메뉴 건너뛰기




Volumn 19, Issue 1, 2006, Pages 27-31

Wnt-1 signal as a potential cancer therapeutic target

Author keywords

[No Author keywords available]

Indexed keywords

FRIZZLED PROTEIN; MONOCLONAL ANTIBODY; PROTEIN INHIBITOR; PROTEIN WNT INHIBITORY FACTOR; UNCLASSIFIED DRUG; WNT1 PROTEIN;

EID: 33645411180     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2006.19.1.965871     Document Type: Review
Times cited : (30)

References (44)
  • 1
    • 0020216124 scopus 로고
    • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    • Nusse, R. and Varmus, H.E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 1982, 31: 99-109.
    • (1982) Cell , vol.31 , pp. 99-109
    • Nusse, R.1    Varmus, H.E.2
  • 2
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan, K.M. and Nusse, R. Wnt signaling: a common theme in animal development. Genes Dev 1997, 11: 3286-305.
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 3
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya, T., Duncan, A.W., Ailles, L. et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003, 423: 409-14.
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1    Duncan, A.W.2    Ailles, L.3
  • 4
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development
    • Wodarz, A. and Nusse, R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998, 14: 59-88.
    • (1998) Annu Rev Cell Dev Biol , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 5
    • 4344584730 scopus 로고    scopus 로고
    • WNT and beta-catenin signalling: Diseases and therapies
    • Moon, R.T., Kohn, A.D., De Ferrari, G.V. and Kaykas, A. WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet 2004, 5: 691-701.
    • (2004) Nat Rev Genet , vol.5 , pp. 691-701
    • Moon, R.T.1    Kohn, A.D.2    De Ferrari, G.V.3    Kaykas, A.4
  • 6
    • 2442694379 scopus 로고    scopus 로고
    • Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells
    • You, L., He, B., Uematsu, K. et al. Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells. Cancer Res 2004, 64: 3474-8.
    • (2004) Cancer Res , vol.64 , pp. 3474-3478
    • You, L.1    He, B.2    Uematsu, K.3
  • 7
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He, T.C., Sparks, A.B., Rago, C. et al. Identification of c-MYC as a target of the APC pathway. Science 1998, 281: 1509-12.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3
  • 8
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    • Veeman, M.T., Axelrod, J.D., and Moon, R.T. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 2003, 5: 367-77.
    • (2003) Dev Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 9
    • 0026060707 scopus 로고
    • A new nomenclature for int-1 and related genes: The Wnt gene family
    • Nusse, R., Brown, A., Papkoff, J. et al. A new nomenclature for int-1 and related genes: the Wnt gene family. Cell 1991, 64: 231.
    • (1991) Cell , vol.64 , pp. 231
    • Nusse, R.1    Brown, A.2    Papkoff, J.3
  • 10
    • 0023653232 scopus 로고
    • The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
    • Rijsewijk, F., Schuermann, M., Wagenaar, E., Parren, P., Weigel, D., and Nusse, R. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 1987, 50: 649-57.
    • (1987) Cell , vol.50 , pp. 649-657
    • Rijsewijk, F.1    Schuermann, M.2    Wagenaar, E.3    Parren, P.4    Weigel, D.5    Nusse, R.6
  • 11
    • 0021744029 scopus 로고
    • Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact
    • van Ooyen, A. and Nusse, R. Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact. Cell 1984, 39: 233-40.
    • (1984) Cell , vol.39 , pp. 233-240
    • Van Ooyen, A.1    Nusse, R.2
  • 12
    • 0022157944 scopus 로고
    • The nucleotide sequence of the human int-1 mammary oncogene: Evolutionary conservation of coding and non-coding sequences
    • van Ooyen, A., Kwee, V., and Nusse, R. The nucleotide sequence of the human int-1 mammary oncogene: evolutionary conservation of coding and non-coding sequences. EMBO J 1985, 4: 2905-9.
    • (1985) EMBO J , vol.4 , pp. 2905-2909
    • Van Ooyen, A.1    Kwee, V.2    Nusse, R.3
  • 13
    • 0022407950 scopus 로고
    • Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene
    • Fung, Y.K., Shackleford, G.M., Brown. A.M., Sanders, G.S., and Varmus, H.E. Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene. Mol Cell Biol 1985, 5: 3337-44.
    • (1985) Mol Cell Biol , vol.5 , pp. 3337-3344
    • Fung, Y.K.1    Shackleford, G.M.2    Brown, A.M.3    Sanders, G.S.4    Varmus, H.E.5
  • 15
    • 4043154959 scopus 로고    scopus 로고
    • Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine
    • Zhai, L., Chaturvedi, D., and Cumberledge, S. Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine. J Biol Chem 2004, 279: 33220-7.
    • (2004) J Biol Chem , vol.279 , pp. 33220-33227
    • Zhai, L.1    Chaturvedi, D.2    Cumberledge, S.3
  • 16
    • 0027359774 scopus 로고
    • Activity of Wnt-1 as a transmembrane protein
    • Parkin, N.T., Kitajewski, J., and Varmus, H.E. Activity of Wnt-1 as a transmembrane protein. Genes Dev 1993, 7: 2181-93.
    • (1993) Genes Dev , vol.7 , pp. 2181-2193
    • Parkin, N.T.1    Kitajewski, J.2    Varmus, H.E.3
  • 17
    • 0026565374 scopus 로고
    • The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells
    • Jue, S.F., Bradley, R.S., Rudnicki, J.A., Varmus, H.E., and Brown, A.M. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol Cell Biol 1992, 12: 321-8.
    • (1992) Mol Cell Biol , vol.12 , pp. 321-328
    • Jue, S.F.1    Bradley, R.S.2    Rudnicki, J.A.3    Varmus, H.E.4    Brown, A.M.5
  • 18
    • 0025188130 scopus 로고
    • The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
    • McMahon, A.P. and Bradley, A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 1990, 62: 1073-85.
    • (1990) Cell , vol.62 , pp. 1073-1085
    • McMahon, A.P.1    Bradley, A.2
  • 19
    • 0025074908 scopus 로고
    • Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
    • Thomas, K.R. and Capecchi, M.R. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 1990, 346: 847-50.
    • (1990) Nature , vol.346 , pp. 847-850
    • Thomas, K.R.1    Capecchi, M.R.2
  • 20
    • 0025696476 scopus 로고
    • Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development
    • Gavin, B.J., McMahon, J.A., and McMahon, A.P. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev, 4: 2319-2332, 1990.
    • (1990) Genes Dev , vol.4 , pp. 2319-2332
    • Gavin, B.J.1    McMahon, J.A.2    McMahon, A.P.3
  • 21
    • 0023623377 scopus 로고
    • Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos
    • Shackleford, G.M. and Varmus, H.E. Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. Cell, 50: 89-95, 1987.
    • (1987) Cell , vol.50 , pp. 89-95
    • Shackleford, G.M.1    Varmus, H.E.2
  • 22
    • 0022993326 scopus 로고
    • A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line
    • Brown, A.M., Wildin, R.S., Prendergast, T.J., and Varmus, H.E. A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell 1986, 46: 1001-9.
    • (1986) Cell , vol.46 , pp. 1001-1009
    • Brown, A.M.1    Wildin, R.S.2    Prendergast, T.J.3    Varmus, H.E.4
  • 24
    • 0037442760 scopus 로고    scopus 로고
    • Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis
    • Gunther, E.J., Moody, S.E., Belka, G.K. et al. Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev 2003, 17: 488-501.
    • (2003) Genes Dev , vol.17 , pp. 488-501
    • Gunther, E.J.1    Moody, S.E.2    Belka, G.K.3
  • 25
    • 18344377028 scopus 로고    scopus 로고
    • Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
    • He, B., Reguart, N., You, L. et al. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene 2005, 24: 3054-8.
    • (2005) Oncogene , vol.24 , pp. 3054-3058
    • He, B.1    Reguart, N.2    You, L.3
  • 26
    • 16444374026 scopus 로고    scopus 로고
    • Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia
    • Simon, M., Grandage, V.L., Linen, D.C., and Khwaja, A. Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. Oncogene 2005, 24: 2410-20.
    • (2005) Oncogene , vol.24 , pp. 2410-2420
    • Simon, M.1    Grandage, V.L.2    Linen, D.C.3    Khwaja, A.4
  • 27
    • 0036144406 scopus 로고    scopus 로고
    • Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells
    • Mizushima, T., Nakagawa, H., Kamberov, Y.G., Wilder, E.L., Klein, P.S., and Rustgi, A.K. Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Cancer Res 2002, 62: 277-82.
    • (2002) Cancer Res , vol.62 , pp. 277-282
    • Mizushima, T.1    Nakagawa, H.2    Kamberov, Y.G.3    Wilder, E.L.4    Klein, P.S.5    Rustgi, A.K.6
  • 28
    • 24744460574 scopus 로고    scopus 로고
    • Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma
    • Zhang, W.M., Lo Muzio, L., Rubini, C., and Van, G. Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma. Oncol Rep 2005, 13: 1095-9.
    • (2005) Oncol Rep , vol.13 , pp. 1095-1099
    • Zhang, W.M.1    Lo Muzio, L.2    Rubini, C.3    Van, G.4
  • 29
    • 4444326415 scopus 로고    scopus 로고
    • Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: Potential pathogenetic and prognostic implications
    • Chen, G. Shukeir, N., Potti, A., Sircar, K., Aprikian, A., Goltzman, D., and Rabbani, S.A. Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications. Cancer 2004, 101: 1345-56.
    • (2004) Cancer , vol.101 , pp. 1345-1356
    • Chen, G.1    Shukeir, N.2    Potti, A.3    Sircar, K.4    Aprikian, A.5    Goltzman, D.6    Rabbani, S.A.7
  • 30
    • 2542546650 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells
    • Cha, M.Y., Kim, C.M., Park, Y.M., and Ryu, W. S. Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatology 2004, 39: 1683-93.
    • (2004) Hepatology , vol.39 , pp. 1683-1693
    • Cha, M.Y.1    Kim, C.M.2    Park, Y.M.3    Ryu, W.S.4
  • 31
    • 17844372967 scopus 로고    scopus 로고
    • Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression
    • Fukutomi, T., Zhou, Y., Kawai, S., Eguchi, H., Wands, J.R., and Li, J. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology 2005, 41: 1096-105.
    • (2005) Hepatology , vol.41 , pp. 1096-1105
    • Fukutomi, T.1    Zhou, Y.2    Kawai, S.3    Eguchi, H.4    Wands, J.R.5    Li, J.6
  • 32
    • 0037179894 scopus 로고    scopus 로고
    • Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
    • Rhee, C.S., Sen, M., Lu, D. et al. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene 2002, 21: 6598-605.
    • (2002) Oncogene , vol.21 , pp. 6598-6605
    • Rhee, C.S.1    Sen, M.2    Lu, D.3
  • 33
    • 1642341682 scopus 로고    scopus 로고
    • A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
    • He, B., You, L., Uematsu, K. et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 2004, 6: 7-14.
    • (2004) Neoplasia , vol.6 , pp. 7-14
    • He, B.1    You, L.2    Uematsu, K.3
  • 34
    • 26844569797 scopus 로고    scopus 로고
    • Efficacy of Wnt-1 monoclonal antibody in sarcoma cells
    • Mikami, I., You, L., He, B. et al. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells. BMC Cancer 2005, 5: 53.
    • (2005) BMC Cancer , vol.5 , pp. 53
    • Mikami, I.1    You, L.2    He, B.3
  • 35
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
    • Suzuki, H., Watkins, D.N., Jair, K.W. et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004, 36: 417-22.
    • (2004) Nat Genet , vol.36 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.W.3
  • 36
    • 7944230668 scopus 로고    scopus 로고
    • An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
    • Bafico, A., Liu, G., Goldin, L., Harris, V., and Aaronson, S.A. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 2004, 6: 497-506.
    • (2004) Cancer Cell , vol.6 , pp. 497-506
    • Bafico, A.1    Liu, G.2    Goldin, L.3    Harris, V.4    Aaronson, S.A.5
  • 37
    • 20444397431 scopus 로고    scopus 로고
    • Identification of bronchioalveolar stem cells in normal lung and lung cancer
    • Kim, C.F., Jackson, E.L., Woolfenden, A.E. et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 2005, 121: 823-35.
    • (2005) Cell , vol.121 , pp. 823-835
    • Kim, C.F.1    Jackson, E.L.2    Woolfenden, A.E.3
  • 38
    • 0043092191 scopus 로고    scopus 로고
    • Wnt pathway activation in mesothelioma: Evidence of Dishevelled overexpression and transcriptional activity of beta-catenin
    • Uematsu, K., Kanazawa, S., You, L. et al. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Res 2003, 63: 4547-51.
    • (2003) Cancer Res , vol.63 , pp. 4547-4551
    • Uematsu, K.1    Kanazawa, S.2    You, L.3
  • 39
    • 0242551656 scopus 로고    scopus 로고
    • Activation of the Wnt pathway in non small cell lung cancer: Evidence of dishevelled overexpression
    • Uematsu, K., He, B., You, L., Xu, Z., McCormick, F., and Jablons, D.M. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene 2003, 22: 7218-21.
    • (2003) Oncogene , vol.22 , pp. 7218-7221
    • Uematsu, K.1    He, B.2    You, L.3    Xu, Z.4    McCormick, F.5    Jablons, D.M.6
  • 40
    • 0031436939 scopus 로고    scopus 로고
    • Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin
    • Porfiri, E., Rubinfeld, B., Albert, I., Hovanes, K., Waterman, M., and Polakis, P. Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. Oncogene 1997, 15: 2833-9.
    • (1997) Oncogene , vol.15 , pp. 2833-2839
    • Porfiri, E.1    Rubinfeld, B.2    Albert, I.3    Hovanes, K.4    Waterman, M.5    Polakis, P.6
  • 41
    • 0037193466 scopus 로고    scopus 로고
    • Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis
    • You, Z., Saims, D., Chen, S. et al. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol 2002, 157: 429-40.
    • (2002) J Cell Biol , vol.157 , pp. 429-440
    • You, Z.1    Saims, D.2    Chen, S.3
  • 42
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu, O. and McCormick, F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398: 422-6.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 43
    • 85047699343 scopus 로고    scopus 로고
    • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA
    • Shou, J., Ali-Osman, F., Multani, A.S., Pathak, S., Fedi, P., and Srivenugopal, K.S. Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene 2002, 21: 878-89.
    • (2002) Oncogene , vol.21 , pp. 878-889
    • Shou, J.1    Ali-Osman, F.2    Multani, A.S.3    Pathak, S.4    Fedi, P.5    Srivenugopal, K.S.6
  • 44
    • 4644302254 scopus 로고    scopus 로고
    • Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma
    • Lee, A.Y., He, B., You, L. et al. Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma. Biochem Biophys Res Commun 2004, 323: 1246-50.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 1246-1250
    • Lee, A.Y.1    He, B.2    You, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.