Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism

Cell

Volumn 108, Issue 6, 2002, Pages 837-847

  Liu, Chunming ^a   Li, Yiming ^a   Semenov, Mikhail ^a   Han, Chun ^b   Baeg, Gyeong Hun ^a   Tan, Yi ^c   Zhang, Zhuohua ^d   Lin, Xinhua ^b   He, Xi ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c CELL SIGNALING TECHNOLOGY   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; CASEIN KINASE I; GLYCOGEN SYNTHASE KINASE 3; ISOENZYME; PROTEIN SERINE THREONINE KINASE; WNT PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0037155691     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00685-2     Document Type: Article

References (67)

1. β-catenin is a target for the ubiquitin-proteasome pathway
2. Functional interaction of beta-catenin with the transcription factor LEF-1
3. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
4. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
5. The renaissance of GSK3
6. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
7. Crystal structure of glycogen synthase kinase 3 beta: Structural basis for phosphate-primed substrate specificity and autoinhibition
8. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling
9. Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos
10. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
11. Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification
12. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family
13. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
14. Casein kinase I phosphorylates and destabalizes the beta-catenin degradation complex
15. Casein kinase I: Spatial organization and positioning of a multifunctional protein kinase family
16. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
17. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
18. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
19. Regulation of GSK-3: A cellular multiprocessor
20. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
21. Activation of the Wnt signaling pathway: A molecular mechanism for lithium action
22. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
23. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
24. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin
25. Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction
26. A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression
27. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
28. Roles of Axin in the Wnt signalling pathway
29. Regulation of beta-catenin signaling in the Wnt pathway
30. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
31. -/- colon carcinoma
32. Human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin
33. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon
34. In situ hybridization of RNA
35. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
36. Beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation
37. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
38. The casein kinase I family in Wnt signaling
39. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
40. WNTs modulate cell fate and behavior during vertebrate development
41. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
42. The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo
43. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
44. Phosphorylation of the Drosophila adherens junction protein Armadillo: Roles for wingless signal and zeste-white 3 kinase
45. Casein kinase I transduces Wnt signals
46. Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3
47. Wnt signaling and cancer
48. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
49. Stabilization of beta-catenin by genetic defects in melanoma cell lines
50. Axin dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1 epsilon
51. Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription
52. Casein kinase I epsilon in the wnt pathway: Regulation of beta-catenin function
53. Control of beta-catenin stability: Reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts
54. Components of wingless signalling in Drosophila
55. Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP
56. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
57. Structure of GSK3beta reveals a primed phosphorylation mechanism
58. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
59. Signal transduction: Signaling specificity a complex affair
60. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
61. Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex
62. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro
63. Mechanisms of Wnt signaling in development
64. Judging a protein by more than its name: Gsk-3
65. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
66. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
67. The mouse fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation