A second canon: Functions and mechanisms of β-catenin-independent Wnt signaling

Developmental Cell

Volumn 5, Issue 3, 2003, Pages 367-377

  Veeman, Michael T ^a   Axelrod, Jeffrey D ^b   Moon, Randall T ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CALCIUM; GUANOSINE TRIPHOSPHATASE; RHO FACTOR; WNT PROTEIN;

CALCIUM SIGNALING; CANONICAL ANALYSIS; CELL MOTION; CELL POLARITY; CONVERGENT EVOLUTION; DROSOPHILA; GASTRULATION; GENE OVEREXPRESSION; HEART DEVELOPMENT; MORPHOGENESIS; MUSCLE DEVELOPMENT; NERVE CELL DIFFERENTIATION; NONHUMAN; OVARY DEVELOPMENT; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

ANIMALS; BETA CATENIN; CALCIUM; CYTOSKELETAL PROTEINS; DROSOPHILA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; WNT PROTEINS; ZEBRAFISH PROTEINS;

VERTEBRATA;

EID: 0041695485     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(03)00266-1     Document Type: Review

References (94)

1. Adler P.N. Planar signaling and morphogenesis in Drosophila Dev. Cell 2 2002 525-535
2. Adler P.N. Lee H. Frizzled signaling and cell-cell interactions in planar polarity Curr. Opin. Cell Biol. 13 2001 635-640
3. Anakwe K. Robson L. Hadley J. Buxton P. Church V. Allen S. Hartmann C. Harfe B. Nohno T. Brown A.M. et al. Wnt signalling regulates myogenic differentiation in the developing avian wing Development 130 2003 3503-3514
4. Axelrod J.D. Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling Genes Dev. 15 2001 1182-1187
5. Axelrod J.D. McNeill H. Coupling planar cell polarity signaling to morphogenesis ScientificWorldJournal 2 2002 434-454
6. Axelrod J.D. Miller J.R. Shulman J.M. Moon R.T. Perrimon N. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways Genes Dev. 12 1998 2610-2622
7. Bastock R. Strutt H. Strutt D. Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning Development 130 2003 3007-3014
8. Bhanot P. Fish M. Jemison J.A. Nusse R. Nathans J. Cadigan K.M. Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development Development 126 1999 4175-4186
9. Bilder D. Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble Nature 403 2000 676-680
10. Boutros M. Paricio N. Strutt D.I. Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and Wingless signaling Cell 94 1998 109-118
11. Carreira-Barbosa F. Concha M.L. Takeuchi M. Ueno N. Wilson S.W. Tada M. Prickle1 regulates cell movements during gastrulation and neuronal migration in zebrafish Development 130 2003 4037-4046
12. 2+ signaling pathway Dev. Biol. 244 2002 342-357
13. Cohen E.D. Mariol M.C. Wallace R.M. Weyers J. Kamberov Y.G. Pradel J. Wilder E.L. DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis Dev. Cell 2 2002 437-448
14. Curtin J.A. Quint E. Tsipouri V. Arkell R.M. Cattanach B. Copp A.J. Henderson D.J. Spurr N. Stanier P. Fisher E.M. et al. Mutation of celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse Curr. Biol. 13 2003 1129-1133
15. Dabdoub A. Donohue M.J. Brennan A. Wolf V. Montcouquiol M. Sassoon D.A. Hseih J.C. Rubin J.S. Salinas P.C. Kelley M.W. Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea Development 130 2003 2375-2384
16. Darken R.S. Scola A.M. Rakeman A.S. Das G. Mlodzik M. Wilson P.A. The planar polarity gene strabismus regulates convergent extension movements in Xenopus EMBO J. 21 2002 976-985
17. Dejmek J. Dib K. Jonsson M. Andersson T. Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion Int. J. Cancer 103 2003 344-351
18. Djiane A. Riou J. Umbhauer M. Boucaut J. Shi D. Role of Frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis Development 127 2000 3091-3100
19. Du S.J. Purcell S.M. Christian J.L. McGrew L.L. Moon R.T. Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos Mol. Cell. Biol. 15 1995 2625-2634
20. Eaton S. Wepf R. Simons K. Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila J. Cell Biol. 135 1996 1277-1289
21. Eisenberg C.A. Eisenberg L.M. WNT11 promotes cardiac tissue formation of early mesoderm Dev. Dyn. 216 1999 45-58
22. Elul T. Keller R. Monopolar protrusive activity: a new morphogenic cell behavior in the neural plate dependent on vertical interactions with the mesoderm in Xenopus Dev. Biol. 224 2000 3-19
23. Feiguin F. Hannus M. Mlodzik M. Eaton S. The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization Dev. Cell 1 2001 93-101
24. Goto T. Keller R. The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus Dev. Biol. 247 2002 165-181
25. Habas R. Kato Y. He X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 Cell 107 2001 843-854
26. Habas R. Dawid I.B. He X. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation Genes Dev. 17 2003 295-309
27. Hall A.C. Lucas F.R. Salinas P.C. Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling Cell 100 2000 525-535
28. He X. Saint-Jeannet J.P. Wang Y. Nathans J. Dawid I. Varmus H. A member of the Frizzled protein family mediating axis induction by Wnt-5A Science 275 1997 1652-1654
29. Heisenberg C.P. Tada M. Rauch G.J. Saude L. Concha M.L. Geisler R. Stemple D.L. Smith J.C. Wilson S.W. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation Nature 405 2000 76-81
30. Huelsken J. Behrens J. The Wnt signalling pathway J. Cell Sci. 115 2002 3977-3978
31. Ishitani T. Ninomiya-Tsuji J. Nagai S. Nishita M. Meneghini M. Barker N. Waterman M. Bowerman B. Clevers H. Shibuya H. Matsumoto K. The TAK1-NLK-MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF Nature 399 1999 798-802
32. 2+ pathway to antagonize Wnt/β-catenin signaling Mol. Cell. Biol. 23 2003 131-139
33. Jessen J.R. Topczewski J. Bingham S. Sepich D.S. Marlow F. Chandrasekhar A. Solnica-Krezel L. Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements Nat. Cell Biol. 4 2002 610-615
34. Keller R. Shaping the vertebrate body plan by polarized embryonic cell movements Science 298 2002 1950-1954
35. Kibar Z. Vogan K.J. Groulx N. Justice M.J. Underhill D.A. Gros P. Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail Nat. Genet. 28 2001 251-255
36. Kilian B. Mansukoski H. Barbosa F.C. Ulrich F. Tada M. Heisenberg C.P. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation Mech. Dev. 120 2003 467-476
37. Kinoshita N. Iioka H. Miyakoshi A. Ueno N. PKCδ is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements Genes Dev. 17 2003 1663-1676
38. Krylova O. Herreros J. Cleverley K.E. Ehler E. Henriquez J.P. Hughes S.M. Salinas P.C. WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons Neuron 35 2002 1043-1056
39. 2+/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus J. Biol. Chem. 275 2000a 12701-12711
40. 2+ pathway: a new vertebrate Wnt signaling pathway takes shape Trends Genet. 16 2000b 279-283
41. Li L. Yuan H. Xie W. Mao J. Caruso A.M. McMahon A. Sussman D.J. Wu D. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells J. Biol. Chem. 274 1999 129-134
42. Marlow F. Topczewski J. Sepich D. Solnica-Krezel L. Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements Curr. Biol. 12 2002 876-884
43. Medina A. Reintsch W. Steinbeisser H. Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis Mech. Dev. 92 2000 227-237
44. 2+ pathways Oncogene 18 1999 7860-7872
45. Mlodzik M. Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet. 18 2002 564-571
46. Montcouquiol M. Rachel R.A. Lanford P.J. Copeland N.G. Jenkins N.A. Kelley M.W. Identification of Vangl2 and Scrb1 as planar polarity genes in mammals Nature 423 2003 173-177
47. Moon R.T. Campbell R.M. Christian J.L. McGrew L.L. Shih J. Fraser S. Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis Development 119 1993 97-111
48. Moriguchi T. Kawachi K. Kamakura S. Masuyama N. Yamanaka H. Matsumoto K. Kikuchi A. Nishida E. Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates J. Biol. Chem. 274 1999 30957-30962
49. Murphy L.L. Hughes C.C. Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 β pathway J. Immunol. 169 2002 3717-3725
50. Myers D.C. Sepich D.S. Solnica-Krezel L. BMP activity gradient regulates convergent extension during zebrafish gastrulation Dev. Biol. 243 2002a 81-98
51. Myers D.C. Sepich D.S. Solnica-Krezel L. Convergence and extension in vertebrate gastrulae: cell movements according to or in search of identity? Trends Genet. 18 2002b 447-455
52. Oishi I. Suzuki H. Onishi N. Takada R. Kani S. Ohkawara B. Koshida I. Suzuki K. Yamada G. Schwabe G.C. et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway Genes Cells 8 2003 645-654
53. Olson D.J. Gibo D.M. Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial cell transformation Exp. Cell Res. 241 1998 134-141
54. Pandur P. Lasche M. Eisenberg L.M. Kühl M. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis Nature 418 2002 636-641
55. Park M. Moon R.T. The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos Nat. Cell Biol. 4 2002 20-25
56. βγ signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation Dev. Biol. 257 2003 302-314
57. Rauch G.J. Hammerschmidt M. Blader P. Schauerte H.E. Strahle U. Ingham P.W. McMahon A.P. Haffter P. Wnt5 is required for tail formation in the zebrafish embryo Cold Spring Harb. Symp. Quant. Biol. 62 1997 227-234
58. Rothbacher U. Laurent M.N. Deardorff M.A. Klein P.S. Cho K.W. Fraser S.E. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis EMBO J. 19 2000 1010-1022
59. Saneyoshi T. Kume S. Amasaki Y. Mikoshiba K. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos Nature 417 2002 295-299
60. Schneider V.A. Mercola M. Wnt antagonism initiates cardiogenesis in Xenopus laevis Genes Dev. 15 2001 304-315
61. Sheldahl L.C. Park M. Malbon C.C. Moon R.T. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner Curr. Biol. 9 1999 695-698
62. 2+ flux, PKC, and CamKII in vertebrate embryos J. Cell Biol. 161 2003 769-777
63. Shulman J.M. Perrimon N. Axelrod J.D. Frizzled signaling and the developmental control of cell polarity Trends Genet. 14 1998 452-458
64. Slack J.M. Isaacs H.V. Song J. Durbin L. Pownall M.E. The role of fibroblast growth factors in early Xenopus development Biochem. Soc. Symp. 62 1996 1-12
65. Slusarski D.C. Corces V.G. Moon R.T. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling Nature 390 1997a 410-413
66. 2+ signaling by Wnt-5A Dev. Biol. 182 1997b 114-120
67. Smith W.C. McKendry R. Ribisi S.Jr. Harland R.M. A nodal-related gene defines a physical and functional domain within the Spemann organizer Cell 82 1995 37-46
68. Song B.H. Choi S.C. Han J.K. Local activation of protein kinase A inhibits morphogenetic movements during Xenopus gastrulation Dev. Dyn. 227 2003 91-103
69. Strutt D.I. Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing Mol. Cell 7 2001 367-375
70. Strutt D.I. Weber U. Mlodzik M. The role of RhoA in tissue polarity and Frizzled signalling Nature 387 1997 292-295
71. Sumanas S. Kim H.J. Hermanson S. Ekker S.C. Zebrafish frizzled-2 morphant displays defects in body axis elongation Genesis 30 2001 114-118
72. Tada M. Smith J.C. Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway Development 127 2000 2227-2238
73. Takeuchi M. Nakabayashi J. Sakaguchi T. Yamamoto T.S. Takahashi H. Takeda H. Ueno N. The prickle-related gene in vertebrates is essential for gastrulation cell movements Curr. Biol. 13 2003 674-679
74. Tamai K. Semenov M. Kato Y. Spokony R. Liu C. Katsuyama Y. Hess F. Saint-Jeannet J.P. He X. LDL-receptor-related proteins in Wnt signal transduction Nature 407 2000 530-535
75. Topczewski J. Sepich D.S. Myers D.C. Walker C. Amores A. Lele Z. Hammerschmidt M. Postlethwait J. Solnica-Krezel L. The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension Dev. Cell 1 2001 251-264
76. Topol L. Jiang X. Choi H. Garrett-Beal L. Carolan P. Yang Y. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3 independent β-catenin degradation J. Cell Biol. 162 2003 899-908
77. Torres M.A. Yang-Snyder J.A. Purcell S.M. DeMarais A.A. McGrew L.L. Moon R.T. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development J. Cell Biol. 133 1996 1123-1137
78. Tree D.R. Shulman J.M. Rousset R. Scott M.P. Gubb D. Axelrod J.D. Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling Cell 109 2002 371-381
79. Usui T. Shima Y. Shimada Y. Hirano S. Burgess R.W. Schwarz T.L. Takeichi M. Uemura T. Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled Cell 98 1999 585-595
80. Veeman M.T. Slusarski D.C. Kaykas A. Louie S.H. Moon R.T. Zebrafish Prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements Curr. Biol. 13 2003 680-685
81. Wallingford J.B. Rowning B.A. Vogeli K.M. Rothbacher U. Fraser S.E. Harland R.M. Dishevelled controls cell polarity during Xenopus gastrulation Nature 405 2000 81-85
82. Wallingford J.B. Ewald A.J. Harland R.M. Fraser S.E. Calcium signaling during convergent extension in Xenopus Curr. Biol. 11 2001 652-661
83. Wallingford J.B. Fraser S.E. Harland R.M. Convergent extension: the molecular control of polarized cell movement during embryonic development Dev. Cell 2 2002 695-706
84. Wang H.Y. Malbon C.C. Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions Science 300 2003 1529-1530
85. Weber U. Paricio N. Mlodzik M. Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye Development 127 2000 3619-3629
86. Weeraratna A.T. Jiang Y. Hostetter G. Rosenblatt K. Duray P. Bittner M. Trent J.M. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma Cancer Cell 1 2002 279-288
87. Wehrli M. Dougan S.T. Caldwell K. O'Keefe L. Schwartz S. Vaizel-Ohayon D. Schejter E. Tomlinson A. DiNardo S. arrow encodes an LDL-receptor-related protein essential for Wingless signalling Nature 407 2000 527-530
88. Westfall T. Brimeyer R. Twedt J. Gladon A. Olberding A. Furutani-Seiki M. Slusarski D.C. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity J. Cell Biol. 162 2003 889-898
89. Winklbauer R. Medina A. Swain R.K. Steinbeisser H. Frizzled-7 signalling controls tissue separation during Xenopus gastrulation Nature 413 2001 856-860
90. Winter C.G. Wang B. Ballew A. Royou A. Karess R. Axelrod J.D. Luo L. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton Cell 105 2001 81-91
91. Yamanaka H. Moriguchi T. Masuyama N. Kusakabe M. Hanafusa H. Takada R. Takada S. Nishida E. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates EMBO Rep. 3 2002 69-75
92. Yamashita S. Miyagi C. Carmany-Rampey A. Shimizu T. Fujii R. Schier A.F. Hirano T. Stat3 controls cell movements during zebrafish gastrulation Dev. Cell 2 2002 363-375
93. Yoshikawa S. McKinnon R.D. Kokel M. Thomas J.B. Wnt-mediated axon guidance via the Drosophila Derailed receptor Nature 422 2003 583-588
94. Zhang Y. Neo S.Y. Wang X. Han J. Lin S.C. Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling J. Biol. Chem. 274 1999 35247-35254