hively, W.P.2
Varmus, H.E.3
-
7
-
-
0020216124
-
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
-
Nusse, R.; Varmus, H.E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 1982, 31, 99-109.
-
(1982)
Cell
, vol.31
, pp. 99-109
-
-
Nusse, R.1
Varmus, H.E.2
-
8
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nusslein-Volhard, C.; Wieschaus, E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287, 795-801.
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
9
-
-
0023653232
-
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
-
Rijsewijk, F.; Schuermann, M.; Wagenaar, E.; Parren, P.; Weigel, D.; Nusse, R. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 1987, 50, 649-657.
-
(1987)
Cell
, vol.50
, pp. 649-657
-
-
Rijsewijk, F.1
Schuermann, M.2
Wagenaar, E.3
Parren, P.4
Weigel, D.5
Nusse, R.6
-
10
-
-
0023117211
-
Multiple functions of segment polarity genes in Drosophila
-
Perrimon, N.; Mahowald, A.P. Multiple functions of segment polarity genes in Drosophila. Dev. Biol. 1987, 119, 587-600.
-
(1987)
Dev. Biol
, vol.119
, pp. 587-600
-
-
Perrimon, N.1
Mahowald, A.P.2
-
11
-
-
0024435879
-
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis
-
McMahon, A.P.; Moon, R.T. Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell 1989, 58, 1075-1084.
-
(1989)
Cell
, vol.58
, pp. 1075-1084
-
-
McMahon, A.P.1
Moon, R.T.2
-
12
-
-
0026060707
-
A new nomenclature for int-1 and related genes: The Wnt gene family
-
Nusse, R.; Brown, A.; Papkoff, J.; Scambler, P.; Shackleford, G.; McMahon, A.; Moon, R.; Varmus, H. A new nomenclature for int-1 and related genes: The Wnt gene family. Cell 1991, 64, 231.
-
(1991)
Cell
, vol.64
, pp. 231
-
-
Nusse, R.1
Brown, A.2
Papkoff, J.3
Scambler, P.4
Shackleford, G.5
McMahon, A.6
Moon, R.7
Varmus, H.8
-
13
-
-
0029994517
-
A new member of the frizzled family from Drosophila functions as a Wingless receptor
-
Bhanot, P.; Brink, M.; Samos, C.H.; Hsieh, J.C.; Wang, Y.; Macke, J.P.; Andrew, D.; Nathans, J.; Nusse, R. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 1996, 382, 225-230.
-
(1996)
Nature
, vol.382
, pp. 225-230
-
-
Bhanot, P.1
Brink, M.2
Samos, C.H.3
Hsieh, J.C.4
Wang, Y.5
Macke, J.P.6
Andrew, D.7
Nathans, J.8
Nusse, R.9
-
14
-
-
0029814396
-
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein
-
Sawa, H.; Lobel, L.; Horvitz, H.R. The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Genes Dev. 1996, 10, 2189-2197.
-
(1996)
Genes Dev
, vol.10
, pp. 2189-2197
-
-
Sawa, H.1
Lobel, L.2
Horvitz, H.R.3
-
15
-
-
0030265570
-
A frizzled homolog functions in a vertebrate Wnt signaling pathway
-
Yang-Snyder, J.; Miller, J.R.; Brown, J.D.; Lai, C.J.; Moon, R.T. A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 1996, 6, 1302-1306.
-
(1996)
Curr. Biol
, vol.6
, pp. 1302-1306
-
-
Yang-Snyder, J.1
Miller, J.R.2
Brown, J.D.3
Lai, C.J.4
Moon, R.T.5
-
16
-
-
0035902074
-
The status of Wnt signalling regulates neural and epidermal fates in the chick embryo
-
Wilson, S.I.; Rydstrom, A.; Trimborn, T.; Willert, K.; Nusse, R.; Jessell, T.M.; Edlund, T. The status of Wnt signalling regulates neural and epidermal fates in the chick embryo. Nature 2001, 411, 325-330.
-
(2001)
Nature
, vol.411
, pp. 325-330
-
-
Wilson, S.I.1
Rydstrom, A.2
Trimborn, T.3
Willert, K.4
Nusse, R.5
Jessell, T.M.6
Edlund, T.7
-
17
-
-
0037737726
-
Wnt proteins are lipid-modified and can act as stem cell growth factors
-
Willert, K.; Brown, J.D.; Danenberg, E.; Duncan, A.W.; Weissman, I.L.; Reya, T.; Yates, J.R., 3rd; Nusse, R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003, 423, 448-452.
-
(2003)
Nature
, vol.423
, pp. 448-452
-
-
Willert, K.1
Brown, J.D.2
Danenberg, E.3
Duncan, A.W.4
Weissman, I.L.5
Reya, T.6
Yates, J.R.7
Nusse, R.8
-
18
-
-
33751318469
-
Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion
-
Takada, R.; Satomi, Y.; Kurata, T.; Ueno, N.; Norioka, S.; Kondoh, H.; Takao, T.; Takada, S. Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion. Dev. Cell 2006, 11, 791-801.
-
(2006)
Dev. Cell
, vol.11
, pp. 791-801
-
-
Takada, R.1
Satomi, Y.2
Kurata, T.3
Ueno, N.4
Norioka, S.5
Kondoh, H.6
Takao, T.7
Takada, S.8
-
19
-
-
0030450052
-
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
-
Kadowaki, T.; Wilder, E.; Klingensmith, J.; Zachary, K.; Perrimon, N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 1996, 10, 3116-3128.
-
(1996)
Genes Dev
, vol.10
, pp. 3116-3128
-
-
Kadowaki, T.1
Wilder, E.2
Klingensmith, J.3
Zachary, K.4
Perrimon, N.5
-
20
-
-
4043154959
-
Drosophila Wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine
-
Zhai, L.; Chaturvedi, D.; Cumberledge, S. Drosophila Wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine. J. Biol. Chem. 2004, 279, 33220-33227.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 33220-33227
-
-
Zhai, L.1
Chaturvedi, D.2
Cumberledge, S.3
-
21
-
-
0027368963
-
Mutations in the segment polarity genes Wingless and porcupine impair secretion of the Wingless protein
-
van den Heuvel, M.; Harryman-Samos, C.; Klingensmith, J.; Perrimon, N.; Nusse, R. Mutations in the segment polarity genes Wingless and porcupine impair secretion of the Wingless protein. EMBO J. 1993, 12, 5293-5302.
-
(1993)
EMBO J
, vol.12
, pp. 5293-5302
-
-
van den Heuvel, M.1
Harryman-Samos, C.2
Klingensmith, J.3
Perrimon, N.4
Nusse, R.5
-
22
-
-
33646134826
-
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
-
Banziger, C.; Soldini, D.; Schutt, C.; Zipperlen, P.; Hausmann, G.; Basler, K. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell 2006, 125, 509-522.
-
(2006)
Cell
, vol.125
, pp. 509-522
-
-
Banziger, C.1
Soldini, D.2
Schutt, C.3
Zipperlen, P.4
Hausmann, G.5
Basler, K.6
-
23
-
-
33646123992
-
Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
-
Bartscherer, K.; Pelte, N.; Ingelfinger, D.; Boutros, M. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 2006, 125, 523-533.
-
(2006)
Cell
, vol.125
, pp. 523-533
-
-
Bartscherer, K.1
Pelte, N.2
Ingelfinger, D.3
Boutros, M.4
-
24
-
-
33947521050
-
Helping Wingless take flight: How Wnt proteins are secreted
-
Hausmann, G.; Banziger, C.; Basler, K. Helping Wingless take flight: How Wnt proteins are secreted. Nat. Rev. Mol. Cell Biol. 2007, 8, 331-336.
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 331-336
-
-
Hausmann, G.1
Banziger, C.2
Basler, K.3
-
25
-
-
38849134055
-
Wingless secretion promotes and requires retromer-dependent cycling of Wntless
-
Port, F.; Kuster, M.; Herr, P.; Furger, E.; Banziger, C.; Hausmann, G.; Basler, K. Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat. Cell Biol. 2008, 10, 178-185.
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 178-185
-
-
Port, F.1
Kuster, M.2
Herr, P.3
Furger, E.4
Banziger, C.5
Hausmann, G.6
Basler, K.7
-
26
-
-
78650302964
-
Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells
-
Silhankova, M.; Port, F.; Harterink, M.; Basler, K.; Korswagen, H.C. Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. EMBO J. 2010, 29, 4094-4105.
-
(2010)
EMBO J
, vol.29
, pp. 4094-4105
-
-
Silhankova, M.1
Port, F.2
Harterink, M.3
Basler, K.4
Korswagen, H.C.5
-
27
-
-
0030746593
-
Genetic evidence that heparin-like glycosaminoglycans are involved in Wingless signaling
-
Binari, R.C.; Staveley, B.E.; Johnson, W.A.; Godavarti, R.; Sasisekharan, R.; Manoukian, A.S. Genetic evidence that heparin-like glycosaminoglycans are involved in Wingless signaling. Development 1997, 124, 2623-2632.
-
(1997)
Development
, vol.124
, pp. 2623-2632
-
-
Binari, R.C.1
Staveley, B.E.2
Johnson, W.A.3
Godavarti, R.4
Sasisekharan, R.5
Manoukian, A.S.6
-
28
-
-
0028060522
-
Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos
-
Itoh, K.; Sokol, S.Y. Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos. Development 1994, 120, 2703-2711.
-
(1994)
Development
, vol.120
, pp. 2703-2711
-
-
Itoh, K.1
Sokol, S.Y.2
-
29
-
-
0029844909
-
Glycosaminoglycans can modulate extracellular localization of the Wingless protein and promote signal transduction
-
Reichsman, F.; Smith, L.; Cumberledge, S. Glycosaminoglycans can modulate extracellular localization of the Wingless protein and promote signal transduction. J. Cell Biol. 1996, 135, 819-827.
-
(1996)
J. Cell Biol
, vol.135
, pp. 819-827
-
-
Reichsman, F.1
Smith, L.2
Cumberledge, S.3
-
30
-
-
59849102420
-
Mammalian Wnt3a is released on lipoprotein particles
-
Neumann, S.; Coudreuse, D.Y.; van der Westhuyzen, D.R.; Eckhardt, E.R.; Korswagen, H.C.; Schmitz, G.; Sprong, H. Mammalian Wnt3a is released on lipoprotein particles. Traffic 2009, 10, 334-343.
-
(2009)
Traffic
, vol.10
, pp. 334-343
-
-
Neumann, S.1
Coudreuse, D.Y.2
van der Westhuyzen, D.R.3
Eckhardt, E.R.4
Korswagen, H.C.5
Schmitz, G.6
Sprong, H.7
-
31
-
-
18344378499
-
Lipoprotein particles are required for Hedgehog and Wingless signalling
-
Panakova, D.; Sprong, H.; Marois, E.; Thiele, C.; Eaton, S. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 2005, 435, 58-65.
-
(2005)
Nature
, vol.435
, pp. 58-65
-
-
Panakova, D.1
Sprong, H.2
Marois, E.3
Thiele, C.4
Eaton, S.5
-
32
-
-
70349932747
-
Towards an integrated view of Wnt signaling in development
-
van Amerongen, R.; Nusse, R. Towards an integrated view of Wnt signaling in development. Development 2009, 136, 3205-3214.
-
(2009)
Development
, vol.136
, pp. 3205-3214
-
-
van Amerongen, R.1
Nusse, R.2
-
33
-
-
70949101564
-
Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo
-
Choi, H.Y.; Dieckmann, M.; Herz, J.; Niemeier, A. Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. PLoS One 2009, 4, e7930.
-
(2009)
PLoS One
, vol.4
-
-
Choi, H.Y.1
Dieckmann, M.2
Herz, J.3
Niemeier, A.4
-
34
-
-
41649116120
-
Non-conventional Frizzled ligands and Wnt receptors
-
Hendrickx, M.; Leyns, L. Non-conventional Frizzled ligands and Wnt receptors. Dev. Growth Differ. 2008, 50, 229-243.
-
(2008)
Dev. Growth Differ
, vol.50
, pp. 229-243
-
-
Hendrickx, M.1
Leyns, L.2
-
35
-
-
77952096764
-
Lrp4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome
-
Li, Y.; Pawlik, B.; Elcioglu, N.; Aglan, M.; Kayserili, H.; Yigit, G.; Percin, F.; Goodman, F.; Nurnberg, G.; Cenani, A.; Urquhart, J.; Chung, B.D.; Ismail, S.; Amr, K.; Aslanger, A.D.; Becker, C.; Netzer, C.; Scambler, P.; Eyaid, W.; Hamamy, H.; Clayton-Smith, J.; Hennekam, R.; Nurnberg, P.; Herz, J.; Temtamy, S.A.; Wollnik, B. Lrp4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. Am. J. Hum. Genet. 86, 696-706.
-
Am. J. Hum. Genet
, vol.86
, pp. 696-706
-
-
Li, Y.1
Pawlik, B.2
Elcioglu, N.3
Aglan, M.4
Kayserili, H.5
Yigit, G.6
Percin, F.7
Goodman, F.8
Nurnberg, G.9
Cenani, A.10
Urquhart, J.11
Chung, B.D.12
Ismail, S.13
Amr, K.14
Aslanger, A.D.15
Becker, C.16
Netzer, C.17
Scambler, P.18
Eyaid, W.19
Hamamy, H.20
Clayton-Smith, J.21
Hennekam, R.22
Nurnberg, P.23
Herz, J.24
Temtamy, S.A.25
Wollnik, B.26
more..
-
36
-
-
0037701521
-
LDL receptor relatives at the crossroad of endocytosis and signaling
-
Schneider, W.J.; Nimpf, J. LDL receptor relatives at the crossroad of endocytosis and signaling. Cell Mol. Life Sci. 2003, 60, 892-903.
-
(2003)
Cell Mol. Life Sci
, vol.60
, pp. 892-903
-
-
Schneider, W.J.1
Nimpf, J.2
-
37
-
-
77954685213
-
Regulation of Lrp6 phosphorylation
-
Niehrs, C.; Shen, J. Regulation of Lrp6 phosphorylation. Cell Mol. Life Sci. 2010, 67, 2551-2562.
-
(2010)
Cell Mol. Life Sci
, vol.67
, pp. 2551-2562
-
-
Niehrs, C.1
Shen, J.2
-
38
-
-
77951888466
-
Dishevelled: The hub of Wnt signaling
-
Gao, C.; Chen, Y.G. Dishevelled: The hub of Wnt signaling. Cell. Signal. 2010, 22, 717-727.
-
(2010)
Cell. Signal
, vol.22
, pp. 717-727
-
-
Gao, C.1
Chen, Y.G.2
-
39
-
-
77953814474
-
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity
-
Jernigan, K.K.; Cselenyi, C.S.; Thorne, C.A.; Hanson, A.J.; Tahinci, E.; Hajicek, N.; Oldham, W.M.; Lee, L.A.; Hamm, H.E.; Hepler, J.R.; Kozasa, T.; Linder, M.E.; Lee, E. Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Sci. Signal. 2010, 3, ra 37.
-
(2010)
Sci. Signal
, vol.3
, pp. 37
-
-
Jernigan, K.K.1
Cselenyi, C.S.2
Thorne, C.A.3
Hanson, A.J.4
Tahinci, E.5
Hajicek, N.6
Oldham, W.M.7
Lee, L.A.8
Hamm, H.E.9
Hepler, J.R.10
Kozasa, T.11
Linder, M.E.12
Lee, E.13
-
40
-
-
27844516613
-
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins
-
Liu, X.; Rubin, J.S.; Kimmel, A.R. Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr. Biol. 2005, 15, 1989-1997.
-
(2005)
Curr. Biol
, vol.15
, pp. 1989-1997
-
-
Liu, X.1
Rubin, J.S.2
Kimmel, A.R.3
-
41
-
-
33644635213
-
Beta-catenin, cancer, and G proteins: Not just for frizzleds anymore
-
Malbon, C.C. Beta-catenin, cancer, and G proteins: Not just for frizzleds anymore. Sci. STKE 2005, 2005, p e35.
-
(2005)
Sci. STKE
, vol.2005
-
-
Malbon, C.C.1
-
42
-
-
75649120756
-
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
-
Cruciat, C.M.; Ohkawara, B.; Acebron, S.P.; Karaulanov, E.; Reinhard, C.; Ingelfinger, D.; Boutros, M.; Niehrs, C. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 2010, 327, 459-463.
-
(2010)
Science
, vol.327
, pp. 459-463
-
-
Cruciat, C.M.1
Ohkawara, B.2
Acebron, S.P.3
Karaulanov, E.4
Reinhard, C.5
Ingelfinger, D.6
Boutros, M.7
Niehrs, C.8
-
43
-
-
33947242782
-
The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling
-
George, A.; Leahy, H.; Zhou, J.; Morin, P.J. The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling. Neurobiol. Dis. 2007, 26, 125-133.
-
(2007)
Neurobiol. Dis
, vol.26
, pp. 125-133
-
-
George, A.1
Leahy, H.2
Zhou, J.3
Morin, P.J.4
-
44
-
-
33746482870
-
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
-
Yamamoto, H.; Komekado, H.; Kikuchi, A. Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 2006, 11, 213-223.
-
(2006)
Dev. Cell
, vol.11
, pp. 213-223
-
-
Yamamoto, H.1
Komekado, H.2
Kikuchi, A.3
-
45
-
-
46049083566
-
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
-
Yamamoto, S.; Nishimura, O.; Misaki, K.; Nishita, M.; Minami, Y.; Yonemura, S.; Tarui, H.; Sasaki, H. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 2008, 15, 23-36.
-
(2008)
Dev. Cell
, vol.15
, pp. 23-36
-
-
Yamamoto, S.1
Nishimura, O.2
Misaki, K.3
Nishita, M.4
Minami, Y.5
Yonemura, S.6
Tarui, H.7
Sasaki, H.8
-
46
-
-
77956564468
-
Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning
-
Ahn, Y.; Sanderson, B.W.; Klein, O.D.; Krumlauf, R. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 2010, 137, 3221-3231.
-
(2010)
Development
, vol.137
, pp. 3221-3231
-
-
Ahn, Y.1
Sanderson, B.W.2
Klein, O.D.3
Krumlauf, R.4
-
47
-
-
80052604376
-
SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer
-
doi: 10.1007/s10549-010-1261-9
-
Clausen, K.A.; Blish, K.R.; Birse, C.E.; Triplette, M.A.; Kute, T.E.; Russell, G.B.; D'Agostino, R.B., Jr.; Miller, L.D.; Torti, F.M.; Torti, S.V. SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer. Breast Cancer Res. Treat. 2010, doi: 10.1007/s10549-010-1261-9.
-
(2010)
Breast Cancer Res. Treat
-
-
Clausen, K.A.1
Blish, K.R.2
Birse, C.E.3
Triplette, M.A.4
Kute, T.E.5
Russell, G.B.6
D'agostino Jr., R.B.7
Miller, L.D.8
Torti, F.M.9
Torti, S.V.10
-
48
-
-
33846449190
-
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
-
Ellies, D.L.; Viviano, B.; McCarthy, J.; Rey, J.P.; Itasaki, N.; Saunders, S.; Krumlauf, R. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J. Bone Miner Res. 2006, 21, 1738-1749.
-
(2006)
J. Bone Miner Res
, vol.21
, pp. 1738-1749
-
-
Ellies, D.L.1
Viviano, B.2
McCarthy, J.3
Rey, J.P.4
Itasaki, N.5
Saunders, S.6
Krumlauf, R.7
-
49
-
-
0038783316
-
Secreted antagonists of the Wnt signalling pathway
-
Kawano, Y.; Kypta, R. Secreted antagonists of the Wnt signalling pathway. J. Cell Sci. 2003, 116, 2627-2634.
-
(2003)
J. Cell Sci
, vol.116
, pp. 2627-2634
-
-
Kawano, Y.1
Kypta, R.2
-
50
-
-
21244480924
-
Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
-
Li, X.; Zhang, Y.; Kang, H.; Liu, W.; Liu, P.; Zhang, J.; Harris, S.E.; Wu, D. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J. Biol. Chem. 2005, 280, 19883-19887.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 19883-19887
-
-
Li, X.1
Zhang, Y.2
Kang, H.3
Liu, W.4
Liu, P.5
Zhang, J.6
Harris, S.E.7
Wu, D.8
-
51
-
-
79952107856
-
SOST and DKK: Antagonists of LRP family signaling as targets for treating bone disease
-
doi: 10.4061/2010/460120
-
Mason, J.J.; Williams, B.O. SOST and DKK: Antagonists of LRP family signaling as targets for treating bone disease. J. Osteoporos. 2010, doi: 10.4061/2010/460120.
-
(2010)
J. Osteoporos
-
-
Mason, J.J.1
Williams, B.O.2
-
52
-
-
33845359084
-
Function and biological roles of the Dickkopf family of Wnt modulators
-
Niehrs, C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006, 25, 7469-7481.
-
(2006)
Oncogene
, vol.25
, pp. 7469-7481
-
-
Niehrs, C.1
-
53
-
-
22844445934
-
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
-
Semenov, M.; Tamai, K.; He, X. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J. Biol. Chem. 2005, 280, 26770-26775.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 26770-26775
-
-
Semenov, M.1
Tamai, K.2
He, X.3
-
54
-
-
38949194936
-
Initiation of Wnt signaling: Control of Wnt coreceptor LRP6 phosphorylation/activation via frizzled, dishevelled and axin functions
-
Zeng, X.; Huang, H.; Tamai, K.; Zhang, X.; Harada, Y.; Yokota, C.; Almeida, K.; Wang, J.; Doble, B.; Woodgett, J.; Wynshaw-Boris, A.; Hsieh, J.C.; He, X. Initiation of Wnt signaling: Control of Wnt coreceptor LRP6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development 2008, 135, 367-375.
-
(2008)
Development
, vol.135
, pp. 367-375
-
-
Zeng, X.1
Huang, H.2
Tamai, K.3
Zhang, X.4
Harada, Y.5
Yokota, C.6
Almeida, K.7
Wang, J.8
Doble, B.9
Woodgett, J.10
Wynshaw-Boris, A.11
Hsieh, J.C.12
He, X.13
-
55
-
-
34250827150
-
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
-
Bilic, J.; Huang, Y.L.; Davidson, G.; Zimmermann, T.; Cruciat, C.M.; Bienz, M.; Niehrs, C. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 2007, 316, 1619-1622.
-
(2007)
Science
, vol.316
, pp. 1619-1622
-
-
Bilic, J.1
Huang, Y.L.2
Davidson, G.3
Zimmermann, T.4
Cruciat, C.M.5
Bienz, M.6
Niehrs, C.7
-
56
-
-
47049121052
-
Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6
-
MacDonald, B.T.; Yokota, C.; Tamai, K.; Zeng, X.; He, X. Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6. J. Biol. Chem. 2008, 283, 16115-16123.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 16115-16123
-
-
Macdonald, B.T.1
Yokota, C.2
Tamai, K.3
Zeng, X.4
He, X.5
-
57
-
-
0037155691
-
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
-
Liu, C.; Li, Y.; Semenov, M.; Han, C.; Baeg, G.H.; Tan, Y.; Zhang, Z.; Lin, X.; He, X. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002, 108, 837-847.
-
(2002)
Cell
, vol.108
, pp. 837-847
-
-
Liu, C.1
Li, Y.2
Semenov, M.3
Han, C.4
Baeg, G.H.5
Tan, Y.6
Zhang, Z.7
Lin, X.8
He, X.9
-
58
-
-
0030978351
-
Beta-catenin is a target for the ubiquitin-proteasome pathway
-
Aberle, H.; Bauer, A.; Stappert, J.; Kispert, A.; Kemler, R. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 1997, 16, 3797-3804.
-
(1997)
EMBO J
, vol.16
, pp. 3797-3804
-
-
Aberle, H.1
Bauer, A.2
Stappert, J.3
Kispert, A.4
Kemler, R.5
-
59
-
-
41949105179
-
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling
-
Wu, X.; Tu, X.; Joeng, K.S.; Hilton, M.J.; Williams, D.A.; Long, F. Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 2008, 133, 340-353.
-
(2008)
Cell
, vol.133
, pp. 340-353
-
-
Wu, X.1
Tu, X.2
Joeng, K.S.3
Hilton, M.J.4
Williams, D.A.5
Long, F.6
-
60
-
-
65549159598
-
A two-step model for colon adenoma initiation and progression caused by APC loss
-
Phelps, R.A.; Chidester, S.; Dehghanizadeh, S.; Phelps, J.; Sandoval, I.T.; Rai, K.; Broadbent, T.; Sarkar, S.; Burt, R.W.; Jones, D.A. A two-step model for colon adenoma initiation and progression caused by APC loss. Cell 2009, 137, 623-634.
-
(2009)
Cell
, vol.137
, pp. 623-634
-
-
Phelps, R.A.1
Chidester, S.2
Dehghanizadeh, S.3
Phelps, J.4
Sandoval, I.T.5
Rai, K.6
Broadbent, T.7
Sarkar, S.8
Burt, R.W.9
Jones, D.A.10
-
62
-
-
62849106337
-
Beta-catenin hits chromatin: Regulation of Wnt target gene activation
-
Mosimann, C.; Hausmann, G.; Basler, K. Beta-catenin hits chromatin: Regulation of Wnt target gene activation. Nat. Rev. Mol. Cell Biol. 2009, 10, 276-286.
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, pp. 276-286
-
-
Mosimann, C.1
Hausmann, G.2
Basler, K.3
-
63
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki, K.; Ouyang, H.; Zhu, T.; Lindvall, C.; Wang, Y.; Zhang, X.; Yang, Q.; Bennett, C.; Harada, Y.; Stankunas, K.; Wang, C.Y.; He, X.; MacDougald, O.A.; You, M.; Williams, B.O.; Guan, K.L. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006, 126, 955-968.
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
Wang, C.Y.11
He, X.12
Macdougald, O.A.13
You, M.14
Williams, B.O.15
Guan, K.L.16
-
64
-
-
69249206717
-
MTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
-
Castilho, R.M.; Squarize, C.H.; Chodosh, L.A.; Williams, B.O.; Gutkind, J.S. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009, 5, 279-289.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 279-289
-
-
Castilho, R.M.1
Squarize, C.H.2
Chodosh, L.A.3
Williams, B.O.4
Gutkind, J.S.5
-
65
-
-
78549289595
-
Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: Implications for human acinic cell carcinoma
-
Diegel, C.R.; Cho, K.R.; El-Naggar, A.K.; Williams, B.O.; Lindvall, C. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: Implications for human acinic cell carcinoma. Cancer Res. 2010, 70, 9143-9152.
-
(2010)
Cancer Res
, vol.70
, pp. 9143-9152
-
-
Diegel, C.R.1
Cho, K.R.2
El-Naggar, A.K.3
Williams, B.O.4
Lindvall, C.5
-
66
-
-
0041695485
-
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
-
Veeman, M.T.; Axelrod, J.D.; Moon, R.T. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev. Cell 2003, 5, 367-377.
-
(2003)
Dev. Cell
, vol.5
, pp. 367-377
-
-
Veeman, M.T.1
Axelrod, J.D.2
Moon, R.T.3
-
67
-
-
78349276165
-
Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
-
Grumolato, L.; Liu, G.; Mong, P.; Mudbhary, R.; Biswas, R.; Arroyave, R.; Vijayakumar, S.; Economides, A.N.; Aaronson, S.A. Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev. 2010, 24, 2517-2530.
-
(2010)
Genes Dev
, vol.24
, pp. 2517-2530
-
-
Grumolato, L.1
Liu, G.2
Mong, P.3
Mudbhary, R.4
Biswas, R.5
Arroyave, R.6
Vijayakumar, S.7
Economides, A.N.8
Aaronson, S.A.9
-
68
-
-
74749106487
-
RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer
-
Lee, J.M.; Kim, I.S.; Kim, H.; Lee, J.S.; Kim, K.; Yim, H.Y.; Jeong, J.; Kim, J.H.; Kim, J.Y.; Lee, H.; Seo, S.B.; Rosenfeld, M.G.; Kim, K.I.; Baek, S.H. RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. Mol. Cell 2010, 37, 183-195.
-
(2010)
Mol. Cell
, vol.37
, pp. 183-195
-
-
Lee, J.M.1
Kim, I.S.2
Kim, H.3
Lee, J.S.4
Kim, K.5
Yim, H.Y.6
Jeong, J.7
Kim, J.H.8
Kim, J.Y.9
Lee, H.10
Seo, S.B.11
Rosenfeld, M.G.12
Kim, K.I.13
Baek, S.H.14
-
69
-
-
55349114398
-
Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis
-
Lyu, J.; Yamamoto, V.; Lu, W. Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev. Cell 2008, 15, 773-780.
-
(2008)
Dev. Cell
, vol.15
, pp. 773-780
-
-
Lyu, J.1
Yamamoto, V.2
Lu, W.3
-
70
-
-
14944357138
-
Wnt, stem cells and cancer in the intestine
-
Pinto, D.; Clevers, H. Wnt, stem cells and cancer in the intestine. Biol. Cell 2005, 97, 185-196.
