The expression of p120ctn protein in breast cancer is independent of α- and β-catenin and E-cadherin

American Journal of Pathology

Volumn 152, Issue 1, 1998, Pages 75-82

  Dillon, Deborah A ^a   D'Aquila, Tom ^a   Reynolds, Albert B ^b   Fearon, Eric R ^c   Rimm, David L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; BETA CATENIN; CADHERIN; CATENIN; UVOMORULIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CELL NUCLEUS; CELLULAR DISTRIBUTION; COLON POLYP; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ADULT; AGED; AGED, 80 AND OVER; ALPHA CATENIN; BETA CATENIN; BREAST NEOPLASMS; CADHERINS; CARCINOMA, DUCTAL, BREAST; CELL ADHESION MOLECULES; COHORT STUDIES; CYTOSKELETAL PROTEINS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MIDDLE AGED; NEOPLASM INVASIVENESS; PHOSPHOPROTEINS; TRANS-ACTIVATORS;

EID: 0031964167     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Takeichi M: Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995, 7:619-627
2. Cowin P, Burke B: Cytoskeletal membrane interactions. Curr Opin Cell Biol 1996, 8:56-65
3. Gamallo C, Palacios J, Suarez A, Pizarro A, Navarro P, Quintanilla M, Cano A: Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 1993, 142:987-992
4. Moll R, Mitze M, Frixen UH, Birchmeier W: Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol 1993, 143:1731-1742
5. Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T, Takatsuka Y, Matsuyoshi N, Hirano S, Takeichi M, Mori T: Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 1993, 53:1696-1701
6. Siitonen SM, Kononen JT, Helin HJ, Rantala IS, Holli KA, Isola JJ: Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer. Am J Clin Pathol 1996, 105:394-402
7. Hiscox S, Jiang WG: Expression Of E-cadherin, alpha, beta and gamma-catenin in human colorectal cancer. Anticancer Res 1997, 17:1349-1354
8. Kanal Y, Oda T, Tsuda H, Ochiai A, Hirohashi S: Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast. Jpn J Cancer Res 1994, 85:1035-1039
9. Berx G, Cletonjansen AM, Strumane K, Deleeuw W, Nollet F, Vanroy F, Cornelisse C: E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 1996, 13:1919-1925
10. Candidus S, Bischoff P, Becker KF, Hofler H: No evidence for mutations in the alpha- and beta-catenin genes in human gastric and breast carcinomas. Cancer Res 1996, 56:49-52
11. Ochiai A, Akimoto S, Shimoyama Y, Nagafuchi A, Tsukita S, Hirohashi S: Frequent loss of alpha catenin expression in scirrhous carcinomas with scattered cell growth. Jpn J Cancer Res 1994, 85:266-273
12. Rimm DL, Sinard JH, Morrow JS: Reduced alpha-catenin and E-cadherin expression in breast cancer. Lab Invest 1995, 72:506-512
13. Zschiesche W, Schonborn I, Behrens J, Herrenknecht K, Hartveit F, Lilleng P, Birchmeier W: Expression Of E-cadherin and catenins in invasive mammary carcinomas. Anticancer Res 1997, 17:561-567
14. Pierceall WE, Woodard AS, Morrow JS, Rimm D, Fearon ER: Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines. Oncogene 1995, 11:1319-1326
15. Hashizume R, Koizumi H, Ihara A, Ohta T, Uchikoshi T: Expression of beta-catenin in normal breast tissue and breast carcinoma: a comparative study with epithelial cadherin and alpha-catenin. Histopathology 1996, 29:139-146
16. Gamallo C, Palacios J, Benito N, Limeres MA, Pizarro A, Suarez A, Pastrana F, Cano A, Calero F: Expression of E-cadherin in 230 infiltrating ductal breast carcinomas: relationship to clinicopathological features. Int J Oncol 1996, 9:1207-1212
17. Kawahara F, Noguchi M, Yagasaki R, Minami M, Earashi M, Kinoshita K, Ohta N, Taniya T, Miyazaki I: The expression of E-cadherin as a prognostic factor in breast cancer. Oncology Rep 1997, 4:401-405
18. Reynolds AB, Kanner SB, Wang HC, Parsons JT: Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins. Mol Cell Biol 1989, 9:3951-3958
19. Downing JR, Reynolds AB: PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate Oncogene 1991, 6:607-613
20. Kanner SB, Reynolds AB, Parsons JT: Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Mol Cell Biol 1991, 11:713-720
21. Reynolds AB, Daniel J, McCrea PD, Wheelock MJ, Wu J, Zhang Z: Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol 1994, 14:8333-8342
22. Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M: Association of p 120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol 1995, 128:949-957
23. Staddon JM, Smales C, Schulze C, Esch FS, Rubin LL: p120, a p120-related protein (p100), and the cadherin/catenin complex. J Cell Biol 1995, 130:369-381
24. Peifer M, Berg S, Reynolds AB: A repeating amino acid motif shared by proteins with diverse cellular roles. Cell 1994, 76:789-791
25. Daniel JM, Reynolds AB: The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol Cell Biol 1995, 15:4819-4824
26. Kinch MS, Clark GJ, Der CJ, Burridge K: Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol 1995, 130:461-471
27. Behrens J: The role of cell adhesion molecules in cancer invasion and metastasis. Breast Cancer Res Treat 1993, 24:175-84
28. Benzeev A: Cytoskeletal and adhesion proteins as tumor suppressors. Curr Opin Cell Biol 1997, 9:99-108
29. Sommers CL, Gelmann EP, Kemler R, Cowin P, Byers SW: Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells. Cancer Res 1994, 54:3544-3552
30. Mo Y-Y, Reynolds A: Identification of murine p120cas (CAS) isoforms and heterogeneous expression of CAS isoforms in human tumor cell lines. Cancer Res 1996, 56:2633-2640
31. Nollet F, Berx G, Molemans F, Vanroy F: Genomic organization of the human beta-catenin gene (ctnnb1). Genomics 1996, 32:413-424
32. Rimm DL, Kebriaei P, Morrow JS: Molecular cloning reveals alternative splicing of human α(E)-catenin. Biochem Biophys Res Commun 1994, 203:1691-1699
33. Donegan W: Tumor-related prognostic factors for breast cancer. CA Cancer J Clin 1997, 47:28-51
34. Norton A, Jordan S, Yeomans P: Brief high-temperature heat denaturation (pressure cooking): a simple and effective method of antigen retrieval for routinely processed specimens. J Pathol 1994, 173:371-379
35. Jiang WG: E-cadherin and its associated protein catenins, cancer invasion and metastasis. Br J Surg 1996, 83:437-446
36. Valizadeh A, Karayiannakis A, El-Hairiy I, Kmiot W, Pignatelli M: Expression of E-cadherin-associated molecules (α-, β-, and γ-catenins and p 120) in colorectal polyps. Am J Pathol 1997, 150: 1977-1984
37. Peifer M: Cancer beta-catenin as oncogene: the smoking gun. Science 1997, 275:1752-1753
38. Skoudy A, Gomez S, Fabre M, Deherreros AG: P120-catenin expression in human colorectal cancer. Int J Cancer 1996, 68:14-20
39. Shimazui T, Schalken JA, Giroldi LA, Jansen C, Akaza H, Koiso K, Debruyne F, Bringuier PP: Prognostic value of cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120(cas)) in bladder tumors. Cancer Res 1996, 56:4154-4158
40. Papkoff J: Regulation of complexed and free catenin pools by distinct mechanisms: differential effects of wnt-1 and v-src. J Biol Chem 1997, 272:4536-4543