메뉴 건너뛰기




Volumn 107, Issue 8, 2010, Pages 3522-3527

Selective targeting of radiation-resistant tumor-initiating cells

Author keywords

Akt and Wnt signaling; DNA damage repair; p53 mouse model

Indexed keywords

BETA CATENIN; CELL SURFACE MARKER; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; SERINE; TENSIN; WNT PROTEIN;

EID: 77649257221     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910179107     Document Type: Article
Times cited : (180)

References (32)
  • 1
    • 67649939163 scopus 로고    scopus 로고
    • The increasing complexity of the cancer stem cell paradigm
    • Rosen JM, Jordan CT (2009) The increasing complexity of the cancer stem cell paradigm. Science 324:1670-1673.
    • (2009) Science , vol.324 , pp. 1670-1673
    • Rosen, J.M.1    Jordan, C.T.2
  • 2
    • 44049100934 scopus 로고    scopus 로고
    • Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
    • Li X, et al. (2008) Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 100:672-679.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 672-679
    • Li, X.1
  • 3
    • 59449089531 scopus 로고    scopus 로고
    • Wnt signalling in human breast cancer: Expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours
    • Veeck J, et al. (2008) Wnt signalling in human breast cancer: Expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours. Breast Cancer Res 10:R82.
    • (2008) Breast Cancer Res , vol.10
    • Veeck, J.1
  • 4
    • 0035941777 scopus 로고    scopus 로고
    • Oncogenic targets of beta-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis
    • Watson SA (2001) Oncogenic targets of beta-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis. Lancet 357:572-573.
    • (2001) Lancet , vol.357 , pp. 572-573
    • Watson, S.A.1
  • 5
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya T, et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423:409-414.
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1
  • 6
    • 30444455577 scopus 로고    scopus 로고
    • PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
    • Groszer M, et al. (2006) PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci USA 103:111-116.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 111-116
    • Groszer, M.1
  • 7
    • 33646351002 scopus 로고    scopus 로고
    • PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
    • Zhang J, et al. (2006) PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 441:518-522.
    • (2006) Nature , vol.441 , pp. 518-522
    • Zhang, J.1
  • 8
    • 18244391514 scopus 로고    scopus 로고
    • Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    • Southeast Sweden Breast Cancer Group
    • Pérez-Tenorio G, Stål O, Southeast Sweden Breast Cancer Group (2002) Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br J Cancer 86:540-545.
    • (2002) Br J Cancer , vol.86 , pp. 540-545
    • Pérez-Tenorio, G.1    Stål, O.2
  • 9
    • 65949086609 scopus 로고    scopus 로고
    • PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
    • Sos ML, et al. (2009) PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res 69:3256-3261.
    • (2009) Cancer Res , vol.69 , pp. 3256-3261
    • Sos, M.L.1
  • 10
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y, et al. (2004) PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6:117-127.
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1
  • 11
    • 31944448885 scopus 로고    scopus 로고
    • Pten deletion leads to the expansion of a prostatic stem/ progenitor cell subpopulation and tumor initiation
    • Wang S, et al. (2006) Pten deletion leads to the expansion of a prostatic stem/ progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci USA 103: 1480-1485.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1480-1485
    • Wang, S.1
  • 12
    • 67649969473 scopus 로고    scopus 로고
    • Korkaya H, et al. (2009) Regulation of mammary stem/progenitor cells by PTEN/Akt/ beta-catenin signaling. PLoS Biol 7:e1000121.
    • Korkaya H, et al. (2009) Regulation of mammary stem/progenitor cells by PTEN/Akt/ beta-catenin signaling. PLoS Biol 7:e1000121.
  • 13
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau AM, et al. (2009) PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4: 226-235.
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1
  • 14
    • 49649085001 scopus 로고    scopus 로고
    • Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    • Zhang M, et al. (2008) Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 68:4674-4682.
    • (2008) Cancer Res , vol.68 , pp. 4674-4682
    • Zhang, M.1
  • 15
    • 30144433093 scopus 로고    scopus 로고
    • Generation of a functional mammary gland from a single stem cell
    • Shackleton M, et al. (2006) Generation of a functional mammary gland from a single stem cell. Nature 439:84-88.
    • (2006) Nature , vol.439 , pp. 84-88
    • Shackleton, M.1
  • 17
    • 0036903037 scopus 로고    scopus 로고
    • DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
    • Fernandez-Capetillo O, et al. (2002) DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol 4:993-997.
    • (2002) Nat Cell Biol , vol.4 , pp. 993-997
    • Fernandez-Capetillo, O.1
  • 18
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M, et al. (2009) Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458:780-783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1
  • 19
    • 34547114987 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation
    • Kao GD, Jiang Z, Fernandes AM, Gupta AK, Maity A (2007) Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. J Biol Chem 282:21206-21212.
    • (2007) J Biol Chem , vol.282 , pp. 21206-21212
    • Kao, G.D.1    Jiang, Z.2    Fernandes, A.M.3    Gupta, A.K.4    Maity, A.5
  • 20
    • 33846600427 scopus 로고    scopus 로고
    • PTEN-deficient intestinal stem cells initiate intestinal polyposis
    • He XC, et al. (2007) PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 39:189-198.
    • (2007) Nat Genet , vol.39 , pp. 189-198
    • He, X.C.1
  • 21
    • 68549133582 scopus 로고    scopus 로고
    • Wnt signaling and stem cell control
    • Nusse R, et al. (2008) Wnt signaling and stem cell control. Cold Spring Harbor Symp Quant Biol 73:59-66.
    • (2008) Cold Spring Harbor Symp Quant Biol , vol.73 , pp. 59-66
    • Nusse, R.1
  • 22
    • 33846287519 scopus 로고    scopus 로고
    • WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    • Woodward WA, et al. (2007) WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci USA 104:618-623.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 618-623
    • Woodward, W.A.1
  • 23
    • 62549131134 scopus 로고    scopus 로고
    • Radiation resistance of breast cancer stem cells: Understanding the clinical framework
    • Debeb BG, Xu W, Woodward WA (2009) Radiation resistance of breast cancer stem cells: Understanding the clinical framework. J Mammary Gland Biol Neoplasia 14: 11-17.
    • (2009) J Mammary Gland Biol Neoplasia , vol.14 , pp. 11-17
    • Debeb, B.G.1    Xu, W.2    Woodward, W.A.3
  • 24
    • 33847369455 scopus 로고    scopus 로고
    • Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line
    • Chen MS, et al. (2007) Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J Cell Sci 120:468-477.
    • (2007) J Cell Sci , vol.120 , pp. 468-477
    • Chen, M.S.1
  • 25
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, et al. (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1
  • 26
    • 0038281227 scopus 로고    scopus 로고
    • Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002
    • Gupta AK, et al. (2003) Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. Int J Radiat Oncol Biol Phys 56:846-853.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 846-853
    • Gupta, A.K.1
  • 27
    • 34249304804 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir
    • Jiang Z, et al. (2007) Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir. Cancer Res 67:4467-4473.
    • (2007) Cancer Res , vol.67 , pp. 4467-4473
    • Jiang, Z.1
  • 28
    • 33746077733 scopus 로고    scopus 로고
    • Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells
    • de la Peña L, et al. (2006) Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells. Mol Cancer Ther 5:1504-1510.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1504-1510
    • de la Peña, L.1
  • 29
    • 70449515802 scopus 로고    scopus 로고
    • Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells
    • Li HF, Kim JS, Waldman T (2009) Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells. Radiat Oncol 4:43.
    • (2009) Radiat Oncol , vol.4 , pp. 43
    • Li, H.F.1    Kim, J.S.2    Waldman, T.3
  • 30
    • 71549161146 scopus 로고    scopus 로고
    • Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
    • Fu L, et al. (2009) Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res 69:8967-8976.
    • (2009) Cancer Res , vol.69 , pp. 8967-8976
    • Fu, L.1
  • 31
    • 0034696344 scopus 로고    scopus 로고
    • A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development
    • Jerry DJ, et al. (2000) A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development. Oncogene 19:1052-1058.
    • (2000) Oncogene , vol.19 , pp. 1052-1058
    • Jerry, D.J.1
  • 32
    • 0029677184 scopus 로고    scopus 로고
    • The mammary gland: A unique organ for the study of development and tumorigenesis
    • Medina D (1996) The mammary gland: A unique organ for the study of development and tumorigenesis. J Mammary Gland Biol Neoplasia 1:5-19.
    • (1996) J Mammary Gland Biol Neoplasia , vol.1 , pp. 5-19
    • Medina, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.