-
(2005)
Biol. Cell
, vol.97
, pp. 185-196
-
-
Pinto, D.1
Clevers, H.2
-
71
-
-
39749092525
-
Current view: Intestinal stem cells and signaling
-
Scoville, D.H.; Sato, T.; He, X.C.; Li, L. Current view: Intestinal stem cells and signaling. Gastroenterology 2008, 134, 849-864.
-
(2008)
Gastroenterology
, vol.134
, pp. 849-864
-
-
Scoville, D.H.1
Sato, T.2
He, X.C.3
Li, L.4
-
72
-
-
0017739418
-
Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation
-
Potten, C.S. Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation. Nature 1977, 269, 518-521.
-
(1977)
Nature
, vol.269
, pp. 518-521
-
-
Potten, C.S.1
-
73
-
-
84989436823
-
Continuous labelling studies on mouse skin and intestine
-
Potten, C.S.; Kovacs, L.; Hamilton, E. Continuous labelling studies on mouse skin and intestine. Cell Tissue Kinet. 1974, 7, 271-283.
-
(1974)
Cell Tissue Kinet
, vol.7
, pp. 271-283
-
-
Potten, C.S.1
Kovacs, L.2
Hamilton, E.3
-
74
-
-
0031848068
-
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
-
Korinek, V.; Barker, N.; Moerer, P.; van Donselaar, E.; Huls, G.; Peters, P.J.; Clevers, H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 1998, 19, 379-383.
-
(1998)
Nat. Genet
, vol.19
, pp. 379-383
-
-
Korinek, V.1
Barker, N.2
Moerer, P.3
van Donselaar, E.4
Huls, G.5
Peters, P.J.6
Clevers, H.7
-
75
-
-
35648969554
-
Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
-
Fevr, T.; Robine, S.; Louvard, D.; Huelsken, J. Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol. Cell Biol. 2007, 27, 7551-7559.
-
(2007)
Mol. Cell Biol
, vol.27
, pp. 7551-7559
-
-
Fevr, T.1
Robine, S.2
Louvard, D.3
Huelsken, J.4
-
76
-
-
0037829660
-
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
-
Pinto, D.; Gregorieff, A.; Begthel, H.; Clevers, H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 2003, 17, 1709-1713.
-
(2003)
Genes Dev
, vol.17
, pp. 1709-1713
-
-
Pinto, D.1
Gregorieff, A.2
Begthel, H.3
Clevers, H.4
-
77
-
-
0346458662
-
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
-
Kuhnert, F.; Davis, C.R.; Wang, H.T.; Chu, P.; Lee, M.; Yuan, J.; Nusse, R.; Kuo, C.J. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl. Acad. Sci. USA 2004, 101, 266-271.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 266-271
-
-
Kuhnert, F.1
Davis, C.R.2
Wang, H.T.3
Chu, P.4
Lee, M.5
Yuan, J.6
Nusse, R.7
Kuo, C.J.8
-
78
-
-
77956934167
-
The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation
-
Rezza, A.; Skah, S.; Roche, C.; Nadjar, J.; Samarut, J.; Plateroti, M. The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation. J. Cell Sci. 2010, 123, 3256-3265.
-
(2010)
J. Cell Sci
, vol.123
, pp. 3256-3265
-
-
Rezza, A.1
Skah, S.2
Roche, C.3
Nadjar, J.4
Samarut, J.5
Plateroti, M.6
-
79
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker, N.; van Es, J.H.; Kuipers, J.; Kujala, P.; van den Born, M.; Cozijnsen, M.; Haegebarth, A.; Korving, J.; Begthel, H.; Peters, P.J.; Clevers, H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449, 1003-1007.
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
van Es, J.H.2
Kuipers, J.3
Kujala, P.4
van den Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
80
-
-
79951577558
-
CD133(+)CD44 (+) subgroups may be human small intestinal stem cells
-
Hou, N.Y.; Yang, K.; Chen, T.; Chen, X.Z.; Zhang, B.; Mo, X.M.; Hu, J.K. CD133(+)CD44 (+) subgroups may be human small intestinal stem cells. Mol. Biol. Rep. 2010, 38, 997-1004.
-
(2010)
Mol. Biol. Rep
, vol.38
, pp. 997-1004
-
-
Hou, N.Y.1
Yang, K.2
Chen, T.3
Chen, X.Z.4
Zhang, B.5
Mo, X.M.6
Hu, J.K.7
-
81
-
-
77957223906
-
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
-
Snippert, H.J.; van der Flier, L.G.; Sato, T.; van Es, J.H.; van den Born, M.; Kroon-Veenboer, C.; Barker, N.; Klein, A.M.; van Rheenen, J.; Simons, B.D.; Clevers, H. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 2010, 143, 134-144.
-
(2010)
Cell
, vol.143
, pp. 134-144
-
-
Snippert, H.J.1
van der Flier, L.G.2
Sato, T.3
van Es, J.H.4
van den Born, M.5
Kroon-Veenboer, C.6
Barker, N.7
Klein, A.M.8
van Rheenen, J.9
Simons, B.D.10
Clevers, H.11
-
82
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
Sato, T.; Vries, R.G.; Snippert, H.J.; van de Wetering, M.; Barker, N.; Stange, D.E.; van Es, J.H.; Abo, A.; Kujala, P.; Peters, P.J.; Clevers, H. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 459, 262-265.
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
Vries, R.G.2
Snippert, H.J.3
van de Wetering, M.4
Barker, N.5
Stange, D.E.6
van Es, J.H.7
Abo, A.8
Kujala, P.9
Peters, P.J.10
Clevers, H.11
-
83
-
-
0036342469
-
Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma
-
Holcombe, R.F.; Marsh, J.L.; Waterman, M.L.; Lin, F.; Milovanovic, T.; Truong, T. Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma. Mol. Pathol. 2002, 55, 220-226.
-
(2002)
Mol. Pathol
, vol.55
, pp. 220-226
-
-
Holcombe, R.F.1
Marsh, J.L.2
Waterman, M.L.3
Lin, F.4
Milovanovic, T.5
Truong, T.6
-
84
-
-
0033780630
-
Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling
-
Liu, W.; Dong, X.; Mai, M.; Seelan, R.S.; Taniguchi, K.; Krishnadath, K.K.; Halling, K.C.; Cunningham, J.M.; Boardman, L.A.; Qian, C.; Christensen, E.; Schmidt, S.S.; Roche, P.C.; Smith, D.I.; Thibodeau, S.N. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Nat. Genet. 2000, 26, 146-147.
-
(2000)
Nat. Genet
, vol.26
, pp. 146-147
-
-
Liu, W.1
Dong, X.2
Mai, M.3
Seelan, R.S.4
Taniguchi, K.5
Krishnadath, K.K.6
Halling, K.C.7
Cunningham, J.M.8
Boardman, L.A.9
Qian, C.10
Christensen, E.11
Schmidt, S.S.12
Roche, P.C.13
Smith, D.I.14
Thibodeau, S.N.15
-
85
-
-
0033895709
-
Wnt signaling and cancer
-
Polakis, P. Wnt signaling and cancer. Genes Dev. 2000, 14, 1837-1851.
-
(2000)
Genes Dev
, vol.14
, pp. 1837-1851
-
-
Polakis, P.1
-
86
-
-
0025899162
-
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
-
Nishisho, I.; Nakamura, Y.; Miyoshi, Y.; Miki, Y.; Ando, H.; Horii, A.; Koyama, K.; Utsunomiya, J.; Baba, S.; Hedge, P. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991, 253, 665-669.
-
(1991)
Science
, vol.253
, pp. 665-669
-
-
Nishisho, I.1
Nakamura, Y.2
Miyoshi, Y.3
Miki, Y.4
Ando, H.5
Horii, A.6
Koyama, K.7
Utsunomiya, J.8
Baba, S.9
Hedge, P.10
-
87
-
-
0025015168
-
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
-
Moser, A.R.; Pitot, H.C.; Dove, W.F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990, 247, 322-324.
-
(1990)
Science
, vol.247
, pp. 322-324
-
-
Moser, A.R.1
Pitot, H.C.2
Dove, W.F.3
-
88
-
-
0033429181
-
Genetic testing and counseling for hereditary forms of colorectal cancer
-
Petersen, G.M.; Brensinger, J.D.; Johnson, K.A.; Giardiello, F.M. Genetic testing and counseling for hereditary forms of colorectal cancer. Cancer 1999, 86, 2540-2550.
-
(1999)
Cancer
, vol.86
, pp. 2540-2550
-
-
Petersen, G.M.1
Brensinger, J.D.2
Johnson, K.A.3
Giardiello, F.M.4
-
89
-
-
0032521433
-
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
-
Sparks, A.B.; Morin, P.J.; Vogelstein, B.; Kinzler, K.W. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res. 1998, 58, 1130-1134.
-
(1998)
Cancer Res
, vol.58
, pp. 1130-1134
-
-
Sparks, A.B.1
Morin, P.J.2
Vogelstein, B.3
Kinzler, K.W.4
-
90
-
-
0344826531
-
Colonic polyposis caused by mtor-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
-
Aoki, K.; Tamai, Y.; Horiike, S.; Oshima, M.; Taketo, M.M. Colonic polyposis caused by mtor-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat. Genet. 2003, 35, 323-330.
-
(2003)
Nat. Genet
, vol.35
, pp. 323-330
-
-
Aoki, K.1
Tamai, Y.2
Horiike, S.3
Oshima, M.4
Taketo, M.M.5
-
91
-
-
0028567875
-
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
-
Fodde, R.; Edelmann, W.; Yang, K.; van Leeuwen, C.; Carlson, C.; Renault, B.; Breukel, C.; Alt, E.; Lipkin, M.; Khan, P.M.; et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc. Natl. Acad. Sci. USA 1994, 91, 8969-8973.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8969-8973
-
-
Fodde, R.1
Edelmann, W.2
Yang, K.3
van Leeuwen, C.4
Carlson, C.5
Renault, B.6
Breukel, C.7
Alt, E.8
Lipkin, M.9
Khan, P.M.10
-
92
-
-
0029047954
-
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
-
Oshima, M.; Oshima, H.; Kitagawa, K.; Kobayashi, M.; Itakura, C.; Taketo, M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl. Acad. Sci. USA 1995, 92, 4482-4486.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4482-4486
-
-
Oshima, M.1
Oshima, H.2
Kitagawa, K.3
Kobayashi, M.4
Itakura, C.5
Taketo, M.6
-
93
-
-
0026562404
-
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
-
Su, L.K.; Kinzler, K.W.; Vogelstein, B.; Preisinger, A.C.; Moser, A.R.; Luongo, C.; Gould, K.A.; Dove, W.F. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992, 256, 668-670.
-
(1992)
Science
, vol.256
, pp. 668-670
-
-
Su, L.K.1
Kinzler, K.W.2
Vogelstein, B.3
Preisinger, A.C.4
Moser, A.R.5
Luongo, C.6
Gould, K.A.7
Dove, W.F.8
-
94
-
-
0026568524
-
The Min (multiple intestinal neoplasia) mutation: Its effect on gut epithelial cell differentiation and interaction with a modifier system
-
Moser, A.R.; Dove, W.F.; Roth, K.A.; Gordon, J.I. The Min (multiple intestinal neoplasia) mutation: Its effect on gut epithelial cell differentiation and interaction with a modifier system. J. Cell Biol. 1992, 116, 1517-1526.
-
(1992)
J. Cell Biol
, vol.116
, pp. 1517-1526
-
-
Moser, A.R.1
Dove, W.F.2
Roth, K.A.3
Gordon, J.I.4
-
95
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker, N.; Ridgway, R.A.; van Es, J.H.; van de Wetering, M.; Begthel, H.; van den Born, M.; Danenberg, E.; Clarke, A.R.; Sansom, O.J.; Clevers, H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009, 457, 608-611.
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
Ridgway, R.A.2
van Es, J.H.3
van de Wetering, M.4
Begthel, H.5
van den Born, M.6
Danenberg, E.7
Clarke, A.R.8
Sansom, O.J.9
Clevers, H.10
-
96
-
-
78649896525
-
Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5
-
Lewis, A.; Segditsas, S.; Deheragoda, M.; Pollard, P.; Jeffery, R.; Nye, E.; Lockstone, H.; Davis, H.; Stamp, G.; Poulsom, R.; Wright, N.; Tomlinson, I. Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5. Gut 2010, 59, 1680-1686.
-
(2010)
Gut
, vol.59
, pp. 1680-1686
-
-
Lewis, A.1
Segditsas, S.2
Deheragoda, M.3
Pollard, P.4
Jeffery, R.5
Nye, E.6
Lockstone, H.7
Davis, H.8
Stamp, G.9
Poulsom, R.10
Wright, N.11
Tomlinson, I.12
-
97
-
-
45549109525
-
Deletion of the Wnt target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis
-
Zeilstra, J.; Joosten, S.P.; Dokter, M.; Verwiel, E.; Spaargaren, M.; Pals, S.T. Deletion of the Wnt target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res. 2008, 68, 3655-3661.
-
(2008)
Cancer Res
, vol.68
, pp. 3655-3661
-
-
Zeilstra, J.1
Joosten, S.P.2
Dokter, M.3
Verwiel, E.4
Spaargaren, M.5
Pals, S.T.6
-
98
-
-
34547193404
-
Phenotypic characterization of human colorectal cancer stem cells
-
Dalerba, P.; Dylla, S.J.; Park, I.K.; Liu, R.; Wang, X.; Cho, R.W.; Hoey, T.; Gurney, A.; Huang, E.H.; Simeone, D.M.; Shelton, A.A.; Parmiani, G.; Castelli, C.; Clarke, M.F. Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. USA 2007, 104, 10158-10163.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10158-10163
-
-
Dalerba, P.1
Dylla, S.J.2
Park, I.K.3
Liu, R.4
Wang, X.5
Cho, R.W.6
Hoey, T.7
Gurney, A.8
Huang, E.H.9
Simeone, D.M.10
Shelton, A.A.11
Parmiani, G.12
Castelli, C.13
Clarke, M.F.14
-
99
-
-
0033119801
-
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
-
Tetsu, O.; McCormick, F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398, 422-426.
-
(1999)
Nature
, vol.398
, pp. 422-426
-
-
Tetsu, O.1
McCormick, F.2
-
100
-
-
18644373146
-
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
van de Wetering, M.; Sancho, E.; Verweij, C.; de Lau, W.; Oving, I.; Hurlstone, A.; van der Horn, K.; Batlle, E.; Coudreuse, D.; Haramis, A.P.; Tjon-Pon-Fong, M.; Moerer, P.; van den Born, M.; Soete, G.; Pals, S.; Eilers, M.; Medema, R.; Clevers, H. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002, 111, 241-250.
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
van de Wetering, M.1
Sancho, E.2
Verweij, C.3
de Lau, W.4
Oving, I.5
Hurlstone, A.6
van der Horn, K.7
Batlle, E.8
Coudreuse, D.9
Haramis, A.P.10
Tjon-Pon-Fong, M.11
Moerer, P.12
van den Born, M.13
Soete, G.14
Pals, S.15
Eilers, M.16
Medema, R.17
Clevers, H.18
-
101
-
-
12144291274
-
Epigenetic inactivation of SFRP genes allows constitutive Wnt signaling in colorectal cancer
-
Suzuki, H.; Watkins, D.N.; Jair, K.W.; Schuebel, K.E.; Markowitz, S.D.; Chen, W.D.; Pretlow, T.P.; Yang, B.; Akiyama, Y.; Van Engeland, M.; Toyota, M.; Tokino, T.; Hinoda, Y.; Imai, K.; Herman, J.G.; Baylin, S.B. Epigenetic inactivation of SFRP genes allows constitutive Wnt signaling in colorectal cancer. Nat. Genet. 2004, 36, 417-422.
-
(2004)
Nat. Genet
, vol.36
, pp. 417-422
-
-
Suzuki, H.1
Watkins, D.N.2
Jair, K.W.3
Schuebel, K.E.4
Markowitz, S.D.5
Chen, W.D.6
Pretlow, T.P.7
Yang, B.8
Akiyama, Y.9
van Engeland, M.10
Toyota, M.11
Tokino, T.12
Hinoda, Y.13
Imai, K.14
Herman, J.G.15
Baylin, S.B.16
-
102
-
-
44449134715
-
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications
-
Jiang, X.; Tan, J.; Li, J.; Kivimae, S.; Yang, X.; Zhuang, L.; Lee, P.L.; Chan, M.T.; Stanton, L.W.; Liu, E.T.; Cheyette, B.N.; Yu, Q. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell 2008, 13, 529-541.
-
(2008)
Cancer Cell
, vol.13
, pp. 529-541
-
-
Jiang, X.1
Tan, J.2
Li, J.3
Kivimae, S.4
Yang, X.5
Zhuang, L.6
Lee, P.L.7
Chan, M.T.8
Stanton, L.W.9
Liu, E.T.10
Cheyette, B.N.11
Yu, Q.12
-
103
-
-
30144433093
-
Generation of a functional mammary gland from a single stem cell
-
Shackleton, M.; Vaillant, F.; Simpson, K.J.; Stingl, J.; Smyth, G.K.; Asselin-Labat, M.L.; Wu, L.; Lindeman, G.J.; Visvader, J.E. Generation of a functional mammary gland from a single stem cell. Nature 2006, 439, 84-88.
-
(2006)
Nature
, vol.439
, pp. 84-88
-
-
Shackleton, M.1
Vaillant, F.2
Simpson, K.J.3
Stingl, J.4
Smyth, G.K.5
Asselin-Labat, M.L.6
Wu, L.7
Lindeman, G.J.8
Visvader, J.E.9
-
104
-
-
33750470097
-
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells
-
Sleeman, K.E.; Kendrick, H.; Ashworth, A.; Isacke, C.M.; Smalley, M.J. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Res. 2006, 8, R7.
-
(2006)
Breast Cancer Res
, vol.8
-
-
Sleeman, K.E.1
Kendrick, H.2
Ashworth, A.3
Isacke, C.M.4
Smalley, M.J.5
-
105
-
-
30144432901
-
Purification and unique properties of mammary epithelial stem cells
-
Stingl, J.; Eirew, P.; Ricketson, I.; Shackleton, M.; Vaillant, F.; Choi, D.; Li, H.I.; Eaves, C.J. Purification and unique properties of mammary epithelial stem cells. Nature 2006, 439, 993-997.
-
(2006)
Nature
, vol.439
, pp. 993-997
-
-
Stingl, J.1
Eirew, P.2
Ricketson, I.3
Shackleton, M.4
Vaillant, F.5
Choi, D.6
Li, H.I.7
Eaves, C.J.8
-
106
-
-
57349148680
-
A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability
-
Eirew, P.; Stingl, J.; Raouf, A.; Turashvili, G.; Aparicio, S.; Emerman, J.T.; Eaves, C.J. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat. Med. 2008, 14, 1384-1389.
-
(2008)
Nat. Med
, vol.14
, pp. 1384-1389
-
-
Eirew, P.1
Stingl, J.2
Raouf, A.3
Turashvili, G.4
Aparicio, S.5
Emerman, J.T.6
Eaves, C.J.7
-
107
-
-
68349130357
-
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
-
Lim, E.; Vaillant, F.; Wu, D.; Forrest, N.C.; Pal, B.; Hart, A.H.; Asselin-Labat, M.L.; Gyorki, D.E.; Ward, T.; Partanen, A.; Feleppa, F.; Huschtscha, L.I.; Thorne, H.J.; Fox, S.B.; Yan, M.; French, J.D.; Brown, M.A.; Smyth, G.K.; Visvader, J.E.; Lindeman, G.J. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat. Med. 2009, 15, 907-913.
-
(2009)
Nat. Med
, vol.15
, pp. 907-913
-
-
Lim, E.1
Vaillant, F.2
Wu, D.3
Forrest, N.C.4
Pal, B.5
Hart, A.H.6
Asselin-Labat, M.L.7
Gyorki, D.E.8
Ward, T.9
Partanen, A.10
Feleppa, F.11
Huschtscha, L.I.12
Thorne, H.J.13
Fox, S.B.14
Yan, M.15
French, J.D.16
Brown, M.A.17
Smyth, G.K.18
Visvader, J.E.19
Lindeman, G.J.20
more..
-
108
-
-
7244261873
-
Canonical Wnt signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis
-
Chu, E.Y.; Hens, J.; Andl, T.; Kairo, A.; Yamaguchi, T.P.; Brisken, C.; Glick, A.; Wysolmerski, J.J.; Millar, S.E. Canonical Wnt signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 2004, 131, 4819-4829.
-
(2004)
Development
, vol.131
, pp. 4819-4829
-
-
Chu, E.Y.1
Hens, J.2
Andl, T.3
Kairo, A.4
Yamaguchi, T.P.5
Brisken, C.6
Glick, A.7
Wysolmerski, J.J.8
Millar, S.E.9
-
109
-
-
0012686993
-
Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation
-
Veltmaat, J.M.; Mailleux, A.A.; Thiery, J.P.; Bellusci, S. Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation. Differentiation 2003, 71, 1-17.
-
(2003)
Differentiation
, vol.71
, pp. 1-17
-
-
Veltmaat, J.M.1
Mailleux, A.A.2
Thiery, J.P.3
Bellusci, S.4
-
110
-
-
67149111600
-
The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development
-
Lindvall, C.; Zylstra, C.R.; Evans, N.; West, R.A.; Dykema, K.; Furge, K.A.; Williams, B.O. The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One 2009, 4, e5813.
-
(2009)
PLoS One
, vol.4
-
-
Lindvall, C.1
Zylstra, C.R.2
Evans, N.3
West, R.A.4
Dykema, K.5
Furge, K.A.6
Williams, B.O.7
-
111
-
-
0036113510
-
Wnt signals are required for the initiation of hair follicle development
-
Andl, T.; Reddy, S.T.; Gaddapara, T.; Millar, S.E. Wnt signals are required for the initiation of hair follicle development. Dev. Cell 2002, 2, 643-653.
-
(2002)
Dev. Cell
, vol.2
, pp. 643-653
-
-
Andl, T.1
Reddy, S.T.2
Gaddapara, T.3
Millar, S.E.4
-
112
-
-
0027945654
-
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
-
van Genderen, C.; Okamura, R.M.; Farinas, I.; Quo, R.G.; Parslow, T.G.; Bruhn, L.; Grosschedl, R. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 1994, 8, 2691-2703.
-
(1994)
Genes Dev
, vol.8
, pp. 2691-2703
-
-
van Genderen, C.1
Okamura, R.M.2
Farinas, I.3
Quo, R.G.4
Parslow, T.G.5
Bruhn, L.6
Grosschedl, R.7
-
113
-
-
33751235462
-
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
-
Kouros-Mehr, H.; Werb, Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev. Dyn. 2006, 235, 3404-3412.
-
(2006)
Dev. Dyn
, vol.235
, pp. 3404-3412
-
-
Kouros-Mehr, H.1
Werb, Z.2
-
114
-
-
33845941448
-
The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis
-
Lindvall, C.; Evans, N.C.; Zylstra, C.R.; Li, Y.; Alexander, C.M.; Williams, B.O. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J. Biol. Chem. 2006, 281, 35081-35087.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 35081-35087
-
-
Lindvall, C.1
Evans, N.C.2
Zylstra, C.R.3
Li, Y.4
Alexander, C.M.5
Williams, B.O.6
-
115
-
-
36549025433
-
Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth
-
Roarty, K.; Serra, R. Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth. Development 2007, 134, 3929-3939.
-
(2007)
Development
, vol.134
, pp. 3929-3939
-
-
Roarty, K.1
Serra, R.2
-
116
-
-
0029114329
-
Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice
-
Bradbury, J.M.; Edwards, P.A.; Niemeyer, C.C.; Dale, T.C. Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice. Dev. Biol. 1995, 170, 553-563.
-
(1995)
Dev. Biol
, vol.170
, pp. 553-563
-
-
Bradbury, J.M.1
Edwards, P.A.2
Niemeyer, C.C.3
Dale, T.C.4
-
117
-
-
78149500341
-
Wnt and mammary stem cells: Hormones cannot fly Wingless
-
Roarty, K.; Rosen, J.M. Wnt and mammary stem cells: Hormones cannot fly Wingless. Curr. Opin. Pharmacol. 2010, 10, 643-649.
-
(2010)
Curr. Opin. Pharmacol
, vol.10
, pp. 643-649
-
-
Roarty, K.1
Rosen, J.M.2
-
118
-
-
77953384898
-
Control of mammary stem cell function by steroid hormone signalling
-
Asselin-Labat, M.L.; Vaillant, F.; Sheridan, J.M.; Pal, B.; Wu, D.; Simpson, E.R.; Yasuda, H.; Smyth, G.K.; Martin, T.J.; Lindeman, G.J.; Visvader, J.E. Control of mammary stem cell function by steroid hormone signalling. Nature 2010, 465, 798-802.
-
(2010)
Nature
, vol.465
, pp. 798-802
-
-
Asselin-Labat, M.L.1
Vaillant, F.2
Sheridan, J.M.3
Pal, B.4
Wu, D.5
Simpson, E.R.6
Yasuda, H.7
Smyth, G.K.8
Martin, T.J.9
Lindeman, G.J.10
Visvader, J.E.11
-
119
-
-
77953388315
-
Progesterone induces adult mammary stem cell expansion
-
Joshi, P.A.; Jackson, H.W.; Beristain, A.G.; Di Grappa, M.A.; Mote, P.A.; Clarke, C.L.; Stingl, J.; Waterhouse, P.D.; Khokha, R. Progesterone induces adult mammary stem cell expansion. Nature 2010, 465, 803-807.
-
(2010)
Nature
, vol.465
, pp. 803-807
-
-
Joshi, P.A.1
Jackson, H.W.2
Beristain, A.G.3
di Grappa, M.A.4
Mote, P.A.5
Clarke, C.L.6
Stingl, J.7
Waterhouse, P.D.8
Khokha, R.9
-
120
-
-
77956628008
-
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
-
Zeng, Y.A.; Nusse, R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 2010, 6, 568-577.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 568-577
-
-
Zeng, Y.A.1
Nusse, R.2
-
121
-
-
0024162530
-
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
-
Tsukamoto, A.S.; Grosschedl, R.; Guzman, R.C.; Parslow, T.; Varmus, H.E. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 1988, 55, 619-625.
-
(1988)
Cell
, vol.55
, pp. 619-625
-
-
Tsukamoto, A.S.1
Grosschedl, R.2
Guzman, R.C.3
Parslow, T.4
Varmus, H.E.5
-
122
-
-
0036733656
-
Pathway pathology: Histological differences between Erbb/Ras and Wnt pathway transgenic mammary tumors
-
Rosner, A.; Miyoshi, K.; Landesman-Bollag, E.; Xu, X.; Seldin, D.C.; Moser, A.R.; MacLeod, C.L.; Shyamala, G.; Gillgrass, A.E.; Cardiff, R.D. Pathway pathology: Histological differences between Erbb/Ras and Wnt pathway transgenic mammary tumors. Am. J. Pathol. 2002, 161, 1087-1097.
-
(2002)
Am. J. Pathol
, vol.161
, pp. 1087-1097
-
-
Rosner, A.1
Miyoshi, K.2
Landesman-Bollag, E.3
Xu, X.4
Seldin, D.C.5
Moser, A.R.6
Macleod, C.L.7
Shyamala, G.8
Gillgrass, A.E.9
Cardiff, R.D.10
-
123
-
-
84887212573
-
MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors
-
Teissedre, B.; Pinderhughes, A.; Incassati, A.; Hatsell, S.J.; Hiremath, M.; Cowin, P. MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS One 2009, 4, e4537.
-
(2009)
PLoS One
, vol.4
-
-
Teissedre, B.1
Pinderhughes, A.2
Incassati, A.3
Hatsell, S.J.4
Hiremath, M.5
Cowin, P.6
-
124
-
-
54249086214
-
The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
-
Vaillant, F.; Asselin-Labat, M.L.; Shackleton, M.; Forrest, N.C.; Lindeman, G.J.; Visvader, J.E. The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res. 2008, 68, 7711-7717.
-
(2008)
Cancer Res
, vol.68
, pp. 7711-7717
-
-
Vaillant, F.1
Asselin-Labat, M.L.2
Shackleton, M.3
Forrest, N.C.4
Lindeman, G.J.5
Visvader, J.E.6
-
125
-
-
0036278085
-
Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival
-
Nakopoulou, L.; Gakiopoulou-Givalou, H.; Karayiannakis, A.J.; Giannopoulou, I.; Keramopoulos, A.; Davaris, P.; Pignatelli, M. Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival. Histopathology 2002, 40, 536-546.
-
(2002)
Histopathology
, vol.40
, pp. 536-546
-
-
Nakopoulou, L.1
Gakiopoulou-Givalou, H.2
Karayiannakis, A.J.3
Giannopoulou, I.4
Keramopoulos, A.5
Davaris, P.6
Pignatelli, M.7
-
126
-
-
63649147784
-
Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer
-
Zardawi, S.J.; O'Toole, S.A.; Sutherland, R.L.; Musgrove, E.A. Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histol. Histopathol. 2009, 24, 385-398.
