Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells

Cancer Research

Volumn 64, Issue 24, 2004, Pages 8860-8866

  Verras, Meletios ^a   Brown, Jeffrey ^a   Li, Xiaomeng ^a   Nusse, Roel ^a   Sun, Zijie ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; BETA CATENIN; CYTOPLASM PROTEIN; GROWTH FACTOR; NUCLEAR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CARCINOGENESIS; CELL GROWTH; CELL LEVEL; CELL STRAIN LNCAP; CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO DEVELOPMENT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN PROSTATE CANCER CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN CONTENT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANDROGENS; BETA CATENIN; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL NUCLEUS; CYTOSKELETAL PROTEINS; CYTOSOL; HUMANS; LIGANDS; MALE; PROSTATIC NEOPLASMS; PROTEINS; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR STEM CELLS; WNT PROTEINS;

EID: 10844230334     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2370     Document Type: Article

References (45)

1. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1999. CA Cancer J Clin 1999;49:8-31.
2. Gelmann EP. Molecular biology of the androgen receptor. J Clin Oncol 2002;20:3001-15.
3. Balk SP. Androgen receptor as a target in androgen-independent prostate cancer. Urology 2002;60:132-8; discussion, 138-9.
4. Kyprianou N, Isaacs JT. Activation of programmed cell death in the rat ventral prostate after castration. Endocrinology 1988;122:552-62.
5. Jenster G. The role of the androgen receptor in the development and progression of prostate cancer. Semin Oncol 1999;26:407-21.
6. Chesire DR, Isaacs WB. Beta-catenin signaling in prostate cancer: an early perspective. Endocr Relat Cancer 2003;10:537-60.
7. Povelones M, Nusse R. Wnt signalling sees spots. Nat Cell Biol 2002;4:E249-50.
8. Nusse R. Wnts and hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development (Camb) 2003;130:5297-305.
9. Pandur P, Maurus D, Kuhl M. Increasingly complex: new players enter the Wnt signaling network. Bioessays 2002;24:881-4.
10. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997;16:3797-804.
11. Molenaar M, van de Wetering M, Oosterwegel M, et al. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 1996;86:391-9.
12. Behrens J, von Kries JP, Kuhl M, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (Lond) 1996;382:638-42.
13. Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51.
14. Morin PJ. Beta-catenin signaling and cancer. Bioessays 1999;21:1021-30.
15. Korinek V, Barker N, Morin PJ, et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (Wash DC) 1997;275:1784-7.
16. Chesire DR, Ewing CM, Sauvageot J, Bova GS, Isaacs WB. Detection and analysis of beta-catenin mutations in prostate cancer. Prostate 2000;45:323-34.
17. Voeller HJ, Truica CI, Gelmann HP. Beta-catenin mutations in human prostate cancer. Cancer Res 1998;58:2520-3.
18. Sasaki CY, Lin H, Morin PJ, Longo DL. Truncation of the extracellular region abrogates cell contact but retains the growth-suppressive activity of E-cadherin. Cancer Res 2000;60:7057-65.
19. Yang F, Li X, Sharma M, et al. Linking beta-catenin to androgen signaling pathway. J Biol Chem 2002;277:11336-44.
20. Truica CI, Byers S, Gelmann EP. Beta-catenin affects androgen receptor transcriptional activity and ligand specificity. Cancer Res 2000;60:4709-13.
21. Mulholland DJ, Cheng H, Reid K, Rennie PS, Nelson CC. The androgen receptor can promote beta-catenin nuclear translocation independently of APC. J Biol Chem 2002;277:17933-43.
22. Nusse R, Brown A, Papkoff J, et al. A new nomenclature for int-1 and related genes: the Wnt gene family. Cell 1991;64:231.
23. Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 1982;31:99-109.
24. Shibamoto S, Higano K, Takada R, et al. Cytoskeletal reorganization by soluble Wnt-3a protein signalling. Genes Cells 1998;3:659-70.
25. Cleutjens KB, van Eekelen CC, van der Korput HA, Brinkman AO, Trapman J. Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specfic antigen promoter. J Biol Chem 1996;271:6379-88.
26. Sui G, Soohoo C, Affar el B, et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA 2002;99:5515-20.
27. Sharma M, Chuang WW, Sun Z. Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation. J Biol Chem 2002;277:30935-41.
28. Sharma M, Li X, Wang Y, et al. hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. EMBO J 2003;22:6101-14.
29. Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (Lond) 2003;423:448-52.
30. Pang S, Dannull J, Kaboo R, et al. Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen. Cancer Res 1997;57:495-9.
31. Mulholland DJ, Read JT, Rennie PS, Cox ME, Nelson CC. Functional localization and competition between, the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis. Oncogene 2003;22:5602-13.
32. Chesire DR, Isaacs WB. Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor. Oncogene 2002;21:8453-69.
33. Reinacher-Schick A, Gumbiner BM. Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. J Cell Biol 2001;152:491-502.
34. Hlsken J, Behrens J. The Wnt signalling pathway. J Cell Sci 2000;113:3545.
35. Willert J, Epping M, Pollack JR, Brown PO, Nusse R. A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol 2002;2:8.
36. Suzuki H, Sato N, Watabe Y, et al. Androgen, receptor gene mutations in human prostate cancer. J Steroid Biochem Mol Biol 1993;46:759-65.
37. Taplin ME, Bubley GJ, Shuster TD, et al. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 1995;332:1393-8.
38. Gaddipati JP, McLeod DG, Heidenberg HB, et al. Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. Cancer Res 1994;54:2861-4.
39. Ruizeveld de Winter JA, Janssen PJ, Sleddens HM. et al. Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer. Am J Pathol 1994;144:735-46.
40. Moilanen AM, Karvonen U, Poukka H, Janne OA, Palvimo JJ. Activation of androgen receptor function by a novel nuclear protein kinase. Mol Biol Cell 1998;9:2527-43.
41. Nazareth LV, Weigel NL. Activation of the human androgen receptor through a protein kinase A signaling pathway. J Biol Chem 1996;271:19900-7.
42. Fu M, Wang C, Reutens AT, et al. p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. J Biol Chem 2000;275:20853-60.
43. Nishida T, Yasuda H. PIASI and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. J Biol Chem 2002;277:41311-7.
44. Wen Y, Hu MC, Makino K, et al. HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Res 2000;60:6841-5.
45. Cabeza-Arvelaiz Y, Thompson TC, Sepulveda JL, Chinault AC. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. Oncogene 2001;20:6707-17.