Identification of a cell of origin for human prostate cancer

Science

Volumn 329, Issue 5991, 2010, Pages 568-571

  Goldstein, Andrew S ^a   Huang, Jiaoti ^a,b   Guo, Changyong ^a,b   Garraway, Isla P ^a,b   Witte, Owen N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; PROSTATE SPECIFIC ANTIGEN;

ANTIGEN; BIOCHEMISTRY; CANCER; CYTOLOGY; DISEASE INCIDENCE; ENZYME ACTIVITY; HISTOLOGY; PUBLIC HEALTH;

ARTICLE; BASAL CELL; HISTOPATHOLOGY; IMMUNE DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY;

ANIMALS; CELL SEPARATION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; EPITHELIUM; FLOW CYTOMETRY; HUMANS; KERATINS; MALE; MICE; MICE, INBRED NOD; MICE, SCID; PROSTATE; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANDROGEN; TRANS-ACTIVATORS; TRANSDUCTION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

MUS;

EID: 77955121375     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1189992     Document Type: Article

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32. We thank B. Anderson for manuscript preparation; D. Cheng for cell sorting; Y. Zong for vectors; H. Zhang for tissue preparation; and A. Chhabra, B. Van Handel, D. Mulholland, C. Soroudi, and T. Stoyanova for discussion and technical help. A.S.G. is supported by an institutional Ruth L. Kirschstein National Research Service Award (GM07185). J.H. is supported by the American Cancer Society, the Department of Defense (DOD) Prostate Cancer Research Program, and the UCLA SPORE in Prostate Cancer (principal investigator, R. Reiter). I.P.G is supported by the DOD and the Jean Perkins Foundation. O.N.W. is an Investigator of the Howard Hughes Medical Institute. J.H., I.P.G., and O.N.W. are supported by a Challenge Award from the Prostate Cancer Foundation.