-
(2009)
Histol. Histopathol
, vol.24
, pp. 385-398
-
-
Zardawi, S.J.1
O'Toole, S.A.2
Sutherland, R.L.3
Musgrove, E.A.4
-
127
-
-
0034840950
-
Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
-
Ryo, A.; Nakamura, M.; Wulf, G.; Liou, Y.C.; Lu, K.P. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 2001, 3, 793-801.
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 793-801
-
-
Ryo, A.1
Nakamura, M.2
Wulf, G.3
Liou, Y.C.4
Lu, K.P.5
-
128
-
-
0034636153
-
Beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
-
Lin, S.Y.; Xia, W.; Wang, J.C.; Kwong, K.Y.; Spohn, B.; Wen, Y.; Pestell, R.G.; Hung, M.C. Beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. USA 2000, 97, 4262-4266.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4262-4266
-
-
Lin, S.Y.1
Xia, W.2
Wang, J.C.3
Kwong, K.Y.4
Spohn, B.5
Wen, Y.6
Pestell, R.G.7
Hung, M.C.8
-
129
-
-
33744938180
-
Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome
-
Dolled-Filhart, M.; McCabe, A.; Giltnane, J.; Cregger, M.; Camp, R.L.; Rimm, D.L. Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res. 2006, 66, 5487-5494.
-
(2006)
Cancer Res
, vol.66
, pp. 5487-5494
-
-
Dolled-Filhart, M.1
McCabe, A.2
Giltnane, J.3
Cregger, M.4
Camp, R.L.5
Rimm, D.L.6
-
130
-
-
0035093364
-
Expression patterns of beta-catenin in in situ and invasive breast cancer
-
Karayiannakis, A.J.; Nakopoulou, L.; Gakiopoulou, H.; Keramopoulos, A.; Davaris, P.S.; Pignatelli, M. Expression patterns of beta-catenin in in situ and invasive breast cancer. Eur. J. Surg. Oncol. 2001, 27, 31-36.
-
(2001)
Eur. J. Surg. Oncol
, vol.27
, pp. 31-36
-
-
Karayiannakis, A.J.1
Nakopoulou, L.2
Gakiopoulou, H.3
Keramopoulos, A.4
Davaris, P.S.5
Pignatelli, M.6
-
131
-
-
0031825010
-
E-cadherin and alpha-, beta-, and gamma-catenin protein expression in relation to metastasis in human breast carcinoma
-
Bukholm, I.K.; Nesland, J.M.; Karesen, R.; Jacobsen, U.; Borresen-Dale, A.L. E-cadherin and alpha-, beta-, and gamma-catenin protein expression in relation to metastasis in human breast carcinoma. J. Pathol. 1998, 185, 262-266.
-
(1998)
J. Pathol
, vol.185
, pp. 262-266
-
-
Bukholm, I.K.1
Nesland, J.M.2
Karesen, R.3
Jacobsen, U.4
Borresen-Dale, A.L.5
-
132
-
-
0031964167
-
The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and e-cadherin
-
Dillon, D.A.; D'Aquila, T.; Reynolds, A.B.; Fearon, E.R.; Rimm, D.L. The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and e-cadherin. Am. J. Pathol. 1998, 152, 75-82.
-
(1998)
Am. J. Pathol
, vol.152
, pp. 75-82
-
-
Dillon, D.A.1
D'aquila, T.2
Reynolds, A.B.3
Fearon, E.R.4
Rimm, D.L.5
-
133
-
-
0036154038
-
Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours
-
Wong, S.C.; Lo, S.F.; Lee, K.C.; Yam, J.W.; Chan, J.K.; Wendy Hsiao, W.L. Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 2002, 196, 145-153.
-
(2002)
J. Pathol
, vol.196
, pp. 145-153
-
-
Wong, S.C.1
Lo, S.F.2
Lee, K.C.3
Yam, J.W.4
Chan, J.K.5
Wendy Hsiao, W.L.6
-
134
-
-
77953183234
-
Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
-
Khramtsov, A.I.; Khramtsova, G.F.; Tretiakova, M.; Huo, D.; Olopade, O.I.; Goss, K.H. Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am. J. Pathol. 2010, 176, 2911-2920.
-
(2010)
Am. J. Pathol
, vol.176
, pp. 2911-2920
-
-
Khramtsov, A.I.1
Khramtsova, G.F.2
Tretiakova, M.3
Huo, D.4
Olopade, O.I.5
Goss, K.H.6
-
135
-
-
0035855667
-
Wnt pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type
-
Ugolini, F.; Charafe-Jauffret, E.; Bardou, V.J.; Geneix, J.; Adelaide, J.; Labat-Moleur, F.; Penault-Llorca, F.; Longy, M.; Jacquemier, J.; Birnbaum, D.; Pebusque, M.J. Wnt pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type. Oncogene 2001, 20, 5810-5817.
-
(2001)
Oncogene
, vol.20
, pp. 5810-5817
-
-
Ugolini, F.1
Charafe-Jauffret, E.2
Bardou, V.J.3
Geneix, J.4
Adelaide, J.5
Labat-Moleur, F.6
Penault-Llorca, F.7
Longy, M.8
Jacquemier, J.9
Birnbaum, D.10
Pebusque, M.J.11
-
136
-
-
47249164378
-
Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis
-
Veeck, J.; Geisler, C.; Noetzel, E.; Alkaya, S.; Hartmann, A.; Knuchel, R.; Dahl, E. Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. Carcinogenesis 2008, 29, 991-998.
-
(2008)
Carcinogenesis
, vol.29
, pp. 991-998
-
-
Veeck, J.1
Geisler, C.2
Noetzel, E.3
Alkaya, S.4
Hartmann, A.5
Knuchel, R.6
Dahl, E.7
-
137
-
-
40849116461
-
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer
-
Suzuki, H.; Toyota, M.; Carraway, H.; Gabrielson, E.; Ohmura, T.; Fujikane, T.; Nishikawa, N.; Sogabe, Y.; Nojima, M.; Sonoda, T.; Mori, M.; Hirata, K.; Imai, K.; Shinomura, Y.; Baylin, S.B.; Tokino, T. Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br. J. Cancer 2008, 98, 1147-1156.
-
(2008)
Br. J. Cancer
, vol.98
, pp. 1147-1156
-
-
Suzuki, H.1
Toyota, M.2
Carraway, H.3
Gabrielson, E.4
Ohmura, T.5
Fujikane, T.6
Nishikawa, N.7
Sogabe, Y.8
Nojima, M.9
Sonoda, T.10
Mori, M.11
Hirata, K.12
Imai, K.13
Shinomura, Y.14
Baylin, S.B.15
Tokino, T.16
-
138
-
-
79551624262
-
Beta-catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
-
Geyer, F.C.; Lacroix-Triki, M.; Savage, K.; Arnedos, M.; Lambros, M.B.; Mackay, A.; Natrajan, R.; Reis-Filho, J.S. Beta-catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation. Mod. Pathol. 2010, 24, 209-231.
-
(2010)
Mod. Pathol
, vol.24
, pp. 209-231
-
-
Geyer, F.C.1
Lacroix-Triki, M.2
Savage, K.3
Arnedos, M.4
Lambros, M.B.5
Mackay, A.6
Natrajan, R.7
Reis-Filho, J.S.8
-
139
-
-
0033900369
-
Somatic mutations of the APC gene in primary breast cancers
-
Furuuchi, K.; Tada, M.; Yamada, H.; Kataoka, A.; Furuuchi, N.; Hamada, J.; Takahashi, M.; Todo, S.; Moriuchi, T. Somatic mutations of the APC gene in primary breast cancers. Am. J. Pathol. 2000, 156, 1997-2005.
-
(2000)
Am. J. Pathol
, vol.156
, pp. 1997-2005
-
-
Furuuchi, K.1
Tada, M.2
Yamada, H.3
Kataoka, A.4
Furuuchi, N.5
Hamada, J.6
Takahashi, M.7
Todo, S.8
Moriuchi, T.9
-
140
-
-
33846287519
-
Wnt/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
-
Woodward, W.A.; Chen, M.S.; Behbod, F.; Alfaro, M.P.; Buchholz, T.A.; Rosen, J.M. Wnt/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc. Natl. Acad. Sci. USA 2007, 104, 618-623.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 618-623
-
-
Woodward, W.A.1
Chen, M.S.2
Behbod, F.3
Alfaro, M.P.4
Buchholz, T.A.5
Rosen, J.M.6
-
141
-
-
62549131134
-
Radiation resistance of breast cancer stem cells: Understanding the clinical framework
-
Debeb, B.G.; Xu, W.; Woodward, W.A. Radiation resistance of breast cancer stem cells: Understanding the clinical framework. J. Mammary Gland Biol. Neoplasia 2009, 14, 11-17.
-
(2009)
J. Mammary Gland Biol. Neoplasia
, vol.14
, pp. 11-17
-
-
Debeb, B.G.1
Xu, W.2
Woodward, W.A.3
-
142
-
-
33847369455
-
Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line
-
Chen, M.S.; Woodward, W.A.; Behbod, F.; Peddibhotla, S.; Alfaro, M.P.; Buchholz, T.A.; Rosen, J.M. Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J. Cell Sci. 2007, 120, 468-477.
-
(2007)
J. Cell Sci
, vol.120
, pp. 468-477
-
-
Chen, M.S.1
Woodward, W.A.2
Behbod, F.3
Peddibhotla, S.4
Alfaro, M.P.5
Buchholz, T.A.6
Rosen, J.M.7
-
143
-
-
77649257221
-
Selective targeting of radiation-resistant tumor-initiating cells
-
Zhang, M.; Atkinson, R.L.; Rosen, J.M. Selective targeting of radiation-resistant tumor-initiating cells. Proc. Natl. Acad. Sci. USA 2010, 107, 3522-3527.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 3522-3527
-
-
Zhang, M.1
Atkinson, R.L.2
Rosen, J.M.3
-
144
-
-
47749131959
-
Prostate development: A historical perspective
-
Timms, B.G. Prostate development: A historical perspective. Differentiation 2008, 76, 565-577.
-
(2008)
Differentiation
, vol.76
, pp. 565-577
-
-
Timms, B.G.1
-
145
-
-
77949889989
-
Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo
-
Garraway, I.P.; Sun, W.; Tran, C.P.; Perner, S.; Zhang, B.; Goldstein, A.S.; Hahm, S.A.; Haider, M.; Head, C.S.; Reiter, R.E.; Rubin, M.A.; Witte, O.N. Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. Prostate 2010, 70, 491-501.
-
(2010)
Prostate
, vol.70
, pp. 491-501
-
-
Garraway, I.P.1
Sun, W.2
Tran, C.P.3
Perner, S.4
Zhang, B.5
Goldstein, A.S.6
Hahm, S.A.7
Haider, M.8
Head, C.S.9
Reiter, R.E.10
Rubin, M.A.11
Witte, O.N.12
-
146
-
-
33846065145
-
Isolation and functional characterization of murine prostate stem cells
-
Lawson, D.A.; Xin, L.; Lukacs, R.U.; Cheng, D.; Witte, O.N. Isolation and functional characterization of murine prostate stem cells. Proc. Natl. Acad. Sci. USA 2007, 104, 181-186.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 181-186
-
-
Lawson, D.A.1
Xin, L.2
Lukacs, R.U.3
Cheng, D.4
Witte, O.N.5
-
147
-
-
77955650998
-
PINing down the origin of prostate cancer
-
Moscatelli, D.; Wilson, E.L. PINing down the origin of prostate cancer. Sci. Transl. Med. 2, 43 ps 38.
-
Sci. Transl. Med
, vol.2
, Issue.43
, pp. 38
-
-
Moscatelli, D.1
Wilson, E.L.2
-
148
-
-
70349438989
-
A luminal epithelial stem cell that is a cell of origin for prostate cancer
-
Wang, X.; Kruithof-de Julio, M.; Economides, K.D.; Walker, D.; Yu, H.; Halili, M.V.; Hu, Y.P.; Price, S.M.; Abate-Shen, C.; Shen, M.M. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 2009, 461, 495-500.
-
(2009)
Nature
, vol.461
, pp. 495-500
-
-
Wang, X.1
Kruithof-De julio, M.2
Economides, K.D.3
Walker, D.4
Yu, H.5
Halili, M.V.6
Hu, Y.P.7
Price, S.M.8
Abate-Shen, C.9
Shen, M.M.10
-
149
-
-
0018936098
-
Correlation of early cytodifferentiation of the human fetal prostate and Leydig cells
-
Kellokumpu-Lehtinen, P.; Santti, R.; Pelliniemi, L.J. Correlation of early cytodifferentiation of the human fetal prostate and Leydig cells. Anat. Rec. 1980, 196, 263-273.
-
(1980)
Anat. Rec
, vol.196
, pp. 263-273
-
-
Kellokumpu-Lehtinen, P.1
Santti, R.2
Pelliniemi, L.J.3
-
150
-
-
0035495974
-
Cell differentiation lineage in the prostate
-
Wang, Y.; Hayward, S.; Cao, M.; Thayer, K.; Cunha, G. Cell differentiation lineage in the prostate. Differentiation 2001, 68, 270-279.
-
(2001)
Differentiation
, vol.68
, pp. 270-279
-
-
Wang, Y.1
Hayward, S.2
Cao, M.3
Thayer, K.4
Cunha, G.5
-
151
-
-
0029865240
-
Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter
-
Cleutjens, K.B.; van Eekelen, C.C.; van der Korput, H.A.; Brinkmann, A.O.; Trapman, J. Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J. Biol. Chem. 1996, 271, 6379-6388.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 6379-6388
-
-
Cleutjens, K.B.1
van Eekelen, C.C.2
van der Korput, H.A.3
Brinkmann, A.O.4
Trapman, J.5
-
152
-
-
34447308493
-
Identification of novel androgen receptor target genes in prostate cancer
-
Jariwala, U.; Prescott, J.; Jia, L.; Barski, A.; Pregizer, S.; Cogan, J.P.; Arasheben, A.; Tilley, W.D.; Scher, H.I.; Gerald, W.L.; Buchanan, G.; Coetzee, G.A.; Frenkel, B. Identification of novel androgen receptor target genes in prostate cancer. Mol. Cancer 2007, 6, 39.
-
(2007)
Mol. Cancer
, vol.6
, pp. 39
-
-
Jariwala, U.1
Prescott, J.2
Jia, L.3
Barski, A.4
Pregizer, S.5
Cogan, J.P.6
Arasheben, A.7
Tilley, W.D.8
Scher, H.I.9
Gerald, W.L.10
Buchanan, G.11
Coetzee, G.A.12
Frenkel, B.13
-
153
-
-
0033198498
-
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2
-
Lin, B.; Ferguson, C.; White, J.T.; Wang, S.; Vessella, R.; True, L.D.; Hood, L.; Nelson, P.S. Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res. 1999, 59, 4180-4184.
-
(1999)
Cancer Res
, vol.59
, pp. 4180-4184
-
-
Lin, B.1
Ferguson, C.2
White, J.T.3
Wang, S.4
Vessella, R.5
True, L.D.6
Hood, L.7
Nelson, P.S.8
-
154
-
-
0018002388
-
The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice
-
Cunha, G.R.; Lung, B. The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice. J. Exp. Zool. 1978, 205, 181-193.
-
(1978)
J. Exp. Zool
, vol.205
, pp. 181-193
-
-
Cunha, G.R.1
Lung, B.2
-
155
-
-
0027142420
-
Differential gene regulation during programmed death (apoptosis) versus proliferation of prostatic glandular cells induced by androgen manipulation
-
Furuya, Y.; Isaacs, J.T. Differential gene regulation during programmed death (apoptosis) versus proliferation of prostatic glandular cells induced by androgen manipulation. Endocrinology 1993, 133, 2660-2666.
-
(1993)
Endocrinology
, vol.133
, pp. 2660-2666
-
-
Furuya, Y.1
Isaacs, J.T.2
-
156
-
-
47749157089
-
Prostate epithelial cell fate
-
Matusik, R.J.; Jin, R.J.; Sun, Q.; Wang, Y.; Yu, X.; Gupta, A.; Nandana, S.; Case, T.C.; Paul, M.; Mirosevich, J.; Oottamasathien, S.; Thomas, J. Prostate epithelial cell fate. Differentiation 2008, 76, 682-698.
-
(2008)
Differentiation
, vol.76
, pp. 682-698
-
-
Matusik, R.J.1
Jin, R.J.2
Sun, Q.3
Wang, Y.4
Yu, X.5
Gupta, A.6
Nandana, S.7
Case, T.C.8
Paul, M.9
Mirosevich, J.10
Oottamasathien, S.11
Thomas, J.12
-
157
-
-
32944468433
-
SAGE reveals expression of Wnt signalling pathway members during mouse prostate development
-
Zhang, T.J.; Hoffman, B.G.; Ruiz de Algara, T.; Helgason, C.D. SAGE reveals expression of Wnt signalling pathway members during mouse prostate development. Gene Expr. Patterns 2006, 6, 310-324.
-
(2006)
Gene Expr. Patterns
, vol.6
, pp. 310-324
-
-
Zhang, T.J.1
Hoffman, B.G.2
de Ruiz Algara, T.3
Helgason, C.D.4
-
158
-
-
48249127604
-
Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling
-
Wang, B.E.; Wang, X.D.; Ernst, J.A.; Polakis, P.; Gao, W.Q. Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling. PLoS One 2008, 3, e2186.
-
(2008)
PLoS One
, vol.3
-
-
Wang, B.E.1
Wang, X.D.2
Ernst, J.A.3
Polakis, P.4
Gao, W.Q.5
-
159
-
-
55749095005
-
Wnt5a selectively inhibits mouse ventral prostate development
-
Allgeier, S.H.; Lin, T.M.; Vezina, C.M.; Moore, R.W.; Fritz, W.A.; Chiu, S.Y.; Zhang, C.; Peterson, R.E. Wnt5a selectively inhibits mouse ventral prostate development. Dev. Biol. 2008, 324, 10-17.
-
(2008)
Dev. Biol
, vol.324
, pp. 10-17
-
-
Allgeier, S.H.1
Lin, T.M.2
Vezina, C.M.3
Moore, R.W.4
Fritz, W.A.5
Chiu, S.Y.6
Zhang, C.7
Peterson, R.E.8
-
160
-
-
63349088904
-
The role of Wnt5a in prostate gland development
-
Huang, L.; Pu, Y.; Hu, W.Y.; Birch, L.; Luccio-Camelo, D.; Yamaguchi, T.; Prins, G.S. The role of Wnt5a in prostate gland development. Dev. Biol. 2009, 328, 188-199.
-
(2009)
Dev. Biol
, vol.328
, pp. 188-199
-
-
Huang, L.1
Pu, Y.2
Hu, W.Y.3
Birch, L.4
Luccio-Camelo, D.5
Yamaguchi, T.6
Prins, G.S.7
-
161
-
-
33646533771
-
Roles and regulation of Wnt signaling and beta-catenin in prostate cancer
-
Verras, M.; Sun, Z. Roles and regulation of Wnt signaling and beta-catenin in prostate cancer. Cancer Lett. 2006, 237, 22-32.
-
(2006)
Cancer Lett
, vol.237
, pp. 22-32
-
-
Verras, M.1
Sun, Z.2
-
163
-
-
52449124149
-
Wnt signaling Cancer prostate
-
Robinson, D.R.; Zylstra, C.R.; Williams, B.O. Wnt signaling and prostate cancer. Curr. Drug Targets 2008, 9, 571-580.
-
(2008)
Curr. Drug Targets
, vol.9
, pp. 571-580
-
-
Robinson, D.R.1
Zylstra, C.R.2
Williams, B.O.3
-
164
-
-
47749145379
-
Does prostate cancerco-opt the developmental program?
-
Marker, P.C. Does prostate cancer co-opt the developmental program? Differentiation 2008, 76, 736-744.
-
(2008)
Differentiation
, vol.76
, pp. 736-744
-
-
Marker, P.C.1
-
165
-
-
24744439747
-
Prostate cancer cells promote osteoblastic bone metastases through Wnts
-
Hall, C.L.; Bafico, A.; Dai, J.; Aaronson, S.A.; Keller, E.T. Prostate cancer cells promote osteoblastic bone metastases through Wnts. Cancer Res. 2005, 65, 7554-7560.
-
(2005)
Cancer Res
, vol.65
, pp. 7554-7560
-
-
Hall, C.L.1
Bafico, A.2
Dai, J.3
Aaronson, S.A.4
Keller, E.T.5
-
166
-
-
4444326415
-
Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: Potential pathogenetic and prognostic implications
-
Chen, G.; Shukeir, N.; Potti, A.; Sircar, K.; Aprikian, A.; Goltzman, D.; Rabbani, S.A. Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: Potential pathogenetic and prognostic implications. Cancer 2004, 101, 1345-1356.
-
(2004)
Cancer
, vol.101
, pp. 1345-1356
-
-
Chen, G.1
Shukeir, N.2
Potti, A.3
Sircar, K.4
Aprikian, A.5
Goltzman, D.6
Rabbani, S.A.7
-
167
-
-
38549095978
-
Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone
-
Li, Z.G.; Yang, J.; Vazquez, E.S.; Rose, D.; Vakar-Lopez, F.; Mathew, P.; Lopez, A.; Logothetis, C.J.; Lin, S.H.; Navone, N.M. Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone. Oncogene 2008, 27, 596-603.
-
(2008)
Oncogene
, vol.27
, pp. 596-603
-
-
Li, Z.G.1
Yang, J.2
Vazquez, E.S.3
Rose, D.4
Vakar-Lopez, F.5
Mathew, P.6
Lopez, A.7
Logothetis, C.J.8
Lin, S.H.9
Navone, N.M.10
-
168
-
-
77949428236
-
Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
-
Uysal-Onganer, P.; Kawano, Y.; Caro, M.; Walker, M.M.; Diez, S.; Darrington, R.S.; Waxman, J.; Kypta, R.M. Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. Mol. Cancer 2010, 9, 55.
-
(2010)
Mol. Cancer
, vol.9
, pp. 55
-
-
Uysal-Onganer, P.1
Kawano, Y.2
Caro, M.3
Walker, M.M.4
Diez, S.5
Darrington, R.S.6
Waxman, J.7
Kypta, R.M.8
-
169
-
-
77950865388
-
Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase
-
Yamamoto, H.; Oue, N.; Sato, A.; Hasegawa, Y.; Matsubara, A.; Yasui, W.; Kikuchi, A. Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. Oncogene 2010, 29, 2036-2046.
-
(2010)
Oncogene
, vol.29
, pp. 2036-2046
-
-
Yamamoto, H.1
Oue, N.2
Sato, A.3
Hasegawa, Y.4
Matsubara, A.5
Yasui, W.6
Kikuchi, A.7
-
170
-
-
50949117119
-
Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis
-
Hall, C.L.; Daignault, S.D.; Shah, R.B.; Pienta, K.J.; Keller, E.T. Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis. Prostate 2008, 68, 1396-1404.
-
(2008)
Prostate
, vol.68
, pp. 1396-1404
-
-
Hall, C.L.1
Daignault, S.D.2
Shah, R.B.3
Pienta, K.J.4
Keller, E.T.5
-
171
-
-
77956290679
-
FZD4 as a mediator of ERG oncogene-induced Wnt signaling and epithelial-to-mesenchymal transition in human prostate cancer cells
-
Gupta, S.; Iljin, K.; Sara, H.; Mpindi, J.P.; Mirtti, T.; Vainio, P.; Rantala, J.; Alanen, K.; Nees, M.; Kallioniemi, O. FZD4 as a mediator of ERG oncogene-induced Wnt signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res. 2010, 70, 6735-6745.
-
(2010)
Cancer Res
, vol.70
, pp. 6735-6745
-
-
Gupta, S.1
Iljin, K.2
Sara, H.3
Mpindi, J.P.4
Mirtti, T.5
Vainio, P.6
Rantala, J.7
Alanen, K.8
Nees, M.9
Kallioniemi, O.10
-
172
-
-
0141995804
-
WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer
-
Wissmann, C.; Wild, P.J.; Kaiser, S.; Roepcke, S.; Stoehr, R.; Woenckhaus, M.; Kristiansen, G.; Hsieh, J.C.; Hofstaedter, F.; Hartmann, A.; Knuechel, R.; Rosenthal, A.; Pilarsky, C. WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. J. Pathol. 2003, 201, 204-212.
-
(2003)
J. Pathol
, vol.201
, pp. 204-212
-
-
Wissmann, C.1
Wild, P.J.2
Kaiser, S.3
Roepcke, S.4
Stoehr, R.5
Woenckhaus, M.6
Kristiansen, G.7
Hsieh, J.C.8
Hofstaedter, F.9
Hartmann, A.10
Knuechel, R.11
Rosenthal, A.12
Pilarsky, C.13
-
173
-
-
77953695990
-
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
-
Yee, D.S.; Tang, Y.; Li, X.; Liu, Z.; Guo, Y.; Ghaffar, S.; McQueen, P.; Atreya, D.; Xie, J.; Simoneau, A.R.; Hoang, B.H.; Zi, X. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol. Cancer 2010, 9, 162.
-
(2010)
Mol. Cancer
, vol.9
, pp. 162
-
-
Yee, D.S.1
Tang, Y.2
Li, X.3
Liu, Z.4
Guo, Y.5
Ghaffar, S.6
McQueen, P.7
Atreya, D.8
Xie, J.9
Simoneau, A.R.10
Hoang, B.H.11
Zi, X.12
-
174
-
-
10144237223
-
Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells
-
Ohigashi, T.; Mizuno, R.; Nakashima, J.; Marumo, K.; Murai, M. Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. Prostate 2005, 62, 61-68.
-
(2005)
Prostate
, vol.62
, pp. 61-68
-
-
Ohigashi, T.1
Mizuno, R.2
Nakashima, J.3
Marumo, K.4
Murai, M.5
-
175
-
-
0035113825
-
Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation
-
Wu, X.; Wu, J.; Huang, J.; Powell, W.C.; Zhang, J.; Matusik, R.J.; Sangiorgi, F.O.; Maxson, R.E.; Sucov, H.M.; Roy-Burman, P. Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech. Dev. 2001, 101, 61-69.
-
(2001)
Mech. Dev
, vol.101
, pp. 61-69
-
-
Wu, X.1
Wu, J.2
Huang, J.3
Powell, W.C.4
Zhang, J.5
Matusik, R.J.6
Sangiorgi, F.O.7
Maxson, R.E.8
Sucov, H.M.9
Roy-Burman, P.10
-
176
-
-
0033663862
-
Detection and analysis of beta-catenin mutations in prostate cancer
-
Chesire, D.R.; Ewing, C.M.; Sauvageot, J.; Bova, G.S.; Isaacs, W.B. Detection and analysis of beta-catenin mutations in prostate cancer. Prostate 2000, 45, 323-334.
-
(2000)
Prostate
, vol.45
, pp. 323-334
-
-
Chesire, D.R.1
Ewing, C.M.2
Sauvageot, J.3
Bova, G.S.4
Isaacs, W.B.5
-
177
-
-
18344363708
-
APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers
-
Gerstein, A.V.; Almeida, T.A.; Zhao, G.; Chess, E.; Shih Ie, M.; Buhler, K.; Pienta, K.; Rubin, M.A.; Vessella, R.; Papadopoulos, N. APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers. Gene. Chromosome. Cancer 2002, 34, 9-16.
-
(2002)
Gene. Chromosome. Cancer
, vol.34
, pp. 9-16
-
-
Gerstein, A.V.1
Almeida, T.A.2
Zhao, G.3
Chess, E.4
Shih, I.M.5
Buhler, K.6
Pienta, K.7
Rubin, M.A.8
Vessella, R.9
Papadopoulos, N.10
-
178
-
-
67650340970
-
Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients
-
Richiardi, L.; Fiano, V.; Vizzini, L.; De Marco, L.; Delsedime, L.; Akre, O.; Tos, A.G.; Merletti, F. Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients. J. Clin. Oncol. 2009, 27, 3161-3168.
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 3161-3168
-
-
Richiardi, L.1
Fiano, V.2
Vizzini, L.3
de Marco, L.4
Delsedime, L.5
Akre, O.6
Tos, A.G.7
Merletti, F.8
-
179
-
-
34047265189
-
Inactivation of Apc in the mouse prostate causes prostate carcinoma
-
Bruxvoort, K.J.; Charbonneau, H.M.; Giambernardi, T.A.; Goolsby, J.C.; Qian, C.N.; Zylstra, C.R.; Robinson, D.R.; Roy-Burman, P.; Shaw, A.K.; Buckner-Berghuis, B.D.; Sigler, R.E.; Resau, J.H.; Sullivan, R.; Bushman, W.; Williams, B.O. Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Res. 2007, 67, 2490-2496.
-
(2007)
Cancer Res
, vol.67
, pp. 2490-2496
-
-
Bruxvoort, K.J.1
Charbonneau, H.M.2
Giambernardi, T.A.3
Goolsby, J.C.4
Qian, C.N.5
Zylstra, C.R.6
Robinson, D.R.7
Roy-Burman, P.8
Shaw, A.K.9
Buckner-Berghuis, B.D.10
Sigler, R.E.11
Resau, J.H.12
Sullivan, R.13
Bushman, W.14
Williams, B.O.15
-
180
-
-
58249105729
-
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse
-
Pearson, H.B.; Phesse, T.J.; Clarke, A.R. K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Res. 2009, 69, 94-101.
-
(2009)
Cancer Res
, vol.69
, pp. 94-101
-
-
Pearson, H.B.1
Phesse, T.J.2
Clarke, A.R.3
-
181
-
-
60849086472
-
Activation of beta-catenin in mouse prostate causes HGPIN and continuous prostate growth after castration
-
Yu, X.; Wang, Y.; Jiang, M.; Bierie, B.; Roy-Burman, P.; Shen, M.M.; Taketo, M.M.; Wills, M.; Matusik, R.J. Activation of beta-catenin in mouse prostate causes HGPIN and continuous prostate growth after castration. Prostate 2009, 69, 249-262.
-
(2009)
Prostate
, vol.69
, pp. 249-262
-
-
Yu, X.1
Wang, Y.2
Jiang, M.3
Bierie, B.4
Roy-Burman, P.5
Shen, M.M.6
Taketo, M.M.7
Wills, M.8
Matusik, R.J.9
-
182
-
-
77956381416
-
Novel targets for prostate cancer chemoprevention
-
Sarkar, F.H.; Li, Y.; Wang, Z.; Kong, D. Novel targets for prostate cancer chemoprevention. Endocr. Relat. Cancer 17, R195-R212.
-
Endocr. Relat. Cancer
, vol.17
-
-
Sarkar, F.H.1
Li, Y.2
Wang, Z.3
Kong, D.4
-
183
-
-
28244472369
-
Prospective identification of tumorigenic prostate cancer stem cells
-
Collins, A.T.; Berry, P.A.; Hyde, C.; Stower, M.J.; Maitland, N.J. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 2005, 65, 10946-10951.
-
(2005)
Cancer Res
, vol.65
, pp. 10946-10951
-
-
Collins, A.T.1
Berry, P.A.2
Hyde, C.3
Stower, M.J.4
Maitland, N.J.5
-
184
-
-
77955121375
-
Identification of a cell of origin for human prostate cancer
-
Goldstein, A.S.; Huang, J.; Guo, C.; Garraway, I.P.; Witte, O.N. Identification of a cell of origin for human prostate cancer. Science 2010,329, 568-571.
-
(2010)
Science
, vol.329
, pp. 568-571
-
-
Goldstein, A.S.1
Huang, J.2
Guo, C.3
Garraway, I.P.4
Witte, O.N.5
-
185
-
-
57649140583
-
Generation of a prostate from a single adult stem cell
-
Leong, K.G.; Wang, B.E.; Johnson, L.; Gao, W.Q. Generation of a prostate from a single adult stem cell. Nature 2008, 456, 804-808.
-
(2008)
Nature
, vol.456
, pp. 804-808
-
-
Leong, K.G.1
Wang, B.E.2
Johnson, L.3
Gao, W.Q.4
-
186
-
-
36049042512
-
Prostate cancer stem cells: A target for new therapies
-
Maitland, N.J.; Bryce, S.D.; Stower, M.J.; Collins, A.T. Prostate cancer stem cells: A target for new therapies. Ernst Schering Found Symp. Proc. 2006, 155-179.
-
(2006)
Ernst Schering Found Symp. Proc
, pp. 155-179
-
-
Maitland, N.J.1
Bryce, S.D.2
Stower, M.J.3
Collins, A.T.4
-
187
-
-
67649948804
-
Wnt signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics
-
Bisson, I.; Prowse, D.M. Wnt signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res. 2009, 19, 683-697.
-
(2009)
Cell Res
, vol.19
, pp. 683-697
-
-
Bisson, I.1
Prowse, D.M.2
-
188
-
-
7444256731
-
Analysis of Wnt gene expression in prostate cancer: Mutual inhibition by Wnt11 and the androgen receptor
-
Zhu, H.; Mazor, M.; Kawano, Y.; Walker, M.M.; Leung, H.Y.; Armstrong, K.; Waxman, J.; Kypta, R.M. Analysis of Wnt gene expression in prostate cancer: Mutual inhibition by Wnt11 and the androgen receptor. Cancer Res. 2004, 64, 7918-7926.
-
(2004)
Cancer Res
, vol.64
, pp. 7918-7926
-
-
Zhu, H.1
Mazor, M.2
Kawano, Y.3
Walker, M.M.4
Leung, H.Y.5
Armstrong, K.6
Waxman, J.7
Kypta, R.M.8
-
189
-
-
10844230334
-
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells
-
Verras, M.; Brown, J.; Li, X.; Nusse, R.; Sun, Z. Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells. Cancer Res. 2004, 64, 8860-8866.
-
(2004)
Cancer Res
, vol.64
, pp. 8860-8866
-
-
Verras, M.1
Brown, J.2
Li, X.3
Nusse, R.4
Sun, Z.5
-
190
-
-
0037129305
-
In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis
-
Chesire, D.R.; Ewing, C.M.; Gage, W.R.; Isaacs, W.B. In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis. Oncogene 2002, 21, 2679-2694.
-
(2002)
Oncogene
, vol.21
, pp. 2679-2694
-
-
Chesire, D.R.1
Ewing, C.M.2
Gage, W.R.3
Isaacs, W.B.4
-
191
-
-
78049275380
-
Wnt signaling in stem and cancer stem cells
-
Wend, P.; Holland, J.D.; Ziebold, U.; Birchmeier, W. Wnt signaling in stem and cancer stem cells. Semin. Cell Dev. Biol. 2010, 21, 855-863.
-
(2010)
Semin. Cell Dev. Biol
, vol.21
, pp. 855-863
-
-
Wend, P.1
Holland, J.D.2
Ziebold, U.3
Birchmeier, W.4
-
192
-
-
33846193290
-
The many ways of Wnt in cancer
-
Polakis, P. The many ways of Wnt in cancer. Curr. Opin. Genet. Dev. 2007, 17, 45-51.
-
(2007)
Curr. Opin. Genet. Dev
, vol.17
, pp. 45-51
-
-
Polakis, P.1
-
193
-
-
33751530490
-
Mining the Wnt pathway for cancer therapeutics
-
Barker, N.; Clevers, H. Mining the Wnt pathway for cancer therapeutics. Nat. Rev. Drug Discov. 2006, 5, 997-1014.
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 997-1014
-
-
Barker, N.1
Clevers, H.2
-
194
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya, T.; Morrison, S.J.; Clarke, M.F.; Weissman, I.L. Stem cells, cancer, and cancer stem cells. Nature 2001, 414, 105-111.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
195
-
-
28544444039
-
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
-
Castellone, M.D.; Teramoto, H.; Williams, B.O.; Druey, K.M.; Gutkind, J.S. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 2005, 310, 1504-1510.
-
(2005)
Science
, vol.310
, pp. 1504-1510
-
-
Castellone, M.D.1
Teramoto, H.2
Williams, B.O.3
Druey, K.M.4
Gutkind, J.S.5
-
196
-
-
0025834849
-
Sulindac causes regression of rectal polyps in familial adenomatous polyposis
-
Labayle, D.; Fischer, D.; Vielh, P.; Drouhin, F.; Pariente, A.; Bories, C.; Duhamel, O.; Trousset, M.; Attali, P. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 1991, 101, 635-639.
-
(1991)
Gastroenterology
, vol.101
, pp. 635-639
-
-
Labayle, D.1
Fischer, D.2
Vielh, P.3
Drouhin, F.4
Pariente, A.5
Bories, C.6
Duhamel, O.7
Trousset, M.8
Attali, P.9
-
197
-
-
0842329914
-
Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines
-
Boon, E.M.; Keller, J.J.; Wormhoudt, T.A.; Giardiello, F.M.; Offerhaus, G.J.; van der Neut, R.; Pals, S.T. Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines. Br. J. Cancer 2004, 90, 224-229.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 224-229
-
-
Boon, E.M.1
Keller, J.J.2
Wormhoudt, T.A.3
Giardiello, F.M.4
Offerhaus, G.J.5
van der Neut, R.6
Pals, S.T.7
-
198
-
-
0035252741
-
The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling
-
Dihlmann, S.; Siermann, A.; von Knebel Doeberitz, M. The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene 2001, 20, 645-653.
-
(2001)
Oncogene
, vol.20
, pp. 645-653
-
-
Dihlmann, S.1
Siermann, A.2
von Knebel Doeberitz, M.3
-
199
-
-
0030610419
-
Vitamin D3 analog, EB1089, inhibits growth of subcutaneous xenografts of the human colon cancer cell line, LoVo, in a nude mouse model
-
Akhter, J.; Chen, X.; Bowrey, P.; Bolton, E.J.; Morris, D.L. Vitamin D3 analog, EB1089, inhibits growth of subcutaneous xenografts of the human colon cancer cell line, LoVo, in a nude mouse model. Dis. Colon Rectum 1997, 40, 317-321.
-
(1997)
Dis. Colon Rectum
, vol.40
, pp. 317-321
-
-
Akhter, J.1
Chen, X.2
Bowrey, P.3
Bolton, E.J.4
Morris, D.L.5
-
200
-
-
9744274548
-
Vitamin D and colon carcinogenesis
-
Harris, D.M.; Go, V.L. Vitamin D and colon carcinogenesis. J. Nutr. 2004, 134, 3463S-3471S.
-
(2004)
J. Nutr
, vol.134
-
-
Harris, D.M.1
Go, V.L.2
-
201
-
-
0010958949
-
Apoptotic regression of MCF-7 xenografts in nude mice treated with the vitamin D3 analog, EB1089
-
VanWeelden, K.; Flanagan, L.; Binderup, L.; Tenniswood, M.; Welsh, J. Apoptotic regression of MCF-7 xenografts in nude mice treated with the vitamin D3 analog, EB1089. Endocrinology 1998, 139, 2102-2110.
-
(1998)
Endocrinology
, vol.139
, pp. 2102-2110
-
-
Vanweelden, K.1
Flanagan, L.2
Binderup, L.3
Tenniswood, M.4
Welsh, J.5
-
202
-
-
18344389705
-
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling
-
Palmer, H.G.; Gonzalez-Sancho, J.M.; Espada, J.; Berciano, M.T.; Puig, I.; Baulida, J.; Quintanilla, M.; Cano, A.; de Herreros, A.G.; Lafarga, M.; Munoz, A. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J. Cell Biol. 2001, 154, 369-387.
-
(2001)
J. Cell Biol
, vol.154
, pp. 369-387
-
-
Palmer, H.G.1
Gonzalez-Sancho, J.M.2
Espada, J.3
Berciano, M.T.4
Puig, I.5
Baulida, J.6
Quintanilla, M.7
Cano, A.8
de Herreros, A.G.9
Lafarga, M.10
Munoz, A.11
-
203
-
-
33644850904
-
The molecular basis of vitamin D receptor and beta-catenin crossregulation
-
Shah, S.; Islam, M.N.; Dakshanamurthy, S.; Rizvi, I.; Rao, M.; Herrell, R.; Zinser, G.; Valrance, M.; Aranda, A.; Moras, D.; Norman, A.; Welsh, J.; Byers, S.W. The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol. Cell 2006, 21, 799-809.
-
(2006)
Mol. Cell
, vol.21
, pp. 799-809
-
-
Shah, S.1
Islam, M.N.2
Dakshanamurthy, S.3
Rizvi, I.4
Rao, M.5
Herrell, R.6
Zinser, G.7
Valrance, M.8
Aranda, A.9
Moras, D.10
Norman, A.11
Welsh, J.12
Byers, S.W.13
-
204
-
-
77957571588
-
The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer
-
Sarkar, F.H.; Li, Y.; Wang, Z.; Kong, D. The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer. Cancer Metastasis Rev. 2010, 29, 383-394.
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 383-394
-
-
Sarkar, F.H.1
Li, Y.2
Wang, Z.3
Kong, D.4
-
205
-
-
0141725483
-
Wise, a context-dependent activator and inhibitor of Wnt signalling
-
Itasaki, N.; Jones, C.M.; Mercurio, S.; Rowe, A.; Domingos, P.M.; Smith, J.C.; Krumlauf, R. Wise, a context-dependent activator and inhibitor of Wnt signalling. Development 2003, 130, 4295-4305.
-
(2003)
Development
, vol.130
, pp. 4295-4305
-
-
Itasaki, N.1
Jones, C.M.2
Mercurio, S.3
Rowe, A.4
Domingos, P.M.5
Smith, J.C.6
Krumlauf, R.7
-
206
-
-
77953100335
-
Mesd is a universal inhibitor of wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells
-
Lu, W.; Liu, C.C.; Thottassery, J.V.; Bu, G.; Li, Y. Mesd is a universal inhibitor of wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells. Biochemistry 2010, 49, 4635-4643.
-
(2010)
Biochemistry
, vol.49
, pp. 4635-4643
-
-
Lu, W.1
Liu, C.C.2
Thottassery, J.V.3
Bu, G.4
Li, Y.5
-
207
-
-
77957266335
-
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
-
Ettenberg, S.A.; Charlat, O.; Daley, M.P.; Liu, S.; Vincent, K.J.; Stuart, D.D.; Schuller, A.G.; Yuan, J.; Ospina, B.; Green, J.; Yu, Q.; Walsh, R.; Li, S.; Schmitz, R.; Heine, H.; Bilic, S.; Ostrom, L.; Mosher, R.; Hartlepp, K.F.; Zhu, Z.; Fawell, S.; Yao, Y.M.; Stover, D.; Finan, P.M.; Porter, J.A.; Sellers, W.R.; Klagge, I.M.; Cong, F. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proc. Natl. Acad. Sci. USA 2010, 107, 15473-15478.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15473-15478
-
-
Ettenberg, S.A.1
Charlat, O.2
Daley, M.P.3
Liu, S.4
Vincent, K.J.5
Stuart, D.D.6
Schuller, A.G.7
Yuan, J.8
Ospina, B.9
Green, J.10
Yu, Q.11
Walsh, R.12
Li, S.13
Schmitz, R.14
Heine, H.15
Bilic, S.16
Ostrom, L.17
Mosher, R.18
Hartlepp, K.F.19
Zhu, Z.20
Fawell, S.21
Yao, Y.M.22
Stover, D.23
Finan, P.M.24
Porter, J.A.25
Sellers, W.R.26
Klagge, I.M.27
Cong, F.28
more..
-
208
-
-
77958599987
-
Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies
-
Gong, Y.; Bourhis, E.; Chiu, C.; Stawicki, S.; DeAlmeida, V.I.; Liu, B.Y.; Phamluong, K.; Cao, T.C.; Carano, R.A.; Ernst, J.A.; Solloway, M.; Rubinfeld, B.; Hannoush, R.N.; Wu, Y.; Polakis, P.; Costa, M. Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS One 2010, 5, e12682.
-
(2010)
PLoS One
, vol.5
-
-
Gong, Y.1
Bourhis, E.2
Chiu, C.3
Stawicki, S.4
Dealmeida, V.I.5
Liu, B.Y.6
Phamluong, K.7
Cao, T.C.8
Carano, R.A.9
Ernst, J.A.10
Solloway, M.11
Rubinfeld, B.12
Hannoush, R.N.13
Wu, Y.14
Polakis, P.15
Costa, M.16
-
209
-
-
1642341682
-
A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
-
He, B.; You, L.; Uematsu, K.; Xu, Z.; Lee, A.Y.; Matsangou, M.; McCormick, F.; Jablons, D.M. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 2004, 6, 7-14.
-
(2004)
Neoplasia
, vol.6
, pp. 7-14
-
-
He, B.1
You, L.2
Uematsu, K.3
Xu, Z.4
Lee, A.Y.5
Matsangou, M.6
McCormick, F.7
Jablons, D.M.8
-
210
-
-
25444496522
-
Wnt2 as a new therapeutic target in malignant pleural mesothelioma
-
Mazieres, J.; You, L.; He, B.; Xu, Z.; Twogood, S.; Lee, A.Y.; Reguart, N.; Batra, S.; Mikami, I.; Jablons, D.M. Wnt2 as a new therapeutic target in malignant pleural mesothelioma. Int. J. Cancer 2005, 117, 326-332.
-
(2005)
Int. J. Cancer
, vol.117
, pp. 326-332
-
-
Mazieres, J.1
You, L.2
He, B.3
Xu, Z.4
Twogood, S.5
Lee, A.Y.6
Reguart, N.7
Batra, S.8
Mikami, I.9
Jablons, D.M.10
-
211
-
-
3442894128
-
An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth
-
You, L.; He, B.; Xu, Z.; Uematsu, K.; Mazieres, J.; Fujii, N.; Mikami, I.; Reguart, N.; McIntosh, J.K.; Kashani-Sabet, M.; McCormick, F.; Jablons, D.M. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Res. 2004, 64, 5385-5389.
-
(2004)
Cancer Res
, vol.64
, pp. 5385-5389
-
-
You, L.1
He, B.2
Xu, Z.3
Uematsu, K.4
Mazieres, J.5
Fujii, N.6
Mikami, I.7
Reguart, N.8
McIntosh, J.K.9
Kashani-Sabet, M.10
McCormick, F.11
Jablons, D.M.12
-
212
-
-
4344570800
-
Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells
-
You, L.; He, B.; Xu, Z.; Uematsu, K.; Mazieres, J.; Mikami, I.; Reguart, N.; Moody, T.W.; Kitajewski, J.; McCormick, F.; Jablons, D.M. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene 2004, 23, 6170-6174.
-
(2004)
Oncogene
, vol.23
, pp. 6170-6174
-
-
You, L.1
He, B.2
Xu, Z.3
Uematsu, K.4
Mazieres, J.5
Mikami, I.6
Reguart, N.7
Moody, T.W.8
Kitajewski, J.9
McCormick, F.10
Jablons, D.M.11
-
213
-
-
33645411180
-
Wnt-1 signal as a potential cancer therapeutic target
-
You, L.; Kim, J.; He, B.; Xu, Z.; McCormick, F.; Jablons, D.M. Wnt-1 signal as a potential cancer therapeutic target. Drug News Perspect. 2006, 19, 27-31.
-
(2006)
Drug News Perspect
, vol.19
, pp. 27-31
-
-
You, L.1
Kim, J.2
He, B.3
Xu, Z.4
McCormick, F.5
Jablons, D.M.6
-
214
-
-
0037179894
-
Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
-
Rhee, C.S.; Sen, M.; Lu, D.; Wu, C.; Leoni, L.; Rubin, J.; Corr, M.; Carson, D.A. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene 2002, 21, 6598-6605.
-
(2002)
Oncogene
, vol.21
, pp. 6598-6605
-
-
Rhee, C.S.1
Sen, M.2
Lu, D.3
Wu, C.4
Leoni, L.5
Rubin, J.6
Corr, M.7
Carson, D.A.8
-
215
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
-
Lepourcelet, M.; Chen, Y.N.; France, D.S.; Wang, H.; Crews, P.; Petersen, F.; Bruseo, C.; Wood, A.W.; Shivdasani, R.A. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell. 2004, 5, 91-102.
-
(2004)
Cancer Cell
, vol.5
, pp. 91-102
-
-
Lepourcelet, M.1
Chen, Y.N.2
France, D.S.3
Wang, H.4
Crews, P.5
Petersen, F.6
Bruseo, C.7
Wood, A.W.8
Shivdasani, R.A.9
-
216
-
-
4344587136
-
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]
-
Emami, K.H.; Nguyen, C.; Ma, H.; Kim, D.H.; Jeong, K.W.; Eguchi, M.; Moon, R.T.; Teo, J.L.; Kim, H.Y.; Moon, S.H.; Ha, J.R.; Kahn, M. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc. Natl. Acad. Sci. USA 2004, 101, 12682-12687.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12682-12687
-
-
Emami, K.H.1
Nguyen, C.2
Ma, H.3
Kim, D.H.4
Jeong, K.W.5
Eguchi, M.6
Moon, R.T.7
Teo, J.L.8
Kim, H.Y.9
Moon, S.H.10
Ha, J.R.11
Kahn, M.12
-
217
-
-
64749113970
-
Drugging the Wnt pathway: Problems and progress
-
Garber, K. Drugging the Wnt pathway: Problems and progress. J. Natl. Cancer Inst. 2009, 101, 548-550.
-
(2009)
J. Natl. Cancer Inst
, vol.101
, pp. 548-550
-
-
Garber, K.1
-
218
-
-
33646845634
-
Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation
-
Zhang, L.; Gao, X.; Wen, J.; Ning, Y.; Chen, Y.G. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J. Biol. Chem. 2006, 281, 8607-8612.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 8607-8612
-
-
Zhang, L.1
Gao, X.2
Wen, J.3
Ning, Y.4
Chen, Y.G.5
-
219
-
-
28244496603
-
Identification of a specific inhibitor of the dishevelled PDZ domain
-
Shan, J.; Shi, D.L.; Wang, J.; Zheng, J. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 2005, 44, 15495-15503.
-
(2005)
Biochemistry
, vol.44
, pp. 15495-15503
-
-
Shan, J.1
Shi, D.L.2
Wang, J.3
Zheng, J.4
-
220
-
-
70349695861
-
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
-
Huang, S.M.; Mishina, Y.M.; Liu, S.; Cheung, A.; Stegmeier, F.; Michaud, G.A.; Charlat, O.; Wiellette, E.; Zhang, Y.; Wiessner, S.; Hild, M.; Shi, X.; Wilson, C.J.; Mickanin, C.; Myer, V.; Fazal, A.; Tomlinson, R.; Serluca, F.; Shao, W.; Cheng, H.; Shultz, M.; Rau, C.; Schirle, M.; Schlegl, J.; Ghidelli, S.; Fawell, S.; Lu, C.; Curtis, D.; Kirschner, M.W.; Lengauer, C.; Finan, P.M.; Tallarico, J.A.; Bouwmeester, T.; Porter, J.A.; Bauer, A.; Cong, F. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 2009, 461, 614-620.
-
(2009)
Nature
, vol.461
, pp. 614-620
-
-
Huang, S.M.1
Mishina, Y.M.2
Liu, S.3
Cheung, A.4
Stegmeier, F.5
Michaud, G.A.6
Charlat, O.7
Wiellette, E.8
Zhang, Y.9
Wiessner, S.10
Hild, M.11
Shi, X.12
Wilson, C.J.13
Mickanin, C.14
Myer, V.15
Fazal, A.16
Tomlinson, R.17
Serluca, F.18
Shao, W.19
Cheng, H.20
Shultz, M.21
Rau, C.22
Schirle, M.23
Schlegl, J.24
Ghidelli, S.25
Fawell, S.26
Lu, C.27
Curtis, D.28
Kirschner, M.W.29
Lengauer, C.30
Finan, P.M.31
Tallarico, J.A.32
Bouwmeester, T.33
Porter, J.A.34
Bauer, A.35
Cong, F.36
more..
-
221
-
-
77958171338
-
Small-molecule inhibition of Wnt signaling through activation of Casein Kinase 1alpha
-
Thorne, C.A.; Hanson, A.J.; Schneider, J.; Tahinci, E.; Orton, D.; Cselenyi, C.S.; Jernigan, K.K.; Meyers, K.C.; Hang, B.I.; Waterson, A.G.; Kim, K.; Melancon, B.; Ghidu, V.P.; Sulikowski, G.A.; LaFleur, B.; Salic, A.; Lee, L.A.; Miller, D.M., 3rd; Lee, E. Small-molecule inhibition of Wnt signaling through activation of Casein Kinase 1alpha. Nat. Chem. Biol. 2010, 6, 829-836.
-
(2010)
Nat. Chem. Biol
, vol.6
, pp. 829-836
-
-
Thorne, C.A.1
Hanson, A.J.2
Schneider, J.3
Tahinci, E.4
Orton, D.5
Cselenyi, C.S.6
Jernigan, K.K.7
Meyers, K.C.8
Hang, B.I.9
Waterson, A.G.10
Kim, K.11
Melancon, B.12
Ghidu, V.P.13
Sulikowski, G.A.14
Lafleur, B.15
Salic, A.16
Lee, L.A.17
Miller, D.M.18
Lee, E.19
-
222
-
-
77954530277
-
1,536-well ultra-high-throughput sirna screen to identify regulators of the Wnt/beta-catenin pathway
-
Chung, N.; Marine, S.; Smith, E.A.; Liehr, R.; Smith, S.T.; Locco, L.; Hudak, E.; Kreamer, A.; Rush, A.; Roberts, B.; Major, M.B.; Moon, R.T.; Arthur, W.; Cleary, M.; Strulovici, B.; Ferrer, M. A 1,536-well ultra-high-throughput sirna screen to identify regulators of the Wnt/beta-catenin pathway. Assay Drug Dev. Technol. 2010, 8, 286-294.
-
(2010)
Assay Drug Dev. Technol
, vol.8
, pp. 286-294
-
-
Chung, N.1
Marine, S.2
Smith, E.A.3
Liehr, R.4
Smith, S.T.5
Locco, L.6
Hudak, E.7
Kreamer, A.8
Rush, A.9
Roberts, B.10
Major, M.B.11
Moon, R.T.12
Arthur, W.13
Cleary, M.14
Strulovici, B.15
Ferrer, M.A.16
-
223
-
-
77954374183
-
Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy
-
Sato, N.; Yamabuki, T.; Takano, A.; Koinuma, J.; Aragaki, M.; Masuda, K.; Ishikawa, N.; Kohno, N.; Ito, H.; Miyamoto, M.; Nakayama, H.; Miyagi, Y.; Tsuchiya, E.; Kondo, S.; Nakamura, Y.; Daigo, Y. Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy. Cancer Res. 2010, 70, 5326-5336.
-
(2010)
Cancer Res
, vol.70
, pp. 5326-5336
-
-
Sato, N.1
Yamabuki, T.2
Takano, A.3
Koinuma, J.4
Aragaki, M.5
Masuda, K.6
Ishikawa, N.7
Kohno, N.8
Ito, H.9
Miyamoto, M.10
Nakayama, H.11
Miyagi, Y.12
Tsuchiya, E.13
Kondo, S.14
Nakamura, Y.15
Daigo, Y.16
-
224
-
-
20444376156
-
Essential role of beta-catenin in postnatal bone acquisition
-
Holmen, S.L.; Zylstra, C.R.; Mukherjee, A.; Sigler, R.E.; Faugere, M.C.; Bouxsein, M.L.; Deng, L.; Clemens, T.L.; Williams, B.O. Essential role of beta-catenin in postnatal bone acquisition. J. Biol. Chem. 2005, 280, 21162-21168.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 21162-21168
-
-
Holmen, S.L.1
Zylstra, C.R.2
Mukherjee, A.3
Sigler, R.E.4
Faugere, M.C.5
Bouxsein, M.L.6
Deng, L.7
Clemens, T.L.8
Williams, B.O.9
-
225
-
-
78649723963
-
Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
-
Heiland, G.R.; Zwerina, K.; Baum, W.; Kireva, T.; Distler, J.H.; Grisanti, M.; Asuncion, F.; Li, X.; Ominsky, M.; Richards, W.; Schett, G.; Zwerina, J. Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression. Ann. Rheum Dis. 2010, 69, 2152-2159.
-
(2010)
Ann. Rheum Dis
, vol.69
, pp. 2152-2159
-
-
Heiland, G.R.1
Zwerina, K.2
Baum, W.3
Kireva, T.4
Distler, J.H.5
Grisanti, M.6
Asuncion, F.7
Li, X.8
Ominsky, M.9
Richards, W.10
Schett, G.11
Zwerina, J.12
-
226
-
-
77950287628
-
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
-
Wang, Y.; Krivtsov, A.V.; Sinha, A.U.; North, T.E.; Goessling, W.; Feng, Z.; Zon, L.I.; Armstrong, S.A. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science 2010, 327, 1650-1653.
-
(2010)
Science
, vol.327
, pp. 1650-1653
-
-
Wang, Y.1
Krivtsov, A.V.2
Sinha, A.U.3
North, T.E.4
Goessling, W.5
Feng, Z.6
Zon, L.I.7
Armstrong, S.A.8
-
227
-
-
34248674146
-
Wnt/beta-catenin signaling in liver health and disease
-
Thompson, M.D.; Monga, S.P. Wnt/beta-catenin signaling in liver health and disease. Hepatology 2007, 45, 1298-1305.
-
(2007)
Hepatology
, vol.45
, pp. 1298-1305
-
-
Thompson, M.D.1
Monga, S.P.2
-
228
-
-
73949153978
-
Wnt modulators in the biotech pipeline
-
Rey, J.P.; Ellies, D.L. Wnt modulators in the biotech pipeline. Dev. Dyn. 2010, 239, 102-114.
-
(2010)
Dev. Dyn
, vol.239
, pp. 102-114
-
-
Rey, J.P.1
Ellies, D.L.2
|