Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation

Mechanisms of Development

Volumn 101, Issue 1-2, 2001, Pages 61-69

  Wu, Xiantuo ^a   Wu, Jian ^a   Huang, Jiapeng ^a   Powell, William C ^a   Zhang, JianFeng ^b   Matusik, Robert J ^b   Sangiorgi, Frank O ^a   Maxson, Robert E ^a   Sucov, Henry M ^a   Roy Burman, Pradip ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bacteriophage DNA recombinase; Prostate specific gene knockout; Prostatic epithelial specific gene targeting; R26R lacZ allele; RXR gene deletion; Transgenic mice

Indexed keywords

CRE RECOMBINASE; MESSENGER RNA; PROBASIN;

ALLELE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE EPITHELIUM; PROSTATE TUMOR; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINAL VESICLE; TRANSGENIC MOUSE;

ALLELES; ANIMALS; CROSSES, GENETIC; EPITHELIUM; FEMALE; GALACTOSIDES; IMMUNOHISTOCHEMISTRY; INDOLES; INTEGRASES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; OVARY; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROSTATE; PROSTATIC NEOPLASMS; RATS; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TESTIS; TIME FACTORS; TISSUE DISTRIBUTION; TRANSGENES; VIRAL PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 0035113825     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(00)00551-7     Document Type: Article

References (27)

1. Bacteriophage P1 site-specific recombination. Purification and properties of the Cre recombinase protein
2. Cre-mediated somatic site-specific recombination in mice
3. Altering the genome by homologous recombination
4. Targeted gene replacement
5. Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis
6. Death before birth: clues from gene knockouts and mutations
7. Molecular advances in prostate cancer
8. The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice
9. Prostate cancer in a transgenic mouse
10. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
11. Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse
12. Cancer of the prostate
13. Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer
14. RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable
15. Inducible gene targeting in mice
16. Multiplicity generates diversity in the retinoic acid signalling pathways
17. Function of retinoic acid receptor gamma in the mouse
18. Prostate specific expression of Cre recombinase in transgenic mice
19. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
20. Molecular genetics and epidemiology of prostate carcinoma
21. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos
22. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1
23. Generalized lacZ expression with the ROSA26 Cre reporter strain
24. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites
25. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
26. Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice
27. A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo