Somatic mutations of the APC gene in primary breast cancers

American Journal of Pathology

Volumn 156, Issue 6, 2000, Pages 1997-2005

  Furuuchi, Keiji ^a   Tada, Mitsuhiro ^a   Yamada, Hidehisa ^a   Kataoka, Akihiko ^a   Furuuchi, Narumi ^a   Hamada, Jun Ichi ^a   Takahashi, Masato ^a   Todo, Satoru ^a   Moriuchi, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ARTICLE; BREAST CARCINOMA; CANCER CLASSIFICATION; COLON POLYPOSIS; COLORECTAL CARCINOMA; GENE EXPRESSION; GENETIC SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

EID: 0033900369     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65072-9     Document Type: Article

References (30)

1. Identification and characterization of the familial adenomatous polyposis coli gene
2. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
3. Frequent somatic mutations of the APC gene in human pancreatic cancer
4. The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer
5. APC gene mutations in the mutation cluster region are rare in esophageal cancers
6. Truncating somatic mutation in exon 15 of the APC gene is a rare event in human breast carcinomas
7. ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias
8. Identification of FAP locus genes from chromosome 5q21
9. Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
10. Molecular diagnosis of familial adenomatous polyposis
11. Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test
12. Detection of APC mutations by a yeast-based protein truncation test (YPTT)
13. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors
14. Detection of heterozygous truncating mutations in the BRCA1 and APC genes by using a rapid screening assay in yeast
15. Screening patients for heterozygous p53 mutations using a functional assay in yeast
16. Multiple methods of visualizing the yeast vacuole permit evaluation of its morphology and inheritance during the cell cycle
17. High frequency of p53 mutations in human oral epithelial dysplasia and primary squamous cell carcinoma detected by yeast functional assay
18. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
19. APC gene: Database of germline and somatic mutations in human tumors and cell lines
20. Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer
21. Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas
22. Reduced expression of APC and DCC gene protein in breast cancer
23. Inhibition of nonsense-mediated messenger RNA decay in clinical samples facilitates detection of human MSH2 mutations with an in vivo fusion protein assay and conventional techniques
24. APC mutations occur early during colorectal tumorigenesis
25. Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium
26. Identification of c-MYC as a target of the APC pathway
27. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
28. Mutations of the APC (adenomatous polyposis coli) gene
29. Cancer statistics, 1993
30. Trends in cancer incidence and mortality