Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Nature Chemical Biology

Volumn 6, Issue 11, 2010, Pages 829-836

  Thorne, Curtis A ^a   Hanson, Alison J ^a   Schneider, Judsen ^a   Tahinci, Emilios ^a   Orton, Darren ^a,b   Cselenyi, Christopher S ^a   Jernigan, Kristin K ^a   Meyers, Kelly C ^a   Hang, Brian I ^a   Waterson, Alex G ^a   Kim, Kwangho ^a   Melancon, Bruce ^a   Ghidu, Victor P ^a,f   Sulikowski, Gary A ^a   Lafleur, Bonnie ^c,e   Salic, Adrian ^d   Lee, Laura A ^a   Miller, David M ^a   Lee, Ethan ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b StemSynergy Therapeutics Inc   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF ARIZONA   (United States)

^f TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; CASEIN KINASE IALPHA; PYRVINIUM EMBONATE; WNT PROTEIN;

ALLOSTERISM; ARTICLE; CANCER CELL; CELL PROLIFERATION; COLON CANCER; COLON POLYPOSIS; DRUG EFFECT; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; IN VITRO STUDY; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN STABILITY; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

METAZOA; PYGOPUS; XENOPUS LAEVIS;

EID: 77958171338     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.453     Document Type: Article

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