Apoptotic regression of MCF-7 xenografts in nude mice treated with the vitamin D3 analog, EB1089

Endocrinology

Volumn 139, Issue 4, 1998, Pages 2102-2110

  Vanweelden, Kathryn ^a,b   Flanagan, Louise ^a,c   Binderup, Lise ^d   Tenniswood, Martin ^a   Welsh, JoEllen ^a  

^a Adirondack Biomedical Research Institute Inc   (United States)

^b CLARKSON UNIVERSITY   (United States)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d LEO PHARMA A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; SEOCALCITOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; SUSTAINED RELEASE PREPARATION; TUMOR REGRESSION; TUMOR XENOGRAFT;

EID: 0010958949     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.4.5892     Document Type: Article

References (22)

1. Nandi S, Guzman R, Yang J 1997 Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis. Proc Natl Acad Sci USA 92:3650-3657
2. Kardinal CG 1995 Endocrine therapy of breast cancer. In: Donegan WL, Spratt JS (eds) Cancer of the Breast, ed 4. Saunders, Philadelphia, pp 534-580
3. 3 inhibitory effect on the growth of two human breast cancer cell lines (MCF-7, BT-20). J Steroid Biochem 24:373-376
4. Colston K, Berger U, Coombes RC 1989 Possible role for vitamin D in controlling breast cancer cell proliferation. Lancet 1:188-191
5. 3 on cell cycle kinetics of T47D human breast cancer cells. J Cell Physiol 138:611-616
6. 3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cells. Cancer Res 55:2822-2830
7. 3 anaolgues in breast cancer cells. Cancer Res 56:2789-2794
8. 3 receptor in breast cancer and relationship to prognosis. Cancer Res 51:239-244
9. Welsh JE 1994 Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogens. Biochem Cell Biol 72:537-545
10. 3 in MCF-7 breast cancer cells. In: Norman AW, Bouillon R, Thomasett M (eds) Proceedings of the Ninth Workshop on Vitamin D. de Gruyter, Berlin, pp 526-527
11. 3 induce morphological and biochemical indices of apoptosis in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 58:367-337
12. 3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 cells. Breast Cancer Res Treat 42:31-41
13. 3 analogues: a novel class of potent inhibitors of proliferation and differentiation of human breast cancer cells. Cancer Res 55:2822-2830
14. 3 and its analogues on induction of apoptosis in breast cancer cells. J Steroid Biochem Mol Biol 58:395-401
15. 3, hypercalcemia, and growth suppression of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. Breast Cancer Res Treat 22:133-140
16. Colston K, Chander SK, Mackay AG, Coombes RC 1992 Effects of synthetic vitamin D analogs on breast cancer cell proliferation in vivo and in vitro. Biochem Pharmacol 44:693-702
17. 3 analogue that inhibits the growth of breast cancer cells in vivo and in vitro. Biochem Pharmacol 44:2273-2280
18. James SY, Mackay A, Binderup L, Colston K 1994 Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen responsive growth of human breast cancer cells. J Endocrinol 141:555-563
19. 3 and its analogs in breast cancer. In: Norman AW, Bouillon R, Thomasett M (eds) Proceedings of the Ninth Workshop on Vitamin D. de Gruyter, Berlin, pp 477-484
20. 3 derivatives and breast cancer. In: Tenniswood M, Michna H (eds) Apoptosis in Hormone Dependent Cancers. Springer Verlag, Berlin, pp 201-224
21. 3 resistant MCF-7 cell line. Endocrinology 137:400-409
22. Kyprianou N, English H, Davidson N, Isaacs J 1991 Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation. Cancer Res 51:162-166