APC/CTNNB1 (β-catenin) pathway alterations in human prostate cancers

Genes Chromosomes and Cancer

Volumn 34, Issue 1, 2002, Pages 9-16

  Gerstein, Amy V ^a   Almeida, Teresa Acosta ^a   Zhao, Guojing ^a   Chess, Eric ^a   Shih, Ie Ming ^b   Buhler, Kent ^c   Pienta, Kenneth ^d   Rubin, Mark A ^d   Vessella, Robert ^c   Papadopoulos, Nickolas ^a,e  

^a Columbia University ^*  (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e GMP Genetics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

ARTICLE; CARCINOGENESIS; CELL LINE; CONTROLLED STUDY; DEGRADATION; GENE MUTATION; GENETIC STABILITY; HUMAN; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; XENOGRAFT;

ANIMALS; BETA CATENIN; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CYTOSKELETAL PROTEINS; DNA MUTATIONAL ANALYSIS; EXONS; GENES, APC; GTP-BINDING PROTEINS; HUMANS; MALE; MICE; MUTATION; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 18344363708     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10037     Document Type: Article

References (22)

1. Detection and analysis of beta-catenin mutations in prostate cancer
2. Five human genes encoding F-box proteins: Chromosome mapping and analysis in human tumors
3. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
4. Allelic loss of chromosome 18q and prognosis in colorectal cancer
5. Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb
6. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
7. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
8. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway tbrough an F-box motif
9. beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos
10. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
11. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
12. Molecular diagnosis of familial adenomatous polyposis
13. Parid ("warm") autopsy study for procurement of metastatic prostate cancer
14. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
15. Stabilization of beta-catenin by genetic defects in melanoma cell lines
16. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
17. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
18. State of adenomatous polyposis coli gene and ras oncogenes in Japanese prostate cancer
19. beta-Catenin mutations in human prostate cancer
20. APC gene mutations in human prostate cancer
21. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
22. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro